KEGG   PATHWAY: opi04020
Entry
opi04020                    Pathway                                
Name
Calcium signaling pathway - Ochotona princeps (American pika)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
opi04020  Calcium signaling pathway
opi04020

Other DBs
GO: 0019722
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101516023  ORAI2; protein orai-2 [KO:K16057]
101516106  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101516125  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101516165  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101516219  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101516221  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101516248  MST1; hepatocyte growth factor-like protein [KO:K23441]
101516289  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101516372  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101516431  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101516441  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
101516467  CALM3; calmodulin-3 [KO:K02183]
101516503  P2RX3; P2X purinoceptor 3 [KO:K05217]
101516509  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101516551  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101516626  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
101516653  SLC8A3; sodium/calcium exchanger 3 isoform X3 [KO:K05849]
101516704  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
101516733  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
101516767  [KO:K04636]
101517012  [KO:K04634]
101517271  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101517326  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101517429  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101517473  TACR2; substance-K receptor [KO:K04223]
101517477  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101517485  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101517594  C15H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
101517747  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101517824  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101517961  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101517963  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
101518087  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101518154  [KO:K15040]
101518174  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101518204  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101518418  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101518513  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
101518742  TPCN2; two pore calcium channel protein 2 [KO:K14077]
101518744  FGF9; fibroblast growth factor 9 [KO:K04358]
101518806  TACR1; substance-P receptor [KO:K04222]
101518840  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
101518851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101519117  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101519137  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101519171  CALML4; calmodulin-like protein 4 [KO:K02183]
101519227  FGF19; fibroblast growth factor 19 [KO:K22603]
101519353  FGF10; fibroblast growth factor 10 [KO:K04358]
101519430  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101519475  FGF4; fibroblast growth factor 4 [KO:K04358]
101519586  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101519593  [KO:K04515] [EC:2.7.11.17]
101519670  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101519686  ORAI3; protein orai-3 [KO:K16058]
101519725  FGF3; fibroblast growth factor 3 [KO:K04358]
101519796  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
101519832  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101519864  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101519888  [KO:K05096] [EC:2.7.10.1]
101519948  P2RX6; P2X purinoceptor 6 [KO:K05221]
101519958  TBXA2R; thromboxane A2 receptor [KO:K04264]
101520150  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101520175  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101520268  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101520285  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101520344  TRDN; triadin [KO:K23449]
101520360  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101520538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101520543  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101520586  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101520631  FGF7; fibroblast growth factor 7 [KO:K04358]
101520691  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101520695  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3 [KO:K04344]
101520829  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101521180  FGF22; fibroblast growth factor 22 [KO:K04358]
101521183  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101521291  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101521583  RYR1; ryanodine receptor 1 [KO:K04961]
101521700  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
101521753  MCOLN1; mucolipin-1 [KO:K04992]
101521854  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101521961  TNNC2; troponin C, skeletal muscle [KO:K12042]
101522068  FGF17; fibroblast growth factor 17 [KO:K04358]
101522075  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101522087  NOS1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
101522140  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101522237  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101522293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
101522397  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101522638  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101522887  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101522951  BDKRB1; B1 bradykinin receptor [KO:K03915]
101523058  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101523367  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101523439  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101523461  NTRK3; NT-3 growth factor receptor isoform X3 [KO:K05101] [EC:2.7.10.1]
101523520  [KO:K05863]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523627  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101523667  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101523894  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
101523935  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101523955  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101524021  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
101524264  SMIM6; small integral membrane protein 6 [KO:K26468]
101524349  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101524356  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
101524440  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
101524545  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101524610  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101524739  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101524859  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101525028  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101525038  HRH2; histamine H2 receptor [KO:K04150]
101525095  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
101525109  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101525119  [KO:K04345] [EC:2.7.11.11]
101525165  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
101525302  P2RX2; P2X purinoceptor 2 isoform X3 [KO:K05216]
101525502  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101525767  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101525805  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101525829  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101526017  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
101526033  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101526040  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101526074  [KO:K04632]
101526097  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101526211  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101526303  OXTR; oxytocin receptor [KO:K04229]
101526379  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
101526399  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101526482  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101526576  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
101526608  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101526641  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
101526659  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101526778  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101526925  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101526944  RYR2; ryanodine receptor 2 [KO:K04962]
101527290  NGF; beta-nerve growth factor [KO:K02582]
101527299  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
101527482  [KO:K04161]
101527552  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101527561  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101527578  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X4 [KO:K05083] [EC:2.7.10.1]
101527799  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101527899  F2R; proteinase-activated receptor 1 [KO:K03914]
101527912  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101528055  NTSR1; neurotensin receptor type 1 [KO:K04211]
101528115  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101528216  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11 [KO:K04515] [EC:2.7.11.17]
101528226  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101528299  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
101528351  FGF23; fibroblast growth factor 23 [KO:K22428]
101528375  STIM2; stromal interaction molecule 2 [KO:K18196]
101528482  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101528562  DRD1; D(1A) dopamine receptor [KO:K04144]
101528594  FGF6; fibroblast growth factor 6 [KO:K04358]
101528643  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
101528658  PTAFR; platelet-activating factor receptor [KO:K04279]
101528674  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101529015  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101529042  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101529054  CALML5; calmodulin-like protein 5 [KO:K02183]
101529100  CCKAR; cholecystokinin receptor type A [KO:K04194]
101529171  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101529226  TACR3; neuromedin-K receptor [KO:K04224]
101529232  TPCN1; two pore calcium channel protein 1 [KO:K16896]
101529238  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101529276  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
101529277  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101529298  CALML3; calmodulin-like protein 3 [KO:K02183]
101529308  PDGFC; platelet-derived growth factor C [KO:K05450]
101529337  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101529368  FGF1; fibroblast growth factor 1 [KO:K18496]
101529525  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101529531  BDKRB2; B2 bradykinin receptor [KO:K03916]
101529649  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
101530124  CASQ1; calsequestrin-1 [KO:K23468]
101530424  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101531222  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101531324  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X2 [KO:K05850] [EC:7.2.2.10]
101531656  SLN; sarcolipin [KO:K22642]
101531698  VEGFD; vascular endothelial growth factor D [KO:K05449]
101531711  AVPR1B; vasopressin V1b receptor [KO:K04227]
101531850  PLN; cardiac phospholamban [KO:K05852]
101531872  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101531941  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101532033  HRH1; histamine H1 receptor [KO:K04149]
101532036  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
101532074  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101532237  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101532282  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101532338  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101532426  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101532440  MCOLN2; LOW QUALITY PROTEIN: mucolipin-2 [KO:K04993]
101532462  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101532472  FGF16; fibroblast growth factor 16 [KO:K04358]
101532513  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101532855  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101532988  RYR3; ryanodine receptor 3 [KO:K04963]
101533044  P2RX4; P2X purinoceptor 4 [KO:K05218]
101533055  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101533103  FGF18; fibroblast growth factor 18 [KO:K04358]
101533232  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101533323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101533375  FGF21; fibroblast growth factor 21 [KO:K22429]
101533431  ADORA2A; adenosine receptor A2a [KO:K04266]
101533513  TFEB; transcription factor EB [KO:K15590]
101533536  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101533832  CCKBR; gastrin/cholecystokinin type B receptor isoform X2 [KO:K04195]
101533834  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
101533860  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101534050  AVPR1A; vasopressin V1a receptor [KO:K04226]
101534161  P2RX5; P2X purinoceptor 5 [KO:K05219]
101534210  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101534251  P2RX1; P2X purinoceptor 1 [KO:K05215]
101534415  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101534431  EDNRB; endothelin receptor type B [KO:K04198]
101534582  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101534591  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101534827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101534898  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101534902  P2RX7; P2X purinoceptor 7 [KO:K05220]
101534918  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101534950  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101535058  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101535059  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101535171  VEGFC; vascular endothelial growth factor C [KO:K05449]
101535274  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101535352  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101535394  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101535590  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101535653  FGF20; fibroblast growth factor 20 [KO:K04358]
101535660  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101535784  FGF5; fibroblast growth factor 5 [KO:K04358]
101535801  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101535807  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101535903  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
101535936  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101536063  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101536064  ADORA2B; adenosine receptor A2b [KO:K04267]
101536206  EGF; pro-epidermal growth factor [KO:K04357]
101536244  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101536351  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101536490  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
101536719  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101536780  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
105941730  MRLN; myoregulin [KO:K22643]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
opi04010  MAPK signaling pathway
opi04070  Phosphatidylinositol signaling system
opi04210  Apoptosis
opi04720  Long-term potentiation
opi04730  Long-term depression
KO pathway
ko04020   

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