KEGG   PATHWAY: opi04010
Entry
opi04010                    Pathway                                
Name
MAPK signaling pathway - Ochotona princeps (American pika)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
opi04010  MAPK signaling pathway
opi04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101516061  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101516125  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101516165  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101516203  CACNA2D1; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101516221  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101516225  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X2 [KO:K04414] [EC:2.7.11.1]
101516300  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101516340  RAP1A; ras-related protein Rap-1A [KO:K04353]
101516431  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101516463  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101516556  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101516664  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
101516702  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
101516800  [KO:K05866] [EC:3.1.3.48]
101516934  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
101517015  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101517130  [KO:K03283]
101517205  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101517271  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101517343  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101517442  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
101517451  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
101517483  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101517636  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101517735  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101517747  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101517768  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101517788  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101517817  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101517932  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
101517961  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101517963  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
101518054  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101518056  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101518298  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101518406  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101518457  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101518461  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101518744  FGF9; fibroblast growth factor 9 [KO:K04358]
101518825  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101518851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101518971  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519073  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101519137  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101519209  CRKL; crk-like protein [KO:K04438]
101519227  FGF19; fibroblast growth factor 19 [KO:K22603]
101519285  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101519353  FGF10; fibroblast growth factor 10 [KO:K04358]
101519459  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101519475  FGF4; fibroblast growth factor 4 [KO:K04358]
101519619  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101519655  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101519711  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101519725  FGF3; fibroblast growth factor 3 [KO:K04358]
101519826  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101519864  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101519866  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101519888  [KO:K05096] [EC:2.7.10.1]
101519949  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101520225  [KO:K03283]
101520285  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101520306  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101520350  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101520360  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101520474  [KO:K03283]
101520550  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101520631  FGF7; fibroblast growth factor 7 [KO:K04358]
101520695  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3 [KO:K04344]
101520715  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101520719  [KO:K07831]
101520785  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
101520805  STK3; serine/threonine-protein kinase 3 [KO:K04412]
101520882  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101520957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101520966  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101521025  AREG; amphiregulin [KO:K09782]
101521180  FGF22; fibroblast growth factor 22 [KO:K04358]
101521183  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101521291  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101521344  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101521555  ANGPT4; angiopoietin-4 [KO:K05467]
101521567  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101521577  STMN1; stathmin isoform X1 [KO:K04381]
101521598  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101521693  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101521899  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101521982  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101522068  FGF17; fibroblast growth factor 17 [KO:K04358]
101522140  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101522285  MYC; myc proto-oncogene protein [KO:K04377]
101522344  RRAS; ras-related protein R-Ras [KO:K07829]
101522594  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101522647  EFNA4; ephrin-A4 [KO:K05462]
101522711  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101522877  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101522886  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101522887  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101523058  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101523208  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101523244  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
101523375  EFNA1; ephrin-A1 [KO:K05462]
101523439  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101523491  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523567  RELB; transcription factor RelB isoform X1 [KO:K09253]
101523711  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101523790  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101523793  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101523800  NRTN; neurturin [KO:K25414]
101523852  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101523935  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101523955  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101523982  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101524033  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101524217  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101524248  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
101524263  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101524339  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101524421  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
101524453  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101524465  NRAS; GTPase NRas [KO:K07828]
101524512  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101524545  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101524571  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101524600  FLNA; filamin-A isoform X1 [KO:K04437]
101524610  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101524731  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101524767  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101524785  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101524869  MAX; protein max isoform X1 [KO:K04453]
101524927  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101525007  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
101525028  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101525099  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101525102  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101525119  [KO:K04345] [EC:2.7.11.11]
101525120  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101525427  [KO:K04371] [EC:2.7.11.24]
101525429  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101525471  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101525496  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
101525561  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101525684  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101525767  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101525794  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101525805  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101526004  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101526027  PSPN; persephin [KO:K25416]
101526067  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101526116  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101526188  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101526563  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101526929  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101527001  CRK; adapter molecule crk isoform X1 [KO:K04438]
101527097  NTF4; neurotrophin-4 [KO:K12457]
101527290  NGF; beta-nerve growth factor [KO:K02582]
101527484  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101527513  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101527518  [KO:K04392]
101527578  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X4 [KO:K05083] [EC:2.7.10.1]
101527710  PGF; placenta growth factor [KO:K16859]
101527835  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101528167  ARTN; artemin [KO:K25415]
101528200  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101528222  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101528245  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101528266  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
101528351  FGF23; fibroblast growth factor 23 [KO:K22428]
101528482  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101528594  FGF6; fibroblast growth factor 6 [KO:K04358]
101528696  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101528854  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101528866  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101528938  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101529015  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101529042  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101529213  IL1B; interleukin-1 beta [KO:K04519]
101529308  PDGFC; platelet-derived growth factor C [KO:K05450]
101529341  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101529368  FGF1; fibroblast growth factor 1 [KO:K18496]
101529472  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101529510  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
101529576  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
101529583  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101529734  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101529776  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101529871  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101529904  [KO:K13375]
101530066  RELA; transcription factor p65 [KO:K04735]
101530167  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101530308  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101530318  NTF3; neurotrophin-3 [KO:K04356]
101530319  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101530376  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101530378  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101530811  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101530838  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
101530885  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
101530887  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101531012  HSPB1; heat shock protein beta-1 [KO:K04455]
101531037  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101531270  SRF; serum response factor [KO:K04378]
101531416  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101531636  HRAS; GTPase HRas [KO:K02833]
101531640  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101531665  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101531698  VEGFD; vascular endothelial growth factor D [KO:K05449]
101531726  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101531872  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101531979  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101532068  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
101532074  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101532426  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101532470  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101532472  FGF16; fibroblast growth factor 16 [KO:K04358]
101532680  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
101532780  MRAS; ras-related protein M-Ras [KO:K07831]
101532855  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101532878  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101532940  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
101532941  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101533103  FGF18; fibroblast growth factor 18 [KO:K04358]
101533160  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101533171  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
101533181  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101533190  ARRB1; beta-arrestin-1 [KO:K04439]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101533374  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101533375  FGF21; fibroblast growth factor 21 [KO:K22429]
101533379  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101533522  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101533623  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101533713  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101533860  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101533865  [KO:K04526]
101533918  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101533949  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
101533974  KITLG; kit ligand isoform X1 [KO:K05461]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101534179  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101534210  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101534278  IGF2; insulin-like growth factor II [KO:K13769]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101534324  IL1A; interleukin-1 alpha [KO:K04383]
101534350  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101534479  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101534480  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101534538  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101534585  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101534591  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101534739  NF1; neurofibromin isoform X1 [KO:K08052]
101534751  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101534766  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101534779  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
101534812  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101534827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101534836  [KO:K04723]
101534863  RASA1; ras GTPase-activating protein 1 [KO:K04352]
101534918  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101534968  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101535058  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101535070  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101535171  VEGFC; vascular endothelial growth factor C [KO:K05449]
101535483  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101535486  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
101535581  [KO:K04393]
101535624  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101535653  FGF20; fibroblast growth factor 20 [KO:K04358]
101535660  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101535681  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101535784  FGF5; fibroblast growth factor 5 [KO:K04358]
101535874  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101535976  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101536045  EFNA2; ephrin-A2 [KO:K05462]
101536063  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101536073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101536206  EGF; pro-epidermal growth factor [KO:K04357]
101536244  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101536245  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
101536351  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101536625  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101536689  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
105942099  [KO:K04369] [EC:2.7.12.2]
118760816  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
opi04070  Phosphatidylinositol signaling system
opi04110  Cell cycle
opi04115  p53 signaling pathway
opi04210  Apoptosis
opi04310  Wnt signaling pathway
opi04668  TNF signaling pathway
KO pathway
ko04010   

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