KEGG   PATHWAY: aamp04510
Entry
aamp04510                   Pathway                                
Name
Focal adhesion - Arvicola amphibius (Eurasian water vole)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
aamp04510  Focal adhesion
aamp04510

Other DBs
GO: 0005925
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119807796  Col1a2; collagen alpha-2(I) chain [KO:K06236]
119811687  Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
119822685  Col2a1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
119804378  Col4a6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
119804832  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
119812350  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
119812512  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
119820835  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
119820836  Col4a3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
119808825  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
119809467  collagen alpha-4(VI) chain-like [KO:K06238]
119822631  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
119809703  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
119823034  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
119820261  Col6a3; collagen alpha-3(VI) chain [KO:K06238]
119814582  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
119823741  Col9a1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
119817443  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
119803917  Lama1; laminin subunit alpha-1 [KO:K05637]
119820891  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
119814499  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
119814925  Lama5; laminin subunit alpha-5 [KO:K06240]
119821243  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
119818873  Lamb1; laminin subunit beta-1 [KO:K05636]
119809168  Lamb2; laminin subunit beta-2 [KO:K06243]
119827216  Lamb3; laminin subunit beta-3 [KO:K06244]
119827740  Lamc1; laminin subunit gamma-1 [KO:K05635]
119827480  Lamc2; laminin subunit gamma-2 [KO:K06246]
119819149  Lamc3; laminin subunit gamma-3 [KO:K06247]
119811323  Chad; chondroadherin [KO:K06248]
119803793  Reln; reelin [KO:K06249] [EC:3.4.21.-]
119815510  Thbs1; thrombospondin-1 [KO:K16857]
119800800  Thbs3; thrombospondin-3 [KO:K04659]
119821374  Thbs2; thrombospondin-2 [KO:K04659]
119809736  Thbs4; thrombospondin-4 [KO:K04659]
119812455  cartilage oligomeric matrix protein [KO:K04659]
119820335  Fn1; fibronectin isoform X1 [KO:K05717]
119823299  Spp1; osteopontin [KO:K06250]
119813249  Vtn; vitronectin [KO:K06251]
119827810  Tnr; tenascin-R [KO:K06252]
119827975  Tnn; tenascin-N isoform X1 [KO:K06252]
119822456  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
119816998  Tnc; tenascin isoform X1 [KO:K06252]
119808130  Vwf; von Willebrand factor [KO:K03900]
119806454  bone sialoprotein 2 [KO:K06253]
119808745  Itga1; integrin alpha-1 [KO:K06480]
119809195  Itga2; integrin alpha-2 [KO:K06481]
119812773  Itga2b; integrin alpha-IIb [KO:K06476]
119812125  Itga3; integrin alpha-3 [KO:K06482]
119819439  Itga4; integrin alpha-4 [KO:K06483]
119822836  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
119819436  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
119803481  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
119816642  Itga8; integrin alpha-8 [KO:K06584]
119810059  Itga9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
119800727  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
119809398  Itga11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
119818595  Itgav; integrin alpha-V isoform X1 [KO:K06487]
119802025  Itgb1; integrin beta-1 [KO:K05719]
119813347  Itgb3; integrin beta-3 [KO:K06493]
119811868  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
119824871  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
119819234  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
119823057  Itgb7; integrin beta-7 [KO:K06590]
119819639  Itgb8; integrin beta-8 [KO:K06591]
119812235  Emp2; epithelial membrane protein 2 [KO:K26256]
119825753  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119823283  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
119810057  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
119826417  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119803277  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119801722  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
119819672  Pgf; placenta growth factor isoform X1 [KO:K16859]
119812191  Vegfc; vascular endothelial growth factor C [KO:K05449]
119805399  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
119803884  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
119807129  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119815474  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119802616  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119813736  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119824995  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119813056  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
119806540  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119811725  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
119807610  Emp1; epithelial membrane protein 1 [KO:K26255]
119814345  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119820528  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
119818951  Arhgap5; LOW QUALITY PROTEIN: rho GTPase-activating protein 5 [KO:K13709]
119807840  transforming protein RhoA-like isoform X1 [KO:K04513]
119810493  Rhoa; transforming protein RhoA [KO:K04513]
119814294  Diaph1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
119814203  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
119807701  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
119825182  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
119827633  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
119814192  Myl9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
119824345  Myl10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
119822975  myosin regulatory light chain 12B-like [KO:K12757]
119803848  Myl12b; myosin regulatory light chain 12B [KO:K12757]
119803849  myosin regulatory light polypeptide 9 [KO:K12757]
119811883  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
119801984  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
119804974  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
119825387  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
119807529  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119803249  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
119827265  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
119821031  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
119815079  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119817116  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
119802026  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
119824616  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119800725  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
119822667  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
119820241  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
119811081  Actg1; actin, cytoplasmic 2 [KO:K05692]
119825660  Actb; actin, cytoplasmic 1 [KO:K05692]
119810089  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
119799550  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
119818917  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
119820444  Actn4; alpha-actinin-4 [KO:K05699]
119809183  Tln2; talin-2 [KO:K06271]
119826299  Tln1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
119804645  Flna; filamin-A isoform X1 [KO:K04437]
119828131  Flnb; filamin-B isoform X1 [KO:K27392]
119824800  Pxn; paxillin isoform X1 [KO:K05760]
119824629  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
119808370  Zyx; zyxin [KO:K06273]
119821529  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
119799742  Vcl; vinculin isoform X1 [KO:K05700]
119823001  Parvg; gamma-parvin isoform X1 [KO:K06275]
119823458  Parvb; beta-parvin isoform X1 [KO:K06275]
119806842  Parva; alpha-parvin isoform X1 [KO:K06275]
119813044  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119808978  Ctnnb1; catenin beta-1 [KO:K02105]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119822917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119820784  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119823930  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119806133  Pten; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119800879  Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730]
119818632  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
119812605  Vav1; proto-oncogene vav [KO:K05730]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119822752  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119812100  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
119802636  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
119824822  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
119804765  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
119821511  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
119815102  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
119814664  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
119806427  cell division control protein 42 homolog [KO:K04393]
119816496  Cdc42; cell division control protein 42 homolog [KO:K04393]
119802091  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
119811835  Crk; adapter molecule crk isoform X1 [KO:K04438]
119824768  Crkl; crk-like protein [KO:K04438]
119814464  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
119818619  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
119800929  Rap1a; ras-related protein Rap-1A [KO:K04353]
119803252  Rap1b; ras-related protein Rap-1b [KO:K07836]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119816694  Jun; transcription factor AP-1 [KO:K04448]
119806667  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119807503  Cav1; caveolin-1 [KO:K06278]
119807487  Cav2; caveolin-2 [KO:K12958]
119808233  Cav3; caveolin-3 [KO:K12959]
119821217  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
119800744  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
119825434  Shc2; SHC-transforming protein 2 [KO:K17447]
119817129  Shc3; SHC-transforming protein 3 [KO:K17448]
119815646  Shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119804537  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119808297  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
119823258  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119809564  baculoviral IAP repeat-containing protein 3 [KO:K16060]
119809632  Birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
119804616  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119827718  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
aamp04010  MAPK signaling pathway
aamp04060  Cytokine-cytokine receptor interaction
aamp04070  Phosphatidylinositol signaling system
aamp04110  Cell cycle
aamp04151  PI3K-Akt signaling pathway
aamp04310  Wnt signaling pathway
aamp04512  ECM-receptor interaction
aamp04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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