KEGG   PATHWAY: aml05160
Entry
aml05160                    Pathway                                
Name
Hepatitis C - Ailuropoda melanoleuca (giant panda)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
aml05160  Hepatitis C
aml05160

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100473450  LDLR; low-density lipoprotein receptor isoform X2 [KO:K12473]
100484067  SCARB1; scavenger receptor class B member 1 isoform X5 [KO:K13885]
100466487  CD81; CD81 antigen [KO:K06508]
100479053  CLDN1; claudin-1 [KO:K06087]
100471002  CLDN22; LOW QUALITY PROTEIN: claudin-22 [KO:K06087]
100469354  CLDN18; claudin-18 [KO:K06087]
100483672  CLDN14; claudin-14 [KO:K06087]
100463924  CLDN8; claudin-8 [KO:K06087]
100476175  CLDN19; claudin-19 [KO:K06087]
100464924  CLDN17; claudin-17 [KO:K06087]
100467658  CLDN10; claudin-10 isoform X2 [KO:K06087]
100474715  CLDN11; claudin-11 [KO:K06087]
100483466  CLDN20; claudin-20 [KO:K06087]
100470443  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
100467921  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
100464589  CLDN2; claudin-2 [KO:K06087]
100475930  CLDN9; claudin-9 [KO:K06087]
100481018  CLDN7; claudin-7 [KO:K06087]
100468457  CLDN15; claudin-15 isoform X1 [KO:K06087]
100467755  CLDN3; claudin-3 [KO:K06087]
100468008  CLDN4; claudin-4 [KO:K06087]
100469200  CLDN25; putative claudin-25 [KO:K06087]
100476182  LOW QUALITY PROTEIN: claudin-6 [KO:K06087]
105238534  CLDN23; claudin-23 [KO:K06087]
109488387  putative claudin-24 [KO:K06087]
100472108  CLDN12; claudin-12 [KO:K06087]
117804192  CLDN6; LOW QUALITY PROTEIN: claudin-6 [KO:K06087]
100464895  OCLN; occludin [KO:K06088]
100469118  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
100468112  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
100469368  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
100469504  RNASEL; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165]
100469453  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
100482674  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100466406  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100484104  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100465112  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100471184  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100474086  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
100476812  interferon alpha-2 [KO:K05414]
100477312  interferon alpha-1/2 [KO:K05414]
100477562  LOW QUALITY PROTEIN: interferon alpha-1/2 [KO:K05414]
100478321  interferon alpha-1/2 [KO:K05414]
100478068  interferon alpha-like [KO:K05414]
100476556  IFNB1; interferon beta [KO:K05415]
100462659  IFNG; interferon gamma precursor [KO:K04687]
100468855  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
100463778  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100483216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100469872  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100471563  TNF; tumor necrosis factor [KO:K03156]
100469693  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100477599  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
100469151  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100479743  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100475038  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
100475782  LOW QUALITY PROTEIN: interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
109488883  interferon-induced protein with tetratricopeptide repeats 1B isoform X1 [KO:K14217]
100464574  EIF3E; eukaryotic translation initiation factor 3 subunit E isoform X1 [KO:K03250]
100470706  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100469938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100475555  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100481921  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100482679  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
100473460  JAK1; tyrosine-protein kinase JAK1 isoform X2 [KO:K11217] [EC:2.7.10.2]
100468422  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100474026  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100472167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100475480  IRF9; interferon regulatory factor 9 [KO:K04693]
100477088  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
100477345  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
100463920  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
100482129  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100482604  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100480910  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X10 [KO:K04354]
100469264  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100478681  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7 [KO:K04354]
100481821  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100464293  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
100473021  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100476969  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
100467733  pro-epidermal growth factor isoform X1 [KO:K04357]
100468916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100474396  SOS2; son of sevenless homolog 2 isoform X9 [KO:K03099]
100482526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100464196  NRAS; GTPase NRas [KO:K07828]
100469346  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100475955  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100484483  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100466234  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100483021  YWHAQ; 14-3-3 protein theta [KO:K16197]
100484851  YWHAE; 14-3-3 protein epsilon isoform X2 [KO:K06630]
100464004  YWHAG; 14-3-3 protein gamma [KO:K16198]
100467650  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100477834  CTNNB1; catenin beta-1 [KO:K02105]
100473937  BAD; bcl2-associated agonist of cell death [KO:K02158]
100484923  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100468314  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100481236  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100476389  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100477714  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
117795744  E2F1; transcription factor E2F1 [KO:K17454]
100475779  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100484544  E2F3; transcription factor E2F3 [KO:K06620]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100483589  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100468235  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100474872  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X4 [KO:K04724]
100465439  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100472241  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100472074  cytochrome c [KO:K08738]
105241648  cytochrome c-like [KO:K08738]
100464163  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100483760  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100473794  PSME3; proteasome activator complex subunit 3 [KO:K06698]
117803475  proteasome activator complex subunit 3-like [KO:K06698]
100479839  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
100474723  PPARA; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
100474551  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
100469787  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
aml03320  PPAR signaling pathway
aml04010  MAPK signaling pathway
aml04144  Endocytosis
aml04210  Apoptosis
aml04514  Cell adhesion molecules
aml04620  Toll-like receptor signaling pathway
aml04622  RIG-I-like receptor signaling pathway
aml04630  JAK-STAT signaling pathway
aml04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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