KEGG   PATHWAY: aml04010
Entry
aml04010                    Pathway                                
Name
MAPK signaling pathway - Ailuropoda melanoleuca (giant panda)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
aml04010  MAPK signaling pathway
aml04010

Other DBs
GO: 0000165
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100473951  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100466608  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100479715  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
100467700  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100466242  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
100468661  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100464603  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100464578  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
100484838  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100472835  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100463812  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5 [KO:K04858]
100480599  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
100483814  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
100480223  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100469411  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
100476165  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
100479948  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X2 [KO:K04864]
100464104  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
100481020  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100467299  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
100477000  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
100480767  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100476315  CACNG5; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
100465788  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
100465284  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X3 [KO:K04872]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100477326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100478007  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100484719  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100465369  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
100477221  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100477225  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
100477289  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100467653  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474970  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100467683  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100479998  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100473097  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
100483012  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105236463  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
100484622  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100471293  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
100484273  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X11 [KO:K08018]
100482656  NF1; neurofibromin [KO:K08052]
100465811  RASA1; ras GTPase-activating protein 1 [KO:K04352]
105240212  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100471801  RAP1A; ras-related protein Rap-1A [KO:K04353]
100480240  RAP1B; ras-related protein Rap-1b [KO:K07836]
100467733  pro-epidermal growth factor isoform X1 [KO:K04357]
100467724  TGFA; protransforming growth factor alpha isoform X3 [KO:K08774]
100464489  EREG; proepiregulin [KO:K09784]
100466983  AREG; amphiregulin [KO:K09782]
100463878  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100479986  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
100482817  FGF8; fibroblast growth factor 8 [KO:K04358]
100474108  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100468641  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100467527  FGF20; fibroblast growth factor 20 [KO:K04358]
100479573  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
100464088  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100470803  fibroblast growth factor 3 [KO:K04358]
100471023  FGF6; fibroblast growth factor 6 [KO:K04358]
100473739  FGF9; fibroblast growth factor 9 [KO:K04358]
100466947  FGF16; fibroblast growth factor 16 [KO:K04358]
100475745  FGF10; fibroblast growth factor 10 [KO:K04358]
100481939  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
100470300  FGF19; fibroblast growth factor 19 [KO:K22603]
100478145  FGF21; fibroblast growth factor 21 [KO:K22429]
100472512  FGF23; fibroblast growth factor 23 [KO:K22428]
100469695  NGF; beta-nerve growth factor [KO:K02582]
100467162  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
100474326  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
100475465  NTF4; neurotrophin-4 [KO:K12457]
100483432  INS; insulin isoform X2 [KO:K04526]
100473254  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
100483184  insulin-like growth factor II isoform X1 [KO:K13769]
100473486  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100475543  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100479872  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100481171  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100467411  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
100469856  KITLG; kit ligand isoform X1 [KO:K05461]
100482983  VEGFA; vascular endothelial growth factor A [KO:K05448]
100465735  VEGFB; vascular endothelial growth factor B [KO:K16858]
100480980  PGF; placenta growth factor isoform X1 [KO:K16859]
100482213  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100483046  VEGFC; vascular endothelial growth factor C [KO:K05449]
100463560  HGF; hepatocyte growth factor isoform X5 [KO:K05460]
100464955  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100467094  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
100474067  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100465489  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100468004  EFNA1; ephrin-A1 [KO:K05462]
100468257  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105238992  EFNA4; ephrin-A4 [KO:K05462]
100469029  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
117802078  NRTN; neurturin [KO:K25414]
105241359  PSPN; persephin [KO:K25416]
100480029  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100468735  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100470612  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100472630  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100468267  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100481826  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100477678  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100478241  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100477127  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
100473956  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100471374  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100464991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100472005  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100472252  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
100465243  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100483963  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100483462  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100478767  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
100484938  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100480742  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
100474998  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100481757  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
100467317  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100468916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100474396  SOS2; son of sevenless homolog 2 isoform X9 [KO:K03099]
100482526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100464196  NRAS; GTPase NRas [KO:K07828]
100467568  RRAS; ras-related protein R-Ras [KO:K07829]
105235280  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100470119  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100475955  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100469346  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100478518  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100463933  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
100470572  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X7 [KO:K04373] [EC:2.7.11.1]
100474764  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100483843  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100464040  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100476284  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100481494  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100471598  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
100484237  SRF; serum response factor isoform X1 [KO:K04378]
100474867  FOS; proto-oncogene c-Fos [KO:K04379]
100476507  MAPT; microtubule-associated protein tau [KO:K04380]
100481903  STMN1; stathmin [KO:K04381]
100470490  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
100482619  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100469987  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100470240  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
100470998  cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
100471563  TNF; tumor necrosis factor [KO:K03156]
100481122  IL1A; interleukin-1 alpha [KO:K04383]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100470703  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
100463584  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100475861  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100472991  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100472192  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
100475698  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
100482939  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100468235  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100467208  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100469737  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100468971  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100465076  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100483589  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100484332  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
100479307  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100484977  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100469127  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100483216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100477654  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100482871  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100470600  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100484077  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
100468085  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100475441  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
100484030  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100470229  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
100470792  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
100472811  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100475388  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100466725  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100464802  STK3; serine/threonine-protein kinase 3 [KO:K04412]
100484678  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
100480593  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100466442  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100480913  MAP3K11; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
100475426  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
100475740  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
100472044  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
100473197  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
100475390  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
100469942  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X4 [KO:K04423] [EC:2.7.11.25]
100467807  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
100479844  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
100479214  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
100475304  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100466506  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100465667  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
100464412  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
100476844  TAOK2; serine/threonine-protein kinase TAO2 isoform X4 [KO:K04429] [EC:2.7.11.1]
100483907  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
100475919  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100475975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100476678  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100469111  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100473891  MAPK8IP1; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
100476457  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100467835  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
100467791  FLNA; filamin-A isoform X1 [KO:K04437]
100466609  CRKL; crk-like protein [KO:K04438]
100467322  CRK; adapter molecule crk isoform X1 [KO:K04438]
100478601  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
100470249  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100465223  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100465476  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100480235  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100480483  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100482977  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
100483931  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100484361  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
100482684  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105236474  RPS6KA4; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
100483177  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100470861  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100477832  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100476526  JUND; transcription factor jun-D [KO:K04449]
100474135  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100479063  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100468226  MAX; protein max isoform X2 [KO:K04453]
100464632  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
100464257  HSPB1; heat shock protein beta-1 [KO:K04455]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100472235  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
100474182  PTPRR; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
100473902  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X2 [KO:K18018] [EC:3.1.3.48]
100470829  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
100483084  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100474524  DUSP5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100468072  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100464243  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100479162  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100470219  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105240775  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100466694  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100478523  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100478038  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100466735  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100472775  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100467132  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100468647  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100483310  heat shock 70 kDa protein 1-like [KO:K03283]
100483558  heat shock 70 kDa protein 1 [KO:K03283]
100469467  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
117800506  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
100482997  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
100468286  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
100470193  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
100481851  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100472260  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100469296  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100474781  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100477158  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
aml04070  Phosphatidylinositol signaling system
aml04110  Cell cycle
aml04115  p53 signaling pathway
aml04210  Apoptosis
aml04310  Wnt signaling pathway
aml04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system