KEGG   PATHWAY: cge05165
Entry
cge05165                    Pathway                                
Name
Human papillomavirus infection - Cricetulus griseus (Chinese hamster)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
cge05165  Human papillomavirus infection
cge05165

Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100766046  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
100761413  Wnt2b; protein Wnt-2b [KO:K00182]
100752722  Wnt2; protein Wnt-2 [KO:K00182]
100764164  Wnt3a; protein Wnt-3a isoform X2 [KO:K00312]
100774849  proto-oncogene Wnt-3 isoform X2 [KO:K00312]
100769003  Wnt4; protein Wnt-4 isoform X3 [KO:K00408]
100753089  Wnt5a; protein Wnt-5a [KO:K00444]
100753017  Wnt5b; protein Wnt-5b isoform X2 [KO:K00444]
100751289  Wnt6; protein Wnt-6 isoform X2 [KO:K00445]
100772978  Wnt7a; protein Wnt-7a isoform X2 [KO:K00572]
100755799  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
100775075  Wnt8b; protein Wnt-8b [KO:K00714]
100752907  Wnt8a; protein Wnt-8a isoform X2 [KO:K00714]
100766088  Wnt9b; protein Wnt-9b isoform X2 [KO:K01064]
100764466  Wnt9a; protein Wnt-9a isoform X2 [KO:K01064]
100770174  Wnt10a; protein Wnt-10a [KO:K01357]
100766340  Wnt10b; protein Wnt-10b [KO:K01357]
100774690  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
100764115  Wnt16; protein Wnt-16 [KO:K01558]
100766658  Fzd7; frizzled-7 isoform X2 [KO:K02432]
100770917  Fzd1; frizzled-1 isoform X2 [KO:K02432]
100763109  Fzd2; frizzled-2 isoform X2 [KO:K02235]
100751712  Fzd3; frizzled-3 isoform X1 [KO:K02329]
100756296  Fzd4; frizzled-4 [KO:K02354]
100762351  Fzd5; frizzled-5 isoform X2 [KO:K02375]
113834637  frizzled-8 [KO:K02375]
100774509  Fzd6; frizzled-6 isoform X2 [KO:K02376]
100755785  Fzd10; frizzled-10 isoform X2 [KO:K02842]
100761155  Fzd9; frizzled-9 isoform X2 [KO:K02842]
100770288  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X4 [KO:K02353]
100762587  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X2 [KO:K02353]
100773535  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
100760865  Gsk3b; glycogen synthase kinase-3 beta isoform X7 [KO:K03083] [EC:2.7.11.26]
100758169  Axin1; axin-1 isoform X1 [KO:K02157]
100750382  Axin2; axin-2 [KO:K04385]
100750563  Apc; adenomatous polyposis coli protein isoform X2 [KO:K02085]
100767273  Apc2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
100773307  Ctnnb1; catenin beta-1 [KO:K02105]
100758298  Csnk1a1; casein kinase I isoform X6 [KO:K08957] [EC:2.7.11.1]
100774541  Tert; telomerase reverse transcriptase isoform X4 [KO:K11126] [EC:2.7.7.49]
100757390  Tcf7; transcription factor 7 isoform X2 [KO:K02620]
100753225  Tcf7l1; transcription factor 7-like 1 isoform X2 [KO:K04490]
100758400  Tcf7l2; transcription factor 7-like 2 isoform X33 [KO:K04491]
100772382  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
100750454  Tlr3; toll-like receptor 3 [KO:K05401]
100769672  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
100756323  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100761646  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X11 [KO:K07211] [EC:2.7.11.10]
100770091  serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]
100765676  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103160615  Ifnb1; interferon beta [KO:K05415]
100762260  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100770451  histone lysine acetyltransferase CREBBP isoform X3 [KO:K04498] [EC:2.3.1.48]
100755727  Tada3; transcriptional adapter 3 [KO:K11315]
100682525  Tp53; cellular tumor antigen p53 [KO:K04451]
100768378  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100764294  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100765823  Pard3; partitioning defective 3 homolog isoform X20 [KO:K04237]
100763804  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100761364  Pard6b; partitioning defective 6 homolog beta isoform X2 [KO:K06093]
100765819  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100756860  protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
100765433  Cdc42; cell division control protein 42 homolog [KO:K04393]
100758586  Scrib; protein scribble homolog isoform X7 [KO:K16175]
100774630  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
107977363  disks large homolog 2 isoform X2 [KO:K12075]
100770281  Dlg3; disks large homolog 3 isoform X5 [KO:K21098]
100755620  Llgl2; LLGL scribble cell polarity complex component 2 [KO:K06094]
100755918  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X2 [KO:K06094]
100762804  Crb3; protein crumbs homolog 3 [KO:K06090]
100755532  Patj; inaD-like protein isoform X3 [KO:K06092]
100762203  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100750531  Vwf; von Willebrand factor [KO:K03900]
100760878  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
100756924  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
100766091  Comp; cartilage oligomeric matrix protein isoform X2 [KO:K04659]
100752022  Thbs2; thrombospondin-2 [KO:K04659]
100762358  Thbs4; thrombospondin-4 isoform X2 [KO:K04659]
100751189  Fn1; fibronectin isoform X1 [KO:K05717]
100759814  Col1a1; collagen alpha-1(I) chain [KO:K06236]
100766269  Col1a2; collagen alpha-2(I) chain isoform X2 [KO:K06236]
100755037  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
107976999  Col4a2; collagen alpha-2(IV) chain isoform X2 [KO:K06237]
100757740  Col4a1; collagen alpha-1(IV) chain isoform X4 [KO:K06237]
103158667  Col4a3; collagen alpha-3(IV) chain isoform X2 [KO:K06237]
100772869  collagen alpha-6(IV) chain isoform X3 [KO:K06237]
100772575  collagen alpha-5(IV) chain isoform X2 [KO:K06237]
100756006  collagen alpha-4(IV) chain isoform X2 [KO:K06237]
100770126  Col6a5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
100754390  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100755078  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
100769833  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
100770413  collagen alpha-4(VI) chain isoform X2 [KO:K06238]
103164567  collagen alpha-3(VI) chain isoform X2 [KO:K06238]
100755811  Col9a1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
100753027  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
100757317  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
100771923  laminin subunit alpha-2 isoform X3 [KO:K05637]
100765555  Lama1; laminin subunit alpha-1 isoform X2 [KO:K05637]
100755004  Lama3; laminin subunit alpha-3 isoform X3 [KO:K06240]
100755091  Lama5; laminin subunit alpha-5 [KO:K06240]
100757321  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100757343  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
100762566  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
100763082  Lamb3; laminin subunit beta-3 [KO:K06244]
100761564  Lamc1; laminin subunit gamma-1 isoform X2 [KO:K05635]
100765048  Lamc2; laminin subunit gamma-2 isoform X2 [KO:K06246]
100751974  Lamc3; laminin subunit gamma-3 isoform X2 [KO:K06247]
100758456  Chad; chondroadherin [KO:K06248]
100758172  Reln; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
100769547  Spp1; osteopontin isoform X2 [KO:K06250]
100767624  Vtn; vitronectin [KO:K06251]
100767397  tenascin-X isoform X2 [KO:K06252]
100754133  Tnc; tenascin isoform X1 [KO:K06252]
100753104  Tnn; tenascin-N [KO:K06252]
100753701  Tnr; tenascin-R isoform X1 [KO:K06252]
100752803  Ibsp; bone sialoprotein 2 isoform X2 [KO:K06253]
100750393  Itga1; integrin alpha-1 [KO:K06480]
100774579  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
100762814  Itga2b; integrin alpha-IIb isoform X2 [KO:K06476]
100758471  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
100762323  Itga4; integrin alpha-4 [KO:K06483]
100768174  Itga5; integrin alpha-5 isoform X2 [KO:K06484]
100769534  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
100773038  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
100769007  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
100754465  Itga9; integrin alpha-9 isoform X2 [KO:K06585]
100754198  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
100761554  Itga11; integrin alpha-11 [KO:K06587]
100752313  Itgav; integrin alpha-V isoform X2 [KO:K06487]
100763033  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100775048  Itgb3; integrin beta-3 isoform X2 [KO:K06493]
100756849  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
100765378  Itgb5; integrin beta-5 isoform X3 [KO:K06588]
100768511  Itgb6; integrin beta-6 [KO:K06589]
100770075  Itgb7; integrin beta-7 [KO:K06590]
100769713  Itgb8; integrin beta-8 [KO:K06591]
100759464  Ptk2; focal adhesion kinase 1 isoform X5 [KO:K05725] [EC:2.7.10.2]
100760740  Pxn; paxillin isoform X1 [KO:K05760]
100764780  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
100765017  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
100758679  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100773293  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100762537  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100774599  Fadd; FAS-associated death domain protein isoform X1 [KO:K02373]
100689369  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100689061  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100689081  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100757400  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
103164195  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
118237628  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382] [EC:3.1.3.16]
100771272  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
100773447  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
100750924  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
100758873  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100774343  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5 [KO:K04354]
100763205  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
100752573  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100760513  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113837435  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta-like isoform X1 [KO:K11583]
100759774  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like [KO:K11583]
100764403  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X4 [KO:K11584]
100769874  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100758888  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100762509  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100754775  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7 [KO:K11584]
100753076  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
100767621  Tsc1; hamartin isoform X1 [KO:K07206]
100755849  Tsc2; tuberin isoform X1 [KO:K07207]
100768233  Rheb; GTP-binding protein Rheb isoform X2 [KO:K07208]
100755421  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100769654  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100757513  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100760227  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100689368  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
100760426  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100764374  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100768647  Foxo1; forkhead box protein O1 isoform X2 [KO:K07201]
100689401  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103160601  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100689063  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100771544  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100766025  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100760122  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100764515  Cdk6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100760464  Ccne2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100753358  Ccne1; G1/S-specific cyclin-E1 isoform X2 [KO:K06626]
100689039  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100752928  Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X2 [KO:K06618]
100755818  Rbl1; retinoblastoma-like protein 1 isoform X2 [KO:K04681]
100770221  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100770051  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
100758556  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 isoform X2 [KO:K17454]
100759649  Ccna2; cyclin-A2 isoform X2 [KO:K06627]
100769969  Ccna1; cyclin-A1 isoform X2 [KO:K06627]
100754226  serine-protein kinase ATM isoform X6 [KO:K04728] [EC:2.7.11.1]
100766256  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100755957  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A isoform X2 [KO:K05448]
100754432  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5 [KO:K04467] [EC:2.7.11.10]
100750488  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100759762  Ikbkg; NF-kappa-B essential modulator isoform X6 [KO:K07210]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100770120  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
100759843  Nfx1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
100764557  Hdac2; histone deacetylase 2 isoform X2 [KO:K06067] [EC:3.5.1.98]
100752721  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
100761556  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
100754178  Chd4; chromodomain-helicase-DNA-binding protein 4 isoform X2 [KO:K11643] [EC:5.6.2.-]
100756092  Irf1; interferon regulatory factor 1 isoform X2 [KO:K09444]
100751579  Tbp; TATA-box-binding protein isoform X1 [KO:K03120]
100768754  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
100689010  MHC class I antigen Hm1-C2 precursor [KO:K06751]
100689011  MHC class I antigen Hm1-C3 precursor [KO:K06751]
103162117  H-2 class I histocompatibility antigen, K-D alpha chain [KO:K06751]
100751667  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100771128  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X2 [KO:K06751]
100751953  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
113832472  class I histocompatibility antigen, Gogo-A*0101 alpha chain-like [KO:K06751]
113832473  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
100772658  HLA class I histocompatibility antigen, alpha chain F [KO:K06751]
100772949  saoe class I histocompatibility antigen, A alpha chain isoform X2 [KO:K06751]
100757234  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
100757524  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X2 [KO:K06751]
100758961  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100758095  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
100753528  RT1 class I histocompatibility antigen, AA alpha chain isoform X2 [KO:K06751]
100762763  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
100762478  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
100757615  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
100759246  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
100751378  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
100689009  MHC class I antigen Hm1-C4 precursor [KO:K06751]
100689008  MHC class I antigen Hm1-C5 isoform X1 [KO:K06751]
103158895  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
100761901  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
113831254  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X4 [KO:K06751]
100773242  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
118237718  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
100770274  Bcap31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
100765300  B-cell receptor-associated protein 31-like [KO:K14009]
100768315  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100774665  Atp6v1b2; V-type proton ATPase subunit B, brain isoform isoform X2 [KO:K02147]
100756094  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100763093  Atp6v1c2; V-type proton ATPase subunit C 2 [KO:K02148]
100773930  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
100762500  Atp6v1d; V-type proton ATPase subunit D isoform X1 [KO:K02149]
100765179  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
100755187  Atp6v1e1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
100752884  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
118239696  V-type proton ATPase subunit F-like [KO:K02151]
100774299  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
100765359  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
100763970  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
100754134  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100769769  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
100755303  Tcirg1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
100766909  Atp6v0a2; V-type proton ATPase 116 kDa subunit a2 isoform X3 [KO:K02154]
100756648  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X4 [KO:K02154]
100758035  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X3 [KO:K02146]
100762360  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
100769759  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
100772184  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100754687  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100760638  Atp6ap1; V-type proton ATPase subunit S1 isoform X2 [KO:K03662]
100763146  Egf; pro-epidermal growth factor isoform X2 [KO:K04357]
100774580  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100769627  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100757521  Sos1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100769325  Sos2; son of sevenless homolog 2 isoform X3 [KO:K03099]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100751220  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100769862  Ptger4; prostaglandin E2 receptor EP4 subtype isoform X2 [KO:K04261]
100689067  Gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
103158534  neuroendocrine secretory protein 55 [KO:K04632]
100768997  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100767097  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100689032  Bax; apoptosis regulator BAX [KO:K02159]
100761582  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100762192  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
100771872  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100766300  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100774488  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100772940  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100764159  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100764402  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X2 [KO:K10691] [EC:2.3.2.27]
100751452  LOW QUALITY PROTEIN: tubulin gamma-2 chain isoform X2 [KO:K10389]
100759432  Tubg1; tubulin gamma-1 chain [KO:K10389]
100751347  Pkm; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
100774420  LOW QUALITY PROTEIN: pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
100760028  interferon alpha-12 [KO:K05414]
100760616  interferon alpha-9 isoform X2 [KO:K05414]
100760323  interferon alpha-12 [KO:K05414]
100762064  interferon alpha-12 [KO:K05414]
100762655  interferon alpha-9 [KO:K05414]
100763520  interferon alpha-3 [KO:K05414]
100765269  interferon alpha-9 [KO:K05414]
100765849  interferon alpha-12 [KO:K05414]
100766144  interferon alpha-12 [KO:K05414]
100766726  interferon alpha-12 [KO:K05414]
100759741  interferon alpha-12 [KO:K05414]
100750635  interferon alpha-12 [KO:K05414]
100750928  interferon alpha-2-like [KO:K05414]
100751221  interferon alpha-12 [KO:K05414]
100769352  interferon alpha-12 [KO:K05414]
100769640  interferon alpha-9 [KO:K05414]
100768581  Ifnar1; interferon alpha/beta receptor 1 isoform X2 [KO:K05130]
100768006  interferon alpha/beta receptor 2 isoform X4 [KO:K05131]
100754824  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100760469  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100755609  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
100764772  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100760392  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100757909  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100750489  Oasl; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
100774966  2'-5'-oligoadenylate synthase-like protein 2 isoform X1 [KO:K14608]
100762031  interferon-induced GTP-binding protein Mx2 [KO:K14754]
100764653  interferon-induced GTP-binding protein Mx1-like isoform X2 [KO:K14754]
100772582  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
100750525  Jag1; protein jagged-1 isoform X3 [KO:K06052]
100761880  Notch1; neurogenic locus notch homolog protein 1 isoform X2 [KO:K02599]
100771788  Notch2; neurogenic locus notch homolog protein 2 isoform X2 [KO:K20994]
100753340  Notch3; neurogenic locus notch homolog protein 3 isoform X3 [KO:K20995]
100765940  Notch4; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 isoform X2 [KO:K20996]
100770550  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
100762397  Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
100762875  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
100771257  Rfng; LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X2 [KO:K05948] [EC:2.4.1.222]
100767462  Maml3; mastermind-like protein 3 isoform X2 [KO:K06061]
100762611  Maml2; LOW QUALITY PROTEIN: mastermind-like protein 2 [KO:K06061]
100768930  LOW QUALITY PROTEIN: mastermind-like protein 1 isoform X3 [KO:K06061]
100774626  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
100759718  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100752756  Hes1; transcription factor HES-1 isoform X2 [KO:K06054]
100756407  Hes2; transcription factor HES-2 [KO:K09087]
100772285  Hes6; transcription cofactor HES-6 isoform X2 [KO:K09087]
113836790  LOW QUALITY PROTEIN: transcription factor HES-7-like [KO:K09087]
100754865  Hes3; transcription factor HES-3 [KO:K09088]
113833739  transcription factor HES-5 [KO:K06055]
100752534  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X3 [KO:K09091]
100771786  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
100755611  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Moody CA, Laimins LA
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
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Chen J
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
PMID:26008697
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Reference
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Public Health Genomics 12:268-80 (2009)
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Reference
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Human papillomavirus proteins as prospective therapeutic targets.
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Microb Pathog 58:55-65 (2013)
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Reference
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
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The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
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McCance DJ
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Reference
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Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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Subbaiah VK, Kranjec C, Thomas M, Banks L
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Reference
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
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Human papillomaviruses, cervical cancer and cell polarity.
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Reference
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Reference
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Reference
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Papillomavirus E5: the smallest oncoprotein with many functions.
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Reference
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Reference
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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Reference
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The E5 proteins.
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Reference
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Reference
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Control of interferon signaling in human papillomavirus infection.
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Reference
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
cge04064  NF-kappa B signaling pathway
cge04110  Cell cycle
cge04115  p53 signaling pathway
cge04150  mTOR signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04210  Apoptosis
cge04310  Wnt signaling pathway
cge04330  Notch signaling pathway
cge04510  Focal adhesion
cge04520  Adherens junction
cge04530  Tight junction
cge04612  Antigen processing and presentation
cge04620  Toll-like receptor signaling pathway
cge04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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