KEGG   PATHWAY: clum04218
Entry
clum04218                   Pathway                                
Name
Cellular senescence - Cyclopterus lumpus (lumpfish)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
clum04218  Cellular senescence
clum04218

Other DBs
GO: 0090398
Organism
Cyclopterus lumpus (lumpfish) [GN:clum]
Gene
117741227  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
117737528  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117728311  tgfb2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [KO:K13376]
117727370  transforming growth factor beta-3 proprotein-like [KO:K13377]
117751643  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
117749425  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117738694  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117750481  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117728169  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117736183  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117728634  mothers against decapentaplegic homolog 3 [KO:K23605]
117731879  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
117731737  cdkn2a/b; cyclin-dependent kinase inhibitor 2A [KO:K04685]
117730594  cdk4; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117738587  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
117735189  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
117727345  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117732710  G1/S-specific cyclin-D1-like [KO:K04503]
117732096  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
117726348  ccnd2b; G1/S-specific cyclin-D2b isoform X1 [KO:K10151]
117734722  ccndx; cyclin Dx [KO:K10151]
117730674  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
117742541  rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
117730559  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
117751419  retinoblastoma-like protein 2 [KO:K04681]
117732247  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
117733420  e2f1; transcription factor E2F1 [KO:K17454]
117725138  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
117745283  transcription factor E2F3-like isoform X1 [KO:K06620]
117739532  e2f3; transcription factor E2F3 [KO:K06620]
117748463  transcription factor E2F4-like [KO:K04682]
117732532  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
117745948  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
117732996  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117729144  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117746514  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117741125  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117747650  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
117736025  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
117740185  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117746515  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117729683  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117729698  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
117746960  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117742401  forkhead box protein O1-A-like [KO:K07201]
117741081  foxo1a; forkhead box protein O1-A [KO:K07201]
117727187  foxo3b; forkhead box protein O3B [KO:K09408]
117739399  foxo6b; forkhead box protein O6b [KO:K09408]
117751106  foxo3a; forkhead box protein O3a [KO:K09408]
117731143  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
117725992  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
117731176  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
117748979  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
117745136  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
117739024  G1/S-specific cyclin-E2-like [KO:K06626]
117738769  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117738770  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117738771  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
117738772  major histocompatibility complex class I-related gene protein-like [KO:K06751]
117738775  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117738776  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
117738777  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117739333  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117739375  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
117731941  kras; GTPase KRas isoform X1 [KO:K07827]
117735017  zgc:55558; GTPase HRas [KO:K07827]
117725949  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
117734871  rras; ras-related protein R-Ras [KO:K07830]
117750221  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
117732119  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117742397  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117743684  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117732835  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117751396  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117741120  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117736924  tsc1a; TSC complex subunit 1a [KO:K07206]
117740320  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
117729575  tsc2; tuberin isoform X1 [KO:K07207]
117731173  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
117747098  rheb; GTP-binding protein Rheb [KO:K07208]
117733186  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117748371  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117743829  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117744020  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
117742791  ccna1; cyclin-A1 [KO:K06627]
117737854  ccna2; cyclin-A2 [KO:K06627]
117730875  mybl2b; v-myb avian myeloblastosis viral oncogene homolog-like 2b [KO:K21769]
117727659  lin9; protein lin-9 homolog [KO:K21773]
117745208  lin37; protein lin-37 homolog [KO:K21774]
117725413  lin52; protein lin-52 homolog [KO:K21775]
117740671  lin54; protein lin-54 homolog [KO:K21776]
117725415  histone-binding protein RBBP4 [KO:K10752]
117725635  rbb4l; histone-binding protein RBBP7 [KO:K10752]
117739289  rbbp4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
117726281  foxm1; forkhead box protein M1 [KO:K09406]
117749293  myca; transcriptional regulator Myc-A [KO:K04377]
117726546  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117747715  tp53; cellular tumor antigen p53 [KO:K04451]
117730738  rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
117737302  fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362]
117730556  si:ch211-160o17.4; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
117749329  hipk3b; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
117731890  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
117732600  homeodomain-interacting protein kinase 3-like isoform X1 [KO:K08826] [EC:2.7.11.1]
117733093  hipk1a; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
117736119  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
117749034  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
117727160  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117751447  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117734761  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117747730  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117733950  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117732847  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117746647  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117729985  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117736137  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117735491  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117741083  ets1; protein C-ets-1 isoform X1 [KO:K02678]
117748744  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117735377  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117731084  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117726208  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
117726295  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
117732507  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117733162  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117734021  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117734164  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117725426  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117736875  gadd45ga; growth arrest and DNA-damage-inducible, gamma a isoform X1 [KO:K04402]
117745927  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117740530  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
117740536  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117730054  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117730108  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117744214  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
117740880  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
117728654  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
117728839  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
117741719  ccnp; cyclin N-terminal domain-containing protein 2 [KO:K21770]
117748048  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
117741300  mre11a; double-strand break repair protein MRE11 [KO:K10865]
117742876  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
117745643  nbn; nibrin [KO:K10867]
117741262  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
117737861  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
117736288  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
117740217  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
117727969  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
117751082  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
117743221  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
117737603  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
117727468  gata4; transcription factor GATA-4 [KO:K09183]
117725122  adapter protein CIKS-like isoform X1 [KO:K21124]
117727890  traf3ip2a; adapter protein CIKS [KO:K21124]
117730078  traf3ip2l; adapter protein CIKS [KO:K21124]
117737787  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
117747396  rela; transcription factor p65 isoform X1 [KO:K04735]
117739248  interleukin-6-like [KO:K05405]
117737801  cxcl8a; interleukin-8 isoform X1 [KO:K10030]
117747746  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
117747747  permeability factor 2-like [KO:K10030]
117729588  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
117747966  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
117736949  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
117740409  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
117734039  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
117730311  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117725185  zfp36l1a; mRNA decay activator protein ZFP36L1a [KO:K18753]
117744206  zfp36l2; mRNA decay activator protein ZFP36L2 [KO:K18753]
117727684  zfp36l1b; mRNA decay activator protein ZFP36L1b [KO:K18753]
117728068  mRNA decay activator protein ZFP36 [KO:K18753]
117741692  zgc:114130; mRNA decay activator protein ZFP36 isoform X1 [KO:K18753]
117733217  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117730481  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
117736243  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
117748575  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
117725453  zgc:136872; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
117743049  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
117744466  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
117730292  capn1b; calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
117747843  capn1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
117743953  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117743954  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117729021  LOW QUALITY PROTEIN: calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117726294  calml4a; calmodulin-like protein 4a [KO:K02183]
117743966  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117727166  calm1b; calmodulin-1b [KO:K02183]
117751249  calm1a; calmodulin-1a isoform X1 [KO:K02183]
117741237  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
117730495  LOW QUALITY PROTEIN: calglandulin-like [KO:K02183]
117735938  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
117742640  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117737855  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117740567  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
117747723  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
117744259  calcineurin subunit B type 1-like [KO:K06268]
117733200  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
117739288  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117728254  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
117731309  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
117733100  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117748329  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117732055  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
117746601  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
117731168  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
117730310  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117732901  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117733021  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
117742455  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
117737450  slc25a5; ADP/ATP translocase 2 [KO:K05863]
117733756  slc25a4; ADP/ATP translocase 1 [KO:K05863]
117737257  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
117743293  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117748799  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
117744212  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
117736822  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117740369  zgc:56235; voltage-dependent anion-selective channel protein 2 [KO:K15041]
117743902  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
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Related
pathway
clum04020  Calcium signaling pathway
clum04068  FoxO signaling pathway
clum04110  Cell cycle
clum04115  p53 signaling pathway
clum04150  mTOR signaling pathway
KO pathway
ko04218   
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