KEGG   PATHWAY: csyr05168
Entry
csyr05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Carlito syrichta (Philippine tarsier)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
csyr05168  Herpes simplex virus 1 infection
csyr05168

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103270148  LTA; lymphotoxin-alpha [KO:K05468]
103263108  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
103267574  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
103252426  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103260228  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103252103  RELA; transcription factor p65 [KO:K04735]
103251545  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103251546  baculoviral IAP repeat-containing protein 2 [KO:K16060]
103264824  C-C motif chemokine 2 [KO:K14624]
103261829  NECTIN1; nectin-1 [KO:K06081]
103250682  NECTIN2; nectin-2 [KO:K06531]
103269529  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
103254188  PILRB; paired immunoglobulin-like type 2 receptor beta [KO:K15411]
103276181  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103256307  ITGA5; integrin alpha-5 [KO:K06484]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103261598  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103250615  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103260915  IFNB1; interferon beta [KO:K05415]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103263117  C3; complement C3 [KO:K03990]
103258021  C5; complement C5 isoform X1 [KO:K03994]
103270868  CFP; properdin [KO:K15412]
103274468  TLR2; toll-like receptor 2 [KO:K10159]
103255929  toll-like receptor 9 isoform X1 [KO:K10161]
103270832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103258420  TLR3; toll-like receptor 3 [KO:K05401]
103276369  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103274081  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103263671  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103259721  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103254079  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103259440  IL1B; interleukin-1 beta [KO:K04519]
103265808  CCL5; C-C motif chemokine 5 [KO:K12499]
103268608  IL6; interleukin-6 [KO:K05405]
103270149  TNF; tumor necrosis factor [KO:K03156]
103258245  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
103265030  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
103263504  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
103256184  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103268983  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103250762  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103257998  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103260907  interferon alpha-5-like [KO:K05414]
103260908  interferon alpha-5-like [KO:K05414]
103260910  interferon alpha-5-like [KO:K05414]
103274154  interferon alpha-5-like [KO:K05414]
103274155  interferon alpha-5-like [KO:K05414]
103274156  interferon alpha-10-like [KO:K05414]
103274157  interferon alpha-17-like [KO:K05414]
103274161  interferon alpha-5-like [KO:K05414]
103274163  interferon alpha-17-like [KO:K05414]
103274165  interferon alpha-5-like [KO:K05414]
103274168  interferon alpha-5-like [KO:K05414]
103258632  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
103249555  TMEM173; stimulator of interferon genes protein [KO:K12654]
103250671  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103252205  serine/threonine-protein phosphatase PP1-beta [KO:K06269] [EC:3.1.3.16]
103251817  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103262486  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103275513  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
103271654  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
103255383  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103271660  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103271661  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103264913  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103272339  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
103274470  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103259686  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
103266533  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
103270113  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
103250658  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
103273281  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
103264095  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
103264100  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
103264101  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
103264102  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103259695  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
103276958  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
103274082  HCFC1; host cell factor 1 [KO:K14966]
103266488  HCFC2; host cell factor 2 [KO:K27390]
103269851  POU2F2; POU domain, class 2, transcription factor 2 isoform X3 [KO:K09364]
103252856  POU2F1; POU domain, class 2, transcription factor 1 isoform X3 [KO:K09364]
103261834  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
103269359  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103269362  interferon alpha/beta receptor 2 [KO:K05131]
103272928  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103250948  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103256404  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103258295  LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like [KO:K11221]
103272248  IRF9; interferon regulatory factor 9 [KO:K04693]
103258314  zinc finger protein 266-like [KO:K09228]
103249607  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103259881  ZNF3; zinc finger protein 3 isoform X1 [KO:K09228]
103259984  LOW QUALITY PROTEIN: zinc finger protein 343-like [KO:K09228]
103260113  ZNF785; zinc finger protein 785 [KO:K09228]
103260115  ZNF768; zinc finger protein 768 [KO:K09228]
103260315  ZNF879; zinc finger protein 879 [KO:K09228]
103260323  ZNF354C; zinc finger protein 354C [KO:K09228]
103269278  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103269496  ZNF114; zinc finger protein 114 isoform X1 [KO:K09228]
110594629  LOW QUALITY PROTEIN: zinc finger protein 480-like [KO:K09228]
103277469  LOW QUALITY PROTEIN: zinc finger protein 160 [KO:K09228]
103250213  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
103249984  ZNF317; zinc finger protein 317 [KO:K09228]
103250179  zinc finger protein 791 isoform X1 [KO:K09228]
103250214  zinc finger protein 724-like [KO:K09228]
103250331  ZNF182; zinc finger protein 182 isoform X2 [KO:K09228]
103250351  ZNF630; zinc finger protein 630 isoform X1 [KO:K09228]
103269810  ZNF331; zinc finger protein 331 isoform X2 [KO:K09228]
103269849  zinc finger protein 573 [KO:K09228]
103250831  ZNF14; zinc finger protein 14 [KO:K09228]
103251050  ZFP92; LOW QUALITY PROTEIN: zinc finger protein 92 homolog [KO:K09228]
103251044  ZNF275; zinc finger protein 275 [KO:K09228]
103250828  ZNF101; zinc finger protein 101 isoform X1 [KO:K09228]
103250849  RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
103261406  ZNF2; zinc finger protein 2 isoform X1 [KO:K09228]
103270187  ZFP1; zinc finger protein 1 homolog isoform X2 [KO:K09228]
110595037  zinc finger protein OZF-like [KO:K09228]
103253877  LOW QUALITY PROTEIN: zinc finger protein 595-like [KO:K09228]
103253889  LOW QUALITY PROTEIN: zinc finger protein 37A-like [KO:K09228]
103251505  ZNF558; zinc finger protein 558 [KO:K09228]
103261689  ZNF599; zinc finger protein 599 [KO:K09228]
103261898  ZNF333; zinc finger protein 333 [KO:K09228]
103261911  zinc finger protein 658B-like [KO:K09228]
103270924  zinc finger protein 658B-like [KO:K09228]
103271107  ZNF792; zinc finger protein 792 [KO:K09228]
103271207  zinc finger protein 569 isoform X1 [KO:K09228]
103271244  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
103271247  zinc finger protein 417-like [KO:K09228]
103271250  ZNF671; zinc finger protein 671 isoform X1 [KO:K09228]
103271251  ZNF154; zinc finger protein 154 [KO:K09228]
103255140  zinc finger protein 93-like isoform X1 [KO:K09228]
103255654  zinc finger protein 208-like [KO:K09228]
103255976  ZNF620; zinc finger protein 620 [KO:K09228]
103256611  zinc finger protein 658B-like [KO:K09228]
103256677  zinc finger protein 658B-like [KO:K09228]
103256705  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103256706  ZNF41; zinc finger protein 41 isoform X1 [KO:K09228]
103257059  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103257145  LOW QUALITY PROTEIN: zinc finger protein 208-like [KO:K09228]
103251728  ZFP90; zinc finger protein 90 homolog [KO:K09228]
103252020  zinc finger protein 85-like [KO:K09228]
103252354  ZNF200; zinc finger protein 200 [KO:K09228]
103262210  ZNF45; zinc finger protein 45 [KO:K09228]
103262212  zinc finger protein 224-like [KO:K09228]
103262213  zinc finger protein 225-like isoform X1 [KO:K09228]
103262214  zinc finger protein 234 [KO:K09228]
103262216  ZNF233; LOW QUALITY PROTEIN: zinc finger protein 233 [KO:K09228]
103271372  ZNF667; zinc finger protein 667 [KO:K09228]
103258269  LOW QUALITY PROTEIN: zinc finger protein 480-like [KO:K09228]
103258271  LOW QUALITY PROTEIN: zinc finger protein 160-like [KO:K09228]
103258313  zinc finger protein 426 isoform X1 [KO:K09228]
103258355  zinc finger protein 432-like [KO:K09228]
103258363  zinc finger protein 841-like isoform X1 [KO:K09228]
103258364  LOW QUALITY PROTEIN: zinc finger protein 615 [KO:K09228]
103258661  ZNF790; zinc finger protein 790 isoform X1 [KO:K09228]
103259060  ZNF707; zinc finger protein 707 isoform X1 [KO:K09228]
103262965  ZNF454; zinc finger protein 454 [KO:K09228]
103271962  LOW QUALITY PROTEIN: zinc finger protein 415-like [KO:K09228]
103272090  ZNF19; LOW QUALITY PROTEIN: zinc finger protein 19 [KO:K09228]
103260036  zinc finger protein 420 isoform X1 [KO:K09228]
103260118  ZNF764; LOW QUALITY PROTEIN: zinc finger protein 764 [KO:K09228]
103260114  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
103260536  ZNF846; zinc finger protein 846 [KO:K09228]
103260562  ZNF169; LOW QUALITY PROTEIN: zinc finger protein 169 [KO:K09228]
103260585  zinc finger protein 43-like [KO:K09228]
103260623  ZNF589; LOW QUALITY PROTEIN: zinc finger protein 589 [KO:K09228]
103261066  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
103261369  LOW QUALITY PROTEIN: zinc finger protein 709 [KO:K09228]
103261416  zinc finger protein OZF-like [KO:K09228]
103253395  ZNF514; zinc finger protein 514 [KO:K09228]
103253422  zinc finger protein 84-like [KO:K09228]
103253890  zinc finger protein 33B isoform X1 [KO:K09228]
103263263  ZNF473; zinc finger protein 473 [KO:K09228]
103263579  zinc finger protein 670-like isoform X1 [KO:K09228]
103272589  zinc finger protein 566 isoform X1 [KO:K09228]
103272592  ZFP82; zinc finger protein 82 homolog [KO:K09228]
103272593  zinc finger protein 14 homolog isoform X3 [KO:K09228]
103272595  ZNF568; zinc finger protein 568 isoform X2 [KO:K09228]
103272723  ZNF713; zinc finger protein 713 [KO:K09228]
103272824  ZNF177; zinc finger protein 177 [KO:K09228]
103272906  ZNF229; zinc finger protein 229 isoform X1 [KO:K09228]
103272907  ZNF285; zinc finger protein 285 [KO:K09228]
103272908  ZNF180; zinc finger protein 180 isoform X1 [KO:K09228]
103261592  zinc finger protein 708-like [KO:K09228]
103261688  ZNF181; zinc finger protein 181 isoform X1 [KO:K09228]
103262157  LOW QUALITY PROTEIN: zinc finger protein 133-like [KO:K09228]
103262218  zinc finger protein 226 isoform X1 [KO:K09228]
110595787  LOW QUALITY PROTEIN: zinc finger protein-like [KO:K09228]
103262215  ZNF227; zinc finger protein 227 isoform X1 [KO:K09228]
103262969  zinc finger protein 354B [KO:K09228]
103263268  zinc finger protein 883 [KO:K09228]
103254637  zinc finger protein 74-like [KO:K09228]
103264167  ZNF436; zinc finger protein 436 [KO:K09228]
103264195  zinc finger protein 252-like [KO:K09228]
103264197  ZNF250; zinc finger protein 250 isoform X1 [KO:K09228]
103264199  ZNF34; zinc finger protein 34 isoform X1 [KO:K09228]
103264201  ZNF7; zinc finger protein 7 isoform X5 [KO:K09228]
103264206  ZNF517; LOW QUALITY PROTEIN: zinc finger protein 517 [KO:K09228]
103264267  zinc finger protein 705A-like isoform X1 [KO:K09228]
103264269  ZNF596; zinc finger protein 596 isoform X2 [KO:K09228]
103264361  ZNF25; zinc finger protein 25 isoform X1 [KO:K09228]
103264371  ZNF689; zinc finger protein 689 [KO:K09228]
103273401  zinc finger protein 737-like [KO:K09228]
103273527  HKR1; Krueppel-related zinc finger protein 1 isoform X1 [KO:K09228]
103273528  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
103263523  zinc finger protein 624 [KO:K09228]
103263589  zinc finger protein 107-like [KO:K09228]
103263955  zinc finger protein 717-like [KO:K09228]
103264370  zinc finger protein 33B-like [KO:K09228]
103265190  ZNF549; zinc finger protein 549 [KO:K09228]
103265189  zinc finger protein interacting with ribonucleoprotein K-like isoform X1 [KO:K09228]
103265352  zinc finger protein 420-like [KO:K09228]
110596071  zinc finger protein 607-like [KO:K09228]
103265374  ZNF268; zinc finger protein 268 isoform X1 [KO:K09228]
110596072  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
103265370  ZNF605; zinc finger protein 605 isoform X1 [KO:K09228]
103254988  LOW QUALITY PROTEIN: zinc finger protein 530-like [KO:K09228]
103255360  ZNF184; zinc finger protein 184 isoform X1 [KO:K09228]
103273686  ZSCAN32; zinc finger and SCAN domain-containing protein 32 isoform X1 [KO:K09228]
103273687  ZNF597; zinc finger protein 597 [KO:K09228]
103265975  LOW QUALITY PROTEIN: zinc finger protein 555 [KO:K09228]
103265977  ZNF57; LOW QUALITY PROTEIN: zinc finger protein 57 [KO:K09228]
110596115  ZNF77; LOW QUALITY PROTEIN: zinc finger protein 77 [KO:K09228]
103266143  ZNF311; zinc finger protein 311 [KO:K09228]
103266323  ZNF205; zinc finger protein 205 [KO:K09228]
103267002  ZNF546; zinc finger protein 546 [KO:K09228]
103266999  LOW QUALITY PROTEIN: zinc finger protein 780B-like [KO:K09228]
103267020  LOW QUALITY PROTEIN: zinc finger protein 658-like [KO:K09228]
103255912  zinc finger protein 717-like [KO:K09228]
103255973  ZNF619; LOW QUALITY PROTEIN: zinc finger protein 619 [KO:K09228]
103255974  ZNF621; zinc finger protein 621 [KO:K09228]
103256024  ZNF214; zinc finger protein 214 [KO:K09228]
103256080  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
103265102  LOW QUALITY PROTEIN: zinc finger protein 778-like [KO:K09228]
103265103  zinc finger protein 778-like isoform X2 [KO:K09228]
103265185  zinc finger protein interacting with ribonucleoprotein K isoform X1 [KO:K09228]
103265186  ZNF416; zinc finger protein 416 [KO:K09228]
103265188  ZNF550; zinc finger protein 550 [KO:K09228]
103265338  zinc finger protein 658-like [KO:K09228]
103265371  ZNF84; zinc finger protein 84 isoform X1 [KO:K09228]
103265372  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
103265380  ZNF26; zinc finger protein 26 isoform X1 [KO:K09228]
103265381  ZNF891; zinc finger protein 891 [KO:K09228]
103274251  ZNF782; zinc finger protein 782 isoform X1 [KO:K09228]
103267931  ZFP69; zinc finger protein ZFP69 isoform X1 [KO:K09228]
103268084  zinc finger protein 773-like [KO:K09228]
103268158  zinc finger protein 124-like [KO:K09228]
103268414  ZNF746; LOW QUALITY PROTEIN: zinc finger protein 746 [KO:K09228]
103268416  ZNF777; LOW QUALITY PROTEIN: zinc finger protein 777 [KO:K09228]
103268419  ZNF282; zinc finger protein 282 [KO:K09228]
103268619  ZFP28; zinc finger protein 28 homolog [KO:K09228]
103268620  ZNF471; zinc finger protein 471 [KO:K09228]
103269652  zinc finger protein 708-like [KO:K09228]
103270628  LOW QUALITY PROTEIN: zinc finger protein 670-like [KO:K09228]
103256484  zinc finger protein 658-like [KO:K09228]
103256495  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103256582  ZNF81; zinc finger protein 81 [KO:K09228]
103256696  ZNF793; zinc finger protein 793 isoform X2 [KO:K09228]
103256697  ZNF570; zinc finger protein 570 [KO:K09228]
103256707  ZNF157; zinc finger protein 157 [KO:K09228]
103256819  ZNF551; zinc finger protein 551 [KO:K09228]
103256895  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103256975  ZNF235; zinc finger protein 235 [KO:K09228]
103256988  ZNF112; zinc finger protein 112 [KO:K09228]
103265579  zinc finger protein 133 isoform X1 [KO:K09228]
103265707  zinc finger protein 613 [KO:K09228]
103265711  zinc finger protein 564 isoform X1 [KO:K09228]
103265841  zinc finger protein 585A [KO:K09228]
103266102  ZNF300; zinc finger protein 300 [KO:K09228]
103266112  zinc finger protein 300-like isoform X1 [KO:K09228]
103275098  zinc finger protein 676-like [KO:K09228]
103270063  zinc finger protein 823-like isoform X1 [KO:K09228]
103270948  LOW QUALITY PROTEIN: zinc finger protein 324A [KO:K09228]
103270949  zinc finger protein 324B [KO:K09228]
103271082  ZNF662; zinc finger protein 662 [KO:K09228]
103271154  ZNF337; LOW QUALITY PROTEIN: zinc finger protein 337 [KO:K09228]
103271258  LOW QUALITY PROTEIN: zinc finger protein 418-like [KO:K09228]
110596601  ZNF256; LOW QUALITY PROTEIN: zinc finger protein 256 [KO:K09228]
110596602  zinc finger protein 587-like [KO:K09228]
103271723  ZNF354A; zinc finger protein 354A [KO:K09228]
103257057  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103257429  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
103266465  ZNF484; zinc finger protein 484 [KO:K09228]
103271996  zinc finger protein 665-like [KO:K09228]
103271997  zinc finger protein 595-like [KO:K09228]
103272001  zinc finger protein 254-like [KO:K09228]
103272091  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
103272303  zinc finger protein 43-like [KO:K09228]
103272517  ZNF251; zinc finger protein 251 isoform X1 [KO:K09228]
103272599  zinc finger protein 829 isoform X1 [KO:K09228]
103272827  ZNF699; zinc finger protein 699 [KO:K09228]
103273900  ZNF853; zinc finger protein 853 [KO:K09228]
103273403  zinc finger protein 595-like [KO:K09228]
103273518  zinc finger protein 132 [KO:K09228]
103273520  ZNF584; zinc finger protein 584 [KO:K09228]
103273746  zinc finger protein 420-like [KO:K09228]
103257817  zinc finger protein 627 [KO:K09228]
103266993  ZFP37; zinc finger protein 37 homolog isoform X1 [KO:K09228]
103267207  ZNF189; zinc finger protein 189 isoform X2 [KO:K09228]
103276060  ZNF548; zinc finger protein 548 [KO:K09228]
103276062  ZNF547; zinc finger protein 547 [KO:K09228]
103276064  ZNF304; zinc finger protein 304 [KO:K09228]
103276065  zinc finger protein 805 [KO:K09228]
103276070  zinc finger protein 17-like [KO:K09228]
103276071  LOW QUALITY PROTEIN: zinc finger protein 543-like [KO:K09228]
103276242  ZNF567; zinc finger protein 567 isoform X1 [KO:K09228]
103276244  ZNF461; zinc finger protein 461 isoform X1 [KO:K09228]
103276246  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
103276247  ZNF529; zinc finger protein 529 [KO:K09228]
103276252  ZNF565; zinc finger protein 565 isoform X1 [KO:K09228]
103276277  zinc finger protein 343-like [KO:K09228]
103276367  zinc finger protein 84-like [KO:K09228]
103274250  LOW QUALITY PROTEIN: zinc finger protein 510-like [KO:K09228]
103274355  zinc finger protein 595-like [KO:K09228]
103258268  ZNF677; zinc finger protein 677 isoform X1 [KO:K09228]
103258357  ZNF432; zinc finger protein 432 [KO:K09228]
103258358  ZNF614; zinc finger protein 614 [KO:K09228]
103258359  zinc finger protein 615-like [KO:K09228]
103258360  ZNF350; zinc finger protein 350 isoform X1 [KO:K09228]
103258447  ZNF12; zinc finger protein 12 isoform X2 [KO:K09228]
103258664  zinc finger protein 571 [KO:K09228]
103258666  zinc finger protein 30 homolog isoform X1 [KO:K09228]
103267401  ZNF136; zinc finger protein 136 isoform X1 [KO:K09228]
103267406  zinc finger protein 883-like [KO:K09228]
103267408  zinc finger protein 596-like isoform X2 [KO:K09228]
103267770  ZNF211; zinc finger protein 211 [KO:K09228]
103258972  ZNF175; zinc finger protein 175 isoform X1 [KO:K09228]
103259049  ZNF623; zinc finger protein 623 [KO:K09228]
103259102  LOW QUALITY PROTEIN: zinc finger protein 658-like [KO:K09228]
103267928  ZNF684; zinc finger protein 684 [KO:K09228]
103267932  ZFP69B; zinc finger protein ZFP69B isoform X1 [KO:K09228]
103267977  LOW QUALITY PROTEIN: zinc finger protein 283 [KO:K09228]
103268010  ZNF641; zinc finger protein 641 [KO:K09228]
103268009  ZNF404; LOW QUALITY PROTEIN: zinc finger protein 404 [KO:K09228]
103268083  ZNF772; zinc finger protein 772 isoform X1 [KO:K09228]
103268405  ZNF212; zinc finger protein 212 [KO:K09228]
103268406  ZNF398; zinc finger protein 398 [KO:K09228]
103268407  ZNF425; zinc finger protein 425 [KO:K09228]
103268409  ZNF786; zinc finger protein 786 [KO:K09228]
103268417  zinc finger protein 282-like [KO:K09228]
103268418  ZNF783; protein ZNF783 [KO:K09228]
103277470  zinc finger protein 83-like [KO:K09228]
103277473  zinc finger protein 347-like [KO:K09228]
103259323  zinc finger protein 260-like [KO:K09228]
103259702  ZNF8; zinc finger protein 8 [KO:K09228]
103259713  zinc finger protein 544 [KO:K09228]
103259720  zinc finger protein 585A-like isoform X2 [KO:K09228]
103259726  ZNF383; zinc finger protein 383 [KO:K09228]
103268615  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
103268617  ZNF582; zinc finger protein 582 [KO:K09228]
103268621  ZNF470; zinc finger protein 470 isoform X1 [KO:K09228]
103268656  zinc finger protein 248 isoform X1 [KO:K09228]
103276072  zinc finger protein 543-like [KO:K09228]
103276074  ZNF460; zinc finger protein 460 [KO:K09228]
103276201  zinc finger protein 658-like [KO:K09228]
103276279  zinc finger protein 343-like [KO:K09228]
103277087  ZFP57; zinc finger protein 57 homolog [KO:K09228]
103271249  ZNF586; zinc finger protein 586 [KO:K09228]
103268463  BST2; bone marrow stromal antigen 2 [KO:K06731]
103269019  IFNG; interferon gamma [KO:K04687]
103256032  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103269363  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103250706  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
103262543  DAXX; death domain-associated protein 6 isoform X2 [KO:K02308]
103267337  nuclear autoantigen Sp-100-like [KO:K15413]
103267339  SP100; LOW QUALITY PROTEIN: nuclear autoantigen Sp-100 [KO:K15413]
103252591  PML; protein PML [KO:K10054] [EC:2.3.2.-]
103271934  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103271932  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103262563  TAPBP; tapasin [KO:K08058]
103262024  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103249397  CALR; calreticulin [KO:K08057]
103269400  calreticulin-like [KO:K08057]
103251393  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103273534  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
103268467  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
103271436  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103273536  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
103276998  HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
103277080  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103254879  B2M; beta-2-microglobulin [KO:K08055]
103262681  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X2 [KO:K06752]
103262695  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103271929  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
103271936  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
103272282  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103262757  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103256945  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
103266905  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X2 [KO:K06752]
103267365  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
103267988  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
103266111  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103250930  TSC1; hamartin isoform X1 [KO:K07206]
103250119  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
103270389  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103272783  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103275306  RHEB; GTP-binding protein Rheb [KO:K07208]
103272291  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103263385  SRPK1; SRSF protein kinase 1 isoform X2 [KO:K15409] [EC:2.7.11.1]
103260406  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
103266661  serine/arginine-rich splicing factor 2-like [KO:K12891]
103267648  SRSF2; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 2 [KO:K12891]
103251432  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
103262951  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
103254235  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
103255731  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
103270599  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
103251154  serine/arginine-rich splicing factor 9 [KO:K21123]
103263289  nuclear RNA export factor 2-like [KO:K14284]
103254730  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
103255629  NXF1; nuclear RNA export factor 1 [KO:K14284]
103274121  nuclear RNA export factor 2-like [KO:K14284]
103262781  ALYREF; THO complex subunit 4 [KO:K12881]
103273211  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
103273943  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103250566  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103269228  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103274231  BID; BH3-interacting domain death agonist [KO:K04726]
103256231  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103262464  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103274703  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103252019  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103255326  cytochrome c 2 [KO:K08738]
110596190  cytochrome c, somatic-like [KO:K08738]
103274909  cytochrome c, somatic [KO:K08738]
103251017  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103260483  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103257846  caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
PMID:15163721
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
csyr03040  Spliceosome
csyr03050  Proteasome
csyr04115  p53 signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04210  Apoptosis
csyr04610  Complement and coagulation cascades
csyr04612  Antigen processing and presentation
csyr04620  Toll-like receptor signaling pathway
csyr04622  RIG-I-like receptor signaling pathway
csyr04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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