KEGG   PATHWAY: csyr05168
Entry
csyr05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Carlito syrichta (Philippine tarsier)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
csyr05168  Herpes simplex virus 1 infection
csyr05168

Disease
H00365  Herpes simplex virus infection
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249397  CALR; calreticulin [KO:K08057]
103249555  TMEM173; stimulator of interferon genes protein [KO:K12654]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103250119  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
103250566  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103250615  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
103250658  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
103250671  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103250682  NECTIN2; nectin-2 [KO:K06531]
103250706  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
103250762  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103250930  TSC1; hamartin isoform X1 [KO:K07206]
103250948  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103251017  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103251154  [KO:K21123]
103251393  [KO:K06751]
103251432  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
103251545  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103251546  [KO:K16060]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103251817  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103252019  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103252103  RELA; transcription factor p65 [KO:K04735]
103252205  [KO:K06269] [EC:3.1.3.16]
103252426  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103252591  PML; protein PML [KO:K10054] [EC:2.3.2.-]
103252856  POU2F1; POU domain, class 2, transcription factor 1 isoform X3 [KO:K09364]
103254079  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103254188  PILRB; paired immunoglobulin-like type 2 receptor beta [KO:K15411]
103254235  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
103254239  [KO:K04456] [EC:2.7.11.1]
103254730  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
103254879  B2M; beta-2-microglobulin [KO:K08055]
103255326  [KO:K08738]
103255383  [KO:K16195] [EC:2.7.11.1]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103255629  NXF1; nuclear RNA export factor 1 [KO:K14284]
103255731  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
103255929  [KO:K10161]
103256032  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103256184  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103256231  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103256307  ITGA5; integrin alpha-5 [KO:K06484]
103256404  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103256945  [KO:K06752]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103257846  [KO:K02187] [EC:3.4.22.56]
103257998  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
103258021  C5; complement C5 isoform X1 [KO:K03994]
103258245  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
103258295  [KO:K11221]
103258420  TLR3; toll-like receptor 3 [KO:K05401]
103258632  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
103259440  IL1B; interleukin-1 beta [KO:K04519]
103259686  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
103259695  [KO:K14216] [EC:2.7.7.84]
103259721  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103260228  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
103260406  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
103260483  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103260907  [KO:K05414]
103260908  [KO:K05414]
103260910  [KO:K05414]
103260915  IFNB1; interferon beta [KO:K05415]
103261598  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103261789  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 [KO:K28004]
103261829  NECTIN1; nectin-1 [KO:K06081]
103261834  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
103262024  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103262464  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103262486  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103262543  DAXX; death domain-associated protein 6 isoform X2 [KO:K02308]
103262563  TAPBP; tapasin [KO:K08058]
103262681  [KO:K06752]
103262695  [KO:K06752]
103262757  [KO:K06752]
103262781  ALYREF; THO complex subunit 4 [KO:K12881]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103262951  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
103263108  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
103263117  C3; complement C3 [KO:K03990]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103263289  [KO:K14284]
103263385  SRPK1; SRSF protein kinase 1 isoform X2 [KO:K15409] [EC:2.7.11.1]
103263504  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
103263671  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103264095  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
103264100  [KO:K14216] [EC:2.7.7.84]
103264101  [KO:K14216] [EC:2.7.7.84]
103264102  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103264824  [KO:K14624]
103264913  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103265030  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
103265808  CCL5; C-C motif chemokine 5 [KO:K12499]
103266111  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103266488  HCFC2; host cell factor 2 [KO:K27390]
103266533  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
103266661  [KO:K12891]
103266905  [KO:K06752]
103267337  [KO:K15413]
103267339  SP100; LOW QUALITY PROTEIN: nuclear autoantigen Sp-100 [KO:K15413]
103267365  [KO:K06752]
103267574  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
103267648  SRSF2; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 2 [KO:K12891]
103267988  [KO:K06752]
103268463  BST2; bone marrow stromal antigen 2 [KO:K06731]
103268467  [KO:K06751]
103268608  IL6; interleukin-6 [KO:K05405]
103268983  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103269019  IFNG; interferon gamma [KO:K04687]
103269228  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103269359  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103269362  [KO:K05131]
103269363  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103269400  [KO:K08057]
103269529  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
103269851  POU2F2; POU domain, class 2, transcription factor 2 isoform X3 [KO:K09364]
103270113  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
103270148  LTA; lymphotoxin-alpha [KO:K05468]
103270149  TNF; tumor necrosis factor [KO:K03156]
103270389  [KO:K07208]
103270599  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
103270832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103270868  CFP; properdin [KO:K15412]
103271436  [KO:K06751]
103271654  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
103271660  [KO:K16195] [EC:2.7.11.1]
103271661  [KO:K16195] [EC:2.7.11.1]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103271929  [KO:K06752]
103271932  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103271934  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103271936  [KO:K06752]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103272248  IRF9; interferon regulatory factor 9 [KO:K04693]
103272282  [KO:K06752]
103272291  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103272339  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
103272783  [KO:K07208]
103272928  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103273211  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
103273281  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103273534  [KO:K06751]
103273536  [KO:K06751]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103273943  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103274081  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103274082  HCFC1; host cell factor 1 [KO:K14966]
103274121  [KO:K14284]
103274154  [KO:K05414]
103274155  [KO:K05414]
103274156  [KO:K05414]
103274157  [KO:K05414]
103274161  [KO:K05414]
103274163  [KO:K05414]
103274165  [KO:K05414]
103274168  [KO:K05414]
103274231  BID; BH3-interacting domain death agonist [KO:K04726]
103274468  TLR2; toll-like receptor 2 [KO:K10159]
103274470  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103274703  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103274909  [KO:K08738]
103275306  RHEB; GTP-binding protein Rheb [KO:K07208]
103275513  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103276181  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103276369  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103276958  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
103276998  [KO:K06751]
103277080  [KO:K06751]
110596190  [KO:K08738]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
csyr03040  Spliceosome
csyr03050  Proteasome
csyr04115  p53 signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04210  Apoptosis
csyr04610  Complement and coagulation cascades
csyr04612  Antigen processing and presentation
csyr04620  Toll-like receptor signaling pathway
csyr04622  RIG-I-like receptor signaling pathway
csyr04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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