KEGG   PATHWAY: ctig04820
Entry
ctig04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Crotalus tigris (Tiger rattlesnake)
Class
Cellular Processes; Cell motility
Pathway map
ctig04820  Cytoskeleton in muscle cells
ctig04820

Organism
Crotalus tigris (Tiger rattlesnake) [GN:ctig]
Gene
120307150  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
120303516  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
120317265  COL3A1; collagen alpha-1(III) chain [KO:K19720]
120318411  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
120317266  COL5A2; collagen alpha-2(V) chain [KO:K19721]
120317571  COL5A1; collagen alpha-1(V) chain [KO:K19721]
120312191  collagen alpha-1(XI) chain-like isoform X1 [KO:K19721]
120297869  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
120298142  COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721]
120320109  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
120301961  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
120314758  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
120309453  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
120307479  DCN; decorin [KO:K04660]
120312219  VCAN; versican core protein isoform X1 [KO:K06793]
120309225  ELN; elastin isoform X1 [KO:K14211]
120304996  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
120304932  collagen alpha-6(VI) chain-like [KO:K06238]
120304995  collagen alpha-6(VI) chain-like [KO:K06238]
120300357  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
120300364  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
120300380  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120307674  THBS1; thrombospondin-1 [KO:K16857]
120317128  THBS3; thrombospondin-3 [KO:K04659]
120314045  THBS2; thrombospondin-2 [KO:K04659]
120303777  THBS4; thrombospondin-4 [KO:K04659]
120298118  cartilage oligomeric matrix protein [KO:K04659]
120315152  FBN1; fibrillin-1 isoform X1 [KO:K06825]
120299577  FBN3; LOW QUALITY PROTEIN: fibrillin-3 [KO:K23342]
120313582  FBN2; fibrillin-2 isoform X1 [KO:K23342]
120311435  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
120311436  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
120300407  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120300408  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
120310373  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120310375  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
120313084  FBLN1; fibulin-1 isoform X1 [KO:K17307]
120302705  fibulin-2-like [KO:K17307]
120319186  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
120312346  NID1; nidogen-1 isoform X1 [KO:K06826]
120297821  NID2; nidogen-2 isoform X1 [KO:K06826]
120307303  FN1; fibronectin isoform X1 [KO:K05717]
120311392  SDC1; syndecan-1 [KO:K06257]
120301482  SDC2; syndecan-2 [KO:K16336]
120301653  SDC3; syndecan-3 isoform X1 [KO:K16337]
120311624  SDC4; syndecan-4 [KO:K16338]
120319241  AGRN; agrin isoform X1 [KO:K06254]
120306160  biglycan-like [KO:K08118]
120301446  biglycan-like [KO:K08118]
120316121  BGN; biglycan [KO:K08118]
120303771  desmocollin-1-like [KO:K07601]
120303759  desmocollin-2-like isoform X1 [KO:K07601]
120303776  DSG2; desmoglein-2 [KO:K07597]
120307496  PKP2; plakophilin-2 [KO:K12642]
120312811  junction plakoglobin [KO:K10056]
120311135  desmoplakin isoform X1 [KO:K10381]
120302669  VIM; vimentin [KO:K07606]
120312988  DES; desmin [KO:K07610]
120299635  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
120306262  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120313756  ITGA1; integrin alpha-1 [KO:K06480]
120313761  ITGA2; integrin alpha-2 [KO:K06481]
120302614  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
120303491  ITGA3; integrin alpha-3 [KO:K06482]
120298608  ITGA4; integrin alpha-4 [KO:K06483]
120308545  ITGA5; integrin alpha-5 [KO:K06484]
120316325  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120306220  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
120302747  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
120305284  ITGA9; integrin alpha-9 [KO:K06585]
120314886  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
120320142  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
120310958  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120308266  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
120302667  ITGB3; integrin beta-3 [KO:K06493]
120301143  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120299200  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
120301313  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120302350  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
120303155  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120306574  TLN2; talin-2 [KO:K06271]
120319774  TLN1; talin-1 isoform X1 [KO:K06271]
120306423  VCL; vinculin isoform X1 [KO:K05700]
120318528  ACTN3; alpha-actinin-3 [KO:K21073]
120318759  ACTN2; alpha-actinin-2 [KO:K21073]
120305545  actin, clone 302-like [KO:K05692]
120309394  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120315823  ACTB; actin, cytoplasmic 1 [KO:K05692]
120299415  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
120304007  DAG1; dystroglycan isoform X1 [KO:K06265]
120303487  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
120307149  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
120319447  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
120313296  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
120313819  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
120300163  SGCZ; zeta-sarcoglycan [KO:K27062]
120314447  SSPN; sarcospan [KO:K22194]
120301896  DMD; dystrophin isoform X1 [KO:K10366]
120308533  SNTA1; alpha-1-syntrophin [KO:K24063]
120317967  SNTB1; beta-1-syntrophin [KO:K24064]
120302438  SNTB2; beta-2-syntrophin [KO:K24064]
120303751  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
120308966  FLNC; filamin-C isoform X1 [KO:K27393]
120311998  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
120296669  sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
120316535  sodium/potassium-transporting ATPase subunit alpha-2-like [KO:K01539] [EC:7.2.2.13]
120318645  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
120298584  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
120305712  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
120314390  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
120316609  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
120318557  ANK3; ankyrin-3 isoform X1 [KO:K09259]
120298144  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
120299267  SPTBN5; spectrin beta chain, non-erythrocytic 5 isoform X1 [KO:K06115]
120308366  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
120316352  SPTBN4; spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
120318527  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
120307955  CSRP2; cysteine and glycine-rich protein 2 isoform X1 [KO:K09377]
120301767  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
120316161  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
120317933  MYH15; myosin-15 [KO:K24220]
120301184  myosin-1B-like [KO:K24220]
120301185  myosin-1B-like [KO:K24220]
120301186  myosin-1B [KO:K24220]
120296982  MYH7B; myosin-7B isoform X1 [KO:K24220]
120298324  myosin-3 [KO:K24220]
120305795  MYH7; myosin-7 [KO:K17751]
120308897  myosin-6-like [KO:K17751]
120304436  myosin-10-like isoform X1 [KO:K10352]
120312403  MYH9; myosin-9 [KO:K10352]
120313321  MYH10; myosin-10 isoform X1 [KO:K10352]
120319278  MYH11; myosin-11 isoform X1 [KO:K10352]
120312338  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
120318044  MYL3; myosin light chain 3 [KO:K12749]
120315199  MYL4; myosin light chain 4 [KO:K12750]
120316716  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120315407  MYL5; myosin light chain 5 [KO:K12753]
120313943  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
120299172  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120302267  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
120316689  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
120315583  MYBPC2; myosin-binding protein C, fast-type isoform X1 [KO:K12558]
120314617  MYBPC3; myosin-binding protein C, cardiac-type isoform X1 [KO:K12568]
120297016  MYBPH; myosin-binding protein H isoform X1 [KO:K24494]
120303392  ACTA1; actin, alpha skeletal muscle [KO:K10354]
120304881  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
120314109  actin, alpha skeletal muscle B-like isoform X1 [KO:K12314]
120312765  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120301774  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
120304494  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
120307546  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
120306729  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
120306732  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
120304515  TNNI3; troponin I, cardiac muscle [KO:K12044]
120301775  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
120306573  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
120317190  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
120319775  TPM2; tropomyosin beta chain isoform X1 [KO:K09290]
120305959  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
120306336  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
120310629  MYOT; myotilin isoform X1 [KO:K19875]
120315241  telethonin [KO:K19879]
120300089  SYNPO2; synaptopodin-2 [KO:K24066]
120301133  NEB; nebulin isoform X1 [KO:K18267]
120302684  NEBL; nebulette isoform X1 [KO:K25865]
120300090  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
120306884  MYOZ3; myozenin-3 [KO:K26050]
120315538  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
120299779  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
120312928  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
120302408  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
120305328  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
120305484  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
120315244  F-actin-capping protein subunit alpha-1-like [KO:K10364]
120313290  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120319629  xin actin-binding repeat-containing protein 1-like isoform X1 [KO:K27381]
120318120  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
120312250  nebulin-related-anchoring protein isoform X1 [KO:K24421]
120299647  MYPN; myopalladin isoform X1 [KO:K22028]
120298809  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
120308000  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
120314077  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
120317223  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
120306404  tropomodulin-3-like isoform X1 [KO:K10370]
120315148  TMOD2; tropomodulin-2 isoform X1 [KO:K10370]
120303797  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
120306068  ZYX; zyxin isoform X1 [KO:K06273]
120313175  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
120301038  FHL2; four and a half LIM domains protein 2 [KO:K14380]
120301665  FHL3; four and a half LIM domains protein 3 [KO:K24414]
120301290  LMOD2; leiomodin-2 [KO:K22030]
120301419  LMOD3; leiomodin-3 [KO:K22030]
120296990  LMOD1; leiomodin-1 [KO:K22030]
120304901  ANKRD1; ankyrin repeat domain-containing protein 1 isoform X1 [KO:K21433]
120302550  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
120312945  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
120318295  formin-like protein 3 [KO:K23957]
120318303  formin-like protein 3 isoform X1 [KO:K23957]
120304623  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
120302624  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
120312172  INF2; inverted formin-2 isoform X1 [KO:K23958]
120305360  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
120297205  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
120300216  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
120302141  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
120301972  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
120310247  FMN2; formin-2 [KO:K02184]
120298639  MYOM2; myomesin-2 [KO:K24495]
120316883  MYOM3; myomesin-3 isoform X1 [KO:K24495]
120311481  MYOM1; myomesin-1 isoform X1 [KO:K24495]
120299703  ENO3; beta-enolase [KO:K01689] [EC:4.2.1.11]
120306104  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
120319140  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
120305902  ANK2; ankyrin-2 isoform X1 [KO:K09255]
120316395  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
120309169  TRIM54; tripartite motif-containing protein 54 isoform X1 [KO:K10653]
120304606  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
120300658  tripartite motif-containing protein 54-like [KO:K10654]
120314312  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
120311094  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120298954  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120314143  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
120318051  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
120300708  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
120317774  PLEC; plectin [KO:K10388]
120313843  SYNE3; nesprin-3 isoform X1 [KO:K21761]
120313894  SYNE1; nesprin-1 isoform X1 [KO:K19326]
120297165  SYNE2; nesprin-2 isoform X1 [KO:K19346]
120304646  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
120315713  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
120302816  TMEM43; transmembrane protein 43 [KO:K27488]
120301459  EMD; emerin [KO:K12569]
120307222  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
120319598  LMNA; lamin [KO:K12641]
120299504  LMNB2; lamin-B2 [KO:K07611]
120315115  lamin-L(III)-like isoform X1 [KO:K07611]
120304058  LMNB1; lamin-B1 [KO:K07611]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
ctig04512  ECM-receptor interaction
ctig04814  Motor proteins
KO pathway
ko04820   
LinkDB

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