KEGG   PATHWAY: dle05165
Entry
dle05165                    Pathway                                
Name
Human papillomavirus infection - Delphinapterus leucas (beluga whale)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
dle05165  Human papillomavirus infection
dle05165

Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111174055  WNT1; proto-oncogene Wnt-1 [KO:K03209]
111179238  WNT2; protein Wnt-2 [KO:K00182]
111180026  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
111169289  WNT3A; protein Wnt-3a [KO:K00312]
111182576  WNT3; proto-oncogene Wnt-3 [KO:K00312]
111163319  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
111174269  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
111176602  WNT5B; protein Wnt-5b [KO:K00444]
111172090  WNT6; protein Wnt-6 [KO:K00445]
111186418  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
111168811  WNT7A; protein Wnt-7a [KO:K00572]
111172662  WNT8B; protein Wnt-8b [KO:K00714]
111182565  WNT8A; protein Wnt-8a [KO:K00714]
111169279  WNT9A; protein Wnt-9a [KO:K01064]
111182925  WNT9B; protein Wnt-9b [KO:K01064]
111174054  WNT10B; protein Wnt-10b [KO:K01357]
111172091  WNT10A; protein Wnt-10a [KO:K01357]
111184814  WNT11; protein Wnt-11 [KO:K01384]
111179093  WNT16; protein Wnt-16 [KO:K01558]
111171737  FZD7; frizzled-7 [KO:K02432]
111180740  FZD1; frizzled-1 [KO:K02432]
111170218  FZD2; frizzled-2 [KO:K02235]
111185390  FZD3; frizzled-3 [KO:K02329]
111184951  FZD4; frizzled-4 [KO:K02354]
111177938  FZD8; frizzled-8 [KO:K02375]
111171775  FZD5; frizzled-5 [KO:K02375]
111180361  FZD6; frizzled-6 [KO:K02376]
111182319  FZD9; frizzled-9 [KO:K02842]
111186950  FZD10; frizzled-10 [KO:K02842]
111187117  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
111173388  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
111185664  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X4 [KO:K02353]
111168040  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111185093  AXIN1; axin-1 isoform X1 [KO:K02157]
111182912  AXIN2; axin-2 isoform X1 [KO:K04385]
111183639  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
111170519  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
111169438  CTNNB1; catenin beta-1 [KO:K02105]
111183077  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
111178537  TERT; telomerase reverse transcriptase isoform X3 [KO:K11126] [EC:2.7.7.49]
111182442  TCF7; transcription factor 7 isoform X1 [KO:K02620]
111165393  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
111172300  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
111187324  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
111173425  TLR3; toll-like receptor 3 [KO:K05401]
111165914  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
111176049  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111184753  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111173795  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111180609  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
111174560  IFNB1; interferon beta [KO:K05415]
111185248  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
111186470  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
111169983  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
111185755  TP53; cellular tumor antigen p53 [KO:K04451]
111174214  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
111172530  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111178033  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
111179629  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
111186751  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
111167310  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
111174192  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
111187277  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
111163214  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
111175094  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
111165145  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
111172354  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
111184929  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
111167775  DLG3; disks large homolog 3 isoform X2 [KO:K21098]
111182827  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
111167666  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
111166062  CRB3; protein crumbs homolog 3 [KO:K06090]
111175886  PATJ; inaD-like protein isoform X1 [KO:K06092]
111173048  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
111176651  VWF; von Willebrand factor [KO:K03900]
111181763  THBS1; thrombospondin-1 [KO:K16857]
111166972  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
111167894  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
111166713  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
111184890  THBS4; thrombospondin-4 [KO:K04659]
111171803  FN1; fibronectin isoform X1 [KO:K05717]
111166407  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
111181088  COL1A2; collagen alpha-2(I) chain [KO:K06236]
111174067  COL2A1; collagen alpha-1(II) chain [KO:K19719]
111171889  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
111171891  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
111165780  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
111165781  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
111176383  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
111176384  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
111168189  collagen alpha-5(VI) chain-like [KO:K06238]
111168165  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
111171971  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111186354  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111186385  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
111175648  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
111186728  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111183266  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
111163079  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
111168261  LAMA2; laminin subunit alpha-2 [KO:K05637]
111181472  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
111186816  LAMA5; laminin subunit alpha-5 [KO:K06240]
111164771  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
111184472  LAMB1; laminin subunit beta-1 [KO:K05636]
111174406  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
111184724  LAMB3; laminin subunit beta-3 [KO:K06244]
111184566  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
111184636  LAMC1; laminin subunit gamma-1 [KO:K05635]
111184637  LAMC2; laminin subunit gamma-2 [KO:K06246]
111177115  LAMC3; laminin subunit gamma-3 [KO:K06247]
111166462  CHAD; chondroadherin [KO:K06248]
111164624  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111179051  SPP1; osteopontin [KO:K06250]
111185668  VTN; vitronectin isoform X1 [KO:K06251]
111165733  TNR; tenascin-R isoform X1 [KO:K06252]
111165706  TNN; tenascin-N isoform X2 [KO:K06252]
111177281  TNC; tenascin isoform X1 [KO:K06252]
111170701  TNXB; tenascin-X [KO:K06252]
111179049  IBSP; bone sialoprotein 2 [KO:K06253]
111186810  ITGA1; integrin alpha-1 [KO:K06480]
111186789  ITGA2; integrin alpha-2 [KO:K06481]
111170236  ITGA2B; integrin alpha-IIb [KO:K06476]
111166388  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
111171621  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
111173917  ITGA5; integrin alpha-5 [KO:K06484]
111172869  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111173908  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
111178094  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
111164302  ITGA9; integrin alpha-9 [KO:K06585]
111179935  ITGA10; integrin alpha-10 [KO:K06586]
111177762  ITGA11; integrin alpha-11 [KO:K06587]
111171639  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111178037  ITGB1; integrin beta-1 [KO:K05719]
111182589  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111182817  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
111171786  ITGB5; integrin beta-5 [KO:K06588]
111172949  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
111173950  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
111181944  ITGB8; integrin beta-8 [KO:K06591]
111165046  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111188135  PXN; paxillin isoform X5 [KO:K05760]
111170657  TNF; tumor necrosis factor [KO:K03156]
111176656  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111179654  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111170265  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111172519  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111183629  FADD; FAS-associated death domain protein [KO:K02373]
111171726  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111173401  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111182862  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
111173481  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111182447  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111168062  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
111181079  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
111179116  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
111183056  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
111185417  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
111172180  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
111168265  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
111179211  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
111173231  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
111183787  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
111176064  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111184699  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111173081  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111178838  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
111177090  TSC1; hamartin [KO:K07206]
111185176  TSC2; tuberin isoform X1 [KO:K07207]
111176675  RHEB; GTP-binding protein Rheb [KO:K07208]
111187265  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111173509  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111183673  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
111163760  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111178690  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
111183810  BAD; bcl2-associated agonist of cell death [KO:K02158]
111183086  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111173839  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111179235  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111187262  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111166652  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111185984  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111175760  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111175267  FOXO1; forkhead box protein O1 [KO:K07201]
111176781  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
111178743  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111183632  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111176638  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111178811  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111173824  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
111180943  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
111180416  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
111180958  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111173897  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
111175081  RB1; retinoblastoma-associated protein [KO:K06618]
111184203  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
111164988  RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
111176166  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
111184273  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
111175243  CCNA1; cyclin-A1 [KO:K06627]
111186072  CCNA2; cyclin-A2 [KO:K06627]
111168050  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111179265  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
111178866  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111172396  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111173552  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111170969  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111179110  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111183745  RELA; transcription factor p65 isoform X1 [KO:K04735]
111173763  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111163098  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
111175514  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
111164824  histone deacetylase 2-like isoform X1 [KO:K06067] [EC:3.5.1.98]
111164829  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
111176670  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
111182415  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
111173316  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
111168028  TBP; TATA-box-binding protein [KO:K03120]
111165948  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
111166690  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
111170644  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
111171394  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
111170578  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
111164226  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
111167895  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
111168992  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
111180364  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
111164453  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
111173049  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
111176589  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
111178650  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
111170660  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
111168339  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
111177288  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
111165851  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
111166249  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
111186888  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
111183651  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
111182722  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
111179634  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
111164943  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
111177071  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
111185469  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
111185201  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
111175714  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
111170959  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
111186135  EGF; pro-epidermal growth factor [KO:K04357]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111176851  KRAS; GTPase KRas [KO:K07827]
111179996  NRAS; GTPase NRas [KO:K07828]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111184673  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111187219  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
111186741  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
111186746  neuroendocrine secretory protein 55 [KO:K04632]
111178380  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111166674  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111180640  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111171769  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111167181  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111188007  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111166195  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
111177962  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
111183987  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111180225  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
111163402  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
111166251  tubulin gamma-1 chain [KO:K10389]
111166370  TUBG2; tubulin gamma-2 chain [KO:K10389]
111177785  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
111171121  interferon alpha-1-like [KO:K05414]
111171122  interferon alpha-1-like isoform X1 [KO:K05414]
111163101  LOW QUALITY PROTEIN: interferon alpha-8-like [KO:K05414]
111163130  interferon alpha-1-like [KO:K05414]
111163780  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
111163874  IFNAR2; interferon alpha/beta receptor 2 isoform X3 [KO:K05131]
111178461  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111166017  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
111171663  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111173869  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111164116  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
111174878  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
111162730  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
111163861  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1-like [KO:K14754]
111187178  ISG15; LOW QUALITY PROTEIN: ubiquitin-like protein ISG15 [KO:K12159]
111165629  JAG1; protein jagged-1 [KO:K06052]
111177023  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
111179961  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
111166554  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
111170944  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
111176287  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
111169357  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
111182674  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
111186217  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
111169262  MAML1; mastermind-like protein 1 [KO:K06061]
111168397  MAML2; mastermind-like protein 2 [KO:K06061]
111179119  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
111170864  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
111184415  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
111172508  HES1; transcription factor HES-1 [KO:K06054]
111185910  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
111187240  HES2; transcription factor HES-2 [KO:K09087]
111172115  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
111187241  HES3; transcription factor HES-3 [KO:K09088]
111187177  HES4; transcription factor HES-4 isoform X2 [KO:K09089]
111187243  HES5; transcription factor HES-5 isoform X1 [KO:K06055]
111175631  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X3 [KO:K09091]
111164944  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
111165345  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Related
pathway
dle04064  NF-kappa B signaling pathway
dle04110  Cell cycle
dle04115  p53 signaling pathway
dle04150  mTOR signaling pathway
dle04151  PI3K-Akt signaling pathway
dle04210  Apoptosis
dle04310  Wnt signaling pathway
dle04330  Notch signaling pathway
dle04510  Focal adhesion
dle04520  Adherens junction
dle04530  Tight junction
dle04612  Antigen processing and presentation
dle04620  Toll-like receptor signaling pathway
dle04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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