KEGG   PATHWAY: dord05168
Entry
dord05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Dipodomys ordii (Ord's kangaroo rat)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
dord05168  Herpes simplex virus 1 infection
dord05168

Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105997012  Lta; lymphotoxin-alpha [KO:K05468]
105990395  Tnfsf14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
105997030  Tnfrsf14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
105995582  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105984909  Traf5; TNF receptor-associated factor 5 [KO:K09849]
105991714  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105986731  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106000155  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105982592  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
105991225  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105989242  Rela; transcription factor p65 isoform X1 [KO:K04735]
105980764  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105985754  C-C motif chemokine 2-like [KO:K14624]
105980623  Pvrl1; nectin-1 [KO:K06081]
105997970  Pvrl2; nectin-2 isoform X1 [KO:K06531]
105990896  paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
105997326  paired immunoglobulin-like type 2 receptor beta-2 [KO:K15411]
105997367  Pilra; paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
105990684  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105997953  Itga5; integrin alpha-5 [KO:K06484]
105998521  Itgb3; integrin beta-3 [KO:K06493]
105981781  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105993222  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105995655  Card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
105994272  Irf3; interferon regulatory factor 3 [KO:K05411]
105988975  Ifnb1; interferon beta [KO:K05415]
105983546  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105990428  C3; complement C3 [KO:K03990]
105996124  LOW QUALITY PROTEIN: complement C5-like [KO:K03994]
106000304  Cfp; properdin [KO:K15412]
105995883  Tlr2; toll-like receptor 2 [KO:K10159]
105994585  toll-like receptor 9 isoform X1 [KO:K10161]
105996289  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105998598  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105992937  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
105990289  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
105987554  Irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
106000170  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105988129  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105985880  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106001529  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
105991989  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105993663  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105988300  Il1b; interleukin-1 beta [KO:K04519]
105983400  Ccl5; C-C motif chemokine 5 [KO:K12499]
105991375  Il6; interleukin-6 [KO:K05405]
105997009  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
105985549  Il12a; interleukin-12 subunit alpha [KO:K05406]
106001299  Il12b; interleukin-12 subunit beta [KO:K05425]
105993403  Ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
105995788  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
105981763  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
105983154  Traf3; TNF receptor-associated factor 3 [KO:K03174]
105986544  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105989073  Tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105988955  interferon alpha-3-like [KO:K05414]
105988956  interferon alpha-3-like [KO:K05414]
105988976  interferon alpha-2-like [KO:K05414]
105988979  interferon alpha-2-like [KO:K05414]
105988997  interferon alpha-3-like [KO:K05414]
105988998  interferon alpha-3-like [KO:K05414]
105989000  interferon alpha-3-like [KO:K05414]
106000092  Mb21d1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105988598  Tmem173; stimulator of interferon genes protein [KO:K12654]
105990644  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105983690  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105989189  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105990960  Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
105983707  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
106000275  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105981018  Eif2ak4; eukaryotic translation initiation factor 2-alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
105982756  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105990675  Eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
106002525  Eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
105986051  Eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
105983689  Eif2b4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
105998364  Eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
105990722  Oas1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
105985004  Rnasel; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
106000166  Hcfc1; host cell factor 1 isoform X1 [KO:K14966]
105987744  Hcfc2; host cell factor 2 [KO:K27390]
105980729  Pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
105989683  Pou2f1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
105998093  Pou2f2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
105994024  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
105994025  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
106003265  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
105988847  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105999053  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
105995197  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105990116  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
105992528  Irf9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
105996922  Znf311; zinc finger protein 311 [KO:K09228]
105996930  Znf184; zinc finger protein 184 [KO:K09228]
105996678  Znf354a; zinc finger protein 354A [KO:K09228]
105980171  Znf350; zinc finger protein 350 [KO:K09228]
105984521  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
105980761  LOW QUALITY PROTEIN: zinc finger protein 260-like [KO:K09228]
105990583  Znf140; zinc finger protein 140 [KO:K09228]
105990660  Znf26; zinc finger protein 26 isoform X1 [KO:K09228]
105990732  Zfp37; zinc finger protein 37 homolog [KO:K09228]
105985280  zinc finger protein 39-like [KO:K09228]
105985298  zinc finger protein 883-like [KO:K09228]
105985418  zinc finger protein 260-like [KO:K09228]
105985420  zinc finger protein OZF-like [KO:K09228]
105985497  zinc finger protein 420-like isoform X1 [KO:K09228]
105985498  zinc finger protein 33B-like [KO:K09228]
105990808  Znf189; zinc finger protein 189 isoform X1 [KO:K09228]
105990875  Znf12; zinc finger protein 12 [KO:K09228]
105990876  Znf853; zinc finger protein 853 [KO:K09228]
105990904  Znf3; zinc finger protein 3 isoform X1 [KO:K09228]
105990977  zinc finger protein 883-like isoform X1 [KO:K09228]
105990995  Znf316; zinc finger protein 316 isoform X1 [KO:K09228]
105990999  Rbak; RB-associated KRAB zinc finger protein [KO:K09228]
105991340  zinc finger protein 717-like isoform X1 [KO:K09228]
105981541  zinc finger protein 37A-like [KO:K09228]
105981771  Znf334; zinc finger protein 334 isoform X1 [KO:K09228]
105981833  zinc finger protein 768 [KO:K09228]
105986193  zinc finger protein ZFP69-like isoform X1 [KO:K09228]
105987274  LOW QUALITY PROTEIN: zinc finger protein 782-like [KO:K09228]
105981881  Znf205; zinc finger protein 205 [KO:K09228]
105981972  Znf200; zinc finger protein 200 isoform X1 [KO:K09228]
105981976  Znf597; zinc finger protein 597 [KO:K09228]
105982006  zinc finger protein 689 [KO:K09228]
105982007  Znf688; zinc finger protein 688 isoform X1 [KO:K09228]
105987505  Znf641; zinc finger protein 641 [KO:K09228]
105993036  Znf792; zinc finger protein 792 [KO:K09228]
105993073  zinc finger protein 850 isoform X1 [KO:K09228]
105993075  LOW QUALITY PROTEIN: zinc finger protein 790-like [KO:K09228]
105993078  zinc finger protein 345-like isoform X1 [KO:K09228]
105993080  Znf569; zinc finger protein 569 [KO:K09228]
105993081  Hkr1; Krueppel-related zinc finger protein 1 isoform X1 [KO:K09228]
105993086  zinc finger protein 420-like [KO:K09228]
105993088  zinc finger protein 14 homolog [KO:K09228]
105993089  zinc finger protein 30 homolog [KO:K09228]
105993090  Znf599; zinc finger protein 599 [KO:K09228]
105993091  Znf565; zinc finger protein 565 [KO:K09228]
105993098  Znf793; zinc finger protein 793 [KO:K09228]
105993126  zinc finger protein 566-like isoform X1 [KO:K09228]
105988178  zinc finger protein 501-like [KO:K09228]
105988261  Znf2; zinc finger protein 2 [KO:K09228]
105993241  Znf484; zinc finger protein 484 isoform X1 [KO:K09228]
105982880  Zfp90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
105983061  Zfp1; zinc finger protein 1 homolog [KO:K09228]
105983151  Znf23; zinc finger protein 23 isoform X1 [KO:K09228]
105983210  Znf286a; zinc finger protein 286A isoform X1 [KO:K09228]
105994158  Znf473; zinc finger protein 473 [KO:K09228]
105994186  zinc finger protein 160-like [KO:K09228]
105994188  zinc finger protein 480-like [KO:K09228]
105994234  Znf324; zinc finger protein 324A [KO:K09228]
105994238  Znf211; LOW QUALITY PROTEIN: zinc finger protein 211 [KO:K09228]
105994307  Znf606; zinc finger protein 606 [KO:K09228]
105994308  zinc finger protein 665-like isoform X1 [KO:K09228]
105994313  zinc finger protein 883-like [KO:K09228]
105994317  Znf8; zinc finger protein 8 [KO:K09228]
105994320  zinc finger protein 154-like isoform X1 [KO:K09228]
105994350  LOW QUALITY PROTEIN: zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
105994364  zinc finger protein 883-like isoform X1 [KO:K09228]
105994365  zinc finger protein 383-like [KO:K09228]
105989512  Znf398; zinc finger protein 398 [KO:K09228]
105989513  Znf282; zinc finger protein 282 [KO:K09228]
105994659  zinc finger protein 239-like [KO:K09228]
105994660  zinc finger protein 431-like [KO:K09228]
105994721  zinc finger protein 564-like isoform X1 [KO:K09228]
105994724  zinc finger protein OZF-like [KO:K09228]
105994726  zinc finger protein 625-like [KO:K09228]
105994767  zinc finger protein 14-like isoform X1 [KO:K09228]
106002755  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
106002825  zinc finger protein OZF-like [KO:K09228]
106002827  zinc finger protein 25-like [KO:K09228]
106002829  LOW QUALITY PROTEIN: zinc finger protein 84-like [KO:K09228]
106002837  zinc finger protein 658B-like [KO:K09228]
106002838  LOW QUALITY PROTEIN: zinc finger protein 585B-like [KO:K09228]
106002842  zinc finger protein 717-like [KO:K09228]
105997062  Zfp57; zinc finger protein 57 homolog [KO:K09228]
105997174  Znf74; zinc finger protein 74 [KO:K09228]
105997794  zinc finger protein 791-like [KO:K09228]
105998468  Znf713; LOW QUALITY PROTEIN: zinc finger protein 713 [KO:K09228]
105998767  zinc finger protein 558-like isoform X1 [KO:K09228]
105998907  Znf248; zinc finger protein 248 [KO:K09228]
105998908  zinc finger protein 25-like [KO:K09228]
105998911  zinc finger protein 33B-like isoform X1 [KO:K09228]
105999004  Znf7; zinc finger protein 7 [KO:K09228]
105999012  Znf251; zinc finger protein 251 [KO:K09228]
105999014  Znf250; zinc finger protein 250 isoform X1 [KO:K09228]
105999019  Znf623; zinc finger protein 623 [KO:K09228]
105999084  Znf560; zinc finger protein 560 [KO:K09228]
105999085  zinc finger protein 26-like [KO:K09228]
105999086  zinc finger protein 561-like [KO:K09228]
105999087  zinc finger protein 709-like [KO:K09228]
105999099  zinc finger protein 717-like [KO:K09228]
105999100  zinc finger protein 709-like [KO:K09228]
105999101  zinc finger protein 709-like isoform X1 [KO:K09228]
105999472  LOW QUALITY PROTEIN: zinc finger protein 772-like [KO:K09228]
105999481  Znf582; LOW QUALITY PROTEIN: zinc finger protein 582 [KO:K09228]
105999491  Znf436; zinc finger protein 436 [KO:K09228]
105999505  zinc finger protein 665-like [KO:K09228]
105999506  zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
105999514  zinc finger protein 260-like [KO:K09228]
105999516  Znf304; zinc finger protein 304 isoform X1 [KO:K09228]
105999517  zinc finger protein 17-like [KO:K09228]
105999519  zinc finger protein 471-like [KO:K09228]
105999520  Znf583; zinc finger protein 583 [KO:K09228]
105999523  Znf667; zinc finger protein 667 [KO:K09228]
105999525  zinc finger protein 805-like [KO:K09228]
105999540  zinc finger protein interacting with ribonucleoprotein K-like isoform X1 [KO:K09228]
105999541  zinc finger protein 239-like [KO:K09228]
105999781  Znf717; zinc finger protein 717 [KO:K09228]
105999956  zinc finger protein 585A-like [KO:K09228]
106000119  Zfp92; zinc finger protein 92 homolog [KO:K09228]
106000293  Znf41; zinc finger protein 41 [KO:K09228]
106000296  Znf182; LOW QUALITY PROTEIN: zinc finger protein 182 [KO:K09228]
106000302  Znf81; zinc finger protein 81 [KO:K09228]
106000553  zinc finger protein OZF-like [KO:K09228]
106000607  zinc finger protein OZF-like [KO:K09228]
106000684  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
106000685  zinc finger protein 33B-like [KO:K09228]
106000815  zinc finger protein 14-like isoform X1 [KO:K09228]
106000991  LOW QUALITY PROTEIN: zinc finger protein 260-like [KO:K09228]
106000993  zinc finger protein OZF-like [KO:K09228]
106000994  LOW QUALITY PROTEIN: zinc finger protein 182-like [KO:K09228]
106001272  Znf777; zinc finger protein 777 [KO:K09228]
106001273  zinc finger protein 398-like [KO:K09228]
106001279  zinc finger protein 212-like [KO:K09228]
106001280  zinc finger protein 382-like [KO:K09228]
106001283  Znf746; zinc finger protein 746 [KO:K09228]
106001332  Znf317; zinc finger protein 317 isoform X1 [KO:K09228]
106001372  LOW QUALITY PROTEIN: zinc finger protein 33A-like [KO:K09228]
106001650  zinc finger protein 717-like [KO:K09228]
106001663  zinc finger protein OZF-like [KO:K09228]
106001673  zinc finger protein 717-like [KO:K09228]
106001697  LOW QUALITY PROTEIN: zinc finger protein 684-like [KO:K09228]
106001698  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
106001702  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
106001716  zinc finger protein 2 homolog isoform X1 [KO:K09228]
106001817  LOW QUALITY PROTEIN: zinc finger protein 182-like [KO:K09228]
106001837  zinc finger protein 260-like [KO:K09228]
106001876  Znf275; zinc finger protein 275 [KO:K09228]
106001892  zinc finger protein 570-like [KO:K09228]
105988764  Ifng; interferon gamma [KO:K04687]
105993592  Ifngr1; interferon gamma receptor 1 [KO:K05132]
105994023  Ifngr2; interferon gamma receptor 2 [KO:K05133]
105987218  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105999884  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
105988876  nuclear autoantigen Sp-100-like [KO:K15413]
105982530  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105999856  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105999854  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105999880  Tapbp; tapasin [KO:K08058]
105981140  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105989921  calreticulin-like [KO:K08057]
105999258  Calr; calreticulin [KO:K08057]
105996874  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
105996957  HLA class I histocompatibility antigen, B-7 alpha chain-like isoform X1 [KO:K06751]
105996958  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
105996964  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
105996972  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
106001400  LOW QUALITY PROTEIN: class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
106001802  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
105981191  B2m; beta-2-microglobulin [KO:K08055]
106002959  HLA class II histocompatibility antigen, DRB1-11 beta chain-like [KO:K06752]
105999831  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
105999834  HLA class II histocompatibility antigen, DR beta 4 chain-like isoform X1 [KO:K06752]
105999835  HLA class II histocompatibility antigen, DRB1-12 beta chain-like [KO:K06752]
105999836  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
105999837  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
105999872  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
105999877  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
105999881  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105999888  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105999890  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
106001844  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
105992564  Cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
105999080  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105999614  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106000559  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
106001473  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105985370  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105986178  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105986533  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105983045  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105998099  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105989408  Tsc1; hamartin isoform X1 [KO:K07206]
105982089  Tsc2; tuberin isoform X1 [KO:K07207]
105993854  Rheb; GTP-binding protein Rheb [KO:K07208]
105997410  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105991823  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105995747  Srpk1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
106003118  Srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
106003086  Srsf2; serine/arginine-rich splicing factor 2 [KO:K12891]
105995772  Srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
105985090  Srsf5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
105981641  Srsf6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
105999518  Srsf4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
105986856  Srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
105984327  Srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
105995265  Nxf1; nuclear RNA export factor 1 [KO:K14284]
106001490  Nxf3; nuclear RNA export factor 3 [KO:K14284]
105998400  Alyref; THO complex subunit 4 [KO:K12881]
105985196  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105986214  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105991035  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105983179  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105989060  Fadd; FAS-associated death domain protein [KO:K02373]
106002598  FAS-associated death domain protein-like [KO:K02373]
105981481  Casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105991113  Bid; BH3-interacting domain death agonist [KO:K04726]
105994373  Bax; apoptosis regulator BAX [KO:K02159]
105999887  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
105989249  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105987599  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
105981697  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105991774  cytochrome c, somatic [KO:K08738]
105994518  cytochrome c, testis-specific [KO:K08738]
105987659  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
105989961  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105992928  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
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Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
dord03040  Spliceosome
dord03050  Proteasome
dord04115  p53 signaling pathway
dord04151  PI3K-Akt signaling pathway
dord04210  Apoptosis
dord04610  Complement and coagulation cascades
dord04612  Antigen processing and presentation
dord04620  Toll-like receptor signaling pathway
dord04622  RIG-I-like receptor signaling pathway
dord04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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