Entry
Name
Cytokine-cytokine receptor interaction - Equus caballus (horse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ecb04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Equus caballus (horse) [GN:
ecb ]
Gene
100034121 CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) precursor [KO:K05505 ]
100056258 MIP-2BETA; uncharacterized protein LOC100056258 precursor [KO:K05505 ]
100033981 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
100033922 CSF3; granulocyte colony-stimulating factor isoform 2 [KO:K05423 ]
100146651 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
100034236 IL1RN; interleukin-1 receptor antagonist protein precursor [KO:K05481 ]
100146493 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
100060470 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
100052326 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
100049906 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
100064377 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
100060254 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
100061872 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
100051061 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
102150292 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100060605 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X2 [KO:K05469 ]
100060504 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
100147233 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
100051550 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
111769683 GDF1; LOW QUALITY PROTEIN: embryonic growth/differentiation factor 1 [KO:K05495 ]
100070292 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
100069676 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
791252 IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
100070311 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
106781070 granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K04737 ]
100054613 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
100069576 LOW QUALITY PROTEIN: cytokine receptor common subunit beta [KO:K04738 ]
102148014 granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
100057673 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
100069253 CSF3R; granulocyte colony-stimulating factor receptor isoform X5 [KO:K05061 ]
102148787 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
100068493 GALT; galactose-1-phosphate uridylyltransferase isoform X2 [KO:K05056 ]
100146965 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
100053757 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X2 [KO:K05064 ]
100062017 IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630 ]
100146590 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100066819 OSMR; oncostatin-M-specific receptor subunit beta isoform X4 [KO:K05057 ]
100071172 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
100052549 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
100073190 IL20RA; LOW QUALITY PROTEIN: interleukin-20 receptor subunit alpha [KO:K05136 ]
100066346 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
100057607 IFNLR1; LOW QUALITY PROTEIN: interferon lambda receptor 1 [KO:K05140 ]
100068726 IL1RAP; interleukin-1 receptor accessory protein isoform X3 [KO:K04723 ]
100050212 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
100059548 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100055840 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X3 [KO:K05141 ]
100059650 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X2 [KO:K03159 ]
100034069 TNFRSF14; tumor necrosis factor receptor superfamily member 14 precursor [KO:K05152 ]
111767395 LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
111770055 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143 ]
100071639 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
100059424 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
100057812 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
102149226 tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
102150834 tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K04722 ]
100068460 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
100060614 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
100065857 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
100069694 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
100065885 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100056617 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
100146755 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
100055885 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
100034049 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
100058657 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
100066167 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
100066195 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
100055833 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
100051166 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
100070724 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
100057564 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
100065672 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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