Entry Name TNF signaling pathway - Gracilinanus agilis (agile gracile opossum)
Description Tumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF is assembled to a homotrimer and binds to its receptors (TNFR1, TNFR2) resulting in the trimerization of TNFR1 or TNFR2. TNFR1 is expressed by nearly all cells and is the major receptor for TNF (also called TNF-alpha). In contrast, TNFR2 is expressed in limited cells such as CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells. It is the receptor for both TNF and LTA (also called TNF-beta). Upon binding of the ligand, TNFR mediates the association of some adaptor proteins such as TRADD or TRAF2, which in turn initiate recruitment of signal transducers. TNFR1 signaling induces activation of many genes, primarily controlled by two distinct pathways, NF-kappa B pathway and the MAPK cascade, or apoptosis and necroptosis. TNFR2 signaling activates NF-kappa B pathway including PI3K-dependent NF-kappa B pathway and JNK pathway leading to survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Gracilinanus agilis (agile gracile opossum) [GN:
gas ]
Gene 123250637 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
123234859 BAG4; BAG family molecular chaperone regulator 4 isoform X1 [KO:K09558 ]
123233277 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
123247914 TRAF5; LOW QUALITY PROTEIN: TNF receptor-associated factor 5 [KO:K09849 ]
123249564 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
123243627 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
123242420 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
123235058 CEBPB; CCAAT/enhancer-binding protein beta isoform X1 [KO:K10048 ]
123242713 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
123247071 CREB3L4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
123242984 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
123249476 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
123232395 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
123252575 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
123242200 ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450 ]
123250763 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
123245162 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049 ]
123256276 FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373 ]
123251660 LOW QUALITY PROTEIN: growth-regulated alpha protein-like [KO:K05505 ]
123241764 IL18R1; LOW QUALITY PROTEIN: interleukin-18 receptor 1 [KO:K05173 ]
123247650 LOW QUALITY PROTEIN: suppressor of cytokine signaling 3-like [KO:K04696 ]
123246855 T-cell-specific guanine nucleotide triphosphate-binding protein 2-like [KO:K17072 ]
123235301 NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165 ]
123242322 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
123242831 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
123240288 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
123236876 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
123256513 phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
123256515 phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
Reference Authors Chu WM
Title Tumor necrosis factor.
Journal Reference Authors Shuh M, Bohorquez H, Loss GE Jr, Cohen AJ
Title Tumor Necrosis Factor-alpha: Life and Death of Hepatocytes During Liver Ischemia/Reperfusion Injury.
Journal Ochsner J 13:119-30 (2013)
Reference Authors MacEwan DJ
Title TNF receptor subtype signalling: differences and cellular consequences.
Journal Reference Authors Newton K, Dixit VM
Title Signaling in innate immunity and inflammation.
Journal Reference Authors Pomerantz JL, Baltimore D
Title NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Journal Reference Authors Naude PJ, den Boer JA, Luiten PG, Eisel UL
Title Tumor necrosis factor receptor cross-talk.
Journal Reference Authors Faustman D, Davis M
Title TNF receptor 2 pathway: drug target for autoimmune diseases.
Journal Reference Authors Chan FK, Shisler J, Bixby JG, Felices M, Zheng L, Appel M, Orenstein J, Moss B, Lenardo MJ
Title A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.
Journal Reference Authors Lee MY, Nam KH, Choi KC
Title iRhoms; Its Functions and Essential Roles.
Journal Related KO pathway LinkDB All DBs
