KEGG   PATHWAY: gas04010
Entry
gas04010                    Pathway                                
Name
MAPK signaling pathway - Gracilinanus agilis (agile gracile opossum)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
gas04010  MAPK signaling pathway
gas04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123230760  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123230767  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
123230768  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
123230817  [KO:K02583]
123230857  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123230946  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
123230981  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
123231024  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
123231134  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
123231136  [KO:K03283]
123231489  FGF10; fibroblast growth factor 10 [KO:K04358]
123231509  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123231861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123232071  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
123232075  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123232104  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123232189  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123232226  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123232273  FGF22; fibroblast growth factor 22 [KO:K04358]
123232293  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123232391  [KO:K02187] [EC:3.4.22.56]
123232459  CRKL; crk-like protein [KO:K04438]
123232515  [KO:K07828]
123232952  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
123233277  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
123233359  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123233417  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
123233503  [KO:K07836]
123233593  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
123233760  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
123233788  FGF18; fibroblast growth factor 18 [KO:K04358]
123233796  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
123233823  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123233824  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123233974  SOS2; son of sevenless homolog 2 [KO:K03099]
123233988  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
123234003  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
123234074  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123234075  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
123234190  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123234220  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
123234255  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123234272  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123234292  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
123234327  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123234491  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
123234542  IL1B; interleukin-1 beta [KO:K04519]
123234658  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123234807  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123234833  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123234910  [KO:K07836]
123235108  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
123235492  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
123235626  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
123235857  PGF; placenta growth factor [KO:K16859]
123235863  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123236227  EFNA5; ephrin-A5 [KO:K05462]
123236241  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123236247  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
123236271  IL1A; interleukin-1 alpha [KO:K04383]
123236476  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123236477  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123236490  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
123236535  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
123236785  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123236829  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123236830  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
123236837  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
123236954  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
123236988  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123237008  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123237050  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123237114  STK4; serine/threonine-protein kinase 4 [KO:K04411]
123237194  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123237389  ANGPT4; angiopoietin-4 [KO:K05467]
123237465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123237492  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123237555  CD14; monocyte differentiation antigen CD14 [KO:K04391]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123237731  MAX; protein max isoform X1 [KO:K04453]
123237759  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
123237804  FOS; proto-oncogene c-Fos [KO:K04379]
123237846  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
123237919  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
123237952  FGF7; fibroblast growth factor 7 [KO:K04358]
123238034  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
123238040  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123238083  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
123238271  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
123238976  [KO:K04393]
123239466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123239917  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
123240362  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123240391  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
123240510  [KO:K04439]
123240520  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
123240604  FGF9; fibroblast growth factor 9 [KO:K04358]
123240716  [KO:K16342] [EC:3.1.1.4]
123240884  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
123240899  STK3; serine/threonine-protein kinase 3 [KO:K04412]
123240981  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
123241052  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123241274  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123241275  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123241296  [KO:K04393]
123241522  MRAS; ras-related protein M-Ras [KO:K07831]
123241543  MYC; myc proto-oncogene protein [KO:K04377]
123241763  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
123242010  [KO:K04723]
123242128  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123242200  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
123242206  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
123242259  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
123242307  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
123242334  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123242409  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
123242540  VEGFD; vascular endothelial growth factor D [KO:K05449]
123242586  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
123242724  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
123242771  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123242827  MECOM; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
123242892  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
123242898  [KO:K16342] [EC:3.1.1.4]
123242932  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
123242957  RELB; transcription factor RelB isoform X1 [KO:K09253]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123243002  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
123243003  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
123243007  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123243043  NTF4; neurotrophin-4 [KO:K12457]
123243164  STMN1; stathmin [KO:K04381]
123243176  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123243627  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
123243674  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123243748  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
123243789  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
123243817  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
123243860  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123243914  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
123244057  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
123244367  NF1; neurofibromin [KO:K08052]
123244374  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
123244406  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
123244534  TP53; cellular tumor antigen p53 [KO:K04451]
123244611  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
123244845  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
123244853  EFNA1; ephrin-A1 [KO:K05462]
123244863  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
123244960  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123245100  TNF; tumor necrosis factor [KO:K03156]
123245130  [KO:K03283]
123245132  [KO:K03283]
123245170  [KO:K05462]
123245201  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
123245203  ARTN; artemin [KO:K25415]
123245233  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
123245315  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
123245333  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123245383  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123245414  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123245523  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123245551  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123245622  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123245714  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
123245896  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123246086  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123246222  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123246229  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
123246422  SRF; serum response factor [KO:K04378]
123246427  VEGFA; vascular endothelial growth factor A [KO:K05448]
123246606  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123246617  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
123246710  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
123246812  CRK; adapter molecule crk [KO:K04438]
123246862  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
123247194  NRAS; GTPase NRas [KO:K07828]
123247200  NGF; beta-nerve growth factor [KO:K02582]
123247336  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
123247361  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
123247379  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123247441  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
123247456  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
123247525  HSPB1; heat shock protein beta-1 [KO:K04455]
123247552  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123247605  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123247653  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123247656  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
123247702  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123247783  [KO:K05462]
123247856  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
123247918  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
123247944  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
123247967  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
123248033  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
123248457  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
123248572  RAP1B; ras-related protein Rap-1b [KO:K07836]
123248588  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
123248655  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123248659  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
123248684  KRAS; GTPase KRas isoform X1 [KO:K07827]
123248756  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
123248853  [KO:K03283]
123249099  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
123249295  [KO:K04393]
123249370  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
123249501  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123249530  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
123249564  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
123249677  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123249682  FGF6; fibroblast growth factor 6 [KO:K04358]
123249688  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
123249991  HGF; hepatocyte growth factor [KO:K05460]
123249992  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
123250048  FGF23; fibroblast growth factor 23 [KO:K22428]
123250056  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
123250074  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
123250075  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123250082  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123250088  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
123250135  KITLG; kit ligand [KO:K05461]
123250283  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
123250354  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
123250360  [KO:K05084] [EC:2.7.10.1]
123250387  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
123250427  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123250637  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123250666  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123250672  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
123250679  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
123250717  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123250743  NTF3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
123250763  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123250911  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
123250969  FGF3; fibroblast growth factor 3 [KO:K04358]
123251051  AREG; amphiregulin [KO:K09782]
123251065  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123251095  FGF19; fibroblast growth factor 19 [KO:K22603]
123251179  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123251290  RELA; transcription factor p65 isoform X1 [KO:K04735]
123251329  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123251330  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
123251436  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123251466  VEGFC; vascular endothelial growth factor C [KO:K05449]
123251483  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
123251682  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123251773  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123251809  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123251828  [KO:K07827]
123251883  [KO:K02187] [EC:3.4.22.56]
123251915  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
123251933  FGF5; fibroblast growth factor 5 [KO:K04358]
123252000  FGF20; fibroblast growth factor 20 [KO:K04358]
123252074  [KO:K02187] [EC:3.4.22.56]
123252097  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123252144  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
123252235  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
123252239  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
123252398  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
123252399  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123252878  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
123252907  RRAS2; ras-related protein R-Ras2 [KO:K07830]
123252924  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123252942  PDGFC; platelet-derived growth factor C [KO:K05450]
123253043  EREG; proepiregulin [KO:K09784]
123253095  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
123253141  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123253463  [KO:K04407] [EC:2.7.11.1]
123253550  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
123253573  [KO:K04437]
123253593  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123253639  FGF16; fibroblast growth factor 16 [KO:K04358]
123253763  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
123253770  [KO:K05096] [EC:2.7.10.1]
123253779  IKBKG; NF-kappa-B essential modulator [KO:K07210]
123253855  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
123254019  [KO:K04345] [EC:2.7.11.11]
123254042  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
123254147  [KO:K04729]
123254168  [KO:K19663] [EC:2.7.11.13]
123254538  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
123254560  [KO:K04449]
123254868  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123254950  [KO:K05462]
123255090  [KO:K04358]
123255143  [KO:K19663] [EC:2.7.11.13]
123255219  ANGPT1; angiopoietin-1 [KO:K05465]
123255353  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
123255401  [KO:K05084] [EC:2.7.10.1]
123255551  [KO:K02187] [EC:3.4.22.56]
123255585  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
123255628  VEGFB; vascular endothelial growth factor B [KO:K16858]
123255768  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
123255917  [KO:K04460] [EC:3.1.3.16]
123255977  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123256016  DAXX; death domain-associated protein 6 [KO:K02308]
123256028  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
123256030  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123256044  INS; insulin [KO:K04526]
123256054  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
123256386  [KO:K03283]
123256466  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
123256602  PSPN; persephin [KO:K25416]
123256657  NRTN; neurturin [KO:K25414]
123256825  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
123256866  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
123256894  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
gas04070  Phosphatidylinositol signaling system
gas04110  Cell cycle
gas04115  p53 signaling pathway
gas04210  Apoptosis
gas04310  Wnt signaling pathway
gas04668  TNF signaling pathway
KO pathway
ko04010   

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