KEGG   PATHWAY: gas04210
Entry
gas04210                    Pathway                                
Name
Apoptosis - Gracilinanus agilis (agile gracile opossum)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
gas04210  Apoptosis
gas04210

Other DBs
GO: 0006915
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123233411  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
123245896  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123256276  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
123245100  TNF; tumor necrosis factor [KO:K03156]
123250637  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123233277  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
123242696  CFLAR; CASP8 and FADD-like apoptosis regulator [KO:K04724]
123242697  caspase-8-like [KO:K04398] [EC:3.4.22.61]
123240075  caspase-8-like [KO:K04398] [EC:3.4.22.61]
123241894  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
123251010  CASP6; caspase-6 [KO:K04396] [EC:3.4.22.59]
123255551  caspase-3-like [KO:K02187] [EC:3.4.22.56]
123232391  caspase-3-like [KO:K02187] [EC:3.4.22.56]
123251682  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123251883  caspase-3-like [KO:K02187] [EC:3.4.22.56]
123252074  caspase-3-like [KO:K02187] [EC:3.4.22.56]
123254583  caspase-7-like [KO:K04397] [EC:3.4.22.60]
123238175  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
123248687  BID; BH3-interacting domain death agonist [KO:K04726]
123242888  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123243961  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
123232344  DIABLO; diablo homolog, mitochondrial [KO:K10522]
123247454  septin-4 [KO:K16943]
123251237  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
123250609  cytochrome c, somatic [KO:K08738]
123239227  cytochrome c, testis-specific [KO:K08738]
123250560  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
123240973  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
123236504  PRF1; perforin-1 [KO:K07818]
123235914  granzyme B-like [KO:K01353] [EC:3.4.21.79]
123241936  TUBA4A; tubulin alpha-4A chain [KO:K07374]
123254937  tubulin alpha-4A chain-like [KO:K07374]
123242747  tubulin alpha-1D chain [KO:K07374]
123249497  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123249504  TUBA8; tubulin alpha-8 chain [KO:K07374]
123243940  tubulin alpha-8 chain [KO:K07374]
123250341  tubulin alpha-1B chain isoform X1 [KO:K07374]
123245653  tubulin alpha-3 chain [KO:K07374]
123245751  tubulin alpha-3 chain [KO:K07374]
123244267  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
123232980  actin, cytoplasmic type 5 [KO:K05692]
123247581  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
123242607  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
123243855  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
123243954  actin, cytoplasmic 2 isoform X1 [KO:K05692]
123244269  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
123244479  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123251262  LOW QUALITY PROTEIN: actin-like [KO:K05692]
123233915  ACTB; actin, cytoplasmic 1 [KO:K05692]
123252825  actin-3-like [KO:K05692]
123234757  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
123234907  actin, cytoplasmic 1-like [KO:K05692]
123237248  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
123246092  LMNA; lamin [KO:K12641]
123231347  LMNB1; lamin-B1 [KO:K07611]
123232227  LMNB2; lamin-B2 [KO:K07611]
123244130  PARP1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
123241289  PARP4; protein mono-ADP-ribosyltransferase PARP4 [KO:K10798] [EC:2.4.2.30]
123238006  PARP2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
123246476  PARP3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
123243090  DFFA; DNA fragmentation factor subunit alpha [KO:K02310]
123243063  DFFB; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
123237242  ENDOG; endonuclease G, mitochondrial [KO:K01173]
123253350  AIFM1; apoptosis-inducing factor 1, mitochondrial [KO:K04727] [EC:1.-.-.-]
123246200  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123237194  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123247136  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
123250011  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123246373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
123251123  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
123244336  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
123241351  caspase-4-like [KO:K04741] [EC:3.4.22.-]
123239005  caspase-13-like isoform X1 [KO:K04741] [EC:3.4.22.-]
123233149  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
123237723  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123250763  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123250717  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123237006  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
123238811  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
123238812  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
123238813  dipeptidyl peptidase 1-like isoform X1 [KO:K01275] [EC:3.4.14.1]
123254360  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
123252850  collagen alpha-1(I) chain-like [KO:K01379] [EC:3.4.23.5]
123252799  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
123234217  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
123244279  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
123235293  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123254911  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123254913  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123237346  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123237347  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123231298  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123231299  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123231300  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123250639  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
123252328  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
123247280  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
123253951  procathepsin L-like [KO:K01375] [EC:3.4.22.43]
123251562  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
123237156  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
123238988  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
123240870  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
123253493  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
123231659  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
123245520  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
123236931  BCL2L11; bcl-2-like protein 11 [KO:K16341]
123237395  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123238254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123256016  DAXX; death domain-associated protein 6 [KO:K02308]
123240537  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
123237373  disabled homolog 2-interacting protein [KO:K19901]
123247967  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
123237465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123238271  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
123251179  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123251373  BAD; bcl2-associated agonist of cell death [KO:K02158]
123247656  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
123237804  FOS; proto-oncogene c-Fos [KO:K04379]
123244534  TP53; cellular tumor antigen p53 [KO:K04451]
123243674  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123236476  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
123233417  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
123253779  IKBKG; NF-kappa-B essential modulator [KO:K07210]
123235754  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123252239  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
123251290  RELA; transcription factor p65 isoform X1 [KO:K04735]
123253110  PTPN13; tyrosine-protein phosphatase non-receptor type 13 [KO:K02374]
123255768  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
123232226  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123251065  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123235384  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
123238111  BCL2A1; bcl-2-related protein A1 [KO:K02162]
123241475  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
123256252  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
123256076  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
123249181  CASP2; caspase-2 [KO:K02186] [EC:3.4.22.55]
123247200  NGF; beta-nerve growth factor [KO:K02582]
123246086  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123241727  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
123250087  CSF2RB; LOW QUALITY PROTEIN: cytokine receptor common subunit beta [KO:K04738]
123242322  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123242831  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123240288  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123236876  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123256513  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
123256515  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
123231496  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123244679  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123248684  KRAS; GTPase KRas isoform X1 [KO:K07827]
123251828  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07827]
123247194  NRAS; GTPase NRas [KO:K07828]
123232515  GTPase NRas-like [KO:K07828]
123239466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123238040  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123243007  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123230857  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123245714  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
gas04010  MAPK signaling pathway
gas04020  Calcium signaling pathway
gas04064  NF-kappa B signaling pathway
gas04115  p53 signaling pathway
gas04141  Protein processing in endoplasmic reticulum
gas04151  PI3K-Akt signaling pathway
gas04650  Natural killer cell mediated cytotoxicity
gas04668  TNF signaling pathway
KO pathway
ko04210   
LinkDB

DBGET integrated database retrieval system