KEGG   PATHWAY: hhv04020
Entry
hhv04020                    Pathway                                
Name
Calcium signaling pathway - Hyaena hyaena (striped hyena)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
hhv04020  Calcium signaling pathway
hhv04020

Other DBs
GO: 0019722
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120224258  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
120225146  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
120239931  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
120237072  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
120228891  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
120221711  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
120231315  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
120249162  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
120222084  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
120221102  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
120223942  ADORA2A; adenosine receptor A2a [KO:K04266]
120228751  ADORA2B; adenosine receptor A2b [KO:K04267]
120235331  ADRB1; beta-1 adrenergic receptor [KO:K04141]
120236558  ADRB2; beta-2 adrenergic receptor [KO:K04142]
120238683  ADRB3; beta-3 adrenergic receptor [KO:K04143]
120236750  DRD1; D(1A) dopamine receptor [KO:K04144]
120242993  DRD5; D(1B) dopamine receptor [KO:K05840]
120236795  HRH2; histamine H2 receptor [KO:K04150]
120236585  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
120230948  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
120246092  5-hydroxytryptamine receptor 5B [KO:K04161]
120229803  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
120219859  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
120234858  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
120234860  neuroendocrine secretory protein 55 [KO:K04632]
120220192  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
120238897  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120225093  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120235801  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120247005  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
120238226  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120221853  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
120236476  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120241649  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120245321  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120241112  PLN; cardiac phospholamban [KO:K05852]
120224564  SLN; sarcolipin [KO:K22642]
120244142  MRLN; myoregulin [KO:K22643]
120246358  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
120228140  SMIM6; small integral membrane protein 6 [KO:K26468]
120224758  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
120239909  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120242255  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
120243480  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
120245122  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
120234691  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
120242940  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
120239285  ORAI2; protein orai-2 isoform X1 [KO:K16057]
120242292  ORAI3; protein orai-3 [KO:K16058]
120243774  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
120239388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120221013  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120228884  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
120245276  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120222772  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120243238  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120229078  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
120241536  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120234330  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120226149  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
120222782  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
120239836  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120236891  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120228230  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
120240145  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
120220963  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
120242306  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
120224764  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
120224513  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
120240343  P2RX3; P2X purinoceptor 3 [KO:K05217]
120221994  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
120224763  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
120238858  P2RX6; P2X purinoceptor 6 [KO:K05221]
120221675  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
120220611  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
120246717  RYR2; ryanodine receptor 2 [KO:K04962]
120241877  RYR3; ryanodine receptor 3 [KO:K04963]
120224833  TRDN; triadin [KO:K23449]
120241372  CASQ1; calsequestrin-1 [KO:K23468]
120238772  CASQ2; calsequestrin-2 [KO:K23445]
120243102  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
120224158  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
120245223  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
120224207  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
120244096  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
120240578  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
120226347  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
120237605  AGTR1; type-1 angiotensin II receptor [KO:K04166]
120246306  EDNRA; endothelin-1 receptor [KO:K04197]
120245405  EDNRB; endothelin receptor type B [KO:K04198]
120240736  F2R; proteinase-activated receptor 1 [KO:K03914]
120231041  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
120246249  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
120232916  GRPR; gastrin-releasing peptide receptor [KO:K04169]
120231272  HRH1; histamine H1 receptor [KO:K04149]
120233354  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
120222758  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
120247968  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
120241027  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
120234916  NTSR1; neurotensin receptor type 1 [KO:K04211]
120231271  OXTR; oxytocin receptor [KO:K04229]
120248059  AVPR1A; vasopressin V1a receptor [KO:K04226]
120228849  AVPR1B; vasopressin V1b receptor [KO:K04227]
120247009  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
120230584  PTAFR; platelet-activating factor receptor [KO:K04279]
120245329  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
120220250  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
120223525  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
120223845  BDKRB1; B1 bradykinin receptor [KO:K03915]
120223849  BDKRB2; B2 bradykinin receptor [KO:K03916]
120236985  TACR1; substance-P receptor [KO:K04222]
120232484  TACR2; substance-K receptor [KO:K04223]
120225568  TACR3; neuromedin-K receptor [KO:K04224]
120242101  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
120243308  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
120224707  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
120234716  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
120221429  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
120230386  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120238451  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120242104  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
120238444  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
120242062  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
120236138  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120236624  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
120227991  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120233377  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120223081  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120246757  PDGFD; platelet-derived growth factor D [KO:K05450]
120234333  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120238033  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120224487  FGF16; fibroblast growth factor 16 [KO:K04358]
120243219  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120233064  FGF10; fibroblast growth factor 10 [KO:K04358]
120233875  FGF4; fibroblast growth factor 4 [KO:K04358]
120233886  FGF3; fibroblast growth factor 3 [KO:K04358]
120234087  FGF18; fibroblast growth factor 18 [KO:K04358]
120239484  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120235046  FGF7; fibroblast growth factor 7 [KO:K04358]
120222265  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
120242355  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
120247465  FGF9; fibroblast growth factor 9 [KO:K04358]
120247728  FGF6; fibroblast growth factor 6 [KO:K04358]
120248082  FGF20; fibroblast growth factor 20 [KO:K04358]
120233885  FGF19; fibroblast growth factor 19 [KO:K22603]
120243454  FGF21; fibroblast growth factor 21 [KO:K22429]
120247734  FGF23; fibroblast growth factor 23 [KO:K22428]
120231199  VEGFA; vascular endothelial growth factor A [KO:K05448]
120240107  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120232932  VEGFD; vascular endothelial growth factor D [KO:K05449]
120222108  VEGFC; vascular endothelial growth factor C [KO:K05449]
120238779  NGF; beta-nerve growth factor [KO:K02582]
120221164  hepatocyte growth factor-like [KO:K05460]
120245413  HGF; hepatocyte growth factor [KO:K05460]
120229402  MST1; hepatocyte growth factor-like protein [KO:K23441]
120244146  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120229105  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
120219930  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120245818  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
120222584  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120236611  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120238662  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120244115  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120231844  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120236775  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120247154  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120225370  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120243048  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120244665  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120224500  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
120220033  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
120223826  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120229379  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
120249234  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
120232448  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
120235107  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
120222292  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
120232253  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
120226357  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
120226638  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120240178  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
120228585  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
120228197  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120230566  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
120243007  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
120237135  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120237482  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120238181  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120237985  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
120234415  TPCN1; two pore calcium channel protein 1 [KO:K16896]
120233904  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
120244840  MCOLN1; mucolipin-1 [KO:K04992]
120241644  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
120241652  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
120228097  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
120242882  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
120233756  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
120238512  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120233718  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120234907  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
120234009  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120240573  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
120222124  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
120246386  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
120248075  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
120237319  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
120239441  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120243296  TNNC2; troponin C, skeletal muscle [KO:K12042]
120232098  CALM1; calmodulin-1 [KO:K02183]
120237182  calmodulin-like [KO:K02183]
120237195  calmodulin-like protein 3 [KO:K02183]
120241014  CALM2; calmodulin-2 [KO:K02183]
120221982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
120241987  CALM3; calmodulin-3 isoform X1 [KO:K02183]
120242524  CALML6; calmodulin-like protein 6 [KO:K02183]
120235665  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
120242267  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
120237995  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
120226890  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
120222155  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
120241961  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
120237364  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120238194  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
120235452  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
120241448  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
120226588  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
120230511  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
120231295  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
120233726  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120238899  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120222252  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120236563  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120224722  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
120225617  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120233735  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120239494  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120220964  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120236651  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120238739  TFEB; transcription factor EB [KO:K15590]
120240942  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120230427  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120223543  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120247040  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
120232363  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
120246360  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
120230927  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
120220032  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
120236707  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120244567  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
120220289  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
120232297  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
120234143  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
120241121  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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Reference
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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  Authors
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  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
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Reference
PMID:10331643
  Authors
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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Crompton M.
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Reference
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
hhv04010  MAPK signaling pathway
hhv04070  Phosphatidylinositol signaling system
hhv04210  Apoptosis
hhv04720  Long-term potentiation
hhv04730  Long-term depression
KO pathway
ko04020   
LinkDB

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