KEGG   PATHWAY: ldi04010
Entry
ldi04010                    Pathway                                
Name
MAPK signaling pathway - Leptosomus discolor (cuckoo roller)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ldi04010  MAPK signaling pathway
ldi04010

Other DBs
GO: 0000165
Organism
Leptosomus discolor (cuckoo roller) [GN:ldi]
Gene
104350010  CATSPER4; cation channel sperm-associated protein 4 [KO:K04849]
104353406  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104342482  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104344271  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104343418  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
104348688  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
104347345  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104344820  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104342569  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
104352136  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
104352235  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
104347642  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104354823  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
104353149  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
104347644  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104347042  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104345924  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104346869  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104348690  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104351425  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104351917  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104347110  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104354251  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104349093  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104352999  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104351578  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104348160  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
104352516  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104344361  NF1; neurofibromin [KO:K08052]
104346586  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104340036  RASA2; ras GTPase-activating protein 2 [KO:K08053]
104353529  RAP1A; ras-related protein Rap-1A [KO:K04353]
104341426  RAP1B; ras-related protein Rap-1b [KO:K07836]
104343767  EGF; pro-epidermal growth factor [KO:K04357]
104346671  EREG; proepiregulin [KO:K09784]
104344880  AREG; amphiregulin [KO:K09782]
104348522  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104342836  FGF2; fibroblast growth factor 2 [KO:K18497]
104341350  FGF3; fibroblast growth factor 3 [KO:K04358]
104346588  FGF18; fibroblast growth factor 18 [KO:K04358]
104351983  FGF8; fibroblast growth factor 8 [KO:K04358]
104347792  FGF17; fibroblast growth factor 17 [KO:K04358]
104343054  fibroblast growth factor 20-like [KO:K04358]
104343647  FGF6; fibroblast growth factor 6 [KO:K04358]
104344051  FGF7; fibroblast growth factor 7 [KO:K04358]
104344994  fibroblast growth factor 9-like [KO:K04358]
104344997  fibroblast growth factor 10-like [KO:K04358]
104350975  fibroblast growth factor 5-like [KO:K04358]
104350537  FGF19; fibroblast growth factor 19 [KO:K22603]
104343567  fibroblast growth factor 23-like [KO:K22428]
104344273  NGF; beta-nerve growth factor [KO:K02582]
104354654  BDNF; brain-derived neurotrophic factor [KO:K04355]
104350399  NTF3; neurotrophin-3 [KO:K04356]
104339708  INS; insulin [KO:K04526]
104352212  IGF1; insulin-like growth factor I [KO:K05459]
104341533  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104355123  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104354057  PDGFD; platelet-derived growth factor D [KO:K05450]
104344045  PDGFC; platelet-derived growth factor C [KO:K05450]
104352046  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104343318  KITLG; kit ligand [KO:K05461]
104340637  VEGFA; vascular endothelial growth factor A [KO:K05448]
104341850  PGF; placenta growth factor [KO:K16859]
104348632  VEGFC; vascular endothelial growth factor C [KO:K05449]
104350289  FIGF; vascular endothelial growth factor D [KO:K05449]
104349387  HGF; hepatocyte growth factor [KO:K05460]
104345453  ANGPT1; angiopoietin-1 [KO:K05465]
104345254  ANGPT2; angiopoietin-2 [KO:K05466]
104343594  EFNA1; ephrin-A1 [KO:K05462]
104348396  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
104344245  neurturin-like [KO:K25414]
104352845  LOW QUALITY PROTEIN: artemin-like [KO:K25415]
104345569  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104350125  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
104354170  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104344589  LOW QUALITY PROTEIN: fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
104347584  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
104352591  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104352929  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104352678  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104352676  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104351254  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104340192  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104346936  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
104352162  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104343182  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
104346507  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104354895  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104344138  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104351977  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104354130  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104342477  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104348272  SOS1; son of sevenless homolog 1 [KO:K03099]
104354294  HRAS; GTPase HRas [KO:K02833]
104346358  KRAS; GTPase KRas isoform X1 [KO:K07827]
104346001  NRAS; GTPase NRas [KO:K07828]
104352204  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104351226  MRAS; ras-related protein M-Ras [KO:K07831]
104353259  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104354943  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104344158  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
104349592  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104349106  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104343823  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
104353047  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104340504  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104342772  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104354812  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104352989  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104354969  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
104345964  SRF; serum response factor [KO:K04378]
104344912  LOW QUALITY PROTEIN: microtubule-associated protein tau-like [KO:K04380]
104342275  STMN1; stathmin [KO:K04381]
104346976  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104347353  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104347356  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104347579  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104352970  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104342813  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104344669  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104349943  LOW QUALITY PROTEIN: interleukin-1 beta-like [KO:K04519]
104349792  TGFB2; transforming growth factor beta-2 [KO:K13376]
104344552  TGFB3; transforming growth factor beta-3 [KO:K13377]
104340091  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104349371  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
104348206  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104345327  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
104349047  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104349491  LOW QUALITY PROTEIN: TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104346858  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104348736  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104347748  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
104348238  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104353083  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104349961  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104349996  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104353695  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104347571  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104346349  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104350177  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104343232  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104343790  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104349085  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104346900  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104344176  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
104352564  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
104353283  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104347740  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104345185  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104349003  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104344174  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104344750  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104349527  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104348091  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
104344381  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104351345  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104348310  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
104346260  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104345650  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
104344415  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104341150  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104346909  MAP3K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104343053  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
104343794  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104342452  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104346570  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104353518  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104349289  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104351617  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
104353792  CRKL; crk-like protein [KO:K04438]
104339862  beta-arrestin-1 [KO:K04439]
104351895  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104354569  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
104350868  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
104343723  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104343731  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104345286  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104340806  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104351286  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104344331  MAP kinase-activated protein kinase 3-like [KO:K04444] [EC:2.7.11.1]
104340798  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104351188  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104354767  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
104354544  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
104348545  JUN; transcription factor AP-1 [KO:K04448]
104348460  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104341711  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
104347389  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104354127  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104349336  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104349338  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104345449  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104345333  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104351976  DUSP1; LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104350932  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104347596  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104347794  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104353980  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104342893  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104348032  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104343209  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104352940  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
104349513  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104343033  MECOM; MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
104349007  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104349714  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104352921  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104340350  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104347575  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104346188  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104350305  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ldi04070  Phosphatidylinositol signaling system
ldi04110  Cell cycle
ldi04115  p53 signaling pathway
ldi04210  Apoptosis
ldi04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system