KEGG   PATHWAY: ming03040
Entry
ming03040                   Pathway                                
Name
Spliceosome - Macadamia integrifolia (macadamia nut)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
ming03040  Spliceosome
ming03040

Other DBs
GO: 0005681
Organism
Macadamia integrifolia (macadamia nut) [GN:ming]
Gene
122068504  U1 spliceosomal RNA [KO:K14276]
122062699  U1 spliceosomal RNA [KO:K14276]
122063508  U1 spliceosomal RNA [KO:K14276]
122064360  U1 spliceosomal RNA [KO:K14276]
122087800  U2 spliceosomal RNA [KO:K14277]
122063509  U2 spliceosomal RNA [KO:K14277]
122090204  U2 spliceosomal RNA [KO:K14277]
122087802  U2 spliceosomal RNA [KO:K14277]
122075002  U4 spliceosomal RNA [KO:K14278]
122080553  U4 spliceosomal RNA [KO:K14278]
122060328  U4 spliceosomal RNA [KO:K14278]
122087081  U5 spliceosomal RNA [KO:K14279]
122060329  U5 spliceosomal RNA [KO:K14279]
122063356  U6 spliceosomal RNA [KO:K14280]
122084089  DEAD-box ATP-dependent RNA helicase 42-like [KO:K12811] [EC:5.6.2.7]
122074489  DEAD-box ATP-dependent RNA helicase 42-like [KO:K12811] [EC:5.6.2.7]
122064390  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
122091480  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
122068336  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
122076544  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 [KO:K12813] [EC:5.6.2.6]
122093672  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
122077016  pre-mRNA-processing factor 17-like isoform X1 [KO:K12816]
122079683  LOW QUALITY PROTEIN: pre-mRNA-processing factor 17-like [KO:K12816]
122091705  pre-mRNA-splicing factor 18 [KO:K12817]
122077096  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
122077941  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
122066325  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
122080121  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 isoform X1 [KO:K12818] [EC:5.6.2.6]
122070547  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DEAH11, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
122083648  ATP-dependent RNA helicase DEAH11, chloroplastic-like isoform X1 [KO:K12818] [EC:5.6.2.6]
122084786  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
122084691  pre-mRNA-splicing factor SLU7 [KO:K12819]
122090504  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 [KO:K12820] [EC:5.6.2.6]
122067085  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
122068049  F-box protein At5g03970-like [KO:K12820] [EC:5.6.2.6]
122078857  small nuclear ribonucleoprotein-associated proteins B and B'-like [KO:K11086]
122083200  small nuclear ribonucleoprotein-associated protein B-like [KO:K11086]
122078648  small nuclear ribonucleoprotein SmD1a [KO:K11087]
122094073  small nuclear ribonucleoprotein SmD1a-like [KO:K11087]
122058484  small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096]
122083280  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
122072877  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
122072993  small nuclear ribonucleoprotein E-like [KO:K11097]
122059515  small nuclear ribonucleoprotein E-like [KO:K11097]
122083501  probable small nuclear ribonucleoprotein F [KO:K11098]
122073308  probable small nuclear ribonucleoprotein F [KO:K11098]
122063880  probable small nuclear ribonucleoprotein G [KO:K11099]
122068953  probable small nuclear ribonucleoprotein G [KO:K11099]
122093570  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
122074839  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
122057793  U1 small nuclear ribonucleoprotein A [KO:K11091]
122089988  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
122091397  U1 small nuclear ribonucleoprotein C [KO:K11095]
122082743  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
122072242  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
122076611  RNA-binding protein 25-like isoform X1 [KO:K12822]
122079973  RNA-binding protein 25-like isoform X1 [KO:K12822]
122076625  DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [KO:K12823] [EC:5.6.2.7]
122076656  ATP-dependent RNA helicase-like protein DB10 isoform X1 [KO:K12823] [EC:5.6.2.7]
122088931  DEAD-box ATP-dependent RNA helicase 40-like [KO:K12823] [EC:5.6.2.7]
122089291  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
122091849  DEAD-box ATP-dependent RNA helicase 40-like isoform X1 [KO:K12823] [EC:5.6.2.7]
122079417  DEAD-box ATP-dependent RNA helicase 20 isoform X1 [KO:K12823] [EC:5.6.2.7]
122079731  ATP-dependent RNA helicase-like protein DB10 [KO:K12823] [EC:5.6.2.7]
122068772  DEAD-box ATP-dependent RNA helicase 14-like isoform X1 [KO:K12823] [EC:5.6.2.7]
122058123  DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [KO:K12823] [EC:5.6.2.7]
122079809  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
122061509  pre-mRNA-processing protein 40C [KO:K12824]
122086947  transcription initiation factor TFIID subunit 15b isoform X1 [KO:K13098]
122078018  U2 small nuclear ribonucleoprotein A' [KO:K11092]
122085721  U2 small nuclear ribonucleoprotein B''-like [KO:K11094]
122064795  probable splicing factor 3A subunit 1 [KO:K12825]
122081095  LOW QUALITY PROTEIN: splicing factor 3A subunit 2 [KO:K12826]
122086503  splicing factor 3A subunit 2-like [KO:K12826]
122066239  splicing factor SF3a60 homolog [KO:K12827]
122087721  splicing factor 3B subunit 1 [KO:K12828]
122088246  splicing factor 3B subunit 2 [KO:K12829]
122088982  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
122069390  spliceosome-associated protein 130 A [KO:K12830]
122060529  oligouridylate-binding protein 1A-like [KO:K12831]
122094787  splicing factor 3B subunit 4-like [KO:K12831]
122084283  splicing factor 3B subunit 4 [KO:K12831]
122059661  RNA-binding protein 7 isoform X1 [KO:K12831]
122069369  uncharacterized protein At4g14342-like [KO:K12832]
122085838  uncharacterized protein At4g14342 isoform X1 [KO:K12832]
122063425  splicing factor 3B subunit 6-like protein [KO:K12833]
122081882  PHD finger-like domain-containing protein 5A [KO:K12834]
122072060  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
122089799  splicing factor U2af small subunit B-like isoform X1 [KO:K12836]
122083700  splicing factor U2af small subunit B-like [KO:K12836]
122071550  splicing factor U2af small subunit B-like [KO:K12836]
122073911  splicing factor U2af small subunit B-like [KO:K12836]
122090133  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
122091338  splicing factor U2af large subunit B-like [KO:K12837]
122093820  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
122071758  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
122084330  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
122084618  splicing factor U2af large subunit B-like [KO:K12837]
122064282  uncharacterized protein LOC122064282 [KO:K12839]
122072996  survival of motor neuron-related-splicing factor 30 [KO:K12839]
122093670  DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840]
122069519  DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840]
122063231  protein RRC1-like isoform X1 [KO:K12842]
122065423  protein RRC1-like [KO:K12842]
122090684  sm-like protein LSM2 [KO:K12621]
122092943  sm-like protein LSM3B [KO:K12622]
122060199  sm-like protein LSM4 [KO:K12623]
122087586  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
122091152  sm-like protein LSM5 isoform X1 [KO:K12624]
122059176  sm-like protein LSM5 [KO:K12624]
122088397  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
122080061  uncharacterized protein LOC122080061 [KO:K12626]
122070987  sm-like protein LSM7 [KO:K12626]
122059693  sm-like protein LSM7 [KO:K12626]
122080921  sm-like protein LSM8 [KO:K12627]
122074056  sm-like protein LSM8 [KO:K12627]
122072959  protein RDM16-like isoform X1 [KO:K12843]
122087135  protein RDM16-like isoform X1 [KO:K12843]
122061150  LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
122089248  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
122065105  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
122073650  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
122086497  U4/U6 small nuclear ribonucleoprotein Prp31 homolog isoform X1 [KO:K12844]
122076373  NHP2-like protein 1 [KO:K12845]
122088928  NHP2-like protein 1 [KO:K12845]
122078911  NHP2-like protein 1 [KO:K12845]
122057216  NHP2-like protein 1 [KO:K12845]
122086582  NHP2-like protein 1 [KO:K12845]
122071737  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
122080138  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
122062955  SART-1 family protein DOT2 [KO:K11984]
122059560  SART-1 family protein DOT2-like isoform X1 [KO:K11984]
122090666  zinc finger matrin-type protein 2-like [KO:K12848]
122063962  zinc finger matrin-type protein 2-like [KO:K12848]
122094413  pre-mRNA-splicing factor 38 [KO:K12849]
122082424  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
122076223  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
122084905  DExH-box ATP-dependent RNA helicase DExH12-like [KO:K12854] [EC:5.6.2.6]
122084501  DExH-box ATP-dependent RNA helicase DExH12-like [KO:K12854] [EC:5.6.2.6]
122079222  protein STABILIZED1 [KO:K12855]
122070269  pre-mRNA-processing-splicing factor 8A [KO:K12856]
122080000  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
122079251  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
122065000  thioredoxin-like protein YLS8 [KO:K12859]
122071782  thioredoxin-like protein YLS8 isoform X1 [KO:K12859]
122091659  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
122074636  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
122093231  cell division cycle 5-like protein [KO:K12860]
122078947  pre-mRNA-splicing factor SPF27 homolog isoform X1 [KO:K12861]
122073439  pre-mRNA-splicing factor SPF27 homolog isoform X1 [KO:K12861]
122057715  protein pleiotropic regulatory locus 1 [KO:K12862]
122094039  protein CWC15 homolog [KO:K12863]
122084628  protein CWC15 homolog isoform X1 [KO:K12863]
122066657  beta-catenin-like protein 1 [KO:K12864]
122084154  beta-catenin-like protein 1 [KO:K12864]
122060606  heat shock cognate 70 kDa protein-like [KO:K03283]
122064300  heat shock 70 kDa protein-like [KO:K03283]
122064301  heat shock 70 kDa protein-like [KO:K03283]
122081562  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
122093972  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
122083546  heat shock 70 kDa protein-like [KO:K03283]
122084689  heat shock 70 kDa protein [KO:K03283]
122086297  heat shock cognate 70 kDa protein 2-like [KO:K03283]
122057814  heat shock 70 kDa protein 1 [KO:K03283]
122057868  heat shock cognate 70 kDa protein 2-like [KO:K03283]
122086494  heat shock cognate 70 kDa protein 2 [KO:K03283]
122079827  uncharacterized protein LOC122079827 isoform X1 [KO:K12865]
122068884  SNW/SKI-interacting protein A [KO:K06063]
122057008  pre-mRNA-splicing factor SYF1 [KO:K12867]
122068969  pre-mRNA-splicing factor syf2-like [KO:K12868]
122089386  crooked neck-like protein 1 [KO:K12869]
122089811  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
122086566  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
122080090  coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
122072627  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
122087918  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
122077842  protein BUD31 homolog 2-like [KO:K12873]
122085049  protein BUD31 homolog 2 [KO:K12873]
122065515  RNA helicase aquarius [KO:K12874]
122078924  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
122073307  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
122093888  eukaryotic initiation factor 4A-III homolog A-like [KO:K13025] [EC:5.6.2.7]
122060080  RNA-binding protein Y14 [KO:K12876]
122081160  protein mago nashi homolog [KO:K12877]
122084998  protein mago nashi homolog [KO:K12877]
122077860  THO complex subunit 1 [KO:K12878]
122079208  THO complex subunit 2-like [KO:K12879]
122079964  THO complex subunit 2-like isoform X1 [KO:K12879]
122093687  THO complex subunit 3 isoform X1 [KO:K12880]
122077060  THO complex subunit 4D-like isoform X1 [KO:K12881]
122079050  THO complex subunit 4C-like [KO:K12881]
122087276  THO complex subunit 4A [KO:K12881]
122076531  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
122061138  nuclear cap-binding protein subunit 2 [KO:K12883]
122075433  nuclear cap-binding protein subunit 2-like [KO:K12883]
122059797  UBP1-associated protein 2C-like [KO:K12741]
122075540  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
122088605  UBP1-associated protein 2A-like [KO:K12741]
122061467  UBP1-associated protein 2B-like [KO:K12741]
122076626  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
122077131  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
122078291  glycine-rich RNA-binding protein 2, mitochondrial-like isoform X1 [KO:K12741]
122090605  UBP1-associated protein 2A-like [KO:K12741]
122093326  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
122067154  UBP1-associated protein 2B-like [KO:K12741]
122069605  UBP1-associated protein 2C-like [KO:K12741]
122083034  UBP1-associated protein 2A-like [KO:K12741]
122083095  UBP1-associated protein 2A-like [KO:K12741]
122070716  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
122086016  UBP1-associated protein 2C-like [KO:K12741]
122091437  serine/arginine-rich-splicing factor SR34-like isoform X1 [KO:K12890]
122057388  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
122059551  serine/arginine-rich splicing factor SR34A-like [KO:K12890]
122069560  serine/arginine-rich splicing factor SC35-like [KO:K12891]
122073857  serine/arginine-rich splicing factor SC35-like [KO:K12891]
122082005  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
122082869  serine/arginine-rich splicing factor RS31-like [KO:K12893]
122087029  serine/arginine-rich splicing factor RS41 isoform X1 [KO:K12893]
122076514  serine/arginine-rich splicing factor RSZ21A isoform X1 [KO:K12896]
122063296  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
122079767  serine/arginine-rich splicing factor RSZ21A-like [KO:K12896]
122073727  serine/arginine-rich splicing factor RSZ22-like [KO:K12896]
122087270  serine/arginine-rich splicing factor RS2Z32-like [KO:K12896]
122080379  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
122084675  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
122057835  serine/arginine-rich splicing factor SR45a-like isoform X1 [KO:K12897]
122089396  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
122061968  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
122091932  serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900]
122071171  serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900]
122057904  serine/arginine-rich SC35-like splicing factor SCL30 isoform X1 [KO:K12900]
122087206  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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