KEGG   PATHWAY: mni04015
Entry
mni04015                    Pathway                                
Name
Rap1 signaling pathway - Macaca nemestrina (pig-tailed macaque)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mni04015  Rap1 signaling pathway
mni04015

Other DBs
GO: 0007264
Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105479203  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
105473408  RAP1B; ras-related protein Rap-1b [KO:K07836]
105469940  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105475677  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
105475271  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
105471967  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105467787  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105481967  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
105464979  CALM2; calmodulin-2 [KO:K02183]
105496718  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
105488029  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105478585  CALM3; calmodulin-3 isoform X1 [KO:K02183]
105467562  CALM1; calmodulin-1 isoform X1 [KO:K02183]
105483519  calmodulin-like [KO:K02183]
105492388  calmodulin-like [KO:K02183]
105494378  CALML3; calmodulin-like protein 3 [KO:K02183]
105494380  CALML5; calmodulin-like protein 5 [KO:K02183]
105475117  F2R; proteinase-activated receptor 1 [KO:K03914]
105492149  F2RL3; proteinase-activated receptor 4 [KO:K04236]
105499019  P2RY1; P2Y purinoceptor 1 [KO:K04270]
105497094  FPR1; fMet-Leu-Phe receptor [KO:K04172]
105475951  lysophosphatidic acid receptor 1 [KO:K04289]
105481062  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
105492735  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105482759  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
105464349  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105484191  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105498492  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
105491088  ADORA2B; adenosine receptor A2b [KO:K04267]
105470579  neuroendocrine secretory protein 55 [KO:K04632]
105470577  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105494232  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105489474  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105479810  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105477872  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105470270  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105492900  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105492251  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105492815  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105467851  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105470060  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
105483229  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
105498714  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105469511  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105481530  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105481533  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105492354  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
105464819  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105469529  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105486254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105466960  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105486416  FGF2; fibroblast growth factor 2 [KO:K18497]
105464242  FGF16; fibroblast growth factor 16 [KO:K04358]
105463317  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105463744  FGF20; fibroblast growth factor 20 [KO:K04358]
105486552  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105487492  FGF10; fibroblast growth factor 10 [KO:K04358]
105490268  FGF9; fibroblast growth factor 9 [KO:K04358]
105490607  FGF7; fibroblast growth factor 7 [KO:K04358]
105480865  FGF18; fibroblast growth factor 18 [KO:K04358]
105478366  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105469729  FGF4; fibroblast growth factor 4 [KO:K04358]
105469730  FGF3; fibroblast growth factor 3 [KO:K04358]
105482098  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105484151  FGF6; fibroblast growth factor 6 [KO:K04358]
105469728  FGF19; fibroblast growth factor 19 [KO:K22603]
105478658  FGF21; fibroblast growth factor 21 [KO:K22429]
105484150  FGF23; fibroblast growth factor 23 [KO:K22428]
105479138  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105469786  INS; insulin isoform X1 [KO:K04526]
105493817  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105483431  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
105464425  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105488621  PDGFC; platelet-derived growth factor C [KO:K05450]
105493695  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105479257  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105483765  KITLG; kit ligand isoform X1 [KO:K05461]
105489557  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105469816  VEGFB; vascular endothelial growth factor B [KO:K16858]
105495787  PGF; placenta growth factor isoform X1 [KO:K16859]
105478154  VEGFD; vascular endothelial growth factor D [KO:K05449]
105466632  VEGFC; vascular endothelial growth factor C [KO:K05449]
105475398  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105475992  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105464176  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105496121  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105486219  EFNA2; ephrin-A2 [KO:K05462]
105497987  EFNA4; ephrin-A4 [KO:K05462]
105497995  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105497996  EFNA1; ephrin-A1 [KO:K05462]
105471088  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105493061  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105476567  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105469674  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105483839  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105484062  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
105472349  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105487005  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105479398  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105463522  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105466873  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105466874  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105463525  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105490192  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
105483981  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105463529  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105475620  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105493864  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105473227  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
105480670  CRKL; crk-like protein [KO:K04438]
105471621  CRK; adapter molecule crk isoform X1 [KO:K04438]
105464055  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
105491272  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105491370  CDH1; cadherin-1 isoform X1 [KO:K05689]
105480261  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105483536  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
105475378  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
105479169  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
105488645  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
105467197  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
105471202  LOW QUALITY PROTEIN: uncharacterized protein LOC105471202 [KO:K10785]
105482859  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
105473108  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
105480850  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
105472310  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
105496357  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105469029  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105485029  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105497021  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105477914  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
105478588  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
105464853  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
105493586  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
105496325  CNR1; cannabinoid receptor 1 [KO:K04277]
105475385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
105479273  GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105480474  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105494072  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105483074  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
105494308  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X2 [KO:K17701]
105469584  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
105464131  SIPA1L2; LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 2 [KO:K17702]
105495419  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
105496159  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
105492481  THBS1; thrombospondin-1 [KO:K16857]
105464075  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
105464203  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
105464191  ral-GDS-related protein-like [KO:K08732]
105480640  ral-GDS-related protein-like [KO:K08732]
112422941  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
105497377  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
105497421  ral-GDS-related protein-like [KO:K08732]
105497757  RALA; ras-related protein Ral-A [KO:K07834]
105492471  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
105497946  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105464493  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105469394  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105480006  LOW QUALITY PROTEIN: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like [KO:K17704]
105485738  TLN1; talin-1 isoform X1 [KO:K06271]
105489073  TLN2; talin-2 isoform X1 [KO:K06271]
105469039  ITGA2B; integrin alpha-IIb [KO:K06476]
105483061  ITGB3; integrin beta-3 [KO:K06493]
105463673  PFN2; profilin-2 isoform X1 [KO:K05759]
105479817  PFN4; profilin-4 [KO:K05759]
105472486  PFN1; profilin-1 [KO:K05759]
105484052  PFN3; profilin-3 [KO:K05759]
105478550  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
105478386  ENAH; protein enabled homolog isoform X1 [KO:K05746]
105467426  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
105497365  ACTB; actin, cytoplasmic 1 [KO:K05692]
105469296  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105466976  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
105480439  RHOA; transforming protein RhoA [KO:K04513]
105496309  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105473764  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
105494398  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105489209  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105471878  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
105484575  VAV1; proto-oncogene vav [KO:K05730]
105472738  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105495968  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
105489258  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105491416  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
105470680  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105496712  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105465838  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
105487581  AFDN; afadin isoform X1 [KO:K05702]
105496075  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
105475490  KRIT1; krev interaction trapped protein 1 [KO:K17705]
105484054  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
105484844  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
105483005  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
105482963  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105472505  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
105479922  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105471274  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105477727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105488275  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105485357  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105480656  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105482882  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105493311  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
105469063  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105474512  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105474514  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
105489757  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105489758  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105480004  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
105494134  HRAS; GTPase HRas isoform X1 [KO:K02833]
105492133  KRAS; GTPase KRas isoform X1 [KO:K07827]
105479146  NRAS; GTPase NRas [KO:K07828]
105497191  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mni04010  MAPK signaling pathway
mni04014  Ras signaling pathway
mni04020  Calcium signaling pathway
mni04151  PI3K-Akt signaling pathway
mni04510  Focal adhesion
mni04520  Adherens junction
mni04660  T cell receptor signaling pathway
mni04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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