KEGG   PATHWAY: ncar05012
Entry
ncar05012                   Pathway                                
Name
Parkinson disease - Sciurus carolinensis (gray squirrel)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ncar05012  Parkinson disease
ncar05012

Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124990229  LOW QUALITY PROTEIN: adenosine receptor A2a-like [KO:K04266]
124965701  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
124978161  neuroendocrine secretory protein 55 [KO:K04632]
124975134  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
124959858  D(2) dopamine receptor [KO:K04145]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124987160  LOW QUALITY PROTEIN: D(1A) dopamine receptor-like [KO:K04144]
124972450  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
124973030  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
124992897  ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
124988961  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
124968426  ubiquitin-60S ribosomal protein L40 [KO:K02927]
124968641  ubiquitin-like [KO:K02927]
124980787  ubiquitin-like [KO:K02927]
124963395  ubiquitin-40S ribosomal protein S27a [KO:K02977]
124980729  polyubiquitin-B [KO:K04551]
124974413  polyubiquitin-B-like [KO:K04551]
124974416  polyubiquitin-like [KO:K04551]
124975875  polyubiquitin-like [KO:K04551]
124991900  polyubiquitin-C [KO:K08770]
124991040  ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
124969269  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
124963283  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
124965632  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
124958349  ubiquitin/ISG15-conjugating enzyme E2 L6-like isoform X1 [KO:K04553] [EC:2.3.2.23]
124958898  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
124989000  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
124986490  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
124992606  uncharacterized protein LOC124992606 isoform X1 [KO:K04555] [EC:2.3.2.23]
124980010  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
124987958  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
124994728  alpha-synuclein [KO:K04528]
124991922  prosaposin receptor GPR37 [KO:K04243]
124990882  septin-5 isoform X1 [KO:K04557]
124987238  synphilin-1 isoform X1 [KO:K04558]
124971341  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
124991689  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
124978206  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
124988985  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
124965646  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
124976222  proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
124964531  proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
124960605  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
124986978  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
124977179  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
124980525  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
124964184  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
124981343  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
124991378  LOW QUALITY PROTEIN: proteasome subunit beta type-2-like [KO:K02734] [EC:3.4.25.1]
124962291  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
124978282  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
124989624  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
124959256  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
124991795  26S proteasome regulatory subunit 7 [KO:K03061]
124975937  26S proteasome regulatory subunit 7-like [KO:K03061]
124977836  26S proteasome regulatory subunit 4 [KO:K03062]
124966865  26S proteasome regulatory subunit 6B [KO:K03063]
124977927  26S proteasome regulatory subunit 10B [KO:K03064]
124994866  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A-like [KO:K03065]
124995331  26S proteasome regulatory subunit 6A [KO:K03065]
124979791  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
124992732  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
124979673  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
124980991  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
124991897  26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
124960430  26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
124980492  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
124981390  26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
124968854  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
124967565  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
124958474  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
124982161  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
124973164  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
124975004  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
124980521  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
124966972  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
124964751  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
124976847  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
124973604  LOW QUALITY PROTEIN: proteasomal ubiquitin receptor ADRM1-like [KO:K06691]
124983588  26S proteasome complex subunit SEM1 [KO:K10881]
124994651  ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1 [KO:K05611] [EC:3.4.19.12]
124976834  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
124967357  calmodulin-1 [KO:K02183]
124967948  calmodulin-like protein 6 [KO:K02183]
124962006  calmodulin-like [KO:K02183]
124962112  calmodulin-A-like [KO:K02183]
124962222  calmodulin-like protein 3 [KO:K02183]
124963056  calmodulin-1 [KO:K02183]
124976085  calmodulin-1 [KO:K02183]
124985817  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124986742  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124994412  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
124990768  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124980973  microtubule-associated protein tau isoform X1 [KO:K04380]
124976404  ryanodine receptor 3 [KO:K04963]
124970932  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124983533  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
124988553  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
124977089  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
124964798  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
124986518  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
124983170  LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein-like [KO:K04452]
124979930  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124991760  LOW QUALITY PROTEIN: uncharacterized protein LOC124991760 [KO:K09027]
124975124  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
124976810  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
124984025  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124958984  tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
124971911  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
124972466  LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
124987217  sodium-dependent dopamine transporter [KO:K05036]
124984605  synaptic vesicular amine transporter [KO:K08155]
124983739  chromaffin granule amine transporter-like [KO:K08155]
124983377  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
124977170  zinc transporter ZIP2-like isoform X1 [KO:K14709]
124984704  zinc transporter ZIP1 isoform X1 [KO:K14709]
124968649  zinc transporter ZIP3 [KO:K14709]
124989055  zinc transporter ZIP4-like isoform X1 [KO:K14710]
124981961  zinc transporter ZIP5-like isoform X1 [KO:K14711]
124988774  zinc transporter SLC39A7 [KO:K14713]
124994791  metal cation symporter ZIP8 [KO:K14714]
124976711  LOW QUALITY PROTEIN: zinc transporter ZIP9-like [KO:K14715]
124980993  zinc transporter ZIP10 [KO:K14716]
124979670  zinc transporter ZIP11 isoform X1 [KO:K14717]
124961992  zinc transporter ZIP12-like isoform X1 [KO:K14718]
124960123  zinc transporter ZIP13 isoform X1 [KO:K14719]
124983326  metal cation symporter ZIP14 isoform X1 [KO:K14720]
124960411  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
124965286  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
124993284  suppressor protein SRP40-like isoform X1 [KO:K03944]
124962734  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
124980697  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
124971899  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
124986769  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
124967150  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
124958341  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124989721  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124991046  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
124966837  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124972400  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124983813  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
124993505  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
124991763  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
124982312  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
124968718  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
124985829  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
124964968  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
124983572  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
124979118  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
124986398  LOW QUALITY PROTEIN: acyl carrier protein, mitochondrial-like [KO:K03955]
124970777  acyl carrier protein, mitochondrial-like [KO:K03955]
124972499  acyl carrier protein, mitochondrial-like [KO:K03955]
124968683  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
124983083  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
124967816  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
124977589  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
124990972  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
124980197  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
124992578  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
124992876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
124987541  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124982958  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124983344  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124964468  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
124968580  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
124984628  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
124962972  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
124970425  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
124971919  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
124979719  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
124994753  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
124958469  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
124987567  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
124992960  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
124987606  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
124968482  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
124958631  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
124994343  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
124981096  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
124960623  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
124986669  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
124994572  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
124961406  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
124958779  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
124967159  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
124976441  cytochrome c1, heme protein, mitochondrial [KO:K00413]
124993792  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
124985946  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
124969833  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
124976494  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
124960250  cytochrome b-c1 complex subunit 7 [KO:K00417]
124963228  cytochrome b-c1 complex subunit 7-like [KO:K00417]
124986976  cytochrome b-c1 complex subunit 8 [KO:K00418]
124991001  cytochrome b-c1 complex subunit 9 [KO:K00419]
124969484  cytochrome b-c1 complex subunit 10 [KO:K00420]
124977244  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
124967440  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
124977063  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
124959708  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
124963339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
124991034  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
124970560  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
124966941  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
124979836  cytochrome c oxidase subunit 6B1-like [KO:K02267]
124966431  cytochrome c oxidase subunit 6B1 [KO:K02267]
124984069  cytochrome c oxidase subunit 6C [KO:K02268]
124979038  cytochrome c oxidase subunit 6C-like [KO:K02268]
124961590  cytochrome c oxidase subunit 6C-like [KO:K02268]
124988296  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
124963329  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
124966433  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
124994104  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
124978951  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
124972073  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
124986386  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124986478  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124987029  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
124980275  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124980291  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124959872  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
124988623  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
124965845  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
124983743  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
124961688  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
124968690  ATP synthase subunit delta, mitochondrial [KO:K02134]
124978256  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
124984257  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
124994886  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
124961875  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
124979929  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
124980241  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
124983026  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
124958764  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
124980569  ATP synthase subunit d, mitochondrial [KO:K02138]
124993299  ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
124992905  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
124983421  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
124985196  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
124982607  LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2-like [KO:K08844] [EC:2.7.11.1]
124970288  heat shock protein 75 kDa, mitochondrial [KO:K09488]
124986880  voltage-dependent anion-selective channel protein 1 [KO:K05862]
124984706  voltage-dependent anion-selective channel protein 2 [KO:K15040]
124983451  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
124994584  ADP/ATP translocase 4 isoform X1 [KO:K05863]
124972172  ADP/ATP translocase 3 [KO:K05863]
124972520  ADP/ATP translocase 2 [KO:K05863]
124983822  ADP/ATP translocase 1 [KO:K05863]
124984875  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
124994683  cytochrome c, somatic-like [KO:K08738]
124991556  cytochrome c, somatic [KO:K08738]
124991711  cytochrome c, somatic-like [KO:K08738]
124979232  cytochrome c, somatic-like [KO:K08738]
124961943  cytochrome c, somatic-like [KO:K08738]
124962143  cytochrome c-like [KO:K08738]
124962144  cytochrome c-like [KO:K08738]
124962145  cytochrome c-like [KO:K08738]
124962146  cytochrome c-like [KO:K08738]
124970186  cytochrome c, somatic-like [KO:K08738]
124980035  cytochrome c, testis-specific [KO:K08738]
124965714  cytochrome c, somatic-like [KO:K08738]
124982341  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
124966493  caspase-9-like [KO:K04399] [EC:3.4.22.62]
124972492  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
124983898  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124983002  Parkinson disease protein 7 homolog [KO:K05687] [EC:3.5.1.124]
124976128  bcl-2-like protein 1 isoform X1 [KO:K04570]
124966672  apoptosis regulator BAX isoform X1 [KO:K02159]
124993046  mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
124978147  mitofusin-2 [KO:K06030] [EC:3.6.5.-]
124961723  kinesin-1 heavy chain [KO:K10396]
124979764  kinesin heavy chain [KO:K10396]
124982292  LOW QUALITY PROTEIN: kinesin heavy chain-like [KO:K10396]
124958444  kinesin light chain 2 isoform X1 [KO:K10407]
124988614  kinesin light chain 4 [KO:K10407]
124976841  kinesin light chain 1 isoform X1 [KO:K10407]
124966675  kinesin light chain 3 [KO:K10407]
124990413  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
124990575  tubulin alpha-3 chain [KO:K07374]
124990878  tubulin alpha-3 chain [KO:K07374]
124992512  tubulin alpha-1A chain-like [KO:K07374]
124978858  tubulin alpha-1D chain [KO:K07374]
124978859  tubulin alpha-4A chain [KO:K07374]
124961678  tubulin alpha-8 chain isoform X1 [KO:K07374]
124961964  tubulin alpha chain-like 3 [KO:K07374]
124982222  tubulin alpha-1B chain isoform X1 [KO:K07374]
124982223  tubulin alpha-1A chain [KO:K07374]
124982391  tubulin alpha-8 chain [KO:K07374]
124986665  tubulin beta chain-like [KO:K07375]
124988071  tubulin beta chain [KO:K07375]
124988155  tubulin beta-2A chain [KO:K07375]
124989446  tubulin beta-2A chain-like [KO:K07375]
124989671  tubulin beta-2B chain [KO:K07375]
124990586  tubulin beta chain-like [KO:K07375]
124968782  tubulin beta-4A chain [KO:K07375]
124978255  tubulin beta-1 chain [KO:K07375]
124964452  tubulin beta-4B chain [KO:K07375]
124965280  tubulin beta-5 chain [KO:K07375]
124966012  tubulin beta-3 chain [KO:K07375]
124980281  cellular tumor antigen p53 [KO:K04451]
124987585  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
124979202  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
124984027  thioredoxin, mitochondrial [KO:K03671]
124984662  thioredoxin-like [KO:K03671]
124964940  thioredoxin [KO:K03671]
124988670  death domain-associated protein 6 [KO:K02308]
124988565  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124992482  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
124968513  LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1 [KO:K10456]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
Reference
PMID:16495942
  Authors
Abou-Sleiman PM, Muqit MM, Wood NW
  Title
Expanding insights of mitochondrial dysfunction in Parkinson's disease.
  Journal
Nat Rev Neurosci 7:207-19 (2006)
DOI:10.1038/nrn1868
Reference
PMID:12938733
  Authors
Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
  Journal
IUBMB Life 55:315-22 (2003)
DOI:10.1080/1521654031000153030
Reference
PMID:26501339
  Authors
Bobela W, Aebischer P, Schneider BL
  Title
Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
  Journal
Biomolecules 5:2675-700 (2015)
DOI:10.3390/biom5042675
Reference
PMID:15767499
  Authors
Eriksen JL, Wszolek Z, Petrucelli L
  Title
Molecular pathogenesis of Parkinson disease.
  Journal
Arch Neurol 62:353-7 (2005)
DOI:10.1001/archneur.62.3.353
Reference
PMID:16972273
  Authors
Olanow CW, McNaught KS
  Title
Ubiquitin-proteasome system and Parkinson's disease.
  Journal
Mov Disord 21:1806-23 (2006)
DOI:10.1002/mds.21013
Reference
PMID:18047737
  Authors
Lim KL, Tan JM
  Title
Role of the ubiquitin proteasome system in Parkinson's disease.
  Journal
BMC Biochem 8 Suppl 1:S13 (2007)
DOI:10.1186/1471-2091-8-S1-S13
Reference
PMID:29090092
  Authors
Maiti P, Manna J, Dunbar GL
  Title
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.
  Journal
Transl Neurodegener 6:28 (2017)
DOI:10.1186/s40035-017-0099-z
Reference
PMID:12814656
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
Part I: parkin-associated proteins and Parkinson's disease.
  Journal
Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4
Reference
PMID:20495568
  Authors
Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G
  Title
Missing pieces in the Parkinson's disease puzzle.
  Journal
Nat Med 16:653-61 (2010)
DOI:10.1038/nm.2165
Reference
PMID:24781149
  Authors
Cali T, Ottolini D, Brini M
  Title
Calcium signaling in Parkinson's disease.
  Journal
Cell Tissue Res 357:439-54 (2014)
DOI:10.1007/s00441-014-1866-0
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:28468938
  Authors
Zaichick SV, McGrath KM, Caraveo G
  Title
The role of Ca(2+) signaling in Parkinson's disease.
  Journal
Dis Model Mech 10:519-535 (2017)
DOI:10.1242/dmm.028738
Reference
PMID:28838811
  Authors
Ludtmann MHR, Abramov AY
  Title
Mitochondrial calcium imbalance in Parkinson's disease.
  Journal
Neurosci Lett 663:86-90 (2018)
DOI:10.1016/j.neulet.2017.08.044
Reference
PMID:19663908
  Authors
Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
DOI:10.1111/j.1742-4658.2009.07201.x
Reference
PMID:23352769
  Authors
Mercado G, Valdes P, Hetz C
  Title
An ERcentric view of Parkinson's disease.
  Journal
Trends Mol Med 19:165-75 (2013)
DOI:10.1016/j.molmed.2012.12.005
Reference
PMID:27103567
  Authors
Mercado G, Castillo V, Soto P, Sidhu A
  Title
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
  Journal
Brain Res 1648:626-632 (2016)
DOI:10.1016/j.brainres.2016.04.042
Reference
PMID:26297973
  Authors
Tsujii S, Ishisaka M, Hara H
  Title
Modulation of endoplasmic reticulum stress in Parkinson's disease.
  Journal
Eur J Pharmacol 765:154-6 (2015)
DOI:10.1016/j.ejphar.2015.08.033
Reference
PMID:31100053
  Authors
Shah A, Chao J, Legido-Quigley C, Chang RC
  Title
Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
  Journal
Nutr Neurosci 1-16 (2019)
DOI:10.1080/1028415X.2019.1613764
Reference
PMID:24548101
  Authors
Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
  Title
Protective and toxic roles of dopamine in Parkinson's disease.
  Journal
J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
PMID:31587020
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
  Journal
Acta Neurobiol Exp (Wars) 79:276-289 (2019)
Reference
PMID:15189334
  Authors
Perez RG, Hastings TG
  Title
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
  Journal
J Neurochem 89:1318-24 (2004)
DOI:10.1111/j.1471-4159.2004.02423.x
Reference
PMID:26487845
  Authors
Segura-Aguilar J
  Title
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
  Journal
Neural Regen Res 10:1225-7 (2015)
DOI:10.4103/1673-5374.162750
Reference
PMID:27546335
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
Reference
PMID:27581196
  Authors
Cieri D, Brini M, Cali T
  Title
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
  Journal
Biochem Biophys Res Commun 483:1020-1030 (2017)
DOI:10.1016/j.bbrc.2016.08.153
Reference
PMID:27829983
  Authors
Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD
  Title
Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
  Journal
Oxid Med Cell Longev 2016:3472032 (2016)
DOI:10.1155/2016/3472032
Reference
PMID:21674642
  Authors
Cali T, Ottolini D, Brini M
  Title
Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
  Journal
Biofactors 37:228-40 (2011)
DOI:10.1002/biof.159
Reference
PMID:24522549
  Authors
Gaki GS, Papavassiliou AG
  Title
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
  Journal
Neuromolecular Med 16:217-30 (2014)
DOI:10.1007/s12017-014-8294-x
Reference
PMID:25761946
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
PMID:22926193
  Authors
de Vries RL, Przedborski S
  Title
Mitophagy and Parkinson's disease: be eaten to stay healthy.
  Journal
Mol Cell Neurosci 55:37-43 (2013)
DOI:10.1016/j.mcn.2012.07.008
Reference
PMID:20736035
  Authors
Deas E, Wood NW, Plun-Favreau H
  Title
Mitophagy and Parkinson's disease: the PINK1-parkin link.
  Journal
Biochim Biophys Acta 1813:623-33 (2011)
DOI:10.1016/j.bbamcr.2010.08.007
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:27911343
  Authors
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
  Title
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
  Journal
J Parkinsons Dis 7:13-29 (2017)
DOI:10.3233/JPD-160989
Reference
PMID:28823929
  Authors
Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
  Title
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
  Journal
Neurobiol Dis 108:65-72 (2017)
DOI:10.1016/j.nbd.2017.08.005
Reference
PMID:29147906
  Authors
Oh SE, Mouradian MM
  Title
Regulation of Signal Transduction by DJ-1.
  Journal
Adv Exp Med Biol 1037:97-131 (2017)
DOI:10.1007/978-981-10-6583-5_8
Reference
PMID:31054074
  Authors
Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
  Title
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
  Journal
J Bioenerg Biomembr 51:175-188 (2019)
DOI:10.1007/s10863-019-09798-4
Reference
PMID:30370500
  Authors
Melo TQ, Copray SJCVM, Ferrari MFR
  Title
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
  Journal
Neurochem Res 43:2212-2223 (2018)
DOI:10.1007/s11064-018-2673-x
Reference
PMID:30937538
  Authors
Zhai S, Shen W, Graves SM, Surmeier DJ
  Title
Dopaminergic modulation of striatal function and Parkinson's disease.
  Journal
J Neural Transm (Vienna) 126:411-422 (2019)
DOI:10.1007/s00702-019-01997-y
Reference
PMID:29720658
  Authors
Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ
  Title
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
  Journal
Nature 557:177-182 (2018)
DOI:10.1038/s41586-018-0090-6
Related
pathway
ncar00190  Oxidative phosphorylation
ncar00350  Tyrosine metabolism
ncar03050  Proteasome
ncar04020  Calcium signaling pathway
ncar04120  Ubiquitin mediated proteolysis
ncar04137  Mitophagy - animal
ncar04141  Protein processing in endoplasmic reticulum
ncar04210  Apoptosis
ncar04728  Dopaminergic synapse
KO pathway
ko05012   
LinkDB

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