KEGG   PATHWAY: nle04072
Entry
nle04072                    Pathway                                
Name
Phospholipase D signaling pathway - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
nle04072  Phospholipase D signaling pathway
nle04072

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100588963  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100583683  PDGFA; platelet-derived growth factor subunit A isoform X6 [KO:K04359]
100586714  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100585549  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100586178  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100587810  KITLG; kit ligand [KO:K05461]
100586809  INS; insulin isoform X2 [KO:K04526]
100597255  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100603207  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100597894  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100603893  KIT; mast/stem cell growth factor receptor Kit isoform X3 [KO:K05091] [EC:2.7.10.1]
100597533  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100588468  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100600534  GAB1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
100581971  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
100606068  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
100591489  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
100589484  SHC3; SHC-transforming protein 3 isoform X3 [KO:K17448]
100591644  SHC4; SHC-transforming protein 4 [KO:K17449]
100602671  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100605369  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100590165  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100600495  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100595274  HRAS; GTPase HRas isoform X1 [KO:K02833]
100593773  KRAS; GTPase KRas isoform X1 [KO:K07827]
100592103  NRAS; GTPase NRas [KO:K07828]
100581488  MRAS; ras-related protein M-Ras [KO:K07831]
100602757  RRAS; ras-related protein R-Ras [KO:K07829]
100604922  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100589231  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100579487  LOW QUALITY PROTEIN: ral-GDS-related protein [KO:K08732]
115835869  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
100603441  RALA; ras-related protein Ral-A [KO:K07834]
100593053  RALB; ras-related protein Ral-B [KO:K07835]
100588218  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100580872  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100584384  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100605788  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100591270  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100599301  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100587112  TSC1; hamartin isoform X2 [KO:K07206]
100604902  tuberin isoform X1 [KO:K07207]
115831278  tuberin isoform X1 [KO:K07207]
100598486  RHEB; GTP-binding protein Rheb [KO:K07208]
100594291  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100607291  RHOA; transforming protein RhoA [KO:K04513]
100607404  ARF1; ADP-ribosylation factor 1 [KO:K07937]
100598238  ARF6; ADP-ribosylation factor 6 [KO:K07941]
100591458  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100604145  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100592223  LOW QUALITY PROTEIN: immunoglobulin heavy variable 3-48 [KO:K06856]
100580467  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha isoform X1 [KO:K08089]
100585306  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta isoform X1 [KO:K08090]
100605169  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
100585303  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100590261  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100591651  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100605600  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100601695  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100593575  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100593907  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100591987  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
100593220  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100591421  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100587969  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
100600403  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
100588358  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
100602654  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100579549  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100592119  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
100598765  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100592000  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100582599  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100579506  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100591827  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100600574  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100584480  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100582763  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100599403  LOW QUALITY PROTEIN: putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
100586076  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
100589134  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [KO:K00889] [EC:2.7.1.68]
100588455  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100580636  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
100592706  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
100599668  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
100595816  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
100598018  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
100594428  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
100595028  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
100593934  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
100594501  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
100592505  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
100581368  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
100580386  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
100606664  PLPP1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
115830389  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
115834360  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
115835047  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
100595467  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100605443  AGT; angiotensinogen [KO:K09821]
100607090  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
100586157  CXCL8; interleukin-8 [KO:K10030]
100603931  AGTR1; type-1 angiotensin II receptor isoform X3 [KO:K04166]
100607663  F2R; proteinase-activated receptor 1 [KO:K03914]
100592587  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100599760  GRM2; metabotropic glutamate receptor 2 isoform X1 [KO:K04605]
100594386  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
100589155  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
100595085  GRM5; metabotropic glutamate receptor 5 isoform X2 [KO:K04604]
100604632  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
100589726  GRM7; metabotropic glutamate receptor 7 isoform X1 [KO:K04609]
100583361  GRM8; metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
100585170  AVPR1A; vasopressin V1a receptor [KO:K04226]
100604248  AVPR1B; vasopressin V1b receptor [KO:K04227]
100595937  AVPR2; vasopressin V2 receptor [KO:K04228]
100589911  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100587344  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
100590490  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
100588179  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100586980  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100588296  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100579684  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100580192  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 1 [KO:K04175]
100598264  C-X-C chemokine receptor type 1 [KO:K04175]
100596676  C-X-C chemokine receptor type 2 [KO:K05050]
100597115  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100600507  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100606558  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100600865  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100591916  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100599503  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100589821  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100586512  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100593257  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100586095  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100603872  CYTH3; cytohesin-3 [KO:K18441]
100580572  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
100599015  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
100587300  CYTH2; cytohesin-2 [KO:K18441]
101176289  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X7 [KO:K04632]
115830355  neuroendocrine secretory protein 55 [KO:K04632]
100595636  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100600367  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100586735  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100603282  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100580455  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100589304  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100587036  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100592592  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100599484  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100592347  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
100602878  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
100599465  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
100594555  DNM3; dynamin-3 isoform X6 [KO:K01528] [EC:3.6.5.5]
100590132  DNM2; LOW QUALITY PROTEIN: dynamin-2 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
nle00561  Glycerolipid metabolism
nle04010  MAPK signaling pathway
nle04014  Ras signaling pathway
nle04020  Calcium signaling pathway
nle04024  cAMP signaling pathway
nle04071  Sphingolipid signaling pathway
nle04144  Endocytosis
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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