PATHWAY: omy04145 Help
Entry
Name
Phagosome - Oncorhynchus mykiss (rainbow trout)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Oncorhynchus mykiss (rainbow trout) [GN:
omy ]
Gene
100305345 sec22bb; SEC22 homolog B, vesicle trafficking protein b precursor [KO:K08517 ]
118946544 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
110501897 major histocompatibility complex class I-related gene protein [KO:K06751 ]
110508877 RT1 class I histocompatibility antigen, AA alpha chain isoform X1 [KO:K06751 ]
110496224 H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751 ]
110496241 class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751 ]
110496247 major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751 ]
110503157 major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751 ]
118936567 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
110488327 H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751 ]
110488352 major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751 ]
110488353 saoe class I histocompatibility antigen, A alpha chain [KO:K06751 ]
110488354 BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751 ]
110535585 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
110490504 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
110490516 H-2 class II histocompatibility antigen, A-Q alpha chain [KO:K06752 ]
110537685 H-2 class II histocompatibility antigen, A-Q alpha chain [KO:K06752 ]
110537686 HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752 ]
110485516 rano class II histocompatibility antigen, A beta chain isoform X1 [KO:K06752 ]
110515374 H-2 class II histocompatibility antigen, A-U beta chain-like [KO:K06752 ]
110516895 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118940033 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
110494409 H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752 ]
110538839 hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
110539185 LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182 ]
110528102 atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
110509654 atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
110533177 tcirg1a; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a3 [KO:K02154 ]
110530320 atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
110498395 dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413 ]
110501457 dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415 ]
110508447 dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415 ]
110530665 dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415 ]
110506301 dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
110520102 dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415 ]
118940999 LOW QUALITY PROTEIN: cytoplasmic dynein 1 intermediate chain 1 [KO:K10415 ]
110496540 dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416 ]
110490494 cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416 ]
110506345 dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
110526283 cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
110505175 lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
110509143 m6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089 ]
100135961 protein transport protein Sec61 subunit alpha isoform B [KO:K10956 ]
100136621 protein transport protein Sec61 subunit alpha isoform A [KO:K10956 ]
110489588 sec61g; protein transport protein Sec61 subunit gamma [KO:K07342 ]
100135858 tap2t; transporter associated with antigen processing, subunit type t, teleost specific [KO:K05654 ] [EC:7.4.2.14 ]
110503800 high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498 ]
110538756 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
110486794 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Related pathway
omy04620 Toll-like receptor signaling pathway
KO pathway
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