KEGG   PATHWAY: pspa04310
Entry
pspa04310                   Pathway                                
Name
Wnt signaling pathway - Polyodon spathula (Mississippi paddlefish)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
pspa04310  Wnt signaling pathway
pspa04310

Other DBs
GO: 0016055
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121328230  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
121307173  wnt1; protein Wnt-1 [KO:K03209]
121299504  protein Wnt-2b-A-like [KO:K00182]
121299512  protein Wnt-2b-A [KO:K00182]
121318223  protein Wnt-2-like [KO:K00182]
121319887  protein Wnt-2-like [KO:K00182]
121301737  wnt3; proto-oncogene Wnt-3 [KO:K00312]
121312840  wnt3a; protein Wnt-3a [KO:K00312]
121314315  protein Wnt-3a-like [KO:K00312]
121325744  protein Wnt-4a-like [KO:K00408]
121328232  protein Wnt-4-like isoform X1 [KO:K00408]
121329401  wnt4; protein Wnt-4a [KO:K00408]
121298157  protein Wnt-5a-like isoform X1 [KO:K00444]
121329260  protein Wnt-5a [KO:K00444]
121318596  protein Wnt-5b-like [KO:K00444]
121319539  protein Wnt-5b [KO:K00444]
121321402  protein Wnt-6-like [KO:K00445]
121322785  wnt6b; protein Wnt-6 [KO:K00445]
121297670  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
121329389  protein Wnt-7a [KO:K00572]
121318524  protein Wnt-7b isoform X1 [KO:K00572]
121297531  protein Wnt-8a-like [KO:K00714]
121297599  protein Wnt-8-like [KO:K00714]
121297602  protein Wnt-8-like [KO:K00714]
121325887  protein Wnt-8b [KO:K00714]
121321844  protein Wnt-8b-like [KO:K00714]
121325035  protein Wnt-8a-like [KO:K00714]
121301699  wnt9b; protein Wnt-9b [KO:K01064]
121312839  wnt9a; protein Wnt-9a [KO:K01064]
121314316  protein Wnt-9a-like isoform X1 [KO:K01064]
121321481  protein Wnt-10a [KO:K01357]
121309033  wnt10b; protein Wnt-10b [KO:K01357]
121322633  protein Wnt-10a-like [KO:K01357]
121295388  protein Wnt-11b-like [KO:K01384]
121320387  protein Wnt-11 isoform X1 [KO:K01384]
121318944  protein Wnt-11b-like [KO:K01384]
121318303  protein Wnt-16-like [KO:K01558]
121319809  protein Wnt-16-like [KO:K01558]
121327960  uncharacterized protein LOC121327960 [KO:K01645]
121310189  dand5; DAN domain family member 5 [KO:K01645]
121300693  carboxylesterase notum2-like [KO:K19882] [EC:3.1.1.98]
121295216  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b isoform X1 [KO:K19882] [EC:3.1.1.98]
121296021  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
121331290  carboxylesterase notum2-like [KO:K19882] [EC:3.1.1.98]
121317988  wif1; wnt inhibitory factor 1 [KO:K01691]
121320093  wnt inhibitory factor 1-like isoform X1 [KO:K01691]
121323922  sost; sclerostin [KO:K16834]
121296417  dickkopf-related protein 2-like [KO:K02165]
121321595  dickkopf-related protein 1-like [KO:K02165]
121321813  dickkopf-related protein 2-like [KO:K02165]
121302390  dickkopf-related protein 4-like [KO:K02165]
121325257  dkk1b; dickkopf-related protein 1b [KO:K02165]
121302999  dickkopf-related protein 4-like [KO:K02165]
121308726  serpinf1; pigment epithelium-derived factor [KO:K19614]
121302146  secreted frizzled-related protein 1-like [KO:K02166]
121303043  secreted frizzled-related protein 1-like [KO:K02166]
121295142  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
121302671  secreted frizzled-related protein 2-like isoform X1 [KO:K02176]
121323020  secreted frizzled-related protein 2-like [KO:K02176]
121323708  secreted frizzled-related protein 3-like [KO:K25481]
121322188  secreted frizzled-related protein 3-like [KO:K25481]
121312783  secreted frizzled-related protein 4-like [KO:K02185]
121314242  secreted frizzled-related sequence protein 4-like isoform X1 [KO:K02185]
121325805  secreted frizzled-related protein 5-like [KO:K02222]
121321523  secreted frizzled-related protein 5-like [KO:K02222]
121303284  rspo1; R-spondin-1 [KO:K19471]
121297824  R-spondin-4-like isoform X1 [KO:K23097]
121314916  R-spondin-2-like [KO:K23097]
121313268  R-spondin-2-like [KO:K23097]
121319480  rspo4; R-spondin-4 [KO:K23097]
121316269  R-spondin-3-like [KO:K23098]
121317394  R-spondin-3-like [KO:K23098]
121294492  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
121330192  leucine-rich repeat-containing G-protein coupled receptor 4-like [KO:K04309]
121318029  leucine-rich repeat-containing G-protein coupled receptor 5-like isoform X1 [KO:K04308]
121320062  leucine-rich repeat-containing G-protein coupled receptor 5-like [KO:K04308]
121300296  leucine-rich repeat-containing G-protein coupled receptor 6-like isoform X1 [KO:K08399]
121300367  leucine-rich repeat-containing G-protein coupled receptor 6-like isoform X1 [KO:K08399]
121308563  E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
121297236  E3 ubiquitin-protein ligase znrf3-like isoform X1 [KO:K16273] [EC:2.3.2.27]
121299925  E3 ubiquitin-protein ligase znrf3-like [KO:K16273] [EC:2.3.2.27]
121315013  frizzled-1-like [KO:K02432]
121322165  frizzled-7-A-like [KO:K02432]
121323682  frizzled-7-A [KO:K02432]
121313174  frizzled-1-like [KO:K02432]
121302009  frizzled-2-like [KO:K02235]
121324847  frizzled-2 [KO:K02235]
121316025  frizzled-3 isoform X1 [KO:K02329]
121302901  fzd4; frizzled-4 [KO:K02354]
121321415  frizzled-5-like [KO:K02375]
121322685  frizzled-5-like [KO:K02375]
121310915  frizzled-8-like [KO:K02375]
121314086  frizzled-8-like [KO:K02375]
121314929  frizzled-6-like [KO:K02376]
121313255  frizzled-6-like isoform X1 [KO:K02376]
121296834  frizzled-10-B-like [KO:K02842]
121299604  frizzled-10-B-like [KO:K02842]
121308541  frizzled-9 [KO:K02842]
121294405  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
121329838  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
121318533  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
121311630  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
121314105  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
121314463  protein APCDD1-like [KO:K25812]
121313524  protein APCDD1-like [KO:K25812]
121298146  protein APCDD1-like [KO:K25812]
121319447  apcdd1l; protein APCDD1-like [KO:K25812]
121306147  casein kinase I [KO:K08960] [EC:2.7.11.1]
121329850  protein Daple-like isoform X1 [KO:K25811]
121324040  protein Daple-like isoform X1 [KO:K25811]
121306550  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
121326761  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
121322921  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
121329152  dvl1a; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
121305697  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
121314972  GSK-3-binding protein-like [KO:K03096]
121313214  GSK-3-binding protein-like [KO:K03096]
121296470  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
121297911  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
121325701  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
121315152  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
121313713  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
121319188  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
121298729  csnk2b; casein kinase II subunit beta [KO:K03115]
121304367  casein kinase II subunit beta [KO:K03115]
121296665  protein naked cuticle homolog 1-like [KO:K03213]
121325840  nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
121309210  protein naked cuticle homolog 2-like [KO:K03213]
121313972  protein naked cuticle homolog 2-like [KO:K03213]
121298534  CXXC-type zinc finger protein 4-like [KO:K03344]
121302171  CXXC-type zinc finger protein 4-like [KO:K03344]
121327954  CXXC-type zinc finger protein 4 [KO:K03344]
121322086  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
121322611  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
121320753  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121327778  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
121314633  catenin beta-1-like [KO:K02105]
121313013  catenin beta-1 isoform X1 [KO:K02105]
121300589  axin-1-like [KO:K02157]
121330874  axin-1-like isoform X1 [KO:K02157]
121295446  axin-2-like [KO:K04385]
121296145  axin-2-like [KO:K04385]
121301150  adenomatous polyposis coli protein 2-like [KO:K02085]
121315888  adenomatous polyposis coli protein-like isoform X1 [KO:K02085]
121301651  adenomatous polyposis coli protein 2-like [KO:K02085]
121301941  adenomatous polyposis coli protein-like isoform X1 [KO:K02085]
121296946  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
121324387  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121297274  transcription factor 7-like 2 isoform X1 [KO:K02620]
121324311  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
121302353  transcription factor 7-like 1-B [KO:K04490]
121303125  transcription factor 7-like 1-A [KO:K04490]
121321701  transcription factor 7-like 2 isoform X1 [KO:K04491]
121325528  transcription factor 7-like 2 isoform X1 [KO:K04491]
121296434  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
121321759  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
121322177  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
121325563  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
121328892  beta-catenin-interacting protein 1 isoform X1 [KO:K04493]
121329276  beta-catenin-interacting protein 1 isoform X1 [KO:K04493]
121297515  uncharacterized protein LOC121297515 [KO:K23402]
121307428  chd8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:5.6.2.-]
121302827  colorectal mutant cancer protein isoform X1 [KO:K26734]
121315149  colorectal mutant cancer protein-like isoform X1 [KO:K26734]
121303182  cell cycle and apoptosis regulator protein 2-like isoform X1 [KO:K25816]
121302362  cell cycle and apoptosis regulator protein 2-like [KO:K25816]
121326144  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
121321631  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
121313437  transcription factor Sox-17-alpha-A-like [KO:K04495]
121314380  sox17; transcription factor SOX-17 [KO:K04495]
121297252  C-terminal-binding protein 2-like [KO:K04496] [EC:1.1.1.428]
121321769  uncharacterized protein LOC121321769 isoform X1 [KO:K04496] [EC:1.1.1.428]
121324447  C-terminal-binding protein 2-like [KO:K04496] [EC:1.1.1.428]
121330963  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
121325404  uncharacterized protein LOC121325404 isoform X1 [KO:K04496] [EC:1.1.1.428]
121325629  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
121300636  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
121300637  transducin-like enhancer protein 1 [KO:K04497]
121298952  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
121299012  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
121299229  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
121294393  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
121301320  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
121301322  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
121318782  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
121318796  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
121313419  catenin delta-2-like isoform X1 [KO:K23491]
121314365  catenin delta-2-like isoform X1 [KO:K23491]
121300700  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
121301211  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
121331048  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
121306077  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
121297877  ruvB-like 1 isoform X1 [KO:K04499] [EC:5.6.2.4]
121329056  ruvB-like 1 isoform X1 [KO:K04499] [EC:5.6.2.4]
121317857  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
121304289  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121294921  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121299241  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121315455  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
121317588  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121306751  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
121308734  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
121317053  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
121298159  transcriptional regulator Myc-B-like [KO:K04377]
121314608  transcriptional regulator Myc-like [KO:K04377]
121307859  transcriptional regulator Myc-B-like [KO:K04377]
121327132  transcription factor AP-1-like [KO:K04448]
121303585  transcription factor AP-1-like [KO:K04448]
121330935  transcription factor AP-1-like [KO:K04448]
121314498  transcription factor AP-1-like [KO:K04448]
121295125  G1/S-specific cyclin-D1 [KO:K04503]
121329999  G1/S-specific cyclin-D1-like [KO:K04503]
121305898  ccndx; cyclin Dx [KO:K04503]
121318077  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
121320013  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
121299920  G1/S-specific cyclin-D2-like [KO:K10152]
121299948  G1/S-specific cyclin-D2-like [KO:K10152]
121304753  G1/S-specific cyclin-D2-like [KO:K10152]
121315148  CCN family member 4-like [KO:K22471]
121313668  CCN family member 4-like [KO:K22471]
121299612  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
121300279  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
121329794  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
121324431  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
121326749  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121310175  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
121331016  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
121306517  cellular tumor antigen p53-like [KO:K04451]
121305685  cellular tumor antigen p53-like [KO:K04451]
121296555  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
121325280  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
121326360  calcyclin-binding protein [KO:K04507]
121297582  S-phase kinase-associated protein 1 [KO:K03094]
121324310  S-phase kinase-associated protein 1-like [KO:K03094]
121320663  F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508]
121326785  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
121327809  F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508]
121322880  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
121297128  F-box/WD repeat-containing protein 11-like isoform X1 [KO:K03362]
121326084  beta-TrCP-like isoform X1 [KO:K03362]
121321847  beta-TrCP isoform X1 [KO:K03362]
121324395  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
121312791  cullin-1 isoform X1 [KO:K03347]
121314253  cullin-1 isoform X1 [KO:K03347]
121306188  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121295407  glypican-4-like [KO:K08110]
121318881  gpc4; glypican-4 [KO:K08110]
121326446  inactive tyrosine-protein kinase transmembrane receptor ROR1-like [KO:K05122] [EC:2.7.10.1]
121330482  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122] [EC:2.7.10.1]
121315688  tyrosine-protein kinase transmembrane receptor ROR2-like isoform X1 [KO:K05123] [EC:2.7.10.1]
121302206  tyrosine-protein kinase transmembrane receptor ROR2-like isoform X1 [KO:K05123] [EC:2.7.10.1]
121323185  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
121320724  vang-like protein 1 [KO:K04510]
121307187  vang-like protein 2 [KO:K04510]
121328096  vang-like protein 1 isoform X1 [KO:K04510]
121302428  vangl2; vang-like protein 2 [KO:K04510]
121298172  prickle-like protein 2 isoform X1 [KO:K04511]
121328967  prickle3; prickle planar cell polarity protein 3 [KO:K04511]
121329204  prickle-like protein 2 isoform X1 [KO:K04511]
121318127  prickle-like protein 1 [KO:K04511]
121319975  prickle-like protein 1 [KO:K04511]
121314683  invs; inversin isoform X1 [KO:K19626]
121316220  disheveled-associated activator of morphogenesis 2-like isoform X1 [KO:K04512]
121317346  LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 2-like [KO:K04512]
121323979  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
121330250  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
121298068  transforming protein RhoA [KO:K04513]
121300002  rho-related GTP-binding protein RhoA-D [KO:K04513]
121328543  rho-related GTP-binding protein RhoA-C [KO:K04513]
121328614  transforming protein RhoA [KO:K04513]
121305409  rho-related GTP-binding protein RhoA-C [KO:K04513]
121315517  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
121317519  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121301266  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
121330795  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121306175  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121306183  ras-related C3 botulinum toxin substrate 2-like isoform X1 [KO:K07860]
121295764  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
121296673  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
121296957  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121325682  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121301569  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121316125  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121321798  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121324174  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121315927  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
121315930  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121317052  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121310099  plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121317660  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
121329668  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
121323975  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
121295509  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121296837  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121321778  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
121322582  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
121303013  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
121323838  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
121325571  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121296291  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121297616  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
121325811  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121321999  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121302376  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121303088  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121324996  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121316113  calcineurin subunit B type 1 [KO:K06268]
121317240  calcineurin subunit B type 1-like [KO:K06268]
121318631  plastin-3-like [KO:K06268]
121295549  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121296360  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
121300719  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121331034  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
121302494  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
121314840  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
121313331  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
121298029  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
121319225  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
121296107  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
121325632  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121307363  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
121305251  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
pspa04010  MAPK signaling pathway
pspa04110  Cell cycle
pspa04115  p53 signaling pathway
pspa04120  Ubiquitin mediated proteolysis
pspa04350  TGF-beta signaling pathway
pspa04510  Focal adhesion
pspa04520  Adherens junction
KO pathway
ko04310   
LinkDB

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