KEGG   PATHWAY: setr04062
Entry
setr04062                   Pathway                                
Name
Chemokine signaling pathway - Suncus etruscus (white-toothed pygmy shrew)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
setr04062  Chemokine signaling pathway
setr04062

Other DBs
GO: 0070098
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
126032263  growth-regulated protein homolog gamma-like [KO:K05505]
126032541  growth-regulated protein homolog gamma-like [KO:K05505]
126032178  C-X-C motif chemokine 6-like [KO:K05506]
126032179  platelet basic protein-like [KO:K10029]
126032265  CXCL8; interleukin-8 [KO:K10030]
126032652  C-X-C motif chemokine 10-like [KO:K12671]
126032188  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
126020631  stromal cell-derived factor 1 [KO:K10031]
126033750  CXCL12; stromal cell-derived factor 1 [KO:K10031]
126032653  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
126032180  platelet factor 4-like [KO:K05407]
126027777  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
126014288  cytokine SCM-1 beta-like [KO:K22675]
126027150  CX3CL1; fractalkine [KO:K05508]
126032234  CCL1; C-C motif chemokine 1 [KO:K05514]
126031719  monocyte chemotactic protein 1B-like [KO:K14624]
126033581  C-C motif chemokine 3-like 1 [KO:K05408]
126033669  C-C motif chemokine 3-like 1 [KO:K05408]
126007604  C-C motif chemokine 4-like [KO:K12964]
126007620  C-C motif chemokine 4-like [KO:K12964]
126033488  CCL5; C-C motif chemokine 5 [KO:K12499]
126007652  C-C motif chemokine 7-like [KO:K05509]
126032026  eotaxin-like [KO:K16597]
126032120  C-C motif chemokine 13-like [KO:K16595]
126007439  CCL14; C-C motif chemokine 14 isoform X1 [KO:K21092]
126028415  CCL17; C-C motif chemokine 17 [KO:K21083]
126005762  CCL19; C-C motif chemokine 19 [KO:K05512]
126001643  CCL20; C-C motif chemokine 20 [KO:K14625]
126009723  CCL21; C-C motif chemokine 21 [KO:K16062]
126028414  CCL22; C-C motif chemokine 22 [KO:K21095]
126029924  CCL24; C-C motif chemokine 24 [KO:K21097]
126030082  CCL25; C-C motif chemokine 25 [KO:K13072]
126029600  CCL26; C-C motif chemokine 26 [KO:K21096]
126009675  CCL27; C-C motif chemokine 27 isoform X1 [KO:K16598]
126009771  uncharacterized protein LOC126009771 isoform X1 [KO:K16598]
126000875  C-X-C chemokine receptor type 2-like [KO:K05050]
126000876  C-X-C chemokine receptor type 2-like [KO:K05050]
126001666  C-X-C chemokine receptor type 2-like [KO:K05050]
125998871  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
126009206  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
126015810  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
126013617  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
126014080  XCR1; chemokine XC receptor 1 [KO:K04193]
125998149  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
125998151  CCR8; C-C chemokine receptor type 8 [KO:K04183]
126014394  CCR9; C-C chemokine receptor type 9 [KO:K04184]
125998148  CCR4; C-C chemokine receptor type 4 [KO:K04179]
126019583  CCR7; C-C chemokine receptor type 7 [KO:K04182]
126014068  C-C chemokine receptor type 2-like [KO:K04177]
126014074  C-C chemokine receptor type 5-like [KO:K04180]
126014395  CCR1; C-C chemokine receptor type 1 [KO:K04176]
126014396  CCR3; C-C chemokine receptor type 3 [KO:K04178]
126009984  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
126030203  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
126009005  STAT1; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
126022154  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
126020260  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
126016963  signal transducer and activator of transcription 5B [KO:K11224]
126014071  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126022872  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125997317  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
126029834  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
126000769  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126024026  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
126001049  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
126026247  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126022668  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126027080  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
125997104  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
126001221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126020443  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
126017360  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
126011407  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
126017330  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126020709  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
126030826  SHC2; SHC-transforming protein 2 [KO:K17447]
126003375  SHC3; SHC-transforming protein 3 [KO:K17448]
126020007  SHC4; SHC-transforming protein 4 [KO:K17449]
126003551  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
126023864  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125999018  SOS2; son of sevenless homolog 2 [KO:K03099]
126019084  HRAS; GTPase HRas [KO:K02833]
126022823  KRAS; GTPase KRas isoform X1 [KO:K07827]
125997372  NRAS; GTPase NRas [KO:K07828]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126010754  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126012035  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126012036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126011501  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
126030200  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126011086  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126001552  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
126022256  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
125998048  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
125998107  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
126010949  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
126013417  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126033346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126028133  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126005875  FOXO3; forkhead box protein O3 [KO:K09408]
126033816  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
126006407  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125999080  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125998702  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
126027696  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
126027544  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126019025  RELA; transcription factor p65 [KO:K04735]
126017861  BAD; bcl2-associated agonist of cell death [KO:K02158]
126028132  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
126026205  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126011949  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
125997407  VAV3; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730]
126031136  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
126009330  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
126030488  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126006381  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126013731  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
126013242  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126017532  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
125994825  cell division control protein 42 homolog [KO:K04393]
126024665  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
125998704  cell division control protein 42 homolog [KO:K04393]
126018299  cell division control protein 42 homolog [KO:K04393]
126011308  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
126028736  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
125999254  WAS; actin nucleation-promoting factor WAS [KO:K05747]
126014129  RHOA; LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
126003668  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
126024093  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
126011605  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126031035  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126006589  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126012077  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126002081  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125999572  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126017910  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
126030791  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126005956  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126026239  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126031195  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126028279  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126020263  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126003829  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126023960  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024701  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126033760  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125999484  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126000312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126010869  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126010895  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126020118  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024681  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126030830  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126010822  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126001569  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126024671  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126020139  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126019117  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
126020404  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
126011896  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
126009430  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126030593  PXN; paxillin isoform X1 [KO:K05760]
126027351  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
126021156  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
126033713  CRKL; crk-like protein [KO:K04438]
126006104  PTK2B; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
126003511  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
126017277  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126024570  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
126017588  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126018105  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126017276  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126027269  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126019028  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
125997373  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
126021897  RAP1B; ras-related protein Rap-1b [KO:K07836]
126006387  ras-related protein Rap-1b [KO:K07836]
126013353  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
126026136  TIAM1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126013204  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
126031245  NCF1; neutrophil cytosol factor 1 [KO:K08011]
126015565  GRK1; LOW QUALITY PROTEIN: rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
126026307  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
126030572  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
126018096  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
126011942  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
125994907  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
126032241  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
126018158  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
126011248  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
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Annu Rev Immunol 23:549-600 (2005)
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Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
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Oncogene 26:7081-91 (2007)
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PMID:9765254
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Korchak HM, Rossi MW, Kilpatrick LE
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Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
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J Biol Chem 273:27292-9 (1998)
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PMID:15046611
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Chemokine inhibition--why, when, where, which and how?
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Biochem Soc Trans 32:366-77 (2004)
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Zhelev DV, Alteraifi A
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Signaling in the motility responses of the human neutrophil.
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Ann Biomed Eng 30:356-70 (2002)
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Phospholipase cbeta is critical for T cell chemotaxis.
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J Immunol 179:2223-7 (2007)
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Cell Signal 16:1-11 (2004)
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Related
pathway
setr04010  MAPK signaling pathway
setr04060  Cytokine-cytokine receptor interaction
setr04120  Ubiquitin mediated proteolysis
setr04630  JAK-STAT signaling pathway
setr04670  Leukocyte transendothelial migration
setr04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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