KEGG   PATHWAY: xma04820
Entry
xma04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Xiphophorus maculatus (southern platyfish)
Class
Cellular Processes; Cell motility
Pathway map
xma04820  Cytoskeleton in muscle cells
xma04820

Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102216393  tmod4; tropomodulin-4 [KO:K10370]
102216404  [KO:K12641]
102216439  [KO:K08131]
102216487  [KO:K07606]
102216659  lmod3; leiomodin-3 [KO:K22030]
102216694  [KO:K24495]
102216697  [KO:K12641]
102216797  [KO:K19721]
102216873  actn3; alpha-actinin-3 [KO:K21073]
102216916  [KO:K04512]
102217063  [KO:K01539] [EC:7.2.2.13]
102217067  [KO:K12565]
102217084  [KO:K10388]
102217130  hspg2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
102217146  [KO:K10373]
102217347  fmnl3; formin-like protein 3 isoform X1 [KO:K23957]
102217613  xirp2; xin actin-binding repeat-containing protein 2 [KO:K27381]
102217617  [KO:K08131]
102217729  [KO:K19867]
102217862  itga8; integrin alpha-8 [KO:K06584]
102217871  bgn; biglycan [KO:K08118]
102217899  [KO:K12749]
102217924  fmnl2; formin-like protein 2 isoform X2 [KO:K23957]
102217961  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
102218145  [KO:K01539] [EC:7.2.2.13]
102218169  [KO:K12642]
102218227  [KO:K10364]
102218259  [KO:K06271]
102218290  snta1; alpha-1-syntrophin [KO:K24063]
102218292  ankrd1; ankyrin repeat domain-containing protein 1 [KO:K21433]
102218310  [KO:K10374]
102218394  [KO:K05692]
102218525  sntb1; beta-1-syntrophin [KO:K24064]
102218602  syne1; nesprin-1 isoform X1 [KO:K19326]
102218802  [KO:K10375]
102218935  [KO:K07610]
102218949  sdc3; syndecan-3 [KO:K16337]
102218997  dcn; decorin [KO:K04660]
102219171  lmnb2; lamin-B2 [KO:K07611]
102219180  [KO:K06115]
102219302  myom1; myomesin-1 isoform X3 [KO:K24495]
102219489  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
102219586  csrp3; cysteine and glycine-rich protein 3 [KO:K09377]
102219605  [KO:K06238]
102219650  col11a1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
102219781  [KO:K07597]
102219802  [KO:K12567] [EC:2.7.11.1]
102219901  sgce; epsilon-sarcoglycan isoform X1 [KO:K27061]
102220019  myoz1; myozenin-1 [KO:K26050]
102220041  [KO:K07597]
102220104  pdlim4; PDZ and LIM domain protein 4 [KO:K23353]
102220172  [KO:K12042]
102220238  tcap; telethonin [KO:K19879]
102220390  [KO:K24220]
102220395  [KO:K09259]
102220434  [KO:K12042]
102220562  dag1; dystroglycan [KO:K06265]
102220696  [KO:K17307]
102220784  sgcd; delta-sarcoglycan isoform X1 [KO:K12563]
102220794  [KO:K06482]
102220853  daam2; disheveled-associated activator of morphogenesis 2 isoform X3 [KO:K04512]
102220863  [KO:K01540]
102220909  [KO:K06115]
102220992  thbs3; thrombospondin-3 [KO:K04659]
102221072  [KO:K06237]
102221107  [KO:K19879]
102221132  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
102221311  [KO:K10351]
102221313  [KO:K06476]
102221335  [KO:K06237]
102221428  lmod2; leiomodin-2 [KO:K22030]
102221501  [KO:K06482]
102221680  capn3; calpain-3 isoform X2 [KO:K08573] [EC:3.4.22.54]
102221802  [KO:K06493]
102221806  fbln1; fibulin-1 [KO:K17307]
102221880  col6a6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
102222084  fbn1; fibrillin-1 [KO:K06825]
102222131  tln1; talin-1 isoform X1 [KO:K06271]
102222263  [KO:K19721]
102222362  [KO:K24494]
102222378  [KO:K14365]
102222437  [KO:K19721]
102222474  [KO:K05700]
102222505  [KO:K01539] [EC:7.2.2.13]
102222514  itga1; integrin alpha-1 [KO:K06480]
102222515  [KO:K06484]
102222528  [KO:K08573] [EC:3.4.22.54]
102222811  [KO:K23957]
102222819  [KO:K12046]
102222831  mypn; myopalladin isoform X4 [KO:K22028]
102222852  [KO:K16336]
102222871  [KO:K09377]
102222883  [KO:K16857]
102222885  actb; actin, cytoplasmic 1 [KO:K05692]
102222899  [KO:K19347]
102223033  [KO:K07610]
102223124  [KO:K12045]
102223151  [KO:K23958]
102223315  itga11; integrin alpha-11 isoform X2 [KO:K06587]
102223392  [KO:K01689] [EC:4.2.1.11]
102223398  itgb5; integrin beta-5 [KO:K06588]
102223470  [KO:K16336]
102223587  agrn; agrin isoform X1 [KO:K06254]
102223721  [KO:K10352]
102223727  [KO:K04659]
102223753  itgav; integrin alpha-V [KO:K06487]
102223796  itgb1; integrin beta-1 isoform X2 [KO:K05719]
102223797  [KO:K04659]
102223868  pdlim7; PDZ and LIM domain protein 7 [KO:K19867]
102223911  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102224109  [KO:K01490] [EC:3.5.4.6]
102224285  [KO:K23957]
102224390  [KO:K07601]
102224566  [KO:K05738]
102224638  [KO:K07597]
102224746  [KO:K01540]
102224849  tpm4; tropomyosin alpha-4 chain isoform X2 [KO:K10375]
102224957  [KO:K19721]
102224997  [KO:K12755]
102225124  [KO:K10352]
102225150  pdlim1; PDZ and LIM domain protein 1 [KO:K23353]
102225160  dsp; desmoplakin isoform X2 [KO:K10381]
102225200  [KO:K12314]
102225234  neb; nebulin isoform X1 [KO:K18267]
102225347  itga2; integrin alpha-2 [KO:K06481]
102225388  eno1; enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
102225528  [KO:K17531] [EC:2.7.11.1]
102225750  [KO:K19867]
102225869  col27a1; collagen alpha-1(XXVII) chain [KO:K19721]
102225927  [KO:K06115]
102225943  [KO:K12043]
102226016  [KO:K10056]
102226053  [KO:K23342]
102226204  [KO:K12043]
102226419  sgcz; zeta-sarcoglycan isoform X1 [KO:K27062]
102226549  eno3; beta-enolase [KO:K01689] [EC:4.2.1.11]
102226553  [KO:K27393]
102226580  [KO:K01490] [EC:3.5.4.6]
102226635  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
102226663  nrap; nebulin-related-anchoring protein isoform X1 [KO:K24421]
102226792  [KO:K12750]
102226824  [KO:K24220]
102226895  col4a1; collagen alpha-1(IV) chain [KO:K06237]
102226915  [KO:K19326]
102227077  [KO:K06238]
102227385  itgb3; integrin beta-3 [KO:K06493]
102227404  [KO:K10654]
102227480  [KO:K24220]
102227487  tmod1; tropomodulin-1 isoform X1 [KO:K10370]
102227509  [KO:K06485]
102227614  [KO:K12314]
102227660  [KO:K12043]
102227699  [KO:K24220]
102227738  [KO:K24220]
102227835  col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
102227872  fhl3; four and a half LIM domains protein 3 isoform X3 [KO:K24414]
102227898  nid2; nidogen-2 isoform X1 [KO:K06826]
102227954  [KO:K24495]
102228062  sgcg; gamma-sarcoglycan isoform X1 [KO:K12564]
102228072  [KO:K05745]
102228139  sgcb; beta-sarcoglycan [KO:K12566]
102228164  vcl; vinculin [KO:K05700]
102228241  lmnb1; lamin-B1 [KO:K07611]
102228327  tnnt1; troponin T, slow skeletal muscle isoform X2 [KO:K10372]
102228467  [KO:K19347]
102228505  [KO:K04659]
102228700  fhl2; four and a half LIM domains protein 2 [KO:K14380]
102228744  [KO:K12758]
102228775  lama1; laminin subunit alpha-1 [KO:K05637]
102228931  myoz2; myozenin-2 [KO:K26050]
102228932  [KO:K07606]
102228942  [KO:K05865]
102229049  sntb2; beta-2-syntrophin [KO:K24064]
102229055  itga7; integrin alpha-7 isoform X1 [KO:K06583]
102229069  [KO:K24495]
102229076  [KO:K10371]
102229121  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X5 [KO:K06114]
102229172  col9a1; collagen alpha-1(IX) chain [KO:K08131]
102229187  [KO:K17307]
102229195  [KO:K24066]
102229236  [KO:K23932]
102229255  [KO:K01689] [EC:4.2.1.11]
102229265  obscn; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
102229338  itgb8; integrin beta-8 [KO:K06591]
102229576  [KO:K17751]
102229585  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102229637  [KO:K12046]
102229709  syne3; nesprin-3 isoform X1 [KO:K21761]
102229823  [KO:K19867]
102229875  [KO:K26050]
102229898  sptbn4; spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
102229978  [KO:K06236]
102230011  [KO:K05717]
102230019  [KO:K17751]
102230159  col9a3; collagen alpha-3(IX) chain [KO:K08131]
102230268  tmod3; tropomodulin-3 [KO:K10370]
102230320  [KO:K12567] [EC:2.7.11.1]
102230362  [KO:K10352]
102230365  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
102230448  [KO:K10654]
102230477  [KO:K09377]
102230712  tpm1; tropomyosin alpha-1 chain isoform X2 [KO:K10373]
102230737  [KO:K10371]
102231053  [KO:K01539] [EC:7.2.2.13]
102231215  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
102231446  [KO:K12045]
102231467  [KO:K06587]
102231613  [KO:K01540]
102231624  [KO:K19347]
102231671  tln2; talin-2 isoform X4 [KO:K06271]
102231807  [KO:K27393]
102231808  [KO:K12043]
102231864  [KO:K24495]
102232000  col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
102232029  daam1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
102232154  [KO:K12558]
102232298  [KO:K09290]
102232449  [KO:K19721]
102232636  itga9; integrin alpha-9 [KO:K06585]
102232649  itgb4; integrin beta-4 isoform X1 [KO:K06525]
102232694  [KO:K17751]
102232699  [KO:K19721]
102232786  [KO:K10371]
102232818  [KO:K23353]
102232822  [KO:K04659]
102232899  tmem43; transmembrane protein 43 [KO:K27488]
102232954  [KO:K17751]
102233211  [KO:K10371]
102233302  mybpc3; myosin-binding protein C, cardiac-type isoform X1 [KO:K12568]
102233396  [KO:K01540]
102233471  [KO:K10371]
102233560  [KO:K26050]
102233599  [KO:K12314]
102233637  [KO:K24220]
102233650  fhl1; four and a half LIM domains protein 1 isoform X2 [KO:K14365]
102233824  myh11; myosin-11 isoform X3 [KO:K10352]
102233885  [KO:K19721]
102233987  [KO:K10371]
102234012  dmd; dystrophin isoform X1 [KO:K10366]
102234141  capzb; F-actin-capping protein subunit beta isoform X2 [KO:K10365]
102234161  [KO:K12758]
102234214  itga10; integrin alpha-10 [KO:K06586]
102234225  col6a1; collagen alpha-1(VI) chain [KO:K06238]
102234247  [KO:K12045]
102234348  [KO:K12045]
102234358  [KO:K12569]
102234375  [KO:K27382]
102234432  sspn; sarcospan [KO:K22194]
102234476  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102234488  [KO:K23957]
102234503  [KO:K06485]
102234547  [KO:K21073]
102234583  nid1; nidogen-1 [KO:K06826]
102234716  [KO:K06484]
102234744  [KO:K26050]
102234760  [KO:K06485]
102235006  [KO:K19867]
102235054  col9a2; collagen alpha-2(IX) chain [KO:K08131]
102235082  mybpc2; myosin-binding protein C, fast-type isoform X1 [KO:K12558]
102235303  csrp2; cysteine and glycine-rich protein 2 [KO:K09377]
102235305  [KO:K06265]
102235473  eno2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
102235526  [KO:K01540]
102235568  itga4; integrin alpha-4 [KO:K06483]
102235720  [KO:K19721]
102235799  [KO:K10351]
102235839  [KO:K24494]
102235859  myot; myotilin isoform X1 [KO:K19875]
102235916  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
102235952  [KO:K02184]
102235985  [KO:K16338]
102235993  atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
102236068  [KO:K01490] [EC:3.5.4.6]
102236084  [KO:K05865]
102236128  [KO:K27382]
102236171  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102236186  diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
102236204  [KO:K06793]
102236272  [KO:K05692]
102236456  ampd1; AMP deaminase 1 isoform X2 [KO:K01490] [EC:3.5.4.6]
102236496  [KO:K01539] [EC:7.2.2.13]
102236504  lmod1; leiomodin-1 [KO:K22030]
102236532  ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
102236679  [KO:K17307]
102236804  ank2; ankyrin-2 isoform X1 [KO:K09255]
102236837  [KO:K10654]
102236892  [KO:K06237]
102236898  thbs1; thrombospondin-1 [KO:K16857]
102236960  nebl; nebulette isoform X1 [KO:K25865]
102237053  [KO:K19721]
102237123  [KO:K09259]
102237153  [KO:K06237]
102237167  itgb6; integrin beta-6 [KO:K06589]
102237249  [KO:K10352]
102237286  [KO:K24220]
102237291  [KO:K27381]
102237315  lbr; lamin-B receptor isoform X1 [KO:K19532] [EC:1.3.1.70]
102237361  [KO:K19346]
102237572  [KO:K12043]
102237700  [KO:K09255]
102237719  pdlim3; PDZ and LIM domain protein 3 [KO:K23353]
102237731  mybpc1; myosin-binding protein C, slow-type [KO:K12557]
102237830  [KO:K09290]
102237870  [KO:K10372]
102237893  [KO:K02184]
102237966  [KO:K10371]
102238118  atp1b4; protein ATP1B4 [KO:K01540]
102238292  zyx; zyxin [KO:K06273]
102238368  [KO:K01540]
102238408  dtna; dystrobrevin alpha isoform X6 [KO:K26998]
106700119  [KO:K07610]
106700286  [KO:K06273]
111605768  [KO:K24220]
111608849  [KO:K27381]
111609666  [KO:K19721]
111609758  col24a1; collagen alpha-1(XXIV) chain [KO:K19721]
111611990  [KO:K14211]
111612294  syne2; nesprin-2 isoform X1 [KO:K19346]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
xma04512  ECM-receptor interaction
xma04814  Motor proteins
KO pathway
ko04820   

DBGET integrated database retrieval system