KEGG   PATHWAY: pdic04510
Entry
pdic04510                   Pathway                                
Name
Focal adhesion - Phyllostomus discolor (pale spear-nosed bat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pdic04510  Focal adhesion
pdic04510

Other DBs
GO: 0005925
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114488127  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
114488355  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
114488551  IGF1R; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
114488654  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
114488721  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
114488773  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
114488787  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
114488904  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
114488957  RAP1A; ras-related protein Rap-1A [KO:K04353]
114489006  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114489188  THBS3; thrombospondin-3 [KO:K04659]
114489752  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114489776  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
114489931  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
114490078  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
114490158  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114490226  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
114490541  ITGB5; integrin beta-5 [KO:K06588]
114490568  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114490993  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114491113  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114491403  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
114491633  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
114491731  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
114491735  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
114492185  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
114492293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114492326  SPP1; osteopontin [KO:K06250]
114492422  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114492590  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114492659  PGF; placenta growth factor isoform X1 [KO:K16859]
114492688  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114492960  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
114493062  TLN2; talin-2 isoform X1 [KO:K06271]
114493180  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
114493248  ITGA8; integrin alpha-8 [KO:K06584]
114493261  [KO:K06253]
114493363  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
114493428  ITGB1; integrin beta-1 [KO:K05719]
114493440  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114493464  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
114493764  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
114493963  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
114493972  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
114494031  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
114494075  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114494110  LAMA2; laminin subunit alpha-2 isoform X3 [KO:K05637]
114494202  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
114494352  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
114494431  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
114494505  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
114494684  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
114494685  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
114494913  TNXB; tenascin-X isoform X1 [KO:K06252]
114494974  VEGFA; vascular endothelial growth factor A [KO:K05448]
114495251  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114495358  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
114495587  FN1; fibronectin isoform X1 [KO:K05717]
114495639  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
114496029  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
114496100  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114496144  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114496428  JUN; transcription factor AP-1 [KO:K04448]
114496643  TNC; tenascin isoform X1 [KO:K06252]
114496697  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
114496710  VAV2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
114496946  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114496983  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114497080  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114497235  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114497407  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114498030  VCL; vinculin isoform X1 [KO:K05700]
114498468  THBS4; thrombospondin-4 [KO:K04659]
114498544  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
114498660  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114498743  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
114499241  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114499392  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
114499451  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
114499504  HRAS; GTPase HRas isoform X2 [KO:K02833]
114499526  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
114499682  PARVA; alpha-parvin isoform X1 [KO:K06275]
114500412  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
114500581  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
114500653  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114500683  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114501023  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114501063  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114501309  [KO:K06238]
114501310  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
114501333  CAV3; caveolin-3 [KO:K12959]
114501452  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114501471  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
114501483  RHOA; transforming protein RhoA [KO:K04513]
114501494  [KO:K06243]
114501505  FLNB; LOW QUALITY PROTEIN: filamin-B [KO:K27392]
114501843  [KO:K06243]
114501905  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
114501968  ITGA9; integrin alpha-9 [KO:K06585]
114502081  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
114502148  CTNNB1; catenin beta-1 [KO:K02105]
114502362  CRK; adapter molecule crk isoform X1 [KO:K04438]
114502378  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
114502459  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114502542  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
114502559  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
114502599  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
114502639  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
114502829  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114502952  [KO:K04513]
114503040  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114503130  ITGA2B; integrin alpha-IIb [KO:K06476]
114503147  [KO:K04659]
114503368  VTN; vitronectin isoform X2 [KO:K06251]
114503433  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114504029  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114504058  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
114504166  SHC2; SHC-transforming protein 2 [KO:K17447]
114504197  ITGB3; integrin beta-3 [KO:K06493]
114504215  PDGFC; platelet-derived growth factor C [KO:K05450]
114504538  [KO:K04725] [EC:2.3.2.27]
114504617  FLNA; filamin-A isoform X2 [KO:K04437]
114504642  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
114504732  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
114504769  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
114504781  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
114505286  [KO:K05096] [EC:2.7.10.1]
114505353  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
114505396  [KO:K04409] [EC:2.7.11.1]
114505994  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
114506016  LAMA1; laminin subunit alpha-1 [KO:K05637]
114506151  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
114506209  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
114506335  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
114506489  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114506571  [KO:K12757]
114506695  [KO:K12757]
114506701  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
114506860  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
114507070  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
114507071  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114507230  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114507258  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
114507267  COL1A2; collagen alpha-2(I) chain [KO:K06236]
114507316  [KO:K04393]
114507521  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
114507559  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
114507565  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114507647  MYL10; myosin regulatory light chain 10 [KO:K12756]
114507681  CAV2; caveolin-2 isoform X1 [KO:K12958]
114507737  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114507852  CAV1; caveolin-1 isoform X1 [KO:K06278]
114507952  ZYX; LOW QUALITY PROTEIN: zyxin [KO:K06273]
114507991  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
114508136  ITGA1; integrin alpha-1 [KO:K06480]
114508297  ITGA2; integrin alpha-2 [KO:K06481]
114508651  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
114508652  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
114508695  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
114509151  ACTB; actin, cytoplasmic 1 [KO:K05692]
114509175  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
114509187  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
114509191  CRKL; crk-like protein [KO:K04438]
114509396  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
114509515  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114509620  PXN; paxillin isoform X1 [KO:K05760]
114509631  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
114509632  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114509650  TLN1; talin-1 isoform X1 [KO:K06271]
114509831  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114510156  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114510403  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
114510957  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114511150  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
114511158  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114511248  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
114511328  [KO:K06274]
114511524  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
114511667  ACTN4; alpha-actinin-4 isoform X5 [KO:K05699]
114511861  LAMC1; laminin subunit gamma-1 [KO:K05635]
114511932  TNR; tenascin-R [KO:K06252]
114511950  LAMC2; laminin subunit gamma-2 [KO:K06246]
114511982  LAMB3; laminin subunit beta-3 [KO:K06244]
114512139  TNN; tenascin-N isoform X1 [KO:K06252]
114512267  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
114512350  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114512462  [KO:K03853] [EC:3.4.22.53]
114512532  SHC3; SHC-transforming protein 3 [KO:K17448]
114512692  RAP1B; ras-related protein Rap-1b [KO:K07836]
114512748  ITGA5; integrin alpha-5 [KO:K06484]
114512963  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
114513024  ITGB7; integrin beta-7 [KO:K06590]
114513096  VWF; von Willebrand factor isoform X1 [KO:K03900]
114513229  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114513274  PARVB; beta-parvin isoform X1 [KO:K06275]
114513386  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
114513472  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114513499  EMP1; epithelial membrane protein 1 [KO:K26255]
114513618  ITGA7; integrin alpha-7 isoform X4 [KO:K06583]
114514069  PARVG; gamma-parvin [KO:K06275]
114514087  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114514158  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
114514474  PTK2; focal adhesion kinase 1 isoform X9 [KO:K05725] [EC:2.7.10.2]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pdic04010  MAPK signaling pathway
pdic04060  Cytokine-cytokine receptor interaction
pdic04070  Phosphatidylinositol signaling system
pdic04110  Cell cycle
pdic04151  PI3K-Akt signaling pathway
pdic04310  Wnt signaling pathway
pdic04512  ECM-receptor interaction
pdic04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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