KEGG   PATHWAY: pleu04062
Entry
pleu04062                   Pathway                                
Name
Chemokine signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pleu04062  Chemokine signaling pathway
pleu04062

Other DBs
GO: 0070098
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680645  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114680674  Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680696  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114681254  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
114681278  Cx3cr1; CX3C chemokine receptor 1 [KO:K04192]
114681285  Ccr8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
114681403  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681747  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
114681835  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114682062  Elmo1; LOW QUALITY PROTEIN: engulfment and cell motility protein 1 [KO:K12366]
114682099  Rela; transcription factor p65 [KO:K04735]
114682519  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114682605  Pxn; paxillin isoform X1 [KO:K05760]
114682714  Crkl; crk-like protein [KO:K04438]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682785  [KO:K11224]
114682786  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114682833  Ccr10; C-C chemokine receptor type 10 isoform X1 [KO:K04185]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683622  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114683897  Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684102  Shc2; SHC-transforming protein 2 [KO:K17447]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114684216  Vav2; guanine nucleotide exchange factor VAV2 isoform X4 [KO:K05730]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684308  Grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
114684706  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
114685127  [KO:K02833]
114685202  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114685356  Gsk3a; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
114685946  [KO:K04177]
114685947  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
114685948  [KO:K04176]
114685951  Ccr1; C-C chemokine receptor type 1 [KO:K04176]
114685952  Xcr1; chemokine XC receptor 1 isoform X1 [KO:K04193]
114685954  Ccr9; C-C chemokine receptor type 9 [KO:K04184]
114685955  Cxcr6; C-X-C chemokine receptor type 6 [KO:K04191]
114685988  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
114686020  Ccl26; C-C motif chemokine 26 [KO:K21096]
114686062  Ccl25; C-C motif chemokine 25 [KO:K13072]
114686123  Grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
114686543  Vav1; proto-oncogene vav [KO:K05730]
114686598  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114686769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
114687039  [KO:K07826]
114687553  Arrb2; beta-arrestin-2 [KO:K04439]
114687554  Cxcl16; C-X-C motif chemokine 16 [KO:K10035]
114687652  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114687957  Jak3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
114688303  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114688340  [KO:K04545]
114688488  [KO:K02833]
114688894  Cxcl14; C-X-C motif chemokine 14 [KO:K10033]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689175  Grk6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
114689488  Shc3; SHC-transforming protein 3 [KO:K17448]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689656  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
114689818  Itk; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
114690020  [KO:K05507]
114690390  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114691292  Cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
114691309  [KO:K04393]
114691397  Ccr6; C-C chemokine receptor type 6 [KO:K04181]
114691441  Crk; adapter molecule crk isoform X1 [KO:K04438]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691549  [KO:K05509]
114691550  [KO:K14624]
114691551  [KO:K16597]
114691605  [KO:K14624]
114691606  [KO:K16596]
114691607  Ccl1; C-C motif chemokine 1 [KO:K05514]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692579  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114692651  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
114692919  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
114693143  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
114693144  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290]
114693311  Rap1b; ras-related protein Rap-1b [KO:K07836]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114693442  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114693493  [KO:K02833]
114693495  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693708  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
114693962  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114694079  Grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694497  Cx3cl1; fractalkine [KO:K05508]
114694559  Ccl17; C-C motif chemokine 17 [KO:K21083]
114694560  Ccl22; C-C motif chemokine 22 [KO:K21095]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695341  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
114695739  Cxcl13; C-X-C motif chemokine 13 [KO:K10032]
114696121  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
114696396  Ccl20; C-C motif chemokine 20 isoform X3 [KO:K14625]
114696553  [KO:K02833]
114696911  [KO:K04634]
114696964  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
114697107  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697457  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114697724  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114698172  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114698273  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
114698453  Tiam1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
114698582  Nras; GTPase NRas [KO:K07828]
114698679  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114698703  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
114698838  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
114699957  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
114699988  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
114700910  [KO:K04513]
114700920  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114701214  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
114701271  Was; wiskott-Aldrich syndrome protein [KO:K05747]
114701275  [KO:K04393]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701716  [KO:K05506]
114701717  [KO:K10029]
114701718  [KO:K05407]
114701719  [KO:K05505]
114701735  [KO:K05505]
114701736  [KO:K05505]
114701751  Cxcl9; C-X-C motif chemokine 9 [KO:K05416]
114701753  Cxcl11; C-X-C motif chemokine 11 [KO:K12672]
114701754  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703230  [KO:K16598]
114703284  Ccl21; C-C motif chemokine 21 [KO:K16062]
114703285  Ccl19; C-C motif chemokine 19 isoform X2 [KO:K05512]
114703666  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114703672  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114704246  Ccl28; C-C motif chemokine 28 [KO:K05513]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704841  Adcy5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
114705035  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
114705216  Rhoa; transforming protein RhoA [KO:K04513]
114705554  Hck; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705775  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
114705921  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114705972  Fgr; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114706957  Ccr7; C-C chemokine receptor type 7 [KO:K04182]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707256  Rap1a; ras-related protein Rap-1A [KO:K04353]
114707316  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
114707517  Foxo3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707716  Ccl16; C-C motif chemokine 16 [KO:K21093]
114707719  [KO:K12964]
114707726  [KO:K12964]
114707727  [KO:K12964]
114707728  [KO:K12964]
114707732  [KO:K05408]
114707747  Ccl5; C-C motif chemokine 5 [KO:K12499]
114707748  Ccl15; C-C motif chemokine 15 [KO:K05511]
114707889  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
114708186  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
114708228  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
114708277  Prkcz; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
114708288  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114708453  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708501  Adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
114708522  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
114708644  Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
114708701  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
114708827  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
114709086  [KO:K04542]
114709099  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
114709238  Ccr4; LOW QUALITY PROTEIN: C-C chemokine receptor type 4 [KO:K04179]
114709324  [KO:K05050]
114709325  [KO:K04175]
114710233  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
114710332  Ccl24; LOW QUALITY PROTEIN: C-C motif chemokine 24 [KO:K21097]
114710385  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114710523  [KO:K04371] [EC:2.7.11.24]
114710615  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
114710658  Dock2; dedicator of cytokinesis protein 2 [KO:K12367]
114710969  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
119088838  [KO:K04438]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
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J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pleu04010  MAPK signaling pathway
pleu04060  Cytokine-cytokine receptor interaction
pleu04120  Ubiquitin mediated proteolysis
pleu04630  JAK-STAT signaling pathway
pleu04670  Leukocyte transendothelial migration
pleu04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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