KEGG   PATHWAY: pswi04530
Entry
pswi04530                   Pathway                                
Name
Tight junction - Pseudoliparis swirei (Mariana hadal snailfish)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pswi04530  Tight junction
pswi04530

Other DBs
GO: 0005923
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130188054  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X1 [KO:K05757]
130188091  dlg2; disks large homolog 2 isoform X1 [KO:K12075]
130188120  [KO:K10352]
130188133  llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
130188232  [KO:K13365]
130188305  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
130188307  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
130188485  micall2a; MICAL-like protein 2a [KO:K21068]
130188497  cldni; claudin i [KO:K06087]
130188701  nf2b; NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor b [KO:K16684]
130188706  [KO:K06087]
130188894  [KO:K10352]
130189140  [KO:K06087]
130189161  arhgap17b; rho GTPase-activating protein 17b isoform X1 [KO:K20638]
130189200  crb3a; protein crumbs homolog 3a [KO:K06090]
130189239  cldnk; claudin k [KO:K06087]
130189340  actb2; actin, cytoplasmic 2 [KO:K05692]
130189504  [KO:K10352]
130189518  [KO:K10352]
130189556  actr2a; actin-related protein 2-A [KO:K17260]
130189643  [KO:K10352]
130189977  si:dkey-92j12.5; multiple PDZ domain protein isoform X1 [KO:K06095]
130190042  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
130190218  [KO:K04345] [EC:2.7.11.11]
130190228  [KO:K06087]
130190328  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
130190431  [KO:K06087]
130190571  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
130190579  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
130190730  actb1; actin, cytoplasmic 1 isoform X1 [KO:K05692]
130190911  dlg1b; discs large homolog 1-like protein isoform X1 [KO:K12076]
130190940  cldn15la; claudin 15-like a [KO:K06087]
130191148  tjap1; LOW QUALITY PROTEIN: tight junction-associated protein 1 [KO:K06105]
130191558  msna; moesin a isoform X1 [KO:K05763]
130191597  pard6gb; par-6 family cell polarity regulator gamma b isoform X1 [KO:K06093]
130191663  [KO:K06087]
130191723  [KO:K05731]
130191762  [KO:K08020]
130191864  [KO:K06785]
130191881  [KO:K06087]
130191995  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
130192052  [KO:K06087]
130192053  [KO:K06087]
130192280  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
130192294  cldn35; claudin-4 [KO:K06087]
130192409  nedd4a; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
130192457  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
130192546  marveld3; LOW QUALITY PROTEIN: MARVEL domain-containing protein 3 [KO:K21099]
130192633  tjp1a; tight junction protein ZO-1 [KO:K05701]
130192696  [KO:K20479]
130192991  cgnb; cingulin isoform X1 [KO:K06102]
130193018  [KO:K06106]
130193419  patj; inaD-like protein isoform X1 [KO:K06092]
130193455  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
130193535  cldn34a; claudin-34 [KO:K06087]
130193537  si:ch73-61d6.3; occludin [KO:K06088]
130193617  dlg1a; disks large homolog 1 isoform X1 [KO:K12076]
130193635  si:ch211-191a24.4; MARVEL domain-containing protein 3 [KO:K21099]
130193702  [KO:K06087]
130193748  [KO:K07901]
130193752  [KO:K06087]
130193998  tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
130194025  [KO:K06087]
130194354  amotl2a; angiomotin-like 2a isoform X1 [KO:K06104]
130194409  [KO:K05754]
130194460  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
130194485  jun; transcription factor AP-1 [KO:K04448]
130194626  cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
130194721  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
130194907  [KO:K04503]
130194954  rab8b; ras-related protein Rab-8B [KO:K07902]
130195230  arhgef1a; rho guanine nucleotide exchange factor 1a isoform X1 [KO:K12791]
130195433  [KO:K21110]
130195686  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
130196123  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
130196338  [KO:K17291]
130196398  [KO:K04382] [EC:3.1.3.16]
130196443  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b isoform X1 [KO:K07199]
130196459  pcna; proliferating cell nuclear antigen [KO:K04802]
130196518  [KO:K06098]
130196543  cldn26; putative claudin-24 [KO:K06087]
130197007  cldn5a; claudin 5a [KO:K06087]
130197072  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
130197323  [KO:K05692]
130197517  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
130197583  arhgef18a; rho guanine nucleotide exchange factor 18a isoform X1 [KO:K21066]
130197818  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
130197906  prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
130197944  [KO:K04448]
130197969  [KO:K06104]
130198141  [KO:K07200]
130198146  cldn18; claudin-18 [KO:K06087]
130198180  prkacbb; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
130198373  [KO:K04237]
130198462  cldn1; claudin-1 [KO:K06087]
130198510  [KO:K07901]
130198641  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
130198886  pard6b; partitioning defective 6 homolog beta [KO:K06093]
130198983  [KO:K07374]
130199033  wasb; WASP actin nucleation promoting factor b [KO:K05747]
130199111  [KO:K07374]
130199137  [KO:K07374]
130199147  [KO:K04513]
130199269  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
130199341  [KO:K04393]
130199381  [KO:K04513]
130199386  [KO:K04513]
130199451  [KO:K04353]
130199545  [KO:K07374]
130199546  [KO:K07374]
130199547  [KO:K07374]
130199605  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
130199617  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
130199706  [KO:K07374]
130199707  [KO:K07374]
130199768  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
130199905  [KO:K05631]
130200092  [KO:K07374]
130200179  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
130200633  hcls1; src substrate protein p85-like isoform X1 [KO:K06106]
130200776  [KO:K07374]
130201220  ezra; ezrin a [KO:K08007]
130201226  pals1a; protein PALS1 [KO:K06091]
130201236  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
130201483  cldn11a; claudin-11a [KO:K06087]
130201489  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
130201520  [KO:K18584]
130201689  cldn23l; claudin-23 [KO:K06087]
130201869  [KO:K06087]
130201873  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
130202275  ezrb; ezrin b [KO:K08007]
130202379  [KO:K17388] [EC:2.7.11.39]
130202471  gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
130202743  pals1b; MAGUK p55 subfamily member 5b isoform X1 [KO:K06091]
130202911  afdna; afadin isoform X1 [KO:K05702]
130203090  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130203142  llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
130203303  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
130203325  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
130203361  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
130203503  arhgap17a; rho GTPase-activating protein 17a isoform X1 [KO:K20638]
130203598  [KO:K04392]
130203646  nherf1a; Na(+)/H(+) exchange regulatory cofactor NHE-RF1a [KO:K13365]
130203857  [KO:K06087]
130204229  [KO:K07374]
130204236  [KO:K08367]
130204261  mpp4b; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
130204356  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
130204359  [KO:K07374]
130204397  cldn10a; claudin-10a [KO:K06087]
130204398  [KO:K06087]
130204413  [KO:K06087]
130204421  [KO:K05762]
130204554  [KO:K18584]
130204612  [KO:K06087]
130204648  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
130204664  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
130204757  [KO:K07374]
130204760  [KO:K07374]
130204933  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
130205032  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
130205216  tjp2a; tight junction protein ZO-2a isoform X1 [KO:K06098]
130205298  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
130205358  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130205448  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
130205543  cldn5b; claudin-5b [KO:K06087]
130205547  jam2b; junctional adhesion molecule 2b isoform X1 [KO:K06735]
130205598  cldn23.1; claudin 23a [KO:K06087]
130205894  scrib; protein scribble homolog [KO:K16175]
130205917  pard3aa; partitioning defective 3 homolog [KO:K04237]
130205921  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
130205980  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
130206126  cldn11b; claudin-11b [KO:K06087]
130206209  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
130206778  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130206788  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
130206814  sympk; symplekin [KO:K06100]
130207122  [KO:K18050] [EC:2.7.11.13]
130207762  cldn19; claudin-19 isoform X1 [KO:K06087]
130207780  [KO:K04353]
130207902  rhoca; ras homolog family member Ca [KO:K04513]
130207937  [KO:K05631]
130207983  [KO:K07374]
130208099  [KO:K04393]
130208155  [KO:K04513]
130208214  [KO:K06087]
130208232  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
130208331  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
130208377  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
130208391  [KO:K05755]
130208515  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
130208564  [KO:K05704] [EC:2.7.10.2]
130208849  myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
130208869  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
130208968  [KO:K06087]
130209231  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
130209240  [KO:K21112]
130209409  hspa4b; heat shock 70 kDa protein 4b isoform X1 [KO:K09489]
130209426  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
130209824  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
130209842  [KO:K04354]
130209924  rap2c; ras-related protein Rap-2c [KO:K07839]
130209935  [KO:K04382] [EC:3.1.3.16]
130210170  [KO:K05763]
130210240  [KO:K04354]
130210317  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
130210358  tiam1b; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
130210488  jam3a; junctional adhesion molecule 3B [KO:K06785]
130210649  [KO:K06087]
130210650  [KO:K06087]
130210768  [KO:K06087]
130210777  [KO:K06087]
130210778  [KO:K06087]
130210791  amot; angiomotin isoform X1 [KO:K16819]
130210857  [KO:K06087]
130210872  [KO:K06087]
130210873  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
130210874  cldn8.1; claudin-8 [KO:K06087]
130210899  cldn8.2; claudin-8 [KO:K06087]
130210940  [KO:K06087]
130210945  [KO:K06087]
130210962  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
130211068  [KO:K06087]
130211128  cldne; claudin e [KO:K06087]
130211190  igsf5b; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
130211208  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
130211270  cldn2; claudin-2 [KO:K06087]
130211601  [KO:K06095]
130211686  zgc:101810; actin-related protein 2 [KO:K17260]
130211797  cldn15a; claudin-15a [KO:K06087]
130211871  hspa4a; heat shock 70 kDa protein 4a isoform X1 [KO:K09489]
130211921  cldn7a; claudin-7-A isoform X1 [KO:K06087]
130212059  igsf5a; immunoglobulin superfamily member 5 [KO:K06786]
130212284  [KO:K06087]
130212299  [KO:K06087]
130212627  cldn12; claudin-12 [KO:K06087]
130212975  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
130213146  [KO:K06102]
130213167  rab13; ras-related protein Rab-13 [KO:K06109]
130213348  epb41l4b; band 4.1-like protein 4B [KO:K21111]
130213488  cdc42l; cell division cycle 42, like [KO:K04393]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
pswi04520  Adherens junction
pswi04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

DBGET integrated database retrieval system