Entry Name T cell receptor signaling pathway - Pan troglodytes (chimpanzee)
Description Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ptr04660 T cell receptor signaling pathway
Ortholog table Other DBs Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 743326 BV7-2; LOW QUALITY PROTEIN: T cell receptor beta variable 7-2 [KO:K10785 ]
472543 BV6-3; T-cell receptor beta chain V region 86T1 [KO:K10785 ]
451584 CD3D; T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450 ]
742330 CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451 ]
451585 CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452 ]
748272 CD247; T-cell surface glycoprotein CD3 zeta chain isoform X7 [KO:K06453 ]
450124 CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454 ]
735755 CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458 ]
470426 CD8B; T-cell surface glycoprotein CD8 beta chain isoform X4 [KO:K06459 ]
471734 LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361 ]
743259 SPNS1; protein spinster homolog 1 isoform X6 [KO:K07362 ]
460720 NCK1; SH2/SH3 adapter protein NCK1 isoform X1 [KO:K07365 ]
459472 NCK2; cytoplasmic protein NCK2 isoform X1 [KO:K19862 ]
473114 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
457076 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
744653 GRAP2; GRB2-related adapter protein 2 isoform X3 [KO:K07366 ]
737245 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
461014 RHOA; transforming protein RhoA isoform X1 [KO:K04513 ]
456609 CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393 ]
458253 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116 ] [EC:3.1.4.11 ]
742406 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
450898 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
455485 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X6 [KO:K04446 ]
469972 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332 ]
454184 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X6 [KO:K17333 ]
459171 SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099 ]
452897 SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099 ]
453316 RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350 ]
460182 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366 ] [EC:2.7.11.1 ]
463235 CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
456984 BCL10; B-cell lymphoma/leukemia 10 isoform X2 [KO:K07368 ]
468549 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X3 [KO:K07369 ] [EC:3.4.22.-]
743199 MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431 ] [EC:2.7.12.2 ]
472749 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209 ] [EC:2.7.11.10 ]
461406 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580 ]
456014 NFKBIB; NF-kappa-B inhibitor beta isoform X5 [KO:K02581 ]
470617 CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470 ]
456565 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
461836 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
460858 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
457922 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
471079 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
748796 PDCD1; programmed cell death protein 1 isoform X4 [KO:K06744 ]
470619 CTLA4; cytotoxic T-lymphocyte protein 4 isoform X2 [KO:K06538 ]
748225 PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293 ] [EC:3.1.3.48 ]
464100 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
471633 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
100614247 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2 [KO:K04382 ] [EC:3.1.3.16 ]
468983 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
466778 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
464068 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
462170 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X10 [KO:K04354 ]
466265 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X7 [KO:K04354 ]
452859 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
460715 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2 [KO:K11583 ]
112207609 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3 [KO:K11583 ]
100609914 putative pyridoxal-dependent decarboxylase domain-containing protein 2 isoform X4 [KO:K11583 ]
453170 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584 ]
462705 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584 ]
457716 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
452962 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584 ]
451305 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
471627 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Chen L.
Title Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Journal Reference Authors Macian F.
Title NFAT proteins: key regulators of T-cell development and function.
Journal Reference Authors Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
Title Tec family kinases in T lymphocyte development and function.
Journal Reference Authors Huang Y, Wange RL.
Title T cell receptor signaling: beyond complex complexes.
Journal Reference Authors Schmitz ML, Bacher S, Dienz O.
Title NF-kappaB activation pathways induced by T cell costimulation.
Journal Reference Authors Alegre ML, Frauwirth KA, Thompson CB.
Title T-cell regulation by CD28 and CTLA-4.
Journal Reference Authors Horejsi V, Zhang W, Schraven B.
Title Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
Journal Reference Authors Baniyash M.
Title TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response.
Journal Reference Authors Sechi AS, Wehland J.
Title Interplay between TCR signalling and actin cytoskeleton dynamics.
Journal Reference Authors Okkenhaug K, Vanhaesebroeck B.
Title PI3K in lymphocyte development, differentiation and activation.
Journal Reference Authors Palacios EH, Weiss A.
Title Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Journal Reference Authors Kane LP, Lin J, Weiss A.
Title It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.
Journal Reference Authors Acuto O, Michel F.
Title CD28-mediated co-stimulation: a quantitative support for TCR signalling.
Journal Reference Authors Finkelstein LD, Schwartzberg PL.
Title Tec kinases: shaping T-cell activation through actin.
Journal Reference Authors Duan L, Reddi AL, Ghosh A, Dimri M, Band H.
Title The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.
Journal Reference Authors Schrum AG, Turka LA, Palmer E.
Title Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.
Journal Reference Authors Smith-Garvin JE, Koretzky GA, Jordan MS
Title T cell activation.
Journal Reference Authors Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
Title Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Journal Reference Authors Blonska M, Lin X
Title CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
Journal Reference Authors Rebeaud F, Hailfinger S, Thome M
Title Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
Journal Reference Authors Ashwell JD
Title The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Journal Reference Authors Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
Title Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Journal Related ptr04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
