KEGG   PATHWAY: tfn05010
Entry
tfn05010                    Pathway                                
Name
Alzheimer disease - Trachypithecus francoisi (Francois's langur)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
tfn05010  Alzheimer disease
tfn05010

Disease
H00056  Alzheimer disease
Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117062157  [KO:K02128]
117062173  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
117062187  IL1A; interleukin-1 alpha [KO:K04383]
117062188  IL1B; interleukin-1 beta [KO:K04519]
117062240  [KO:K10881]
117062271  [KO:K00134] [EC:1.2.1.12]
117062295  RTN4; reticulon-4 isoform X1 [KO:K20720]
117062348  CALM2; calmodulin-2 [KO:K02183]
117062413  [KO:K02270]
117062468  EIF2AK2; LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
117062750  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
117062944  [KO:K00235] [EC:1.3.5.1]
117063516  IRS2; insulin receptor substrate 2 [KO:K07187]
117063629  [KO:K03947]
117063944  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
117063948  [KO:K03957]
117063959  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117063974  SLC39A6; zinc transporter ZIP6 [KO:K14712]
117064038  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
117064141  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
117064172  TUBB6; tubulin beta-6 chain [KO:K07375]
117064180  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117064599  WNT8A; protein Wnt-8a [KO:K00714]
117064660  [KO:K00234] [EC:1.3.5.1]
117064675  SDHA; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
117064676  [KO:K00234] [EC:1.3.5.1]
117064716  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
117064808  [KO:K07375]
117064818  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
117064943  [KO:K02272]
117065109  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
117065132  [KO:K02272]
117065203  [KO:K03938]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117065216  [KO:K00134] [EC:1.2.1.12]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065587  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
117065757  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
117065867  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117065879  [KO:K00418]
117066612  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
117066643  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
117066659  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
117066706  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
117066878  FZD2; frizzled-2 [KO:K02235]
117066937  BECN1; beclin-1 isoform X1 [KO:K08334]
117067034  [KO:K00312]
117067078  PSMD3; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
117067104  [KO:K02272]
117067118  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
117067177  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
117067211  WNT9B; protein Wnt-9b [KO:K01064]
117067378  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
117067390  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
117067402  AXIN2; axin-2 isoform X1 [KO:K04385]
117067424  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117067435  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
117067470  WNT3; proto-oncogene Wnt-3 [KO:K00312]
117067542  CDK5R1; cyclin-dependent kinase 5 activator 1 isoform X1 [KO:K11716]
117067543  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
117067605  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
117067730  [KO:K02267]
117067800  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
117067872  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
117067902  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
117068009  [KO:K03960]
117068386  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
117068469  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117068471  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117068492  WNT8B; protein Wnt-8b [KO:K00714]
117068535  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117068593  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117068615  [KO:K02263]
117068693  [KO:K02272]
117069008  TUBB1; tubulin beta-1 chain [KO:K07375]
117069010  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
117069034  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
117069039  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
117069095  FRAT2; LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2 [KO:K03096]
117069266  [KO:K03069]
117069370  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
117069407  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
117069444  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117069576  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
117069604  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
117069640  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
117069703  [KO:K03963]
117069794  [KO:K03964]
117069813  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
117069878  [KO:K02183]
117069984  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
117070068  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
117070318  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
117070355  [KO:K02264]
117070385  [KO:K08960] [EC:2.7.11.1]
117070400  [KO:K02127]
117070455  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117070473  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117070501  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
117070543  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
117070589  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
117070827  [KO:K02183]
117070870  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117070905  [KO:K08957] [EC:2.7.11.1]
117070926  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
117070928  [KO:K02272]
117070941  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
117070977  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
117071124  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
117071177  [KO:K02136]
117071184  [KO:K03959]
117071286  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117071291  [KO:K03960]
117071314  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
117071444  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
117071500  [KO:K02273]
117071524  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117071553  CALM1; calmodulin-1 [KO:K02183]
117071556  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
117071608  [KO:K02272]
117072292  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
117072297  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117072298  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
117072332  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117072476  [KO:K02272]
117072525  [KO:K08738]
117072635  FZD1; frizzled-1 [KO:K02432]
117072719  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
117072720  [KO:K07374]
117072793  IL6; interleukin-6 isoform X1 [KO:K05405]
117072825  [KO:K08738]
117072838  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
117072941  WNT2; protein Wnt-2 [KO:K00182]
117073003  [KO:K02263]
117073094  FZD9; frizzled-9 [KO:K02842]
117073224  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
117073263  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
117073269  WNT16; protein Wnt-16 [KO:K01558]
117073294  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
117073751  [KO:K07374]
117074239  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117074284  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117074335  BECN2; beclin-2 [KO:K08334]
117074342  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
117074535  WNT3A; protein Wnt-3a [KO:K00312]
117074572  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
117074573  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
117074634  NRAS; GTPase NRas [KO:K07828]
117074640  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
117074655  TUBB4A; tubulin beta-4A chain [KO:K07375]
117074665  WNT9A; protein Wnt-9a [KO:K01064]
117074672  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
117074969  [KO:K00236]
117074996  [KO:K02127]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117075139  [KO:K02187] [EC:3.4.22.56]
117075199  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
117075209  [KO:K03938]
117075323  [KO:K00420]
117075478  [KO:K07375]
117075517  [KO:K03956]
117075518  [KO:K03956]
117075699  SLC39A3; zinc transporter ZIP3 [KO:K14709]
117075702  [KO:K02128]
117075723  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
117075732  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
117075785  NCSTN; nicastrin [KO:K06171]
117075856  [KO:K02126]
117075878  [KO:K02126]
117075932  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
117076037  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
117076186  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
117076189  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117076305  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
117076331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117076373  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
117076376  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
117076490  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117076502  WNT2B; protein Wnt-2b [KO:K00182]
117076644  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
117076657  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
117076663  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
117076717  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117076742  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
117076746  [KO:K02271]
117076767  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
117076828  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117076830  [KO:K03949]
117077276  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117077312  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117077366  [KO:K02272]
117077518  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
117077563  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
117077670  [KO:K03948]
117077892  [KO:K02272]
117077936  [KO:K05863]
117077947  [KO:K02272]
117078078  [KO:K02270]
117078288  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
117078298  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117078337  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
117078341  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
117078522  [KO:K02271]
117078537  [KO:K21421] [EC:1.-.-.-]
117078767  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
117078854  FZD6; frizzled-6 isoform X1 [KO:K02376]
117078869  [KO:K02268]
117078921  [KO:K08738]
117078953  [KO:K08738]
117079196  [KO:K03959]
117079278  [KO:K07375]
117079304  [KO:K00413]
117079397  [KO:K00417]
117079542  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
117079553  [KO:K02183]
117079579  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
117079600  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
117079812  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
117079868  [KO:K08738]
117079885  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
117079889  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
117079974  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
117079989  FADD; FAS-associated death domain protein [KO:K02373]
117080117  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
117080124  WNT11; protein Wnt-11 [KO:K01384]
117080171  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
117080186  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
117080413  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
117080414  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
117080458  [KO:K03061]
117080478  KLC2; kinesin light chain 2 [KO:K10407]
117080568  NOX4; LOW QUALITY PROTEIN: NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
117080608  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117080612  BAD; bcl2-associated agonist of cell death [KO:K02158]
117080679  [KO:K02272]
117080718  [KO:K08738]
117080779  [KO:K03062]
117080785  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
117080933  [KO:K00414]
117080942  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
117081005  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
117081060  [KO:K02273]
117081115  RTN3; reticulon-3 isoform X1 [KO:K20723]
117081143  INS; insulin [KO:K04526]
117081150  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
117081165  FZD4; frizzled-4 isoform X1 [KO:K02354]
117081344  [KO:K02266]
117081405  RELA; transcription factor p65 [KO:K04735]
117081497  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
117081555  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
117081557  [KO:K08738]
117081573  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
117081580  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
117081585  [KO:K02273]
117081688  HRAS; GTPase HRas isoform X1 [KO:K02833]
117082093  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
117082132  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
117082197  CALML3; calmodulin-like protein 3 [KO:K02183]
117082198  CALML5; calmodulin-like protein 5 [KO:K02183]
117082220  [KO:K02738] [EC:3.4.25.1]
117082240  [KO:K02128]
117082326  [KO:K03948]
117082413  [KO:K02090] [EC:2.7.11.22]
117082443  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
117082460  SLC39A12; zinc transporter ZIP12 [KO:K14718]
117082510  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
117082599  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117082738  KIF5B; kinesin-1 heavy chain [KO:K10396]
117082746  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
117082784  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117083004  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117083018  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
117083033  [KO:K08738]
117083084  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
117083173  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117083269  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117083292  WNT7A; protein Wnt-7a [KO:K00572]
117083313  [KO:K02187] [EC:3.4.22.56]
117083450  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
117083458  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117083769  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
117083812  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
117083822  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
117083938  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117084196  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
117084391  [KO:K03949]
117084440  [KO:K03960]
117084476  [KO:K02726] [EC:3.4.25.1]
117084479  [KO:K04366] [EC:2.7.11.1]
117084498  [KO:K07375]
117084830  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
117084835  [KO:K07374]
117084864  [KO:K02272]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085388  [KO:K02138]
117085400  [KO:K02265]
117085655  [KO:K02271]
117085676  SNCA; alpha-synuclein isoform X1 [KO:K04528]
117085709  SLC39A8; zinc transporter ZIP8 [KO:K14714]
117085710  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117085753  DKK2; dickkopf-related protein 2 [KO:K02165]
117085890  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
117085908  DKK1; dickkopf-related protein 1 [KO:K02165]
117085925  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
117086072  [KO:K11351]
117086196  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117086204  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
117086221  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117086238  [KO:K07375]
117086624  TUBB2A; tubulin beta-2A chain [KO:K07375]
117086926  TNF; tumor necrosis factor isoform X1 [KO:K03156]
117086944  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
117086989  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
117087031  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
117087057  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117087240  KLC4; kinesin light chain 4 [KO:K10407]
117087463  [KO:K02270]
117087492  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
117087515  [KO:K00415]
117087546  [KO:K07374]
117087574  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117087581  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117087695  [KO:K03947]
117087707  [KO:K02266]
117087739  [KO:K02728] [EC:3.4.25.1]
117087870  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
117087884  [KO:K02137]
117087914  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
117087981  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
117088155  [KO:K02263]
117088198  [KO:K02090] [EC:2.7.11.22]
117088210  FZD8; frizzled-8 [KO:K02375]
117088263  [KO:K07375]
117088384  TUBB; tubulin beta chain [KO:K07375]
117088583  [KO:K10407]
117088659  [KO:K02272]
117089166  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
117089178  FZD10; frizzled-10 [KO:K02842]
117089263  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
117089300  [KO:K02266]
117089332  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
117089420  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
117089559  [KO:K02734] [EC:3.4.25.1]
117089565  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
117089604  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
117089611  [KO:K03945]
117089867  KIF5A; kinesin heavy chain [KO:K10396]
117089884  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117089896  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
117089900  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
117089918  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
117089940  SLC39A5; zinc transporter ZIP5 [KO:K14711]
117090028  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
117090099  ATG101; autophagy-related protein 101 [KO:K19730]
117090124  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
117090172  [KO:K07374]
117090173  TUBA1C; tubulin alpha-1C chain [KO:K07374]
117090175  [KO:K07374]
117090185  WNT1; proto-oncogene Wnt-1 [KO:K03209]
117090187  WNT10B; protein Wnt-10b [KO:K01357]
117090367  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117090480  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117090502  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
117090640  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
117090649  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117090671  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
117090701  [KO:K04850]
117090718  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
117091372  APOE; LOW QUALITY PROTEIN: apolipoprotein E [KO:K04524]
117091396  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
117091446  CALM3; calmodulin-3 [KO:K02183]
117091505  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117091736  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
117091738  [KO:K02267]
117091873  [KO:K08683] [EC:1.1.1.35 1.1.1.178]
117091956  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117092025  [KO:K00411] [EC:7.1.1.8]
117092233  [KO:K03948]
117092255  [KO:K00411] [EC:7.1.1.8]
117092366  [KO:K02267]
117092377  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
117092474  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
117092536  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
117092657  [KO:K00416]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117092766  [KO:K00236]
117092829  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
117092871  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
117092898  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
117093159  WNT4; protein Wnt-4 [KO:K00408]
117093177  SLC39A14; zinc transporter ZIP14 isoform X1 [KO:K14720]
117093179  [KO:K02272]
117093193  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117093237  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
117093253  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
117093322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117093380  [KO:K08738]
117093472  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
117093644  [KO:K03955]
117093658  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
117093839  [KO:K02272]
117093967  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
117094272  FZD3; frizzled-3 isoform X1 [KO:K02329]
117094305  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
117094392  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
117094439  IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172]
117094495  [KO:K07374]
117094507  WNT10A; protein Wnt-10a [KO:K01357]
117094509  WNT6; protein Wnt-6 [KO:K00445]
117094596  FZD5; frizzled-5 [KO:K02375]
117094614  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
117094645  FZD7; frizzled-7 [KO:K02432]
117094661  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117094699  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
117094831  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
117094935  [KO:K00134] [EC:1.2.1.12]
117094952  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
117095022  KIF5C; kinesin heavy chain [KO:K10396]
117095055  [KO:K02137]
117095064  [KO:K02183]
117095227  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117095317  [KO:K02735] [EC:3.4.25.1]
117095320  [KO:K03948]
117095431  [KO:K02272]
117095627  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
117095628  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
117095630  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117095682  [KO:K03062]
117095688  [KO:K00417]
117095696  DKK4; dickkopf-related protein 4 [KO:K02165]
117095701  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117095725  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
117095749  [KO:K02270]
117095807  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
117095835  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
117096062  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
117096070  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
117096137  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
117096163  [KO:K00419]
117096327  WNT7B; protein Wnt-7b [KO:K00572]
117096387  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
117096463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117096477  [KO:K02265]
117096542  SLC39A1; zinc transporter ZIP1 [KO:K14709]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117096655  [KO:K03946]
117096842  [KO:K08738]
117096846  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
117097168  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
117097361  [KO:K03949]
117097478  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117097668  [KO:K05209]
117097828  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
117097916  AXIN1; axin-1 isoform X1 [KO:K02157]
117097957  [KO:K08738]
117098307  [KO:K05862]
117098435  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
117098492  [KO:K08738]
117098684  [KO:K03037]
117098709  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
117098726  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
117098896  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117099095  TUBB4B; tubulin beta-4B chain [KO:K07375]
117099100  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117099135  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117099374  [KO:K07375]
117099608  [KO:K00134] [EC:1.2.1.12]
117099609  [KO:K02265]
117099768  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
117099787  [KO:K02128]
18985073  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
18985074  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
18985075  COX2; cytochrome c oxidase subunit II [KO:K02261]
18985076  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
18985077  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
18985078  COX3; cytochrome c oxidase subunit III [KO:K02262]
18985079  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
18985080  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
18985081  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
18985082  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
18985083  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
18985084  CYTB; cytochrome b [KO:K00412]
18985085  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
tfn00190  Oxidative phosphorylation
tfn03050  Proteasome
tfn04020  Calcium signaling pathway
tfn04140  Autophagy - animal
tfn04141  Protein processing in endoplasmic reticulum
tfn04210  Apoptosis
tfn04310  Wnt signaling pathway
tfn04910  Insulin signaling pathway
tfn04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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