KEGG   PATHWAY: xla04621
Entry
xla04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Xenopus laevis (African clawed frog)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
xla04621  NOD-like receptor signaling pathway
xla04621

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036815  cxcl8.L; uncharacterized protein LOC100036815 precursor [KO:K10030]
100036859  birc2.S; uncharacterized protein LOC100036859 [KO:K16060]
100037000  XB5945946.L; uncharacterized protein LOC100037000 precursor [KO:K10030]
100037005  mcu.L; calcium uniporter protein, mitochondrial [KO:K20858]
100037235  [KO:K03671]
100049143  atg16l1.S; autophagy related 16 like 1 S homeolog [KO:K17890]
100126654  atg12.S; autophagy related 12 S homeolog [KO:K08336]
100137625  tnf.L; tumor necrosis factor L homeolog [KO:K03156]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
100381036  gbp6.L; guanylate binding protein family member 6 L homeolog [KO:K20899]
100381060  ccl5.L; C-C motif chemokine 5 [KO:K12499]
108695339  [KO:K03671]
108695377  ripk2.S; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
108695474  [KO:K10630] [EC:2.3.2.31]
108695682  naip.L; baculoviral IAP repeat-containing protein 1 [KO:K12807]
108695762  [KO:K06068] [EC:2.7.11.13]
108695903  [KO:K05411]
108695918  [KO:K20899]
108695919  [KO:K20899]
108695921  [KO:K20899]
108695923  [KO:K20899]
108696435  nlrx1.L; NLR family member X1 isoform X1 [KO:K12653]
108696842  [KO:K03671]
108697133  [KO:K12648]
108697189  [KO:K06068] [EC:2.7.11.13]
108697191  [KO:K06068] [EC:2.7.11.13]
108697483  mcu.S; calcium uniporter protein, mitochondrial [KO:K20858]
108697551  mfn2.S; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
108697611  [KO:K05482]
108697612  [KO:K05482]
108697781  irf3.S; interferon regulatory factor 3 [KO:K05411]
108698135  traf2.L; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108698185  card9.L; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
108698322  [KO:K06068] [EC:2.7.11.13]
108698335  [KO:K06068] [EC:2.7.11.13]
108698359  [KO:K06068] [EC:2.7.11.13]
108698553  [KO:K15838]
108698781  [KO:K04079]
108698786  traf3.L; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108699254  plcb2.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
108699327  ripk3l.1.L; receptor-interacting serine/threonine-protein kinase 4 isoform X1 [KO:K08847] [EC:2.7.11.1]
108699460  [KO:K23691]
108699773  traf3.S; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108699906  card9.S; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
108700046  [KO:K10160]
108700223  [KO:K15838]
108700235  tnf.S; tumor necrosis factor [KO:K03156]
108700347  txnip.S; thioredoxin-interacting protein [KO:K20910]
108700666  [KO:K04448]
108700971  [KO:K04570]
108701403  [KO:K06068] [EC:2.7.11.13]
108701480  trpm2.L; transient receptor potential cation channel subfamily M member 2 isoform X4 [KO:K04977] [EC:3.6.1.13]
108702184  [KO:K05414]
108702185  [KO:K05414]
108702186  [KO:K05414]
108702193  [KO:K06068] [EC:2.7.11.13]
108702302  [KO:K06068] [EC:2.7.11.13]
108702967  tank.S; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
108703082  stat1.S; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
108703754  [KO:K12798]
108703939  [KO:K12798]
108704084  cyba.S; cytochrome b-245 light chain [KO:K08009]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108704277  [KO:K06068] [EC:2.7.11.13]
108705403  [KO:K20909]
108705586  [KO:K06068] [EC:2.7.11.13]
108705600  [KO:K06068] [EC:2.7.11.13]
108706143  [KO:K10030]
108706149  [KO:K10030]
108706331  [KO:K03671]
108706736  nfkb1.S; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108706768  cxcl2.S; growth-regulated alpha protein [KO:K10030]
108706769  cxcl8.S; interleukin-8 [KO:K10030]
108706818  antxr2.S; anthrax toxin receptor 2 [KO:K20909]
108707009  irf9.S; interferon regulatory factor 4 isoform X1 [KO:K04693]
108707283  [KO:K12796]
108707419  [KO:K05131]
108707608  trim26.L; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
108707873  [KO:K05130]
108707932  trpv2.L; transient receptor potential cation channel subfamily V member 1 [KO:K04971]
108708023  [KO:K06068] [EC:2.7.11.13]
108708028  ywhae.L; 14-3-3 protein epsilon isoform X1 [KO:K06630]
108708144  [KO:K04441] [EC:2.7.11.24]
108708573  stat2.L; signal transducer and activator of transcription 2 [KO:K11221]
108708749  panx1.L; pannexin-1 [KO:K03443]
108708983  sugt1.S; protein SGT1 homolog [KO:K12795]
108709094  ccl5.S; eotaxin isoform X1 [KO:K12499]
108709188  trpv2.S; transient receptor potential cation channel subfamily V member 1 [KO:K04971]
108709230  [KO:K05130]
108709291  casr.S; extracellular calcium-sensing receptor [KO:K04612]
108709364  [KO:K06068] [EC:2.7.11.13]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
108709441  [KO:K04960]
108709484  ikbke.S; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
108709686  [KO:K12793]
108709841  stat2.S; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
108710098  [KO:K04977] [EC:3.6.1.13]
108710178  [KO:K04959]
108710550  [KO:K06071] [EC:2.7.11.13]
108710805  vdac1.L; voltage-dependent anion-selective channel protein 1 [KO:K05862]
108711085  cxcl2.L; interleukin-8 isoform X1 [KO:K10030]
108711090  [KO:K10030]
108711093  [KO:K10030]
108711122  irak4.L; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108711159  [KO:K04441] [EC:2.7.11.24]
108711276  pstpip1.L; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
108711406  trpm7.L; transient receptor potential cation channel subfamily M member 7 L homeolog [KO:K04982] [EC:2.7.11.1]
108711407  [KO:K04982] [EC:2.7.11.1]
108711429  tp53bp1.L; TP53-binding protein 1 isoform X1 [KO:K20915]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
108711547  antxr1.L; anthrax toxin receptor 1 [KO:K20909]
108711577  il1b.L; interleukin-1 beta [KO:K04519]
108711679  pkn1.L; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
108712214  [KO:K05842]
108712223  antxr2.L; anthrax toxin receptor 2 [KO:K20909]
108712371  tbk1.S; serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
108712451  [KO:K06068] [EC:2.7.11.13]
108712650  sting1.S; stimulator of interferon genes protein [KO:K12654]
108712739  [KO:K04519]
108712766  antxr1.S; anthrax toxin receptor 1 [KO:K20909]
108712895  trpm7.S; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
108713564  [KO:K06071] [EC:2.7.11.13]
108713779  fadd.L; FAS-associated death domain protein [KO:K02373]
108713897  irf7.L; interferon regulatory factor 3 [KO:K09447]
108713898  [KO:K10435]
108713994  nod2l.L; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
108714222  jak1.L; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108714625  [KO:K04958]
108715017  ripk3.L; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
108715128  rela.S; putative transcription factor p65 homolog [KO:K04735]
108715162  [KO:K10435]
108715263  [KO:K06068] [EC:2.7.11.13]
108715442  gabarapl2.S; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108715668  pkn2.S; serine/threonine-protein kinase N2 isoform X2 [KO:K23691]
108715722  txn2.S; thioredoxin, mitochondrial [KO:K03671]
108715765  tab1.S; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108715909  [KO:K04441] [EC:2.7.11.24]
108716102  [KO:K04079]
108716157  [KO:K04622]
108716158  [KO:K04622]
108716159  [KO:K04622]
108716160  [KO:K04622]
108716168  [KO:K06068] [EC:2.7.11.13]
108716346  [KO:K06068] [EC:2.7.11.13]
108716399  plcb4.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
108716400  [KO:K05858] [EC:3.1.4.11]
108716445  traf5.L; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
108716606  [KO:K06068] [EC:2.7.11.13]
108716654  nlrc4.L; NLR family CARD domain-containing protein 4 [KO:K12805]
108716751  tab2.L; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
108716806  [KO:K04622]
108716808  gprc6a.L; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
108717696  [KO:K12807]
108717703  [KO:K12807]
108717779  [KO:K06068] [EC:2.7.11.13]
108717862  [KO:K06068] [EC:2.7.11.13]
108717890  tab2.S; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108718060  [KO:K06068] [EC:2.7.11.13]
108718091  [KO:K12796]
108718487  il6.L; interleukin-6 [KO:K05405]
108718586  [KO:K06068] [EC:2.7.11.13]
108718629  camp1.L; cathelicidin-related peptide Pt_CRAMP2 [KO:K13916]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
108719184  [KO:K06068] [EC:2.7.11.13]
108719312  [KO:K11974] [EC:2.3.2.31]
108719325  ripk2.L; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
108719472  [KO:K10630] [EC:2.3.2.31]
108719598  [KO:K06068] [EC:2.7.11.13]
108719978  nod1.S; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
108720077  ripk1.S; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
121402296  [KO:K08341]
373559  casp8.L; caspase 8 L homeolog [KO:K04398] [EC:3.4.22.61]
373606  il1b.S; interleukin 1 beta S homeolog [KO:K04519]
378669  casp1.S; caspase-1-B [KO:K01370] [EC:3.4.22.36]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
379244  MGC53884; Dynamin-1-like protein-like [KO:K17065] [EC:3.6.5.5]
379257  ctsb.S; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
379270  tab3.L; mitogen-activated protein kinase kinase kinase 7-interacting protein 3 homolog [KO:K12793]
379275  irf3.L; interferon regulatory factor 3 [KO:K05411]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379399  map3k7.S; mitogen-activated protein kinase kinase kinase 7 S homeolog [KO:K04427] [EC:2.7.11.25]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
379556  map1lc3a.S; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
379704  gbp4.S; guanylate binding protein 4 S homeolog [KO:K20899]
379758  txn2.L; thioredoxin 2 L homeolog [KO:K03671]
379875  dnm1l.L; dynamin 1-like L homeolog [KO:K17065] [EC:3.6.5.5]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
380102  ctsb.L; uncharacterized protein LOC380102 precursor [KO:K01363] [EC:3.4.22.1]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
380234  map1lc3a.L; microtubule associated protein 1 light chain 3 alpha L homeolog [KO:K10435]
380376  vdac1.S; voltage-dependent anion channel 1 S homeolog [KO:K05862]
380397  ywhae.S; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon S homeolog [KO:K06630]
394321  myd88.L; myeloid differentiation primary response protein MyD88-A [KO:K04729]
394353  rela.L; putative transcription factor p65 homolog [KO:K04735]
397692  plcb3.L; phospholipase C beta 3 L homeolog [KO:K05858] [EC:3.1.4.11]
397719  casp1.L; caspase-1-A [KO:K01370] [EC:3.4.22.36]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
398025  tab1.L; TGF-beta activated kinase 1/MAP3K7 binding protein 1 L homeolog [KO:K04403]
398208  tp53bp1.S; tumor protein p53 binding protein 1 S homeolog [KO:K20915]
398251  bcl2l1.S; apoptosis regulator R11 [KO:K04570]
398286  p2rx7.L; purinergic receptor P2X, ligand gated ion channel, 7 L homeolog [KO:K05220]
398324  stat1.L; signal transducer and activator of transcription 1 L homeolog [KO:K11220]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
398502  nampt.S; nicotinamide phosphoribosyltransferase S homeolog [KO:K03462] [EC:2.4.2.12]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
398692  [KO:K20899]
398857  map1lc3b.S; uncharacterized protein LOC398857 [KO:K10435]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399254  itpr1.S; inositol 1,4,5-trisphosphate receptor type 1 S homeolog [KO:K04958]
399366  pkn2.L; serine/threonine-protein kinase N2 [KO:K23691]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
399459  map3k7.L; mitogen-activated protein kinase kinase kinase 7 L homeolog [KO:K04427] [EC:2.7.11.25]
404226  prkcd.S; protein kinase C delta S homeolog [KO:K06068] [EC:2.7.11.13]
404227  prkcd.L; protein kinase C delta L homeolog [KO:K06068] [EC:2.7.11.13]
414477  gabarap.L; uncharacterized protein LOC414477 [KO:K08341]
414882  nek7.S; NIMA-related kinase 7 S homeolog [KO:K20876] [EC:2.7.11.34]
431892  irf9.L; interferon regulatory factor 9 L homeolog [KO:K04693]
431918  mfn2.L; mitofusin 2 L homeolog [KO:K06030] [EC:3.6.5.-]
431974  traf2.S; TNF receptor associated factor 2 S homeolog [KO:K03173] [EC:2.3.2.27]
432200  ikbkb.L; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog [KO:K07209] [EC:2.7.11.10]
432309  sugt1.L; SGT1 homolog, MIS12 kinetochore complex assembly cochaperone L homeolog [KO:K12795]
443756  atg5.L; autophagy related 5 L homeolog [KO:K08339]
443782  vdac3.L; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
443948  XB5909790.S; MGC80314 protein S homeolog [KO:K03671]
443958  mfn1.L; mitofusin 1 L homeolog [KO:K21356] [EC:3.6.5.-]
443979  gabarapl1.S; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
444089  tyk2.L; tyrosine kinase 2 L homeolog [KO:K11219] [EC:2.7.10.2]
444353  cybb.L; cytochrome b-245, beta polypeptide L homeolog [KO:K21421] [EC:1.-.-.-]
444556  chuk.S; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
444777  traf6.L; TNF receptor-associated factor 6-B [KO:K03175] [EC:2.3.2.27]
444817  pycard.L; PYD and CARD domain containing L homeolog [KO:K12799]
445848  plcb4.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
446351  tbk1.L; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
446457  txnip.L; thioredoxin interacting protein L homeolog [KO:K20910]
446459  hsp90ab1.S; heat shock protein 90kDa alpha family class B member 1 S homeolog [KO:K04079]
446568  birc2.L; baculoviral IAP repeat containing 2 L homeolog [KO:K16060]
446697  jak1.S; Janus kinase 1 (a protein tyrosine kinase) S homeolog [KO:K11217] [EC:2.7.10.2]
446833  nfkbia.L; NFKB inhibitor alpha L homeolog [KO:K04734]
446853  cyba.L; cytochrome b-245 alpha polypeptide L homeolog [KO:K08009]
446998  tnfaip3.S; TNF alpha induced protein 3 S homeolog [KO:K11859] [EC:3.4.19.12]
447517  gbp7.S; guanylate binding protein 7 S homeolog [KO:K20899]
447609  pstpip1.S; proline-serine-threonine phosphatase interacting protein 1 S homeolog [KO:K12804]
447632  nfkb1.L; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog [KO:K02580]
447688  brcc3.L; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
494762  gabarapl1.L; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
495314  mfn1.S; mitofusin 1 S homeolog [KO:K21356] [EC:3.6.5.-]
495354  txn.L; thioredoxin L homeolog [KO:K03671]
495517  [KO:K05131]
495838  atg16l1.L; autophagy-related protein 16 isoform X1 [KO:K17890]
496105  [KO:K05131]
496403  fadd.S; Fas associated via death domain S homeolog [KO:K02373]
733220  map1lc3b.L; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
733235  xiap.L; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
733239  ripk3L.2.L; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
733258  plcb1.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
733315  tank.L; TRAF interacting protein TANK [KO:K12650]
734234  ripk1.L; receptor interacting serine/threonine kinase 1 L homeolog [KO:K02861] [EC:2.7.11.1]
734297  nfkbia.S; uncharacterized protein LOC734297 [KO:K04734]
734302  myd88.S; myeloid differentiation primary response protein MyD88-B [KO:K04729]
734449  vdac2.S; voltage-dependent anion-selective channel protein 2 [KO:K15040]
734814  gabarapl2.L; GABA(A) receptor-associated protein like 2 L homeolog [KO:K08341]
734896  ikbke.L; inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog [KO:K07211] [EC:2.7.11.10]
734929  traf6.S; TNF receptor-associated factor 6-A [KO:K03175] [EC:2.3.2.27]
735059  nampt.L; uncharacterized protein LOC735059 [KO:K03462] [EC:2.4.2.12]
735069  ikbkg.L; inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog [KO:K07210]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
779323  map1lc3c.L; microtubule associated protein 1 light chain 3 gamma L homeolog [KO:K10435]
779341  rnf31.S; ring finger protein 31 S homeolog [KO:K11974] [EC:2.3.2.31]
779422  gbp1.L; guanylate binding protein 1, interferon-inducible L homeolog [KO:K20899]
779441  dhx33.L; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
xla04010  MAPK signaling pathway
xla04140  Autophagy - animal
xla04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

KEGG   PATHWAY: xla04621
Entry
xla04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Xenopus laevis (African clawed frog)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
xla04621  NOD-like receptor signaling pathway
xla04621

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036815  cxcl8.L; uncharacterized protein LOC100036815 precursor [KO:K10030]
100036859  birc2.S; uncharacterized protein LOC100036859 [KO:K16060]
100037000  XB5945946.L; uncharacterized protein LOC100037000 precursor [KO:K10030]
100037005  mcu.L; calcium uniporter protein, mitochondrial [KO:K20858]
100037235  [KO:K03671]
100049143  atg16l1.S; autophagy related 16 like 1 S homeolog [KO:K17890]
100126654  atg12.S; autophagy related 12 S homeolog [KO:K08336]
100137625  tnf.L; tumor necrosis factor L homeolog [KO:K03156]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
100381036  gbp6.L; guanylate binding protein family member 6 L homeolog [KO:K20899]
100381060  ccl5.L; C-C motif chemokine 5 [KO:K12499]
108695339  [KO:K03671]
108695377  ripk2.S; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
108695474  [KO:K10630] [EC:2.3.2.31]
108695682  naip.L; baculoviral IAP repeat-containing protein 1 [KO:K12807]
108695762  [KO:K06068] [EC:2.7.11.13]
108695903  [KO:K05411]
108695918  [KO:K20899]
108695919  [KO:K20899]
108695921  [KO:K20899]
108695923  [KO:K20899]
108696435  nlrx1.L; NLR family member X1 isoform X1 [KO:K12653]
108696842  [KO:K03671]
108697133  [KO:K12648]
108697189  [KO:K06068] [EC:2.7.11.13]
108697191  [KO:K06068] [EC:2.7.11.13]
108697483  mcu.S; calcium uniporter protein, mitochondrial [KO:K20858]
108697551  mfn2.S; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
108697611  [KO:K05482]
108697612  [KO:K05482]
108697781  irf3.S; interferon regulatory factor 3 [KO:K05411]
108698135  traf2.L; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108698185  card9.L; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
108698322  [KO:K06068] [EC:2.7.11.13]
108698335  [KO:K06068] [EC:2.7.11.13]
108698359  [KO:K06068] [EC:2.7.11.13]
108698553  [KO:K15838]
108698781  [KO:K04079]
108698786  traf3.L; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108699254  plcb2.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
108699327  ripk3l.1.L; receptor-interacting serine/threonine-protein kinase 4 isoform X1 [KO:K08847] [EC:2.7.11.1]
108699460  [KO:K23691]
108699773  traf3.S; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108699906  card9.S; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
108700046  [KO:K10160]
108700223  [KO:K15838]
108700235  tnf.S; tumor necrosis factor [KO:K03156]
108700347  txnip.S; thioredoxin-interacting protein [KO:K20910]
108700666  [KO:K04448]
108700971  [KO:K04570]
108701403  [KO:K06068] [EC:2.7.11.13]
108701480  trpm2.L; transient receptor potential cation channel subfamily M member 2 isoform X4 [KO:K04977] [EC:3.6.1.13]
108702184  [KO:K05414]
108702185  [KO:K05414]
108702186  [KO:K05414]
108702193  [KO:K06068] [EC:2.7.11.13]
108702302  [KO:K06068] [EC:2.7.11.13]
108702967  tank.S; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
108703082  stat1.S; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
108703754  [KO:K12798]
108703939  [KO:K12798]
108704084  cyba.S; cytochrome b-245 light chain [KO:K08009]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108704277  [KO:K06068] [EC:2.7.11.13]
108705403  [KO:K20909]
108705586  [KO:K06068] [EC:2.7.11.13]
108705600  [KO:K06068] [EC:2.7.11.13]
108706143  [KO:K10030]
108706149  [KO:K10030]
108706331  [KO:K03671]
108706736  nfkb1.S; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108706768  cxcl2.S; growth-regulated alpha protein [KO:K10030]
108706769  cxcl8.S; interleukin-8 [KO:K10030]
108706818  antxr2.S; anthrax toxin receptor 2 [KO:K20909]
108707009  irf9.S; interferon regulatory factor 4 isoform X1 [KO:K04693]
108707283  [KO:K12796]
108707419  [KO:K05131]
108707608  trim26.L; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
108707873  [KO:K05130]
108707932  trpv2.L; transient receptor potential cation channel subfamily V member 1 [KO:K04971]
108708023  [KO:K06068] [EC:2.7.11.13]
108708028  ywhae.L; 14-3-3 protein epsilon isoform X1 [KO:K06630]
108708144  [KO:K04441] [EC:2.7.11.24]
108708573  stat2.L; signal transducer and activator of transcription 2 [KO:K11221]
108708749  panx1.L; pannexin-1 [KO:K03443]
108708983  sugt1.S; protein SGT1 homolog [KO:K12795]
108709094  ccl5.S; eotaxin isoform X1 [KO:K12499]
108709188  trpv2.S; transient receptor potential cation channel subfamily V member 1 [KO:K04971]
108709230  [KO:K05130]
108709291  casr.S; extracellular calcium-sensing receptor [KO:K04612]
108709364  [KO:K06068] [EC:2.7.11.13]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
108709441  [KO:K04960]
108709484  ikbke.S; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
108709686  [KO:K12793]
108709841  stat2.S; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
108710098  [KO:K04977] [EC:3.6.1.13]
108710178  [KO:K04959]
108710550  [KO:K06071] [EC:2.7.11.13]
108710805  vdac1.L; voltage-dependent anion-selective channel protein 1 [KO:K05862]
108711085  cxcl2.L; interleukin-8 isoform X1 [KO:K10030]
108711090  [KO:K10030]
108711093  [KO:K10030]
108711122  irak4.L; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108711159  [KO:K04441] [EC:2.7.11.24]
108711276  pstpip1.L; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
108711406  trpm7.L; transient receptor potential cation channel subfamily M member 7 L homeolog [KO:K04982] [EC:2.7.11.1]
108711407  [KO:K04982] [EC:2.7.11.1]
108711429  tp53bp1.L; TP53-binding protein 1 isoform X1 [KO:K20915]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
108711547  antxr1.L; anthrax toxin receptor 1 [KO:K20909]
108711577  il1b.L; interleukin-1 beta [KO:K04519]
108711679  pkn1.L; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
108712214  [KO:K05842]
108712223  antxr2.L; anthrax toxin receptor 2 [KO:K20909]
108712371  tbk1.S; serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
108712451  [KO:K06068] [EC:2.7.11.13]
108712650  sting1.S; stimulator of interferon genes protein [KO:K12654]
108712739  [KO:K04519]
108712766  antxr1.S; anthrax toxin receptor 1 [KO:K20909]
108712895  trpm7.S; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
108713564  [KO:K06071] [EC:2.7.11.13]
108713779  fadd.L; FAS-associated death domain protein [KO:K02373]
108713897  irf7.L; interferon regulatory factor 3 [KO:K09447]
108713898  [KO:K10435]
108713994  nod2l.L; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
108714222  jak1.L; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108714625  [KO:K04958]
108715017  ripk3.L; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
108715128  rela.S; putative transcription factor p65 homolog [KO:K04735]
108715162  [KO:K10435]
108715263  [KO:K06068] [EC:2.7.11.13]
108715442  gabarapl2.S; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108715668  pkn2.S; serine/threonine-protein kinase N2 isoform X2 [KO:K23691]
108715722  txn2.S; thioredoxin, mitochondrial [KO:K03671]
108715765  tab1.S; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108715909  [KO:K04441] [EC:2.7.11.24]
108716102  [KO:K04079]
108716157  [KO:K04622]
108716158  [KO:K04622]
108716159  [KO:K04622]
108716160  [KO:K04622]
108716168  [KO:K06068] [EC:2.7.11.13]
108716346  [KO:K06068] [EC:2.7.11.13]
108716399  plcb4.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
108716400  [KO:K05858] [EC:3.1.4.11]
108716445  traf5.L; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
108716606  [KO:K06068] [EC:2.7.11.13]
108716654  nlrc4.L; NLR family CARD domain-containing protein 4 [KO:K12805]
108716751  tab2.L; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
108716806  [KO:K04622]
108716808  gprc6a.L; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
108717696  [KO:K12807]
108717703  [KO:K12807]
108717779  [KO:K06068] [EC:2.7.11.13]
108717862  [KO:K06068] [EC:2.7.11.13]
108717890  tab2.S; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108718060  [KO:K06068] [EC:2.7.11.13]
108718091  [KO:K12796]
108718487  il6.L; interleukin-6 [KO:K05405]
108718586  [KO:K06068] [EC:2.7.11.13]
108718629  camp1.L; cathelicidin-related peptide Pt_CRAMP2 [KO:K13916]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
108719184  [KO:K06068] [EC:2.7.11.13]
108719312  [KO:K11974] [EC:2.3.2.31]
108719325  ripk2.L; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
108719472  [KO:K10630] [EC:2.3.2.31]
108719598  [KO:K06068] [EC:2.7.11.13]
108719978  nod1.S; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
108720077  ripk1.S; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
121402296  [KO:K08341]
373559  casp8.L; caspase 8 L homeolog [KO:K04398] [EC:3.4.22.61]
373606  il1b.S; interleukin 1 beta S homeolog [KO:K04519]
378669  casp1.S; caspase-1-B [KO:K01370] [EC:3.4.22.36]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
379244  MGC53884; Dynamin-1-like protein-like [KO:K17065] [EC:3.6.5.5]
379257  ctsb.S; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
379270  tab3.L; mitogen-activated protein kinase kinase kinase 7-interacting protein 3 homolog [KO:K12793]
379275  irf3.L; interferon regulatory factor 3 [KO:K05411]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379399  map3k7.S; mitogen-activated protein kinase kinase kinase 7 S homeolog [KO:K04427] [EC:2.7.11.25]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
379556  map1lc3a.S; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
379704  gbp4.S; guanylate binding protein 4 S homeolog [KO:K20899]
379758  txn2.L; thioredoxin 2 L homeolog [KO:K03671]
379875  dnm1l.L; dynamin 1-like L homeolog [KO:K17065] [EC:3.6.5.5]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
380102  ctsb.L; uncharacterized protein LOC380102 precursor [KO:K01363] [EC:3.4.22.1]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
380234  map1lc3a.L; microtubule associated protein 1 light chain 3 alpha L homeolog [KO:K10435]
380376  vdac1.S; voltage-dependent anion channel 1 S homeolog [KO:K05862]
380397  ywhae.S; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon S homeolog [KO:K06630]
394321  myd88.L; myeloid differentiation primary response protein MyD88-A [KO:K04729]
394353  rela.L; putative transcription factor p65 homolog [KO:K04735]
397692  plcb3.L; phospholipase C beta 3 L homeolog [KO:K05858] [EC:3.1.4.11]
397719  casp1.L; caspase-1-A [KO:K01370] [EC:3.4.22.36]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
398025  tab1.L; TGF-beta activated kinase 1/MAP3K7 binding protein 1 L homeolog [KO:K04403]
398208  tp53bp1.S; tumor protein p53 binding protein 1 S homeolog [KO:K20915]
398251  bcl2l1.S; apoptosis regulator R11 [KO:K04570]
398286  p2rx7.L; purinergic receptor P2X, ligand gated ion channel, 7 L homeolog [KO:K05220]
398324  stat1.L; signal transducer and activator of transcription 1 L homeolog [KO:K11220]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
398502  nampt.S; nicotinamide phosphoribosyltransferase S homeolog [KO:K03462] [EC:2.4.2.12]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
398692  [KO:K20899]
398857  map1lc3b.S; uncharacterized protein LOC398857 [KO:K10435]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399254  itpr1.S; inositol 1,4,5-trisphosphate receptor type 1 S homeolog [KO:K04958]
399366  pkn2.L; serine/threonine-protein kinase N2 [KO:K23691]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
399459  map3k7.L; mitogen-activated protein kinase kinase kinase 7 L homeolog [KO:K04427] [EC:2.7.11.25]
404226  prkcd.S; protein kinase C delta S homeolog [KO:K06068] [EC:2.7.11.13]
404227  prkcd.L; protein kinase C delta L homeolog [KO:K06068] [EC:2.7.11.13]
414477  gabarap.L; uncharacterized protein LOC414477 [KO:K08341]
414882  nek7.S; NIMA-related kinase 7 S homeolog [KO:K20876] [EC:2.7.11.34]
431892  irf9.L; interferon regulatory factor 9 L homeolog [KO:K04693]
431918  mfn2.L; mitofusin 2 L homeolog [KO:K06030] [EC:3.6.5.-]
431974  traf2.S; TNF receptor associated factor 2 S homeolog [KO:K03173] [EC:2.3.2.27]
432200  ikbkb.L; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog [KO:K07209] [EC:2.7.11.10]
432309  sugt1.L; SGT1 homolog, MIS12 kinetochore complex assembly cochaperone L homeolog [KO:K12795]
443756  atg5.L; autophagy related 5 L homeolog [KO:K08339]
443782  vdac3.L; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
443948  XB5909790.S; MGC80314 protein S homeolog [KO:K03671]
443958  mfn1.L; mitofusin 1 L homeolog [KO:K21356] [EC:3.6.5.-]
443979  gabarapl1.S; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
444089  tyk2.L; tyrosine kinase 2 L homeolog [KO:K11219] [EC:2.7.10.2]
444353  cybb.L; cytochrome b-245, beta polypeptide L homeolog [KO:K21421] [EC:1.-.-.-]
444556  chuk.S; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
444777  traf6.L; TNF receptor-associated factor 6-B [KO:K03175] [EC:2.3.2.27]
444817  pycard.L; PYD and CARD domain containing L homeolog [KO:K12799]
445848  plcb4.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
446351  tbk1.L; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
446457  txnip.L; thioredoxin interacting protein L homeolog [KO:K20910]
446459  hsp90ab1.S; heat shock protein 90kDa alpha family class B member 1 S homeolog [KO:K04079]
446568  birc2.L; baculoviral IAP repeat containing 2 L homeolog [KO:K16060]
446697  jak1.S; Janus kinase 1 (a protein tyrosine kinase) S homeolog [KO:K11217] [EC:2.7.10.2]
446833  nfkbia.L; NFKB inhibitor alpha L homeolog [KO:K04734]
446853  cyba.L; cytochrome b-245 alpha polypeptide L homeolog [KO:K08009]
446998  tnfaip3.S; TNF alpha induced protein 3 S homeolog [KO:K11859] [EC:3.4.19.12]
447517  gbp7.S; guanylate binding protein 7 S homeolog [KO:K20899]
447609  pstpip1.S; proline-serine-threonine phosphatase interacting protein 1 S homeolog [KO:K12804]
447632  nfkb1.L; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog [KO:K02580]
447688  brcc3.L; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
494762  gabarapl1.L; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
495314  mfn1.S; mitofusin 1 S homeolog [KO:K21356] [EC:3.6.5.-]
495354  txn.L; thioredoxin L homeolog [KO:K03671]
495517  [KO:K05131]
495838  atg16l1.L; autophagy-related protein 16 isoform X1 [KO:K17890]
496105  [KO:K05131]
496403  fadd.S; Fas associated via death domain S homeolog [KO:K02373]
733220  map1lc3b.L; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
733235  xiap.L; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
733239  ripk3L.2.L; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
733258  plcb1.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
733315  tank.L; TRAF interacting protein TANK [KO:K12650]
734234  ripk1.L; receptor interacting serine/threonine kinase 1 L homeolog [KO:K02861] [EC:2.7.11.1]
734297  nfkbia.S; uncharacterized protein LOC734297 [KO:K04734]
734302  myd88.S; myeloid differentiation primary response protein MyD88-B [KO:K04729]
734449  vdac2.S; voltage-dependent anion-selective channel protein 2 [KO:K15040]
734814  gabarapl2.L; GABA(A) receptor-associated protein like 2 L homeolog [KO:K08341]
734896  ikbke.L; inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog [KO:K07211] [EC:2.7.11.10]
734929  traf6.S; TNF receptor-associated factor 6-A [KO:K03175] [EC:2.3.2.27]
735059  nampt.L; uncharacterized protein LOC735059 [KO:K03462] [EC:2.4.2.12]
735069  ikbkg.L; inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog [KO:K07210]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
779323  map1lc3c.L; microtubule associated protein 1 light chain 3 gamma L homeolog [KO:K10435]
779341  rnf31.S; ring finger protein 31 S homeolog [KO:K11974] [EC:2.3.2.31]
779422  gbp1.L; guanylate binding protein 1, interferon-inducible L homeolog [KO:K20899]
779441  dhx33.L; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Related
pathway
xla04010  MAPK signaling pathway
xla04140  Autophagy - animal
xla04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

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