KEGG   PATHWAY: xla04140
Entry
xla04140                    Pathway                                
Name
Autophagy - animal - Xenopus laevis (African clawed frog)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
xla04140  Autophagy - animal
xla04140

Other DBs
GO: 0006914
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036782  rraga.L; Ras-related GTP binding A L homeolog [KO:K16185]
100036928  rab7b.S; RAB7B, member RAS oncogene family S homeolog [KO:K07898]
100036954  optn.S; uncharacterized protein LOC100036954 [KO:K19946]
100037230  rab8a.S; ras-related protein Rab-8A [KO:K07901]
100049143  atg16l1.S; autophagy related 16 like 1 S homeolog [KO:K17890]
100101276  prkaca.S; protein kinase, cAMP-dependent, alpha catalytic subunit S homeolog [KO:K04345] [EC:2.7.11.11]
100124683  tax1bp1.L; Tax1 binding protein 1 L homeolog [KO:K21347]
100126654  atg12.S; autophagy related 12 S homeolog [KO:K08336]
100137698  atg4d.S; uncharacterized protein LOC100137698 [KO:K08342] [EC:3.4.22.-]
100158448  vps33a.L; VPS33A, CORVET/HOPS core subunit L homeolog [KO:K20182]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
100505423  [KO:K07827]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108695291  rb1cc1.S; RB1-inducible coiled-coil protein 1 [KO:K17589]
108695427  deptor.S; DEP domain-containing mTOR-interacting protein [KO:K20402]
108695762  [KO:K06068] [EC:2.7.11.13]
108695888  epg5.L; ectopic P granules protein 5 homolog [KO:K23883]
108696086  nrbf2.L; nuclear receptor-binding factor 2 [KO:K21246]
108696110  bnip3.L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
108696230  ddit4.L; DNA damage-inducible transcript 4 protein [KO:K08270]
108696363  [KO:K07203] [EC:2.7.11.1]
108696456  vps11.L; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
108696729  [KO:K07830]
108696734  XB5961731.L; insulin [KO:K04526]
108697189  [KO:K06068] [EC:2.7.11.13]
108697191  [KO:K06068] [EC:2.7.11.13]
108697366  nrbf2.S; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
108697591  [KO:K08860] [EC:2.7.11.1]
108697778  [KO:K07830]
108697792  kras.S; GTPase HRas [KO:K07827]
108698219  tsc1.L; hamartin isoform X1 [KO:K07206]
108698322  [KO:K06068] [EC:2.7.11.13]
108698335  [KO:K06068] [EC:2.7.11.13]
108698359  [KO:K06068] [EC:2.7.11.13]
108698392  rab39b.L; ras-related protein Rab-39B [KO:K07925]
108698409  [KO:K08342] [EC:3.4.22.-]
108698603  zfyve1l.L; zinc finger FYVE domain-containing protein 1 [KO:K17603]
108698738  atg2b.L; autophagy-related protein 2 homolog B [KO:K17906]
108698803  [KO:K04456] [EC:2.7.11.1]
108698983  vps39.L; vam6/Vps39-like protein [KO:K20183]
108699170  atg14.L; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
108699185  zfyve1.L; zinc finger FYVE domain-containing protein 1 [KO:K17603]
108699198  [KO:K16196] [EC:2.7.11.1]
108699292  [KO:K03237]
108699293  eif2s1.L; eukaryotic translation initiation factor 2 subunit 1 isoform X2 [KO:K03237]
108699808  atg2b.S; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
108699932  tsc1.S; hamartin isoform X1 [KO:K07206]
108700004  MGC75872.S; ras-related protein Rab-7a [KO:K07897]
108700018  [KO:K18052] [EC:2.7.11.13]
108700021  [KO:K18052] [EC:2.7.11.13]
108700095  rab39b.S; ras-related protein Rab-39B [KO:K07925]
108700257  [KO:K17603]
108700356  [KO:K08803] [EC:2.7.11.1]
108700813  [KO:K21348]
108700887  plekhm1.L; pleckstrin homology domain-containing family M member 1 [KO:K23282]
108700971  [KO:K04570]
108700989  [KO:K07204]
108701062  tp53inp2.L; tumor protein p53-inducible nuclear protein 2 [KO:K21247]
108701169  [KO:K22991]
108701211  ern1.L; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108701286  atg9a.L; autophagy-related protein 9A [KO:K17907]
108701403  [KO:K06068] [EC:2.7.11.13]
108701437  cflar.L; CASP8 and FADD-like apoptosis regulator isoform X2 [KO:K04724]
108701627  ern2.L; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108701656  tsc2.L; tuberin isoform X3 [KO:K07207]
108701680  smcr8.L; guanine nucleotide exchange protein SMCR8 [KO:K23611]
108701789  [KO:K08334]
108702036  deptorl.L; LOW QUALITY PROTEIN: DEP domain-containing mTOR-interacting protein [KO:K20402]
108702193  [KO:K06068] [EC:2.7.11.13]
108702302  [KO:K06068] [EC:2.7.11.13]
108702523  calcoco2.S; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
108702586  plekhm1.S; pleckstrin homology domain-containing family M member 1 [KO:K23282]
108702722  [KO:K08334]
108702726  nbr1.S; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
108702862  ern1.S; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108702900  mras.S; ras-related protein M-Ras [KO:K07831]
108702922  atg9a.S; autophagy-related protein 9A [KO:K17907]
108702967  tank.S; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
108703133  pdpk1.S; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
108703213  tsc2.S; tuberin isoform X1 [KO:K07207]
108703233  smcr8.S; guanine nucleotide exchange protein SMCR8 [KO:K23611]
108704011  [KO:K08337]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
108704099  [KO:K22262]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108704277  [KO:K06068] [EC:2.7.11.13]
108704638  atg9b.L; autophagy-related protein 9A [KO:K17907]
108704678  rubcn.L; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
108705035  [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108705344  tp53inp2.S; tumor protein p53-inducible nuclear protein 2 [KO:K21247]
108705528  pik3c3.S; phosphatidylinositol 3-kinase catalytic subunit type 3-like isoform X1 [KO:K00914] [EC:2.7.1.137]
108705586  [KO:K06068] [EC:2.7.11.13]
108705600  [KO:K06068] [EC:2.7.11.13]
108705684  vps33a.S; vacuolar protein sorting-associated protein 33A [KO:K20182]
108706679  rab33b.S; ras-related protein Rab-33B [KO:K07920]
108706827  [KO:K04382] [EC:3.1.3.16]
108706844  stk11.S; serine/threonine-protein kinase stk11-like [KO:K07298] [EC:2.7.11.1]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706905  [KO:K02927]
108707144  ulk1.S; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108707155  ubc.S; polyubiquitin-C [KO:K08770]
108707162  camkk2.S; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
108707474  rragc.L; ras-related GTP-binding protein C [KO:K16186]
108707498  atg3.L; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
108707934  [KO:K08770]
108708023  [KO:K06068] [EC:2.7.11.13]
108708057  [KO:K18052] [EC:2.7.11.13]
108708092  rab39a.L; ras-related protein Rab-39B [KO:K07925]
108708293  ulk2.L; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
108708462  [KO:K07187]
108708685  supt20h.L; transcription factor SPT20 homolog isoform X1 [KO:K21245]
108708826  [KO:K20868]
108709322  mtmr4.S; myotubularin-related protein 4-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108709364  [KO:K06068] [EC:2.7.11.13]
108709529  [KO:K07925]
108709606  vmp1.S; vacuole membrane protein 1 [KO:K21248]
108709614  [KO:K08269] [EC:2.7.11.1]
108709741  [KO:K07187]
108709809  atg101.S; autophagy-related protein 101 [KO:K19730]
108709952  [KO:K10802]
108710101  vps16.S; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
108710144  [KO:K18052] [EC:2.7.11.13]
108710334  [KO:K20184]
108711231  prkcq.L; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
108711286  [KO:K08803] [EC:2.7.11.1]
108711337  [KO:K01365] [EC:3.4.22.15]
108711478  igf1r.L; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
108711543  [KO:K22262]
108711677  prkaca.L; protein kinase, cAMP-dependent, alpha catalytic subunit L homeolog [KO:K04345] [EC:2.7.11.11]
108711802  irs2.L; insulin receptor substrate 1 [KO:K16172]
108712280  vps41.S; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184]
108712371  tbk1.S; serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
108712451  [KO:K06068] [EC:2.7.11.13]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108712618  ppp2ca.S; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
108712999  [KO:K08803] [EC:2.7.11.1]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108713072  rab8a.L; ras-related protein Rab-8A [KO:K07901]
108713767  atg13.L; autophagy-related protein 13 isoform X2 [KO:K08331]
108713886  atg2a.L; autophagy-related protein 2 homolog A [KO:K17906]
108713898  [KO:K10435]
108713905  [KO:K02158]
108714187  prkacb.L; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108714230  atg4c.L; cysteine protease ATG4C-like isoform X1 [KO:K08342] [EC:3.4.22.-]
108714249  [KO:K07198] [EC:2.7.11.31]
108714401  sh3glb1.L; endophilin-B1 isoform X1 [KO:K11248]
108714625  [KO:K04958]
108715151  [KO:K02158]
108715162  [KO:K10435]
108715245  ambra1.S; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
108715246  atg13.S; autophagy-related protein 13 isoform X4 [KO:K08331]
108715263  [KO:K06068] [EC:2.7.11.13]
108715442  gabarapl2.S; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108715541  [KO:K07198] [EC:2.7.11.31]
108716168  [KO:K06068] [EC:2.7.11.13]
108716267  ulk1.L; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
108716346  [KO:K06068] [EC:2.7.11.13]
108716411  rps27a.L; ubiquitin-40S ribosomal protein S27a [KO:K02977]
108716425  [KO:K08770]
108716606  [KO:K06068] [EC:2.7.11.13]
108716679  birc6.L; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
108716832  camkk2.L; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
108716876  [KO:K16186]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108717564  atg10.L; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
108717623  rab1a.S; ras-related protein Rab-1A [KO:K07874]
108717779  [KO:K06068] [EC:2.7.11.13]
108717825  birc6.S; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
108717862  [KO:K06068] [EC:2.7.11.13]
108717959  wdr41.L; WD repeat-containing protein 41 [KO:K23610]
108717971  rragd.S; ras-related GTP-binding protein D [KO:K16186]
108718060  [KO:K06068] [EC:2.7.11.13]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718134  [KO:K16172]
108718161  atg4b.S; cysteine protease ATG4B-like isoform X1 [KO:K08342] [EC:3.4.22.-]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108718586  [KO:K06068] [EC:2.7.11.13]
108718721  [KO:K26797]
108718957  pik3r4.L; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
108719184  [KO:K06068] [EC:2.7.11.13]
108719396  deptor.L; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
108719598  [KO:K06068] [EC:2.7.11.13]
108719819  [KO:K07208]
113939961  [KO:K01365] [EC:3.4.22.15]
121397099  [KO:K07897]
121402296  [KO:K08341]
121402910  [KO:K17985]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
378695  ins.L; insulin-2 precursor [KO:K04526]
378696  ins.S; insulin-1 precursor [KO:K04526]
379257  ctsb.S; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
379276  ubb.L; ubiquitin B L homeolog [KO:K08770]
379358  stx7.L; syntaxin 7 L homeolog [KO:K08488]
379399  map3k7.S; mitogen-activated protein kinase kinase kinase 7 S homeolog [KO:K04427] [EC:2.7.11.25]
379481  ddit4.S; DNA damage-inducible transcript 4 protein [KO:K08270]
379556  map1lc3a.S; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
379610  sqstm1.L; sequestosome 1 L homeolog [KO:K14381]
379658  nbr1.L; neighbor of BRCA1 gene 1 L homeolog [KO:K17987]
379701  mtmr3.L; myotubularin related protein 3 homeolog L [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
379728  rab33b.L; RAB33B, member RAS oncogene family L homeolog [KO:K07920]
379768  snap29.L; synaptosome associated protein 29kDa L homeolog [KO:K08509]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
379830  rab1a.L; RAB1A, member RAS oncogene family L homeolog [KO:K07874]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
379965  mtmr4.L; myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
380011  wipi2.L; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
380045  ppp2cal.S; protein phosphatase 2 catalytic subunit alpha-like S homeolog [KO:K04382] [EC:3.1.3.16]
380102  ctsb.L; uncharacterized protein LOC380102 precursor [KO:K01363] [EC:3.4.22.1]
380141  hif1a.L; hypoxia inducible factor 1 subunit alpha L homeolog [KO:K08268]
380186  rheb.L; Ras homolog, mTORC1 binding L homeolog [KO:K07208]
380211  gorasp2.L; golgi reassembly stacking protein 2 L homeolog [KO:K26797]
380234  map1lc3a.L; microtubule associated protein 1 light chain 3 alpha L homeolog [KO:K10435]
380388  prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345] [EC:2.7.11.11]
380444  eif2s1.S; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
380530  hmgb1.L; high mobility group box 1 L homeolog [KO:K10802]
394276  rps6kb1.S; ribosomal protein S6 kinase B1 S homeolog [KO:K04688] [EC:2.7.11.1]
394347  rps6kb1.L; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
398022  igf1r.S; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
398034  ykt6.S; synaptobrevin homolog YKT6-A [KO:K08516]
398251  bcl2l1.S; apoptosis regulator R11 [KO:K04570]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
398786  bnip3.S; BCL2/adenovirus E1B 19kDa interacting protein 3 S homeolog [KO:K15464]
398857  map1lc3b.S; uncharacterized protein LOC398857 [KO:K10435]
398880  rab7a.L; RAB7A, member RAS oncogene family L homeolog [KO:K07897]
398895  mlst8.L; target of rapamycin complex subunit lst8 [KO:K08266]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
398994  napsa.L; napsin A aspartic peptidase L homeolog precursor [KO:K01379] [EC:3.4.23.5]
399100  stk11.L; serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
399172  prkaa2.S; protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog [KO:K07198] [EC:2.7.11.31]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
399254  itpr1.S; inositol 1,4,5-trisphosphate receptor type 1 S homeolog [KO:K04958]
399299  irs1.L; insulin receptor substrate 1-A [KO:K16172]
399343  ppp2cb.L; protein phosphatase 2, catalytic subunit, beta isozyme L homeolog [KO:K04382] [EC:3.1.3.16]
399388  irs4.S; insulin receptor substrate 2-A [KO:K07187]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
399407  pik3r4.S; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
399446  nras.L; GTPase NRas [KO:K07828]
399459  map3k7.L; mitogen-activated protein kinase kinase kinase 7 L homeolog [KO:K04427] [EC:2.7.11.25]
403386  eif2ak3.S; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
404226  prkcd.S; protein kinase C delta S homeolog [KO:K06068] [EC:2.7.11.13]
404227  prkcd.L; protein kinase C delta L homeolog [KO:K06068] [EC:2.7.11.13]
414477  gabarap.L; uncharacterized protein LOC414477 [KO:K08341]
414552  tax1bp1.S; Tax1 binding protein 1 S homeolog [KO:K21347]
414701  igbp1.L; immunoglobulin (CD79A) binding protein 1 L homeolog [KO:K17606]
431807  dapk1.S; death associated protein kinase 1 S homeolog [KO:K08803] [EC:2.7.11.1]
431814  akt1s1.S; AKT1 substrate 1 (proline rich) S homeolog [KO:K16184]
432161  dapk3.S; uncharacterized protein LOC432161 [KO:K08803] [EC:2.7.11.1]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
432249  vmp1.L; vacuole membrane protein 1 [KO:K21248]
443721  ctsd.S; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
443756  atg5.L; autophagy related 5 L homeolog [KO:K08339]
443816  rraga.S; Ras-related GTP binding A S homeolog [KO:K16185]
443829  [KO:K01379] [EC:3.4.23.5]
443857  sh3glb1.S; SH3 domain GRB2 like, endophilin B1 S homeolog [KO:K11248]
443882  uba52.L; ubiquitin A-52 residue ribosomal protein fusion product 1 L homeolog [KO:K02927]
443885  atg3.S; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
443932  mras.L; muscle RAS oncogene homolog L homeolog [KO:K07831]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
443979  gabarapl1.S; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
444071  vps18.S; VPS18, CORVET/HOPS core subunit S homeolog [KO:K20181]
444075  ern2.S; endoplasmic reticulum to nucleus signaling 2 S homeolog precursor [KO:K08852] [EC:2.7.11.1 3.1.26.-]
444163  ctsl.L; cathepsin L L homeolog [KO:K01365] [EC:3.4.22.15]
444172  rab7b.L; RAB7B, member RAS oncogene family L homeolog [KO:K07898]
444178  becn1.L; beclin-1 [KO:K08334]
444191  rras2.S; RAS related 2 S homeolog [KO:K07830]
444494  rps27a.S; ribosomal protein S27a S homeolog [KO:K02977]
444529  pdpk1.L; 3-phosphoinositide dependent protein kinase 1 L homeolog [KO:K06276] [EC:2.7.11.1]
444700  zfyve1.S; zinc finger FYVE-type containing 1 S homeolog [KO:K17603]
444777  traf6.L; TNF receptor-associated factor 6-B [KO:K03175] [EC:2.3.2.27]
445838  [KO:K08268]
446253  atg4a.S; autophagy related 4A cysteine peptidase S homeolog [KO:K08342] [EC:3.4.22.-]
446351  tbk1.L; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
446504  atg101.L; autophagy-related protein 101 [KO:K19730]
446562  dapk1.L; death associated protein kinase 1 L homeolog [KO:K08803] [EC:2.7.11.1]
446671  pik3c3.L; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
446709  wipi1.L; WD repeat domain, phosphoinositide interacting 1 L homeolog [KO:K17908]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
446841  rab7a.S; RAB7A, member RAS oncogene family S homeolog [KO:K07897]
446846  wdr45.S; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
446877  lamp1.L; lysosomal-associated membrane protein 1 L homeolog precursor [KO:K06528]
446901  wipi1.S; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
447203  lamp1.S; lysosomal-associated membrane protein 1 S homeolog precursor [KO:K06528]
447241  atg4d.L; LOW QUALITY PROTEIN: cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
447310  wdr45b.S; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
447313  ctsv.L; cathepsin L2 precursor [KO:K01365] [EC:3.4.22.15]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
447742  lamp2.S; lysosome-associated membrane glycoprotein 2 precursor [KO:K06528]
494717  atg4b.L; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
494749  mtmr3.S; myotubularin related protein 3 homeolog S [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
494762  gabarapl1.L; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
495075  akt1s1.L; uncharacterized protein LOC495075 [KO:K16184]
495080  atg4c.S; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
495255  vamp8.L; vesicle associated membrane protein 8 L homeolog [KO:K08512]
495258  rragc.S; Ras related GTP binding C S homeolog [KO:K16186]
495262  vps11.S; VPS11, CORVET/HOPS core subunit S homeolog [KO:K20179]
495290  prkaa1.L; protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog [KO:K07198] [EC:2.7.11.31]
495836  irs4.L; insulin receptor substrate 2-B [KO:K07187]
495838  atg16l1.L; autophagy-related protein 16 isoform X1 [KO:K17890]
496218  vamp8.S; vesicle associated membrane protein 8 S homeolog [KO:K08512]
496250  optn.L; optineurin [KO:K19946]
496290  c9orf72.L; uncharacterized protein LOC496290 [KO:K23609]
496293  dapk2.L; death-associated protein kinase 2 L homeolog [KO:K08803] [EC:2.7.11.1]
496352  deptorl.S; DEP domain containing MTOR interacting protein like S homeolog [KO:K20402]
733167  rb1cc1.L; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
733220  map1lc3b.L; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
733315  tank.L; TRAF interacting protein TANK [KO:K12650]
733384  lamp2.L; lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
734511  gorasp2.S; uncharacterized protein LOC734511 [KO:K26797]
734514  dapk3.L; death-associated protein kinase 3 L homeolog [KO:K08803] [EC:2.7.11.1]
734683  snap29.S; uncharacterized protein LOC734683 [KO:K08509]
734814  gabarapl2.L; GABA(A) receptor-associated protein like 2 L homeolog [KO:K08341]
734929  traf6.S; TNF receptor-associated factor 6-A [KO:K03175] [EC:2.3.2.27]
734951  mtmr14.S; myotubularin related protein 14 S homeolog [KO:K18086] [EC:3.1.3.64 3.1.3.95]
735229  ykt6.L; synaptobrevin homolog YKT6-B [KO:K08516]
735238  uvrag.L; UV radiation resistance associated L homeolog [KO:K21249]
735244  supt20h.S; SPT20 homolog, SAGA complex component S homeolog [KO:K21245]
779088  [KO:K07830]
779151  uvrag.S; UV radiation resistance associated S homeolog [KO:K21249]
779323  map1lc3c.L; microtubule associated protein 1 light chain 3 gamma L homeolog [KO:K10435]
780745  cflar.S; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
xla04010  MAPK signaling pathway
xla04141  Protein processing in endoplasmic reticulum
xla04142  Lysosome
xla04150  mTOR signaling pathway
xla04910  Insulin signaling pathway
KO pathway
ko04140   

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