KEGG    Network variation - Pathogenic Escherichia coli
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ENTRYnt06180
NamePathogenic Escherichia coli
CategoryDisease view; Bacterial infection
Pathwayhsa05130 Pathogenic Escherichia coli infection
DiseaseH00277 Enterohemorrhagic Escherichia coli (EHEC) infection
H00278 Enteropathogenic Escherichia coli (EPEC) infection
Display drug-target relation   disease type
TNF signaling
N00446    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAK1+TAB1/2)MKK4/7JNKAP1
N00930            NleDJNK
N00444    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAK1+TAB1/2)MKK3/6MAPK14MSK1/2CREB
N00931            NleDMAPK14
N00151    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00928    NleBGAPDH(RIPK1+TRAF2)
N00927        NleE(TAB2/3)
N00932            NleH1RPS3NFKB
N00929              NleCRELA
 
TLR signaling
N00438    (TLR2,TLR4)(TIRAP+MYD88)(IRAK4+IRAK1)(TRAF6+TAK1+TAB2)(MEK,MKK3/6,MKK4/7..(ERK,p38,JNK)AP1
N00926      TirSHP1/2(TRAF6+TAK1+TAB2)
 
NLR signaling
N00742      (NLRP3+PYCARD)CASP1(IL1B,IL18,IL33)
N00933    NleA(NLRP3+PYCARD)
N00934    LPSCASP4/5(NLRP3+PYCARD+CASP..(IL1B,IL18)
N00935    NleFCASP4
 
Cytoskeletal regulation
N01287    (OCLN,CLDN)=TJP1=CTTN=ARP2/3=(ACTB,ACTG1)
N01288    EspFTJP1
N01097    LPALPARGNA12/13(ARHGEF12,ARHGEF1,..RHOAROCK1/2
N01088        EspH(ARHGEF12,ARHGEF1)
N01095      MapNHERF1EZRRHOAROCK1/2
N01089          EspMRHOAROCK1/2
N01285      (TUBA+TUBB)ARHGEF2RHOAROCK1/2
N01286    (EspG,EspG2)(TUBA+TUBB)
N01068    FN1(ITGA+ITGB)(SRC,PTK2)(PXN,CRK+BCAR1)(DOCK1+ELMO1)RAC
N01086            EspTRAC1(WASF2+ABI1)ARP2/3(ACTB,ACTG1)
N01087            EspWRAC1
N01090      IGGFCGRCRKDOCK1RAC
N01091    EspJSRCFCGR
N01070    FN1(ITGA+ITGB)(SRC,PTK2)PXN(GIT2+ARHGEF7)CDC42
N01096            MapCDC42WASLARP2/3(ACTB,ACTG1)
N01066    ARNOARF6ARF1(WASF+ABI1+HSPC300..ARP2/3(ACTB,ACTG1)
N01084    (EspG,EspG2)ARF6
N01085      (EspG,EspG2)ARF1
N01078    EGFEGFRSRCCTTNNCK(WASL+WIPF)ARP2/3(ACTB,ACTG1)
N01092        EaeTirNCK(WASL+WIPF)ARP2/3(ACTB,ACTG1)
N01093      EspJ(FYN,ABL)TirNCK
N01094      EaeTir(IRTKS,IRSp53)TccPWASLARP2/3(ACTB,ACTG1)
 
Membrane trafficking
N01293    GBF1ARF1=(KDELR+TMED2+TMED1..=(COPI+TMED4/9+TMED..
N01294      NleFTMED10
N01289    SEC12SAR1=(SEC23+SEC24)=(SEC13+SEC31)
N01290      NleASEC24
N01291    TRAPPIRAB1
N01292    (EspG,EspG2)RAB1