KEGG    Network variation - TNF signaling
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ENTRYnt06516
NameTNF signaling
CategoryPathway view; Signal transduction
Pathwayhsa04668 TNF signaling pathway
hsa04064 NF-kappa B signaling pathway
Display drug-target relation   disease type
N00446    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAK1+TAB1/2)→MKK4/7→JNK→AP1
N01125    Salmonella       AvrA⊣MAP2K7
N00447    HIV         (Vpr,Tat)→JNK→AP1
N00930    Escherichia         NleD⊣JNK
N00503    HTLV-1         TAX→(MAPK8,MAPK9,MAPK1..→JUN⇒MMP7
 
N00444    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAK1+TAB1/2)→MKK3/6→MAPK14→MSK1/2→CREB
    IMD57     RIPK1*
N00445    HIV         (Tat,Nef)→MAPK14
N00931    Escherichia         NleD⊣MAPK14
 
N00151    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAB1/2/3+TAK1)→IKK→NFKBIA→NFKB
    TRAPS/MS5   TNFRSF1A*
    EDAID1/IP         IKBKG*
    EDAID1         IKBKG*↗
    CMCU             RELA*
N00441    HIV Env→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAB1/2/3+TAK1)→IKK→NFKBIA→NFKB
N01114    Salmonella SseK3⊣TNFRSF1A
N00442    HIV   Nef→(RIPK1+TRADD+TRAF2..→(TAB1/2/3+TAK1)→IKK→NFKBIA→NFKB
N01113    Salmonella   SseK1⊣(RIPK1+TRADD+TRAF2..
N00173    KSHV   K15→TRAF2→TAK1→IKK→NFKBIA→NFKB
N00265    EBV   LMP1→(TRADD+TRAF6)→(TAB1/2+TAK1)→IKK→NFKBIA→NFKB
N00525    HCV   NS5A⊣(TRADD+TRAF2)
N00928    Escherichia NleB⊣GAPDH→(RIPK1+TRAF2)
N00944    Shigella OspI⊣UBC13→TRAF2
N00945    Shigella IpaH1.4/2.5⊣RFN31→RIPK1
N00927    Escherichia/Shigella     NleE⊣(TAB2/3)
N00171    KSHV       vFLIP→IKK→NFKBIA→NFKB
N00504    HTLV-1       TAX→IKK→NFKBIA→NFKB
N00397    HCMV       UL26⊣IKK
N00942    Shigella       OspG⊣(UBE2D2+(RBX1+CUL1..→NFKBIA
N01117    Salmonella       GogB⊣SKP1→NFKBIA
N01116    Salmonella         SseL⊣NFKBIA
N01123    Salmonella         AvrA⊣NFKBIA
N01118    Salmonella       SpvD⊣XPO2→(KPNA1+KPNA3)→NFKB
N00398    HCMV           IE2-86⊣NFKB
N00389    HCMV           IE1-72⇒NFKB
N00269    HCV           Core→NFKB
N00443    HIV           (Vpr,Nef,Tat)→NFKB
N00932    Escherichia         NleH1⊣RPS3→NFKB
N00929    Escherichia           NleC⊣RELA
N00943    Shigella           IpaH4.5⊣RELA
N01122    Salmonella           PipA⊣RELA
N01545    (RBCK1+RNF31+SHARP..→(RIPK1,IKBKG,TNFRS..
    PGBM1 RBCK1*
N01546    (OTULIN,TNFAIP3)⊣(RIPK1,IKBKG)
    AIPDS OTULIN*
    AIFBL1 TNFAIP3*
 
N00145    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→FADD→CASP8→(CASP3,CASP7)
    AIEFL     RIPK1*↗
N01583      XIAP⊣(RIPK1+RIPK3+FADD+..
    XLP2   XIAP*
 
N01797    EDA→(EDAR+EDARADD+TRAF..→(MAP3K7+TAB2)
    ECTD1/STHAGX1 EDA*
    ECTD10   EDAR*
    ECTD11   EDARADD*
 
N00505    CD40LG→CD40→(TRAF2+TRAF3)→NIK→IKKA→(NFKB2+RELB)
    HIGM1 CD40LG*
    HIGM3   CD40*
    IMD132B     TRAF3*
N00506    HTLV-1     TAX=IKBKG→IKKA→(NFKB2+RELB)
 
N01798    TNFSF11→TNFRSF11A→TRAF2/5/6
    OPTB2 TNFSF11*
    OPTB7   TNFRSF11A*
    PDB2/FEO   TNFRSF11A*↗
 
N01796    TNFSF4→TNFRSF4→TRAF2/3/5
    IMD16   TNFRSF4*
 
N01799    CD70→CD27→TRAF2/5
    LPFS3 CD70*
    LPFS2   CD27*
 
N01801    TNFSF13/13B→TNFRSF13B/C→TRAF2/3/5/6
    CVID2   TNFRSF13B*
    CVID4   TNFRSF13C*
 
N00374    TNF→TNFRSF1B→IRF1⇒IFNB1
N00375    HPV   (E7+HDAC+CHD4)⊣IRF1
 
N00559    TNFSF14→TNFRSF14→TRAF2/5→IKK→NFKBIA→NFKB
N00560    HSV GD→TNFRSF14→TRAF2/5→IKK→NFKBIA→NFKB⇒(BIRC2,BIRC3,NFKB1..

Disease nameDisease category
SalmonellaH00113SalmonellosisBacterial infectious disease
HIVH01563HIV infectionViral infectious disease
EscherichiaH00277Enterohemorrhagic Escherichia coli (EHEC) infectionBacterial infectious disease
H00278Enteropathogenic Escherichia coli (EPEC) infectionBacterial infectious disease
HTLV-1H00009Adult T-cell leukemiaCancer
IMD57H02525Disorders of innate immunityImmune system disease
TRAPS/MS5H00912Tumor necrosis factor receptor-associated periodic syndromeImmune system disease
H01490Multiple sclerosisImmune system disease
EDAID1/IPH00540Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)Congenital malformation
H00645Incontinentia pigmentiCongenital malformation
EDAID1H00540Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)Congenital malformation
CMCUH02593Chronic mucocutaneous ulcerationImmune system disease
KSHVH00041Kaposi sarcomaCancer
EBVH00008Burkitt lymphomaCancer
H00007Hodgkin lymphomaCancer
H00054Nasopharyngeal cancerCancer
HCVH00048Hepatocellular carcinomaCancer
ShigellaH00299ShigellosisBacterial infectious disease
Escherichia/ShigellaH00277Enterohemorrhagic Escherichia coli (EHEC) infectionBacterial infectious disease
H00278Enteropathogenic Escherichia coli (EPEC) infectionBacterial infectious disease
H00299ShigellosisBacterial infectious disease
HCMVH00368Cytomegalovirus infectionViral infectious disease
PGBM1H01744Polyglucosan body myopathyImmune system disease
AIPDSH02414Autoinflammation, panniculitis, and dermatosis syndromeImmune system disease
AIFBL1H02592Familial Behcet-like autoinflammatory syndromeImmune system disease
AIEFLH02620Autoinflammation with episodic fever and lymphadenopathyImmune system disease
XLP2H01969X-linked lymphoproliferative syndromePrimary immunodeficiency
ECTD1/STHAGX1H00651Hypohidrotic ectodermal dysplasiaCongenital malformation
H00625Tooth agenesisCongenital malformation
ECTD10H00651Hypohidrotic ectodermal dysplasiaCongenital malformation
ECTD11H00651Hypohidrotic ectodermal dysplasiaCongenital malformation
HIGM1H00086Immunodeficiency with hyper-IgMImmune system disease
HIGM3H00086Immunodeficiency with hyper-IgMImmune system disease
IMD132BH01725Primary immunodeficiency diseaseImmune system disease
OPTB2H00436OsteopetrosisCongenital malformation
OPTB7H00436OsteopetrosisCongenital malformation
PDB2/FEOH00437Paget disease of boneMusculoskeletal disease
H02042Familial expansile osteolysisMusculoskeletal disease
IMD16H00093Combined immunodeficiencyPrimary immunodeficiency
LPFS3H01970Lymphoproliferative syndromePrimary immunodeficiency
LPFS2H01970Lymphoproliferative syndromePrimary immunodeficiency
CVID2H00088Common variable immunodeficiencyImmune system disease
CVID4H00088Common variable immunodeficiencyImmune system disease
HPVH00030Cervical cancerCancer
HSVH00365Herpes simplex virus infectionViral infectious disease