KEGG   PATHWAY: eai04062
Entry
eai04062                    Pathway                                
Name
Chemokine signaling pathway - Equus asinus (ass)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
eai04062  Chemokine signaling pathway
eai04062

Other DBs
GO: 0070098
Organism
Equus asinus (ass) [GN:eai]
Gene
106822010  CRK; adapter molecule crk isoform X1 [KO:K04438]
106822197  CCL17; C-C motif chemokine 17 isoform X1 [KO:K21083]
106822234  CX3CL1; fractalkine isoform X1 [KO:K05508]
106822266  CCL22; C-C motif chemokine 22 [KO:K21095]
106822593  [KO:K02649]
106822932  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
106822994  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
106823001  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
106823010  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
106823182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
106823191  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106823728  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
106823831  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106824013  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106824036  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106824126  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
106824833  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
106824916  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
106824973  HRAS; GTPase HRas isoform X1 [KO:K02833]
106824990  CCL28; C-C motif chemokine 28 [KO:K05513]
106824993  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106825068  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106825232  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
106825548  KRAS; GTPase KRas isoform X2 [KO:K07827]
106825688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106825835  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
106825844  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
106825951  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106826021  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
106826327  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
106826362  STAT5B; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224]
106826447  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
106826465  CCR7; C-C chemokine receptor type 7 [KO:K04182]
106826508  CCR10; C-C chemokine receptor type 10 [KO:K04185]
106826827  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
106826868  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106826929  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
106827137  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
106827362  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
106827371  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
106827440  WAS; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein [KO:K05747]
106827867  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
106828516  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
106828599  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
106828796  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
106828814  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106828868  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
106828957  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
106829188  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106829312  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106829313  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106829345  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106829397  [KO:K07827]
106829703  [KO:K05506]
106829714  [KO:K05505]
106829728  [KO:K05505]
106829729  [KO:K05505]
106829736  [KO:K10029]
106829746  [KO:K05407]
106829766  FOXO3; forkhead box protein O3 [KO:K09408]
106830292  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
106830690  RHOA; transforming protein RhoA [KO:K04513]
106830727  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X2 [KO:K04630]
106830858  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
106830866  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
106830991  [KO:K04366] [EC:2.7.11.1]
106832127  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
106832511  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
106832766  VAV1; proto-oncogene vav [KO:K05730]
106832855  [KO:K05859] [EC:3.1.4.11]
106832955  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
106833450  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
106833505  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
106833569  RELA; transcription factor p65 isoform X1 [KO:K04735]
106833617  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
106833626  BAD; bcl2-associated agonist of cell death [KO:K02158]
106833627  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
106833726  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
106834157  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
106834253  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
106834358  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
106834701  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
106835088  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106835113  CXCL8; interleukin-8 [KO:K10030]
106835172  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106835457  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106835678  NRAS; GTPase NRas [KO:K07828]
106835699  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
106836078  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
106836191  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
106836364  GRK5; G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
106836546  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
106836623  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
106836695  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106836825  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
106837090  CCL24; C-C motif chemokine 24 [KO:K21097]
106837136  CCL26; C-C motif chemokine 26 [KO:K21096]
106837154  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
106837369  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
106837585  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
106838005  CCR4; C-C chemokine receptor type 4 [KO:K04179]
106838100  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106838155  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
106838386  CCR2; C-C chemokine receptor type 2 [KO:K04177]
106838387  [KO:K04180]
106838390  [KO:K04178]
106838391  [KO:K04176]
106838392  XCR1; chemokine XC receptor 1 [KO:K04193]
106838394  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
106838395  CCR9; C-C chemokine receptor type 9 [KO:K04184]
106838436  [KO:K05050]
106838440  [KO:K04175]
106838625  SHC4; SHC-transforming protein 4 [KO:K17449]
106838803  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
106838935  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106838940  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
106839104  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
106839312  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
106839490  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
106839506  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
106839597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106840004  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
106840141  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106840290  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
106840410  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
106840518  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
106840602  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106840982  NCF1; neutrophil cytosol factor 1 [KO:K08011]
106841140  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
106841374  [KO:K05512]
106841406  CCL27; C-C motif chemokine 27 [KO:K16598]
106841408  [KO:K16062]
106841562  XCL1; lymphotactin [KO:K05507]
106841633  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
106841654  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
106841709  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
106842066  CCR6; C-C chemokine receptor type 6 [KO:K04181]
106842618  BRAF; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
106842851  CCR8; C-C chemokine receptor type 8 [KO:K04183]
106842867  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
106842897  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
106842910  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
106843289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106843404  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
106843586  RAP1B; ras-related protein Rap-1b [KO:K07836]
106843620  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
106844136  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
106844157  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
106844316  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106844497  CCL25; C-C motif chemokine 25 [KO:K13072]
106844558  [KO:K16597]
106844630  [KO:K14624]
106844631  [KO:K05509]
106844632  [KO:K16595]
106844633  [KO:K16596]
106844634  CCL1; C-C motif chemokine 1 [KO:K05514]
106844660  CCL5; C-C motif chemokine 5 [KO:K12499]
106844662  CCL16; C-C motif chemokine 16 [KO:K21093]
106844663  CCL14; C-C motif chemokine 14 [KO:K21092]
106844664  CCL15; C-C motif chemokine 15 isoform X1 [KO:K05511]
106844665  [KO:K05408]
106844666  [KO:K05408]
106844667  [KO:K05408]
106844668  [KO:K12964]
106844784  PXN; paxillin isoform X1 [KO:K05760]
106845213  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
106845218  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
106845291  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
106845632  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106845727  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
106845751  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
106846040  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
106846070  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
106846305  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
106846337  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
106846705  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106846789  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
106846798  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
106846803  CXCL9; C-X-C motif chemokine 9 isoform X1 [KO:K05416]
106847274  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
106847320  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
106847952  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
106848207  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
106848262  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106848274  CRKL; crk-like protein [KO:K04438]
106848607  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123280049  [KO:K05512]
123280097  [KO:K16598]
123280098  CCL21; C-C motif chemokine 21 [KO:K16062]
123281285  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
eai04010  MAPK signaling pathway
eai04060  Cytokine-cytokine receptor interaction
eai04120  Ubiquitin mediated proteolysis
eai04630  JAK-STAT signaling pathway
eai04670  Leukocyte transendothelial migration
eai04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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