KEGG   PATHWAY: lcat04517
Entry
lcat04517                   Pathway                                
Name
IgSF CAM signaling - Lemur catta (Ring-tailed lemur)
Description
Immunoglobulin superfamily cell adhesion molecules (IgSF CAMs) are cell surface proteins that mediate calcium-independent adhesion via their Ig-like domains. These extracellular regions commonly form homophilic interactions with similar molecules on adjacent cells but can also bind heterophilically to various other molecular partners. Their intracellular tails associate with cytoskeletal and adaptor proteins, linking external adhesion events to intracellular signaling. Through these mechanisms, IgSF CAMs play key roles in both normal physiological regulation and disease processes such as cancer development.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
lcat04517  IgSF CAM signaling
lcat04517

Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620245  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
123620440  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
123620522  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
123620572  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
123620974  CNTNAP1; contactin-associated protein 1 [KO:K07379]
123621008  MPP3; MAGUK p55 subfamily member 3 isoform X1 [KO:K24049]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123621260  PMP22; peripheral myelin protein 22 [KO:K19289]
123621478  CDH2; cadherin-2 [KO:K06736]
123621565  [KO:K12757]
123621566  [KO:K12757]
123621616  CABLES1; CDK5 and ABL1 enzyme substrate 1 isoform X1 [KO:K28621]
123621640  CD226; CD226 antigen isoform X1 [KO:K06567]
123621670  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
123621771  [KO:K17269]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621824  TUBB6; tubulin beta-6 chain [KO:K07375]
123621892  EPB41L3; band 4.1-like protein 3 isoform X1 [KO:K23961]
123621959  DCC; netrin receptor DCC [KO:K06765]
123622277  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123622324  TUBB1; tubulin beta-1 chain [KO:K07375]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123622378  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123622382  EPB41L1; band 4.1-like protein 1 isoform X1 [KO:K23961]
123622725  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123622754  CABLES2; CDK5 and ABL1 enzyme substrate 2 [KO:K28621]
123622772  KCNQ2; potassium voltage-gated channel subfamily KQT member 2 isoform X1 [KO:K04927]
123622844  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
123623040  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
123623074  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
123623278  RHOA; transforming protein RhoA [KO:K04513]
123623374  SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526]
123623474  UNC5A; netrin receptor UNC5A [KO:K07521]
123623521  CTNNB1; catenin beta-1 [KO:K02105]
123623594  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123623774  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
123623787  MYH14; myosin-14 isoform X1 [KO:K10352]
123623836  PPFIA3; liprin-alpha-3 [KO:K26226]
123623981  NECTIN2; nectin-2 isoform X1 [KO:K06531]
123623988  PVR; poliovirus receptor [KO:K06539]
123624017  CADM4; cell adhesion molecule 4 [KO:K06783]
123624155  [KO:K05735] [EC:2.7.11.1]
123624233  KIRREL2; kin of IRRE-like protein 2 [KO:K25874]
123624311  [KO:K06115]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123624353  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
123624368  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123624393  CSK; tyrosine-protein kinase CSK [KO:K05728] [EC:2.7.10.4]
123624453  NPHS1; nephrin isoform X1 [KO:K24496]
123624484  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123625139  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
123625167  CDH1; cadherin-1 [KO:K05689]
123625220  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
123625428  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
123625454  MTSS2; protein MTSS 2 isoform X1 [KO:K20128]
123625473  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123625927  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
123625938  PXN; paxillin isoform X1 [KO:K05760]
123625991  GRIP2; glutamate receptor-interacting protein 2 [KO:K20251]
123625996  PLXNA1; plexin-A1 [KO:K06820]
123626029  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
123626065  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
123626156  [KO:K07374]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626246  [KO:K07374]
123626406  DOK2; docking protein 2 isoform X1 [KO:K20234]
123626413  UNC5D; netrin receptor UNC5D [KO:K07521]
123626590  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
123626667  NRP1; neuropilin-1 isoform X1 [KO:K06724]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123626683  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123626895  PLXNA2; plexin-A2 [KO:K06820]
123626955  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
123626964  [KO:K07374]
123626972  PPFIA4; liprin-alpha-4 [KO:K26226]
123627007  NFASC; neurofascin [KO:K06757]
123627008  CNTN2; contactin-2 [KO:K06760]
123627032  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
123627125  SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
123627266  UNC5C; netrin receptor UNC5C isoform X1 [KO:K07521]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627770  ANK2; ankyrin-2 isoform X1 [KO:K09255]
123627977  IL1RAPL2; X-linked interleukin-1 receptor accessory protein-like 2 [KO:K05170]
123628059  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
123628100  [KO:K12757]
123628412  NLGN4X; neuroligin-4, X-linked [KO:K07378]
123628465  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
123628490  PLXNA3; plexin-A3 isoform X1 [KO:K06820]
123628595  MSN; moesin [KO:K05763]
123628742  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
123628850  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
123628877  SH2D1A; SH2 domain-containing protein 1A isoform X1 [KO:K07990]
123628901  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
123629487  NCK1; cytoplasmic protein NCK1 isoform X1 [KO:K07365]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630254  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
123630271  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123630388  [KO:K04723]
123630427  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123630468  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123630490  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
123630505  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123630513  CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412]
123630560  CD96; LOW QUALITY PROTEIN: T-cell surface protein tactile [KO:K06517]
123630561  NECTIN3; nectin-3 isoform X1 [KO:K06592]
123630634  ROBO1; roundabout homolog 1 [KO:K06753]
123630635  ROBO2; roundabout homolog 2 isoform X1 [KO:K06754]
123630649  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
123630656  JAM2; junctional adhesion molecule B [KO:K06735]
123630660  [KO:K04520]
123630752  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
123630775  [KO:K06464]
123630818  ITGB2; integrin beta-2 [KO:K06464]
123631372  CASKIN1; caskin-1 [KO:K21952]
123631504  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123631525  ACTB; actin, cytoplasmic 1 [KO:K05692]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631571  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
123631573  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631697  TUBB; tubulin beta chain [KO:K07375]
123632034  [KO:K06462]
123632413  MYH11; myosin-11 isoform X1 [KO:K10352]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123632686  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123632733  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123632925  [KO:K13738]
123632992  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
123633175  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
123633257  EPB41L2; band 4.1-like protein 2 isoform X1 [KO:K23961]
123633419  EZR; ezrin isoform X1 [KO:K08007]
123633442  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
123633458  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123634153  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123634187  [KO:K02649]
123634195  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
123634243  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123634654  SLAMF7; SLAM family member 7 isoform X1 [KO:K06733]
123634657  MPZ; myelin protein P0 [KO:K06770]
123634968  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123635023  KCNA2; potassium voltage-gated channel subfamily A member 2 [KO:K04875]
123635037  RAP1A; ras-related protein Rap-1A [KO:K04353]
123635102  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
123635144  KIRREL1; kin of IRRE-like protein 1 isoform X1 [KO:K25874]
123635160  CADM3; cell adhesion molecule 3 [KO:K06780]
123635195  SLAMF6; SLAM family member 6 isoform X1 [KO:K16852]
123635196  CD84; SLAM family member 5 isoform X1 [KO:K06511]
123635197  SLAMF1; signaling lymphocytic activation molecule isoform X1 [KO:K06536]
123635198  CD48; CD48 antigen isoform X1 [KO:K06479]
123635199  LY9; LOW QUALITY PROTEIN: T-lymphocyte surface antigen Ly-9 [KO:K06570]
123635200  CD244; natural killer cell receptor 2B4 isoform X1 [KO:K06582]
123635203  F11R; junctional adhesion molecule A [KO:K06089]
123635208  NECTIN4; nectin-4 isoform X1 [KO:K06593]
123635238  SH2D1B; SH2 domain-containing protein 1B [KO:K07989]
123635254  NPHS2; podocin isoform X1 [KO:K18268]
123635417  [KO:K06563]
123635437  [KO:K06563]
123635467  [KO:K06085]
123635834  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123635877  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
123635959  TUBB4A; tubulin beta-4A chain [KO:K07375]
123636456  LRRTM4; leucine-rich repeat transmembrane neuronal protein 4 [KO:K28622]
123636662  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
123636875  [KO:K05756]
123636920  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
123636985  ACTR2; actin-related protein 2 [KO:K17260]
123637091  DOK1; docking protein 1 isoform X1 [KO:K14752]
123637289  NCK2; cytoplasmic protein NCK2 [KO:K19862]
123637329  [KO:K06839]
123637738  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
123637973  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
123637979  SLIT3; slit homolog 3 protein [KO:K06850]
123638169  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
123638178  TUBB2A; tubulin beta-2A chain [KO:K07375]
123638179  [KO:K07375]
123638505  FGB; fibrinogen beta chain [KO:K03904]
123638506  FGA; fibrinogen alpha chain [KO:K03903]
123638507  FGG; fibrinogen gamma chain [KO:K03905]
123638526  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123638764  [KO:K07375]
123638794  [KO:K08018]
123638804  [KO:K08018]
123639309  MYH9; myosin-9 [KO:K10352]
123639478  PPFIA2; liprin-alpha-2 isoform X1 [KO:K26226]
123639540  RAP1B; ras-related protein Rap-1b [KO:K07836]
123639544  GRIP1; glutamate receptor-interacting protein 1 [KO:K20251]
123639565  SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 [KO:K07526]
123639660  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
123639661  MYL6; LOW QUALITY PROTEIN: myosin light polypeptide 6 [KO:K12751]
123639686  ITGA5; integrin alpha-5 [KO:K06484]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123639852  CNTN1; contactin-1 [KO:K06759]
123640090  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
123640169  TUBA8; tubulin alpha-8 chain [KO:K07374]
123640196  ERC1; ELKS/Rab6-interacting/CAST family member 1 isoform X1 [KO:K16072]
123640358  SCN8A; LOW QUALITY PROTEIN: sodium channel protein type 8 subunit alpha [KO:K04840]
123640420  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123640422  [KO:K07374]
123640424  [KO:K07374]
123640715  KCNA1; potassium voltage-gated channel subfamily A member 1 [KO:K04874]
123640717  KCNA6; potassium voltage-gated channel subfamily A member 6 [KO:K04879]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123640914  GLDN; gliomedin [KO:K16364]
123641138  JAM3; junctional adhesion molecule C [KO:K06785]
123641189  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
123641192  ROBO3; roundabout homolog 3 [KO:K06755]
123641193  ROBO4; roundabout homolog 4 isoform X1 [KO:K06784]
123641223  [KO:K06789]
123641229  CRTAM; cytotoxic and regulatory T-cell molecule [KO:K16361]
123641466  NECTIN1; nectin-1 isoform X1 [KO:K06081]
123641524  JAML; junctional adhesion molecule-like [KO:K28137]
123641640  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
123641663  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
123641672  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
123641715  KCNA4; potassium voltage-gated channel subfamily A member 4 [KO:K04877]
123641723  RDX; radixin isoform X1 [KO:K05762]
123641740  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
123641990  TRPC6; short transient receptor potential channel 6 [KO:K04969]
123642055  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
123642301  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123642541  CADM2; cell adhesion molecule 2 isoform X1 [KO:K06782]
123642600  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123642603  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
123642616  KIRREL3; kin of IRRE-like protein 3 [KO:K25874]
123642795  PPFIA1; liprin-alpha-1 isoform X1 [KO:K26226]
123642872  LRFN4; leucine-rich repeat and fibronectin type-III domain-containing protein 4 [KO:K16357]
123642877  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
123643208  MAP2; microtubule-associated protein 2 isoform X1 [KO:K10430]
123643505  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
123643616  [KO:K04513]
123643670  ITGA4; integrin alpha-4 [KO:K06483]
123643747  ACTR3; actin-related protein 3 [KO:K18584]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123643825  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
123643862  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
123643981  TUBA4A; tubulin alpha-4A chain [KO:K07374]
123644032  NRP2; neuropilin-2 isoform X1 [KO:K06819]
123644312  KCNQ3; potassium voltage-gated channel subfamily KQT member 3 [KO:K04928]
123644435  MTSS1; protein MTSS 1 isoform X1 [KO:K20128]
123644532  PMP2; myelin P2 protein [KO:K24977]
123644599  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123644610  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
123645034  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
123645104  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
123645162  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
123645690  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
123645814  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
123645886  TJP2; LOW QUALITY PROTEIN: tight junction protein ZO-2 [KO:K06098]
123645993  TUBB4B; tubulin beta-4B chain [KO:K07375]
123646053  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
123646399  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
123646592  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
123646698  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
123646904  PTPRZ1; receptor-type tyrosine-protein phosphatase zeta [KO:K08114] [EC:3.1.3.48]
123646972  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
123647054  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
123647117  PALS2; protein PALS2 [KO:K28619]
123647328  PLXNA4; plexin-A4 isoform X1 [KO:K06820]
123647516  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123647564  CNTNAP2; contactin-associated protein-like 2 isoform X1 [KO:K07380]
123647694  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
123647707  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
123648443  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
123648486  TRIO; triple functional domain protein isoform X1 [KO:K08810] [EC:2.7.11.1]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123648790  SLITRK5; SLIT and NTRK-like protein 5 isoform X1 [KO:K25836]
123648856  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
123649234  FOXO1; forkhead box protein O1 [KO:K07201]
123649467  LMO7; LIM domain only protein 7 isoform X1 [KO:K06084]
123649477  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
123649488  ARF6; ADP-ribosylation factor 6 [KO:K07941]
123649731  [KO:K06838]
123649823  LRFN5; leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1 [KO:K16358]
123650207  ANK3; ankyrin-3 isoform X1 [KO:K09259]
123650282  VCL; vinculin isoform X1 [KO:K05700]
123650348  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
123650354  UNC5B; netrin receptor UNC5B isoform X1 [KO:K07521]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650678  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
123650686  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123650794  CASKIN2; caskin-2 isoform X1 [KO:K21952]
123650871  NLGN2; LOW QUALITY PROTEIN: neuroligin-2 [KO:K07378]
123650937  MYH10; myosin-10 [KO:K10352]
123650943  NTN1; netrin-1 [KO:K06843]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04927  N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C06140  GT1b
C06141  GD1b
Reference
PMID:26909348
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Leshchyns'ka I, Sytnyk V
  Title
Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.
  Journal
Front Cell Dev Biol 4:9 (2016)
DOI:10.3389/fcell.2016.00009
Reference
PMID:33451101
  Authors
Kalafatakis I, Savvaki M, Velona T, Karagogeos D
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Implication of Contactins in Demyelinating Pathologies.
  Journal
Life (Basel) 11:life11010051 (2021)
DOI:10.3390/life11010051
Reference
PMID:34975399
  Authors
Gao Y, Kong L, Liu S, Liu K, Zhu J
  Title
Impact of Neurofascin on Chronic Inflammatory Demyelinating Polyneuropathy via Changing the Node of Ranvier Function: A Review.
  Journal
Front Mol Neurosci 14:779385 (2021)
DOI:10.3389/fnmol.2021.779385
Reference
PMID:23183391
  Authors
Pollerberg GE, Thelen K, Theiss MO, Hochlehnert BC
  Title
The role of cell adhesion molecules for navigating axons: density matters.
  Journal
Mech Dev 130:359-72 (2013)
DOI:10.1016/j.mod.2012.11.002
Reference
PMID:27871938
  Authors
Gennarini G, Bizzoca A, Picocci S, Puzzo D, Corsi P, Furley AJW
  Title
The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders.
  Journal
Mol Cell Neurosci 81:49-63 (2017)
DOI:10.1016/j.mcn.2016.11.006
Reference
PMID:32085570
  Authors
Raasakka A, Kursula P
  Title
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease.
  Journal
Cells 9:cells9020470 (2020)
DOI:10.3390/cells9020470
Reference
PMID:18455953
  Authors
Bradford D, Cole SJ, Cooper HM
  Title
Netrin-1: diversity in development.
  Journal
Int J Biochem Cell Biol 41:487-93 (2009)
DOI:10.1016/j.biocel.2008.03.014
Reference
PMID:30108487
  Authors
Boyer NP, Gupton SL
  Title
Revisiting Netrin-1: One Who Guides (Axons).
  Journal
Front Cell Neurosci 12:221 (2018)
DOI:10.3389/fncel.2018.00221
Reference
PMID:31258778
  Authors
Tong M, Jun T, Nie Y, Hao J, Fan D
  Title
The Role of the Slit/Robo Signaling Pathway.
  Journal
J Cancer 10:2694-2705 (2019)
DOI:10.7150/jca.31877
Reference
PMID:31939155
  Authors
Bisiak F, McCarthy AA
  Title
Structure and Function of Roundabout Receptors.
  Journal
Subcell Biochem 93:291-319 (2019)
DOI:10.1007/978-3-030-28151-9_9
Reference
PMID:37497439
  Authors
Feng L, Shu HP, Sun LL, Tu YC, Liao QQ, Yao LJ
  Title
Role of the SLIT-ROBO signaling pathway in renal pathophysiology and various renal diseases.
  Journal
Front Physiol 14:1226341 (2023)
DOI:10.3389/fphys.2023.1226341
Reference
PMID:35659057
  Authors
Kostovska I, Trajkovska KT, Topuzovska S, Cekovska S, Labudovic D, Kostovski O, Spasovski G
  Title
Nephrinuria and podocytopathies.
  Journal
Adv Clin Chem 108:1-36 (2022)
DOI:10.1016/bs.acc.2021.08.001
Reference
PMID:38391953
  Authors
Guerra-Espinosa C, Jimenez-Fernandez M, Sanchez-Madrid F, Serrador JM
  Title
ICAMs in Immunity, Intercellular Adhesion and Communication.
  Journal
Cells 13:cells13040339 (2024)
DOI:10.3390/cells13040339
Reference
PMID:15962512
  Authors
Turowski P, Adamson P, Greenwood J
  Title
Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation.
  Journal
Cell Mol Neurobiol 25:153-70 (2005)
DOI:10.1007/s10571-004-1380-0
Reference
PMID:37251372
  Authors
Farhangnia P, Ghomi SM, Mollazadehghomi S, Nickho H, Akbarpour M, Delbandi AA
  Title
SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy.
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Front Immunol 14:1174138 (2023)
DOI:10.3389/fimmu.2023.1174138
Reference
PMID:40382610
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Li J, Fan T, Wang D, Xiao C, Deng Z, Cai W, Ji Y, Li C, He J
  Title
SLAMF receptors: key regulators of tumor progression and emerging targets for cancer immunotherapy.
  Journal
Mol Cancer 24:145 (2025)
DOI:10.1186/s12943-025-02308-8
Reference
PMID:38279272
  Authors
Ciesielska-Figlon K, Lisowska KA
  Title
The Role of the CD28 Family Receptors in T-Cell Immunomodulation.
  Journal
Int J Mol Sci 25:ijms25021274 (2024)
DOI:10.3390/ijms25021274
Reference
PMID:24595739
  Authors
Garrido-Urbani S, Bradfield PF, Imhof BA
  Title
Tight junction dynamics: the role of junctional adhesion molecules (JAMs).
  Journal
Cell Tissue Res 355:701-15 (2014)
DOI:10.1007/s00441-014-1820-1
Reference
PMID:34966732
  Authors
Cornejo F, Cortes BI, Findlay GM, Cancino GI
  Title
LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain.
  Journal
Front Cell Dev Biol 9:659951 (2021)
DOI:10.3389/fcell.2021.659951
Reference
PMID:23916315
  Authors
Um JW, Ko J
  Title
LAR-RPTPs: synaptic adhesion molecules that shape synapse development.
  Journal
Trends Cell Biol 23:465-75 (2013)
DOI:10.1016/j.tcb.2013.07.004
Reference
PMID:36867287
  Authors
Hermans D, Rodriguez-Mogeda C, Kemps H, Bronckaers A, de Vries HE, Broux B
  Title
Nectins and Nectin-like molecules drive vascular development and barrier function.
  Journal
Angiogenesis 26:349-362 (2023)
DOI:10.1007/s10456-023-09871-y
Reference
PMID:40025835
  Authors
Yadav SS, Srinivasan K, Sharma SS, Datusalia AK
  Title
Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders.
  Journal
ACS Chem Neurosci 16:1000-1020 (2025)
DOI:10.1021/acschemneuro.5c00069
Related
pathway
lcat04014  Ras signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04360  Axon guidance
lcat04510  Focal adhesion
lcat04514  Cell adhesion molecule (CAM) interaction
lcat04520  Adherens junction
lcat04530  Tight junction
lcat04660  T cell receptor signaling pathway
lcat04670  Leukocyte transendothelial migration
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko04517   

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