KEGG   PATHWAY: nsu04510
Entry
nsu04510                    Pathway                                
Name
Focal adhesion - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nsu04510  Focal adhesion
nsu04510

Other DBs
GO: 0005925
Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110569652  CTNNB1; catenin beta-1 [KO:K02105]
110569664  ITGA9; integrin alpha-9 [KO:K06585]
110569766  MYL5; myosin light chain 5 [KO:K12753]
110569873  LAMA5; laminin subunit alpha-5 [KO:K06240]
110570210  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110570379  ITGB3; integrin beta-3 [KO:K06493]
110570410  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110570444  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
110570517  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
110570596  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
110570611  RAP1B; ras-related protein Rap-1b [KO:K07836]
110570657  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
110570658  [KO:K06238]
110570750  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110570948  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
110571035  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
110571294  [KO:K04513]
110571384  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
110571415  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
110571448  PGF; placenta growth factor isoform X2 [KO:K16859]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571716  ACTN1; alpha-actinin-1 [KO:K05699]
110571958  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110572001  ACTB; actin, cytoplasmic 1 [KO:K05692]
110572341  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
110572370  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110572418  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110572558  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110572597  [KO:K12757]
110572604  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110572650  VEGFD; vascular endothelial growth factor D [KO:K05449]
110572663  [KO:K04392]
110572770  [KO:K06274]
110572924  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
110573267  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
110573481  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
110573574  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110573626  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110573994  TNR; tenascin-R isoform X1 [KO:K06252]
110574078  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
110574097  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
110574114  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110574201  LAMC1; laminin subunit gamma-1 [KO:K05635]
110574213  TNN; tenascin-N [KO:K06252]
110574240  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110574287  LAMB1; laminin subunit beta-1 [KO:K05636]
110574288  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
110574310  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
110574312  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
110574410  [KO:K04659]
110574483  FLNA; filamin-A isoform X1 [KO:K04437]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  [KO:K02649]
110575086  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110575167  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110575423  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
110575510  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
110575938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
110575945  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110576035  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110576391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110576525  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
110576574  PARVA; alpha-parvin [KO:K06275]
110576795  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
110576827  [KO:K12757]
110576828  [KO:K12757]
110576837  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
110576845  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
110576957  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
110577050  [KO:K04393]
110577152  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
110577274  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
110577355  [KO:K04725] [EC:2.3.2.27]
110577390  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
110577463  ITGA5; integrin alpha-5 [KO:K06484]
110577506  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110577553  RHOA; transforming protein RhoA [KO:K04513]
110577559  LAMB2; laminin subunit beta-2 [KO:K06243]
110577746  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
110578055  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110578113  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110578163  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110578277  PARVB; beta-parvin [KO:K06275]
110578278  PARVG; gamma-parvin [KO:K06275]
110578336  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110578344  CRKL; crk-like protein isoform X1 [KO:K04438]
110578563  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
110578587  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110579255  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
110579436  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110579470  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110579592  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
110579699  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
110579928  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110580084  ITGB8; integrin beta-8 [KO:K06591]
110580160  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110580280  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110580283  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
110580572  RAP1A; ras-related protein Rap-1A [KO:K04353]
110580662  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
110580753  VWF; von Willebrand factor [KO:K03900]
110580853  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110580973  EMP1; epithelial membrane protein 1 [KO:K26255]
110581363  TNC; tenascin [KO:K06252]
110581425  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
110581482  TLN1; talin-1 [KO:K06271]
110581544  LAMC3; laminin subunit gamma-3 [KO:K06247]
110581631  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
110581886  ITGB4; integrin beta-4 [KO:K06525]
110581991  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110582036  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110582103  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
110582206  HRAS; GTPase HRas isoform X1 [KO:K02833]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110582355  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110582565  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
110582708  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
110582720  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110582747  ZYX; zyxin [KO:K06273]
110582758  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110583019  THBS2; thrombospondin-2 [KO:K04659]
110583252  LAMA2; laminin subunit alpha-2 [KO:K05637]
110583670  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
110583696  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
110583735  ITGA11; integrin alpha-11 [KO:K06587]
110583812  TLN2; talin-2 isoform X1 [KO:K06271]
110584023  SHC4; SHC-transforming protein 4 [KO:K17449]
110584045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110584200  VEGFC; vascular endothelial growth factor C [KO:K05449]
110584282  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
110584374  SHC3; SHC-transforming protein 3 [KO:K17448]
110584443  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
110584758  FLNB; filamin-B isoform X1 [KO:K27392]
110584860  CAV3; caveolin-3 [KO:K12959]
110584928  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110585136  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
110585214  ITGA1; integrin alpha-1 [KO:K06480]
110585240  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110585587  THBS1; thrombospondin-1 [KO:K16857]
110585841  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
110585858  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
110586349  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
110586350  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
110586385  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110586470  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
110586749  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110586782  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110586907  TNXB; tenascin-X [KO:K06252]
110587156  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110587287  [KO:K12757]
110587399  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
110587585  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110587808  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
110587954  EMP2; epithelial membrane protein 2 [KO:K26256]
110588228  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
110588340  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110588527  PDGFC; platelet-derived growth factor C [KO:K05450]
110588887  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110588903  CAV2; caveolin-2 isoform X1 [KO:K12958]
110588982  CAV1; caveolin-1 isoform X1 [KO:K06278]
110589275  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
110589609  VCL; vinculin isoform X2 [KO:K05700]
110589690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110589825  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110589851  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
110589911  MYL10; myosin regulatory light chain 10 [KO:K12756]
110589982  ITGA2; integrin alpha-2 [KO:K06481]
110590081  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590342  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
110590530  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110590753  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110590873  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110591296  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
110591392  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110591433  SPP1; osteopontin isoform X2 [KO:K06250]
110591437  [KO:K06253]
110591806  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
110591950  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
110592014  ITGA4; integrin alpha-4 [KO:K06483]
110592022  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
110592312  FN1; fibronectin isoform X1 [KO:K05717]
110592349  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
110592586  PXN; paxillin isoform X1 [KO:K05760]
110592602  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
110592687  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110592745  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
110592861  ITGA3; integrin alpha-3 [KO:K06482]
110592943  CRK; adapter molecule crk isoform X1 [KO:K04438]
110592960  VTN; vitronectin [KO:K06251]
110593078  COL1A1; collagen alpha-1(I) chain [KO:K06236]
110593180  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X5 [KO:K05083] [EC:2.7.10.1]
110593282  CHAD; chondroadherin [KO:K06248]
110593463  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110593502  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
110593623  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
110594070  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
110594105  SHC2; SHC-transforming protein 2 [KO:K17447]
110594122  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
123323805  [KO:K02833]
123325993  [KO:K04393]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
nsu04010  MAPK signaling pathway
nsu04060  Cytokine-cytokine receptor interaction
nsu04070  Phosphatidylinositol signaling system
nsu04110  Cell cycle
nsu04151  PI3K-Akt signaling pathway
nsu04310  Wnt signaling pathway
nsu04512  ECM-receptor interaction
nsu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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