KEGG   PATHWAY: nsu04010
Entry
nsu04010                    Pathway                                
Name
MAPK signaling pathway - Neomonachus schauinslandi (Hawaiian monk seal)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
nsu04010  MAPK signaling pathway
nsu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110569660  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
110569786  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110569991  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
110570210  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110570244  FGF9; fibroblast growth factor 9 [KO:K04358]
110570275  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110570388  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X2 [KO:K04421] [EC:2.7.11.25]
110570407  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
110570408  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
110570409  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
110570410  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110570428  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
110570453  MAPT; microtubule-associated protein tau isoform X2 [KO:K04380]
110570547  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
110570611  RAP1B; ras-related protein Rap-1b [KO:K07836]
110570715  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
110570742  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110570821  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
110570864  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110571297  [KO:K05866] [EC:3.1.3.48]
110571415  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
110571448  PGF; placenta growth factor isoform X2 [KO:K16859]
110571456  FOS; proto-oncogene c-Fos [KO:K04379]
110571460  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110571461  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
110571509  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
110571621  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571814  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
110571845  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110571937  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
110571958  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110572074  IL1R1; LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386]
110572075  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
110572107  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
110572137  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110572155  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110572341  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
110572370  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110572418  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110572604  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110572635  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
110572650  VEGFD; vascular endothelial growth factor D [KO:K05449]
110572663  [KO:K04392]
110572759  RELB; transcription factor RelB [KO:K09253]
110572791  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
110572846  FGF21; LOW QUALITY PROTEIN: fibroblast growth factor 21 [KO:K22429]
110572858  NTF4; neurotrophin-4 [KO:K12457]
110572873  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110572880  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
110573062  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
110573154  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110573165  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110573171  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110573200  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
110573455  [KO:K03176] [EC:2.7.10.1]
110573487  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
110573566  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
110573567  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
110573590  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
110573626  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110573628  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
110573702  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
110573703  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
110573846  [KO:K04442] [EC:2.7.11.1]
110573851  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
110573862  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110573949  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
110574012  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110574092  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110574194  IKBKG; NF-kappa-B essential modulator [KO:K07210]
110574204  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
110574245  [KO:K03283]
110574421  JUND; transcription factor jun-D [KO:K04449]
110574483  FLNA; filamin-A isoform X1 [KO:K04437]
110574588  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110574775  STMN1; stathmin [KO:K04381]
110575020  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
110575086  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
110575141  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110575167  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110575189  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
110575399  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
110575510  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
110575583  DAXX; death domain-associated protein 6 isoform X2 [KO:K02308]
110575614  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
110575674  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110575938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
110575951  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
110575955  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
110575984  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
110575986  RELA; transcription factor p65 [KO:K04735]
110576064  FGF4; fibroblast growth factor 4 [KO:K04358]
110576067  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
110576079  IGF2; insulin-like growth factor II [KO:K13769]
110576080  INS; insulin [KO:K04526]
110576187  [KO:K04414] [EC:2.7.11.1]
110576212  FGF19; fibroblast growth factor 19 [KO:K22603]
110576213  FGF3; fibroblast growth factor 3 [KO:K04358]
110576276  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110576593  RRAS2; ras-related protein R-Ras2 [KO:K07830]
110576632  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
110576669  BDNF; brain-derived neurotrophic factor [KO:K04355]
110576910  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110577050  [KO:K04393]
110577249  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
110577280  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
110577397  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
110577506  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110577527  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
110577533  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
110577612  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
110577757  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110577775  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
110577941  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110577997  KITLG; kit ligand [KO:K05461]
110577999  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
110578055  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110578102  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
110578105  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
110578113  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110578163  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110578169  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110578173  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110578262  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
110578302  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578303  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578336  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110578344  CRKL; crk-like protein isoform X1 [KO:K04438]
110578384  FGF16; fibroblast growth factor 16 [KO:K04358]
110578785  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
110578833  ARTN; artemin [KO:K25415]
110578930  MYC; myc proto-oncogene protein [KO:K04377]
110579145  STK3; serine/threonine-protein kinase 3 [KO:K04412]
110579344  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
110579420  ANGPT4; angiopoietin-4 [KO:K05467]
110579448  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
110580141  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
110580160  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110580280  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110580283  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
110580319  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110580342  NRAS; GTPase NRas [KO:K07828]
110580497  NGF; beta-nerve growth factor [KO:K02582]
110580572  RAP1A; ras-related protein Rap-1A [KO:K04353]
110580659  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
110580741  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
110580858  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110580861  KRAS; GTPase KRas isoform X1 [KO:K07827]
110580878  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110580991  NTF3; neurotrophin-3 [KO:K04356]
110581002  FGF23; fibroblast growth factor 23 [KO:K22428]
110581023  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110581035  FGF6; fibroblast growth factor 6 [KO:K04358]
110581190  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
110581233  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110581302  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
110581497  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
110581718  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110581974  SRF; serum response factor isoform X1 [KO:K04378]
110581991  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110582206  HRAS; GTPase HRas isoform X1 [KO:K02833]
110582212  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110582355  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110582357  MAP3K13; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
110582733  [KO:K04723]
110582758  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110583064  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
110583155  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
110583163  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
110583336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
110583654  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
110583815  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
110583827  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110584045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110584084  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110584089  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
110584200  VEGFC; vascular endothelial growth factor C [KO:K05449]
110584236  FGF20; fibroblast growth factor 20 [KO:K04358]
110584268  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
110584301  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
110584435  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110584444  TP53; cellular tumor antigen p53 [KO:K04451]
110584510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
110584511  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
110584596  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
110584761  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
110584803  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110584928  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110585062  DUSP7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110585416  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110585417  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
110585419  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
110585435  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110585551  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
110585644  [KO:K04453]
110585725  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
110585971  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110586000  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
110586138  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
110586368  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
110586385  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110586488  FGF10; fibroblast growth factor 10 [KO:K04358]
110586569  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
110586650  [KO:K03283]
110586713  TNF; tumor necrosis factor [KO:K03156]
110586749  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110586849  [KO:K03283]
110586850  [KO:K03283]
110586857  [KO:K03283]
110587156  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110587160  IL1B; interleukin-1 beta [KO:K04519]
110587162  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
110587286  RASGRP3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
110587400  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110587564  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
110587626  [KO:K04347]
110587797  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
110587886  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
110588038  FGF18; fibroblast growth factor 18 [KO:K04358]
110588080  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
110588122  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110588137  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
110588176  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
110588213  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
110588368  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
110588399  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110588527  PDGFC; platelet-derived growth factor C [KO:K05450]
110588591  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110588665  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110588681  [KO:K04347]
110588715  TGFA; protransforming growth factor alpha [KO:K08774]
110588763  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
110588887  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110589011  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
110589069  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110589202  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
110589205  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110589216  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110589447  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110589506  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
110589690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110589703  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110589758  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
110589825  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110589935  HSPB1; heat shock protein beta-1 [KO:K04455]
110590079  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
110590084  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
110590120  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110590249  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590253  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
110590366  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
110590511  MAX; protein max isoform X1 [KO:K04453]
110590530  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110590625  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
110590694  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
110590753  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110590818  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110590873  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110590962  RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
110590990  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110591020  CD14; monocyte differentiation antigen CD14 [KO:K04391]
110591245  [KO:K16510] [EC:2.7.11.1]
110591252  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
110591375  EREG; proepiregulin [KO:K09784]
110591392  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110591486  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110591506  AREG; amphiregulin [KO:K09782]
110591643  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
110591893  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
110592019  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
110592356  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
110592390  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110592572  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
110592687  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110592729  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110592800  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110592808  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
110592921  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
110592943  CRK; adapter molecule crk isoform X1 [KO:K04438]
110593075  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
110593082  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
110593102  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110593180  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X5 [KO:K05083] [EC:2.7.10.1]
110593313  TAOK1; serine/threonine-protein kinase TAO1 isoform X2 [KO:K04429] [EC:2.7.11.1]
110593352  ARRB1; beta-arrestin-1 [KO:K04439]
110593463  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110593539  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
110593540  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
110593647  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
110593671  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110593734  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110593738  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
110593751  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
110593832  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
110593844  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
110593849  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110593959  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
110593961  [KO:K25414]
110594058  PSPN; persephin [KO:K25416]
110594092  EFNA2; ephrin-A2 [KO:K05462]
110594123  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110594240  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123323631  [KO:K03176] [EC:2.7.10.1]
123323805  [KO:K02833]
123323821  [KO:K25414]
123323854  [KO:K04414] [EC:2.7.11.1]
123325993  [KO:K04393]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Genes Cells 7:1099-111 (2002)
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
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PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
nsu04070  Phosphatidylinositol signaling system
nsu04110  Cell cycle
nsu04115  p53 signaling pathway
nsu04210  Apoptosis
nsu04310  Wnt signaling pathway
nsu04668  TNF signaling pathway
KO pathway
ko04010   

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