KEGG   PATHWAY: oaa04810
Entry
oaa04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Ornithorhynchus anatinus (platypus)
Class
Cellular Processes; Cell motility
Pathway map
oaa04810  Regulation of actin cytoskeleton
oaa04810

Other DBs
GO: 0030036
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100077696  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
114812808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
114807801  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100082099  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
100079713  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100081028  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
114813183  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
114810063  INS; insulin [KO:K04526]
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100078822  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114815531  FGF2; fibroblast growth factor 2 [KO:K18497]
100075228  FGF4; fibroblast growth factor 4 [KO:K04358]
100075300  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
100089319  FGF9; fibroblast growth factor 9 [KO:K04358]
100073730  FGF5; fibroblast growth factor 5 [KO:K04358]
100093377  FGF18; fibroblast growth factor 18 [KO:K04358]
100089414  FGF22; fibroblast growth factor 22 [KO:K04358]
100088500  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100089135  FGF20; fibroblast growth factor 20 [KO:K04358]
100080372  FGF8; fibroblast growth factor 8 [KO:K04358]
100075757  FGF10; fibroblast growth factor 10 [KO:K04358]
103165700  FGF6; fibroblast growth factor 6 [KO:K04358]
100084373  FGF16; fibroblast growth factor 16 [KO:K04358]
114813732  FGF7; fibroblast growth factor 7 [KO:K04358]
100075189  FGF19; fibroblast growth factor 19 [KO:K22603]
114807786  FGF23; fibroblast growth factor 23 [KO:K22428]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100681708  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100074240  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100084641  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100084071  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100081967  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100078116  FN1; fibronectin isoform X5 [KO:K05717]
100085556  ITGA1; integrin alpha-1 [KO:K06480]
100076348  ITGA2; integrin alpha-2 [KO:K06481]
114815046  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
100080433  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100085588  ITGA4; integrin alpha-4 [KO:K06483]
100090507  ITGA5; integrin alpha-5 [KO:K06484]
100084141  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100087799  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100077343  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100086578  ITGA9; integrin alpha-9 [KO:K06585]
100088855  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
100085786  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100085661  ITGAV; integrin alpha-V [KO:K06487]
100090742  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100085462  integrin alpha-M isoform X3 [KO:K06461]
100084666  integrin alpha-X-like [KO:K06462]
100077899  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100092394  ITGB2; integrin beta-2 [KO:K06464]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100090852  ITGB4; integrin beta-4 [KO:K06525]
100083529  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100081941  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
100087765  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100084596  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100680799  KNG1; kininogen-1 isoform X1 [KO:K03898]
100081162  BDKRB1; B1 bradykinin receptor [KO:K03915]
100081132  BDKRB2; B2 bradykinin receptor [KO:K03916]
100086064  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
114815970  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04129]
100075952  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100084007  CHRM3; muscarinic acetylcholine receptor M3 isoform X2 [KO:K04131]
100085485  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
100681650  C5; complement C5 [KO:K03994]
100075246  C6; complement component C6 isoform X1 [KO:K03995]
100088665  C7; complement component C7 isoform X1 [KO:K03996]
100090039  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
100081005  C8B; complement component C8 beta chain [KO:K03998]
100075936  C9; complement component C9 [KO:K04000]
100082592  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103166871  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
100078907  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100081920  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100079139  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
100084520  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X2 [KO:K05722]
100076789  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100085802  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100092854  CRK; adapter molecule crk isoform X1 [KO:K04438]
100076081  CRKL; crk-like protein [KO:K04438]
103169480  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
107547224  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
114814624  RRAS; ras-related protein R-Ras [KO:K07829]
100090494  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103169212  MRAS; ras-related protein M-Ras [KO:K07831]
100083576  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100075831  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100073433  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100085604  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100088712  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100084423  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100086380  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100083505  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100076158  RGCC; regulator of cell cycle RGCC [KO:K26108]
100680878  regulator of cell cycle RGCC-like [KO:K26108]
100078658  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
100073922  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100079765  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100079193  transforming protein RhoA-like [KO:K04513]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100092844  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114808823  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100086186  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100086384  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100075896  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100073584  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
103169124  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100084350  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100084781  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100084578  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
103167582  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
100079648  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100073941  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100092442  MYLK3; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100091283  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
100079091  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100074395  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X3 [KO:K06269] [EC:3.1.3.16]
100078635  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100092226  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100077235  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100077407  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100087416  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
100074559  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100083806  MYL5; myosin light chain 5 [KO:K12753]
100091153  myosin regulatory light chain 2, atrial isoform [KO:K12754]
114815109  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100073924  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100073541  MYL10; myosin regulatory light chain 10 [KO:K12756]
100092114  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
100088546  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100074328  MYH9; myosin-9 [KO:K10352]
100681420  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
100682142  MYH10; myosin-10 isoform X1 [KO:K10352]
100086990  MYH11; myosin-11 isoform X2 [KO:K10352]
100092243  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
100081978  DIAPH2; LOW QUALITY PROTEIN: protein diaphanous homolog 2 [KO:K05741]
100088668  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100074263  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100080469  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103168955  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
100079689  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
100680666  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
100090187  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
100076756  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100079954  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100074515  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
100078701  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
100093411  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
100081889  ENAH; protein enabled homolog isoform X1 [KO:K05746]
100076423  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
100681465  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
100075880  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
100075972  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
100085340  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
100083674  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
100074766  ABI2; abl interactor 2 isoform X8 [KO:K05751]
114806611  BRK1; protein BRICK1 [KO:K05752]
100075943  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
100082798  ACTR2; actin-related protein 2 [KO:K17260]
100082329  ACTR3B; actin-related protein 3B [KO:K18584]
114813209  ACTR3; actin-related protein 3 [KO:K18584]
100078800  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100078836  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100085685  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100073901  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100681488  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
100078118  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100081992  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100085078  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100092493  actin, cytoplasmic type 5 [KO:K05692]
100078865  ACTB; actin, cytoplasmic 1 [KO:K05692]
100087807  PFN3; profilin-3 [KO:K05759]
100076098  PFN2; profilin-2 isoform X1 [KO:K05759]
100078341  PFN4; profilin-4 isoform X2 [KO:K05759]
114808039  PFN1; profilin-1 [KO:K05759]
100092267  PXN; paxillin isoform X1 [KO:K05760]
100090068  EZR; ezrin [KO:K08007]
100076248  RDX; radixin isoform X1 [KO:K05762]
100089510  MSN; moesin [KO:K05763]
100082242  TMSB4X; thymosin beta-4 [KO:K05764]
100081338  CFL2; LOW QUALITY PROTEIN: cofilin-2 [KO:K05765]
114810163  CFL1; cofilin-1 [KO:K05765]
100079088  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100076705  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103167640  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100075715  VCL; vinculin isoform X1 [KO:K05700]
100085128  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100083169  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
103168426  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
100081862  GSN; gelsolin isoform X1 [KO:K05768]
100079687  SCIN; adseverin isoform X1 [KO:K05768]
100089387  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103165750  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100082114  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100682203  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
100077858  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
100090035  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
oaa04010  MAPK signaling pathway
oaa04510  Focal adhesion
oaa04520  Adherens junction
KO pathway
ko04810   
LinkDB

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