KEGG   PATHWAY: btax05205
Entry
btax05205                   Pathway                                
Name
Proteoglycans in cancer - Budorcas taxicolor (takin)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
btax05205  Proteoglycans in cancer
btax05205

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128059811  CD44; CD44 antigen isoform X1 [KO:K06256]
128058174  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128047701  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
128068664  CTTN; src substrate cortactin isoform X1 [KO:K06106]
128064538  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128050828  VAV1; proto-oncogene vav [KO:K05730]
128044678  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
128055501  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128047937  KRAS; GTPase KRas [KO:K07827]
128044537  NRAS; GTPase NRas [KO:K07828]
128063078  RRAS; ras-related protein R-Ras [KO:K07829]
128060054  RRAS2; ras-related protein R-Ras2 [KO:K07830]
128044902  MRAS; ras-related protein M-Ras [KO:K07831]
128046969  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128070468  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128066364  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
128066401  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128070470  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
128053203  ESR1; estrogen receptor isoform X1 [KO:K08550]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128043956  ACTB; actin, cytoplasmic 1 [KO:K05692]
128064385  ACTG1; actin, cytoplasmic 2 [KO:K05692]
128070229  FLNA; filamin-A isoform X1 [KO:K04437]
128068496  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
128047488  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
128063153  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
128044567  RHOA; transforming protein RhoA [KO:K04513]
128067328  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
128055373  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
128068405  ANK1; ankyrin-1 [KO:K10380]
128049449  ANK2; ankyrin-2 [KO:K09255]
128048871  ANK3; ankyrin-3 [KO:K09259]
128062226  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128063641  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
128055125  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
128062181  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
128068503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
128047405  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
128061235  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
128063185  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
128060102  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
128067818  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128050399  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
128047085  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
128047602  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
128049625  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
128048658  NANOG; homeobox protein NANOG [KO:K10164]
128064738  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
128065980  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
128065049  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
128045451  TWIST2; twist-related protein 2 [KO:K09069]
128046773  TWIST1; twist-related protein 1 [KO:K09069]
128043374  HOXD10; homeobox protein Hox-D10 [KO:K09295]
128047380  DCN; decorin [KO:K04660]
128048032  IGF1; insulin-like growth factor I [KO:K05459]
128066571  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128060129  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
128064578  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
128068526  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
128047355  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
128067666  eukaryotic translation initiation factor 4B-like [KO:K03258]
128052165  RPS6; 40S ribosomal protein S6 [KO:K02991]
128055152  40S ribosomal protein S6 [KO:K02991]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128046440  CAV1; caveolin-1 isoform X1 [KO:K06278]
128046728  CAV2; caveolin-2 [KO:K12958]
128046664  CAV3; caveolin-3 [KO:K12959]
128069659  CD63 antigen-like [KO:K06497]
128047713  CD63; CD63 antigen [KO:K06497]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128063320  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128062410  TLR2; toll-like receptor 2 [KO:K10159]
128052396  TLR4; toll-like receptor 4 [KO:K10160]
128067814  PDCD4; programmed cell death protein 4 [KO:K16865]
128056772  TNF; tumor necrosis factor [KO:K03156]
128051514  IL12B; interleukin-12 subunit beta [KO:K05425]
128047384  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128061017  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128058237  CTNNB1; catenin beta-1 [KO:K02105]
128053931  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
128071424  TFAP4; transcription factor AP-4 [KO:K09108]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128049477  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128046469  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128060264  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
128048919  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
128054540  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
128062791  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
128058597  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
128048005  LUM; lumican [KO:K08122]
128061812  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128067871  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128047314  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
128049822  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128061503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128067292  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
128049931  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
128067914  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
128056498  SDC1; syndecan-1 [KO:K06257]
128047779  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
128063594  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
128065257  COL1A1; collagen alpha-1(I) chain [KO:K06236]
128046458  COL1A2; collagen alpha-2(I) chain [KO:K06236]
128066170  ITGA2; integrin alpha-2 [KO:K06481]
128058839  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128065568  VTN; vitronectin [KO:K06251]
128061467  ITGAV; integrin alpha-V [KO:K06487]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128071425  fibronectin-like [KO:K05717]
128068063  FN1; fibronectin isoform X1 [KO:K05717]
128061565  ITGB5; integrin beta-5 [KO:K06588]
128046678  HGF; hepatocyte growth factor [KO:K05460]
128048884  WNT1; proto-oncogene Wnt-1 [KO:K03209]
128070496  FZD7; frizzled-7 [KO:K02432]
128046799  FZD1; frizzled-1 [KO:K02432]
128065200  FZD2; frizzled-2 [KO:K02235]
128052483  FZD3; frizzled-3 [KO:K02329]
128068654  FZD4; frizzled-4 [KO:K02354]
128071105  frizzled-5 [KO:K02375]
128058547  FZD8; frizzled-8 [KO:K02375]
128065941  FZD5; frizzled-5 [KO:K02375]
128059374  FZD6; frizzled-6 [KO:K02376]
128043337  FZD9; frizzled-9 [KO:K02842]
128062458  FZD10; frizzled-10 [KO:K02842]
128048841  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
128059550  SDC2; syndecan-2 isoform X1 [KO:K16336]
128053049  EZR; ezrin [KO:K08007]
128059812  RDX; radixin [KO:K05762]
128070048  MSN; moesin [KO:K05763]
128058528  SDC4; syndecan-4 [KO:K16338]
128062082  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
128068375  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128048439  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
128062064  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
128061515  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128058189  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
128063111  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128043270  NUDT16L1; tudor-interacting repair regulator protein [KO:K16867]
128062630  PXN; paxillin isoform X1 [KO:K05760]
128059235  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128050714  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
128044909  GPC1; glypican-1 [KO:K08107]
128068647  IGF2; insulin-like growth factor II [KO:K13769]
128069849  GPC3; glypican-3 [KO:K08109]
128044967  WNT2B; protein Wnt-2b [KO:K00182]
128046758  WNT2; protein Wnt-2 [KO:K00182]
128051398  WNT3A; protein Wnt-3a [KO:K00312]
128065491  WNT3; proto-oncogene Wnt-3 [KO:K00312]
128064929  WNT4; protein Wnt-4 [KO:K00408]
128051429  WNT5A; protein Wnt-5a [KO:K00444]
128047274  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
128043631  WNT6; protein Wnt-6 [KO:K00445]
128054243  WNT7A; protein Wnt-7a [KO:K00572]
128048826  WNT7B; protein Wnt-7b [KO:K00572]
128051617  WNT8A; protein Wnt-8a [KO:K00714]
128067661  WNT8B; protein Wnt-8b [KO:K00714]
128051174  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
128065456  WNT9B; protein Wnt-9b [KO:K01064]
128043684  WNT10A; protein Wnt-10a [KO:K01357]
128048628  WNT10B; protein Wnt-10b [KO:K01357]
128060249  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
128046389  WNT16; protein Wnt-16 [KO:K01558]
128046961  SHH; sonic hedgehog protein [KO:K11988]
128043611  IHH; indian hedgehog protein [KO:K11989]
128052308  PTCH1; protein patched homolog 1 [KO:K06225]
128046623  SMO; smoothened homolog isoform X1 [KO:K06226]
128043424  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
128052286  procathepsin L [KO:K01365] [EC:3.4.22.15]
128052428  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128061000  HSPB2; heat shock protein beta-2 [KO:K09543]
128047743  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
btax04010  MAPK signaling pathway
btax04020  Calcium signaling pathway
btax04066  HIF-1 signaling pathway
btax04150  mTOR signaling pathway
btax04151  PI3K-Akt signaling pathway
btax04210  Apoptosis
btax04310  Wnt signaling pathway
btax04340  Hedgehog signaling pathway
btax04350  TGF-beta signaling pathway
btax04370  VEGF signaling pathway
btax04510  Focal adhesion
btax04520  Adherens junction
btax04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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