KEGG   PATHWAY: cata04810
Entry
cata04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Cygnus atratus (black swan)
Class
Cellular Processes; Cell motility
Pathway map
cata04810  Regulation of actin cytoskeleton
cata04810

Other DBs
GO: 0030036
Organism
Cygnus atratus (black swan) [GN:cata]
Gene
118257021  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
118261069  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
118245449  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
118260970  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
118249306  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
118252579  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118244272  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
118251420  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
118244761  INS; insulin [KO:K04526]
118254590  EGF; pro-epidermal growth factor [KO:K04357]
118254886  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118251228  FGF2; fibroblast growth factor 2 [KO:K18497]
118247617  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
118260053  FGF22; fibroblast growth factor 22 [KO:K04358]
118248655  FGF8; fibroblast growth factor 8 [KO:K04358]
118256164  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
118256023  FGF17; fibroblast growth factor 17 [KO:K04358]
118250779  FGF3; fibroblast growth factor 3 isoform X1 [KO:K04358]
118250820  FGF4; fibroblast growth factor 4 [KO:K04358]
118250874  FGF5; fibroblast growth factor 5 [KO:K04358]
118245199  FGF20; fibroblast growth factor 20 [KO:K04358]
118245387  FGF16; fibroblast growth factor 16 [KO:K04358]
118251706  FGF7; fibroblast growth factor 7 isoform X2 [KO:K04358]
118257796  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
118245958  FGF9; fibroblast growth factor 9 [KO:K04358]
118250765  FGF19; fibroblast growth factor 19 [KO:K22603]
118247709  FGF23; fibroblast growth factor 23 [KO:K22428]
118249111  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118250471  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
118249045  PDGFC; platelet-derived growth factor C [KO:K05450]
118245944  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118258617  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
118250916  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118256011  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118248680  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118248370  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118254384  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118248600  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118260560  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118243103  FN1; fibronectin isoform X1 [KO:K05717]
118260105  ITGA1; integrin alpha-1 [KO:K06480]
118260104  ITGA2; integrin alpha-2 [KO:K06481]
118258290  ITGA2B; integrin alpha-IIb [KO:K06476]
118259138  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
118259798  ITGA4; integrin alpha-4 [KO:K06483]
118258934  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118261026  ITGA7; integrin alpha-7 [KO:K06583]
118247363  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
118250954  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
118261574  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
118259686  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
118259181  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118255071  ITGAE; integrin alpha-E [KO:K06524]
118247524  ITGB1; integrin beta-1 [KO:K05719]
118260399  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
118258887  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
118253873  ITGB4; integrin beta-4 [KO:K06525]
118243059  ITGB5; integrin beta-5 [KO:K06588]
118243089  ITGB6; integrin beta-6 [KO:K06589]
118255920  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
118253176  KNG1; kininogen-1 [KO:K03898]
118244575  BDKRB1; B1 bradykinin receptor [KO:K03915]
118244604  BDKRB2; B2 bradykinin receptor [KO:K03916]
118259206  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118254916  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118244472  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
118244610  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118252322  C5; complement C5 [KO:K03994]
118257783  C6; complement component C6 [KO:K03995]
118257791  C7; complement component C7 [KO:K03996]
118243533  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
118243625  C8B; LOW QUALITY PROTEIN: complement component C8 beta chain [KO:K03998]
118260732  C8G; complement component C8 gamma chain [KO:K03999]
118256713  C9; complement component C9 [KO:K04000]
118249105  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
118253924  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
118256969  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118253637  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
118255495  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
118246530  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
118254099  CRK; adapter molecule crk isoform X1 [KO:K04438]
118252963  CRKL; crk-like protein [KO:K04438]
118248567  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
118248896  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
118250305  SOS2; son of sevenless homolog 2 [KO:K03099]
118251111  SOS1; son of sevenless homolog 1 [KO:K03099]
118250718  HRAS; GTPase HRas [KO:K02833]
118245139  KRAS; GTPase KRas isoform X1 [KO:K07827]
118255298  NRAS; GTPase NRas [KO:K07828]
118249900  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
118261251  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
118245498  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
118247018  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118253156  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118253338  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118243598  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118251494  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
118258749  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118243477  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
118261167  VAV1; proto-oncogene vav [KO:K05730]
118252197  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
118247646  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X2 [KO:K05731]
118259202  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
118253692  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118251269  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
118252022  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118258785  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118252877  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118261257  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118250209  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118256722  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118251327  RGCC; regulator of cell cycle RGCC [KO:K26108]
118245391  regulator of cell cycle RGCC-like [KO:K26108]
118252551  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
118261626  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
118261154  RHOA; transforming protein RhoA [KO:K04513]
118249373  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
118250700  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118259247  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118258809  CDC42; cell division control protein 42 homolog [KO:K04393]
118254800  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118247234  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118245566  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
118261462  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
118251177  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118244683  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
118253098  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
118255090  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
118256775  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118255936  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118243109  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
118251060  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
118258395  MYLK2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118246333  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
118258235  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
118256031  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118244447  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
118257540  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
118246795  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
118255436  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
118257545  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
118248803  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
118254151  MYL10; myosin regulatory light chain 10 [KO:K12756]
118256818  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
118256819  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
118261518  MYL11; myosin regulatory light chain 11 [KO:K12758]
118249065  MYH11; myosin-11 isoform X1 [KO:K10352]
118255544  MYH10; myosin-10 isoform X2 [KO:K10352]
118250660  MYH9; myosin-9 [KO:K10352]
118245605  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
118255811  SLC9A1; LOW QUALITY PROTEIN: sodium/hydrogen exchanger 1 [KO:K05742]
118253764  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
118260437  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
118258974  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
118247342  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
118259971  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
118243071  PIKFYVE; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
118254105  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
118252848  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
118251373  DIAPH3; LOW QUALITY PROTEIN: protein diaphanous homolog 3 [KO:K05745]
118259267  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2 [KO:K05627]
118253646  ENAH; protein enabled homolog isoform X2 [KO:K05746]
118254264  WASL; actin nucleation-promoting factor WASL [KO:K23612]
118255818  WASF2; actin-binding protein WASF2 isoform X3 [KO:K05748]
118253622  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
118254522  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
118243139  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
118261155  ABI2; abl interactor 2 isoform X1 [KO:K05751]
118261157  BRK1; protein BRICK1 [KO:K05752]
118257145  WASF1; actin-binding protein WASF1 [KO:K05753]
118251159  ACTR2; actin-related protein 2 [KO:K17260]
118251853  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
118252645  ACTR3; actin-related protein 3 [KO:K18584]
118256492  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
118256495  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
118243160  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
118257251  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
118248101  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
118243633  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
118252295  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
118256416  ACTB; LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
118258163  actin, cytoplasmic type 5 [KO:K05692]
118257979  PFN2; profilin-2 isoform X1 [KO:K05759]
118252897  PXN; paxillin isoform X1 [KO:K05760]
118243912  EZR; ezrin isoform X1 [KO:K08007]
118246018  RDX; radixin isoform X1 [KO:K05762]
118245636  MSN; moesin [KO:K05763]
118254919  thymosin beta-12-like [KO:K05764]
118245770  TMSB4X; thymosin beta-4 [KO:K05764]
118250719  CFL2; cofilin-2 isoform X1 [KO:K05765]
118255193  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
118244321  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
118257612  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
118246121  VCL; vinculin isoform X1 [KO:K05700]
118259406  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
118260695  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
118251419  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
118247496  SCIN; scinderin isoform X1 [KO:K05768]
118252325  GSN; gelsolin isoform X1 [KO:K05768]
118261467  ACTN4; alpha-actinin-4 [KO:K05699]
118244428  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
118260855  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
118255974  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118246929  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
118245861  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
cata04010  MAPK signaling pathway
cata04510  Focal adhesion
cata04520  Adherens junction
KO pathway
ko04810   
LinkDB

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