KEGG   PATHWAY: clud04510
Entry
clud04510                   Pathway                                
Name
Focal adhesion - Canis lupus dingo (dingo)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
clud04510  Focal adhesion
clud04510

Other DBs
GO: 0005925
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112674906  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112655086  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
112678247  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
112669820  COL4A4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
112669822  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
112649263  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
112649264  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112656116  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
112656117  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
112669237  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112669238  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
112661076  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
112661147  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
112661094  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
112669965  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112674244  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
112642312  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
112658392  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
112648045  LAMA1; laminin subunit alpha-1 [KO:K05637]
112644554  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
112647953  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
112674230  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
112658627  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
112661476  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
112665771  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
112648343  LAMB3; laminin subunit beta-3 [KO:K06244]
112661363  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
112648478  LAMC1; laminin subunit gamma-1 [KO:K05635]
112648481  LAMC2; laminin subunit gamma-2 [KO:K06246]
112677344  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
112655130  CHAD; chondroadherin [KO:K06248]
112661278  RELN; reelin [KO:K06249] [EC:3.4.21.-]
112676140  THBS1; thrombospondin-1 [KO:K16857]
112666762  cartilage oligomeric matrix protein [KO:K04659]
112644448  THBS2; thrombospondin-2 [KO:K04659]
112648934  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112653497  THBS4; thrombospondin-4 [KO:K04659]
112656719  FN1; fibronectin isoform X1 [KO:K05717]
112645608  SPP1; osteopontin isoform X1 [KO:K06250]
112677673  VTN; vitronectin [KO:K06251]
112648572  TNR; LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
112648576  TNN; tenascin-N isoform X1 [KO:K06252]
112649762  TNC; tenascin isoform X1 [KO:K06252]
112641331  TNXB; tenascin-X isoform X1 [KO:K06252]
112669074  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
112645619  bone sialoprotein 2 [KO:K06253]
112651694  ITGA1; integrin alpha-1 [KO:K06480]
112651978  ITGA2; integrin alpha-2 [KO:K06481]
112655470  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
112655049  ITGA3; integrin alpha-3 [KO:K06482]
112668203  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
112667148  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
112668097  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112678053  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112658818  ITGA8; integrin alpha-8 [KO:K06584]
112668768  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
112664057  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112675693  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
112668239  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
112679018  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
112652894  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
112672808  ITGB4; integrin beta-4 isoform X5 [KO:K06525]
112676939  ITGB5; integrin beta-5 [KO:K06588]
112674692  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112667269  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
112670545  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
112640385  EMP2; epithelial membrane protein 2 [KO:K26256]
112640154  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
112667672  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
112671430  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112654298  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
112671646  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112654388  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
112641644  VEGFA; vascular endothelial growth factor A [KO:K05448]
112659346  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112657742  PGF; placenta growth factor isoform X1 [KO:K16859]
112651106  VEGFC; vascular endothelial growth factor C [KO:K05449]
112653161  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
112661349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112652233  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112651939  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112653816  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112652118  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112661500  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112669481  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
112659573  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112670796  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
112655065  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
112665419  EMP1; epithelial membrane protein 1 [KO:K26255]
112673919  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112645253  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
112657858  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
112665784  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
112651615  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
112658944  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
112647981  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
112664826  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
112676544  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
112653394  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
112650716  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
112673894  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
112646387  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
112648013  myosin regulatory light polypeptide 9 [KO:K12757]
112648016  myosin regulatory light chain 12B [KO:K12757]
112655917  myosin regulatory light polypeptide 9-like [KO:K12757]
112652250  myosin regulatory light polypeptide 9-like [KO:K12757]
112640089  MYL11; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
112659369  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112664593  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112676539  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112654323  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
112667052  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
112645002  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
112659408  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
112673771  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112642441  MYLK3; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
112677106  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
112644758  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
112663971  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
112666280  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
112646354  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
112672928  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112653534  actin, cytoplasmic 2-like [KO:K05692]
112653482  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
112648848  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
112645512  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
112658028  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
112650160  TLN1; talin-1 isoform X1 [KO:K06271]
112675814  TLN2; talin-2 isoform X1 [KO:K06271]
112668365  FLNA; filamin-A isoform X1 [KO:K04437]
112665965  FLNB; filamin-B isoform X1 [KO:K27392]
112676659  PXN; paxillin isoform X5 [KO:K05760]
112667559  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
112650881  ZYX; zyxin isoform X1 [KO:K06273]
112645295  vasodilator-stimulated phosphoprotein isoform X3 [KO:K06274]
112653666  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein-like [KO:K06274]
112651562  VCL; vinculin isoform X2 [KO:K05700]
112667646  PARVA; LOW QUALITY PROTEIN: alpha-parvin [KO:K06275]
112666279  PARVG; gamma-parvin isoform X4 [KO:K06275]
112666298  PARVB; beta-parvin isoform X1 [KO:K06275]
112640520  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112677588  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
112668716  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112652873  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
112640230  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112645036  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112662017  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112656209  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112677396  VAV2; guanine nucleotide exchange factor VAV2 isoform X8 [KO:K05730]
112640748  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
112666384  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
112646333  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
112668452  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
112672959  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112642133  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112676536  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
112649243  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
112645492  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
112673605  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
112676129  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
112659940  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112672066  cell division control protein 42 homolog [KO:K04393]
112660852  cell division control protein 42 homolog [KO:K04393]
112675684  cell division control protein 42 homolog [KO:K04393]
112646654  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
112677583  CRK; adapter molecule crk isoform X1 [KO:K04438]
112677012  CRKL; crk-like protein isoform X1 [KO:K04438]
112672498  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
112677353  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
112663891  RAP1A; ras-related protein Rap-1A [KO:K04353]
112677882  RAP1B; ras-related protein Rap-1b [KO:K07836]
112645941  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112659577  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112671968  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
112647115  JUN; transcription factor Jun [KO:K04448]
112650991  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
112670793  CAV1; caveolin-1 isoform X1 [KO:K06278]
112670794  CAV2; caveolin-2 isoform X1 [KO:K12958]
112662331  CAV3; caveolin-3 [KO:K12959]
112658623  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
112648956  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112666141  SHC2; SHC-transforming protein 2 isoform X3 [KO:K17447]
112644865  SHC3; SHC-transforming protein 3 [KO:K17448]
112675960  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
112672798  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112657995  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112664493  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112669083  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
112673250  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112663184  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112669048  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112641579  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
112671444  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
112671445  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
112649057  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
112659359  BAD; bcl2-associated agonist of cell death [KO:K02158]
112644027  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
clud04010  MAPK signaling pathway
clud04060  Cytokine-cytokine receptor interaction
clud04070  Phosphatidylinositol signaling system
clud04110  Cell cycle
clud04151  PI3K-Akt signaling pathway
clud04310  Wnt signaling pathway
clud04512  ECM-receptor interaction
clud04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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