KEGG   PATHWAY: csav03040
Entry
csav03040                   Pathway                                
Name
Spliceosome - Cannabis sativa (hemp)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
csav03040  Spliceosome
csav03040

Other DBs
GO: 0005681
Organism
Cannabis sativa (hemp) [GN:csav]
Gene
115715450  U1 spliceosomal RNA [KO:K14276]
115703293  U1 spliceosomal RNA [KO:K14276]
115724381  U1 spliceosomal RNA [KO:K14276]
115715509  U1 spliceosomal RNA [KO:K14276]
115695999  U2 spliceosomal RNA [KO:K14277]
115696012  U2 spliceosomal RNA [KO:K14277]
115715390  U2 spliceosomal RNA [KO:K14277]
115715424  U2 spliceosomal RNA [KO:K14277]
115711818  U2 spliceosomal RNA [KO:K14277]
115718272  U4 spliceosomal RNA [KO:K14278]
115721529  U4 spliceosomal RNA [KO:K14278]
115703350  U4 spliceosomal RNA [KO:K14278]
115711812  U5 spliceosomal RNA [KO:K14279]
115721586  U6 spliceosomal RNA [KO:K14280]
115696114  U6 spliceosomal RNA [KO:K14280]
115711835  U6 spliceosomal RNA [KO:K14280]
115718722  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
115710711  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
115711676  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
115705283  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:5.6.2.7]
115697999  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:5.6.2.7]
115708696  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 [KO:K12813] [EC:5.6.2.6]
115709732  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 isoform X1 [KO:K12815] [EC:5.6.2.6]
115699122  pre-mRNA-processing factor 17 [KO:K12816]
115703796  pre-mRNA-splicing factor 18 [KO:K12817]
115699635  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
115714389  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 [KO:K12818] [EC:5.6.2.6]
115714546  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 isoform X1 [KO:K12818] [EC:5.6.2.6]
115715093  ATP-dependent RNA helicase DEAH11, chloroplastic [KO:K12818] [EC:5.6.2.6]
115709173  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
115722750  pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
115712808  pre-mRNA-splicing factor SLU7-A [KO:K12819]
115698037  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 [KO:K12820] [EC:5.6.2.6]
115709604  small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
115714378  small nuclear ribonucleoprotein SmD1a [KO:K11087]
115698095  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
115713831  small nuclear ribonucleoprotein SmD3b [KO:K11088]
115700876  small nuclear ribonucleoprotein SmD3b [KO:K11088]
115695693  small nuclear ribonucleoprotein E [KO:K11097]
115701386  probable small nuclear ribonucleoprotein F [KO:K11098]
115697945  probable small nuclear ribonucleoprotein F [KO:K11098]
115701124  probable small nuclear ribonucleoprotein G [KO:K11099]
115714413  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
115716552  U1 small nuclear ribonucleoprotein A [KO:K11091]
115723141  U1 small nuclear ribonucleoprotein C [KO:K11095]
115705432  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
115696486  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
115712717  RNA-binding protein 25 isoform X1 [KO:K12822]
115719389  DEAD-box ATP-dependent RNA helicase 20 isoform X1 [KO:K12823] [EC:5.6.2.7]
115699541  DEAD-box ATP-dependent RNA helicase 14 [KO:K12823] [EC:5.6.2.7]
115706932  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
115709485  DEAD-box ATP-dependent RNA helicase 30 [KO:K12823] [EC:5.6.2.7]
115697534  DEAD-box ATP-dependent RNA helicase 40 [KO:K12823] [EC:5.6.2.7]
115699400  pre-mRNA-processing protein 40C [KO:K12824]
115718953  LOW QUALITY PROTEIN: transcription initiation factor TFIID subunit 15b [KO:K13098]
115718041  U2 small nuclear ribonucleoprotein B''-like [KO:K11094]
115720762  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
115699725  probable splicing factor 3A subunit 1 [KO:K12825]
115709906  splicing factor 3A subunit 2 [KO:K12826]
115725273  splicing factor SF3a60 homolog [KO:K12827]
115714394  splicing factor 3B subunit 1 [KO:K12828]
115697315  splicing factor 3B subunit 2 [KO:K12829]
115699205  DNA damage-binding protein 1 [KO:K12830]
115707264  spliceosome-associated protein 130 A [KO:K12830]
115714428  splicing factor 3B subunit 4 [KO:K12831]
115715247  protein HSH49 [KO:K12831]
115718393  uncharacterized protein At4g14342 [KO:K12832]
115721918  uncharacterized protein At4g14342 [KO:K12832]
115694844  splicing factor 3B subunit 6-like protein [KO:K12833]
115721425  PHD finger-like domain-containing protein 5B [KO:K12834]
115708010  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
115718907  splicing factor U2af small subunit B [KO:K12836]
115709357  splicing factor U2af small subunit B [KO:K12836]
115722171  uncharacterized protein LOC115722171 [KO:K12837]
115714405  splicing factor U2af large subunit B isoform X1 [KO:K12837]
115697459  splicing factor U2af large subunit B isoform X1 [KO:K12837]
115712739  survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
115697213  LOW QUALITY PROTEIN: DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840]
115697708  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
115694840  protein RRC1 isoform X1 [KO:K12842]
115708245  sm-like protein LSM2 [KO:K12621]
115709368  sm-like protein LSM3A [KO:K12622]
115697784  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
115697868  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
115712123  sm-like protein LSM5 [KO:K12624]
115712126  sm-like protein LSM5 [KO:K12624]
115721151  sm-like protein LSM36B [KO:K12625]
115695734  sm-like protein LSM7 [KO:K12626]
115722369  protein RDM16 isoform X1 [KO:K12843]
115710076  LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
115711124  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
115705383  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
115705407  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
115695721  NHP2-like protein 1 [KO:K12845]
115725705  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
115707363  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
115699446  SART-1 family protein DOT2 [KO:K11984]
115721382  zinc finger matrin-type protein 2 [KO:K12848]
115719221  pre-mRNA-splicing factor 38 [KO:K12849]
115722191  pre-mRNA splicing factor SR-like 1 [KO:K12850]
115712844  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
115713786  LOW QUALITY PROTEIN: 110 kDa U5 small nuclear ribonucleoprotein component CLO-like [KO:K12852]
115722263  DExH-box ATP-dependent RNA helicase DExH12 [KO:K12854] [EC:5.6.2.6]
115709072  DExH-box ATP-dependent RNA helicase DExH12 [KO:K12854] [EC:5.6.2.6]
115705238  pre-mRNA-processing-splicing factor 8A [KO:K12856]
115708042  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
115720772  LOW QUALITY PROTEIN: DEAD-box ATP-dependent RNA helicase 21-like [KO:K12858] [EC:5.6.2.7]
115717163  thioredoxin-like protein YLS8 [KO:K12859]
115723337  thioredoxin-like protein YLS8 [KO:K12859]
115721693  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
115719168  cell division cycle 5-like protein [KO:K12860]
115708755  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
115711533  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
115722706  protein pleiotropic regulatory locus 1 [KO:K12862]
115706287  protein CWC15 homolog A [KO:K12863]
115697253  beta-catenin-like protein 1 isoform X1 [KO:K12864]
115716201  probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283]
115716233  probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283]
115707966  heat shock 70 kDa protein [KO:K03283]
115707967  heat shock 70 kDa protein [KO:K03283]
115695984  heat shock 70 kDa protein-like [KO:K03283]
115725252  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
115722771  uncharacterized protein LOC115722771 [KO:K12865]
115707308  SNW/SKI-interacting protein A [KO:K06063]
115722140  pre-mRNA-splicing factor SYF1 [KO:K12867]
115722811  pre-mRNA-splicing factor syf2 [KO:K12868]
115698875  crooked neck-like protein 1 [KO:K12869]
115716719  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
115701131  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
115698197  coiled-coil domain-containing protein 12 [KO:K12871]
115697421  zinc finger CCCH domain-containing protein 40 [KO:K12872]
115701272  protein BUD31 homolog 2 [KO:K12873]
115708911  protein BUD31 homolog 2-like [KO:K12873]
115711610  protein BUD31 homolog 2 [KO:K12873]
115700975  RNA helicase aquarius [KO:K12874]
115714666  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
115699465  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
115696233  eukaryotic initiation factor 4A-III homolog A [KO:K13025] [EC:5.6.2.7]
115720794  RNA-binding protein Y14 [KO:K12876]
115710094  protein mago nashi homolog [KO:K12877]
115705095  LOW QUALITY PROTEIN: THO complex subunit 1-like [KO:K12878]
115721800  THO complex subunit 2 [KO:K12879]
115724445  THO complex subunit 3 [KO:K12880]
115720304  THO complex subunit 4A [KO:K12881]
115699271  THO complex subunit 4D [KO:K12881]
115720866  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
115700793  nuclear cap-binding protein subunit 2 [KO:K12883]
115720637  UBP1-associated protein 2B [KO:K12741]
115719510  UBP1-associated protein 2A [KO:K12741]
115712643  UBP1-associated protein 2A [KO:K12741]
115714066  UBP1-associated protein 2A [KO:K12741]
115697179  UBP1-associated protein 2C [KO:K12741]
115697375  UBP1-associated protein 2C [KO:K12741]
115716841  serine/arginine-rich splicing factor SR34A isoform X1 [KO:K12890]
115696009  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
115696283  serine/arginine-rich splicing factor SR34B-like isoform X1 [KO:K12890]
115725126  serine/arginine-rich splicing factor SC35 isoform X1 [KO:K12891]
115718181  serine/arginine-rich splicing factor RS40 isoform X1 [KO:K12893]
115705478  serine/arginine-rich splicing factor RS31 [KO:K12893]
115706600  serine/arginine-rich splicing factor RS41 isoform X1 [KO:K12893]
115700176  serine/arginine-rich splicing factor RSZ22A isoform X1 [KO:K12896]
115713961  serine/arginine-rich splicing factor RSZ21 [KO:K12896]
115705305  serine/arginine-rich splicing factor RS2Z32 isoform X1 [KO:K12896]
115709457  serine/arginine-rich splicing factor RS2Z33 isoform X1 [KO:K12896]
115716272  serine/arginine-rich splicing factor SR45a [KO:K12897]
115702792  serine/arginine-rich splicing factor SR45a [KO:K12897]
115722691  serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900]
115699226  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
115703815  uncharacterized protein LOC115703815 [KO:K12900]
115706268  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
115725578  serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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