KEGG   PATHWAY: dro05164
Entry
dro05164                    Pathway                                
Name
Influenza A - Desmodus rotundus (common vampire bat)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
dro05164  Influenza A
dro05164

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112298273  tryptase alpha/beta-1-like [KO:K01340] [EC:3.4.21.59]
112298274  tryptase alpha/beta-1-like [KO:K01340] [EC:3.4.21.59]
112297415  PLG; plasminogen isoform X1 [KO:K01315] [EC:3.4.21.7]
112299912  PRSS2; LOW QUALITY PROTEIN: trypsin-2 [KO:K01312] [EC:3.4.21.4]
112306012  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
112314231  TMPRSS4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
112320144  TMPRSS11D; transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112310771  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
112317826  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
112310467  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
112296814  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
112301385  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
112312311  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
112298045  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112311304  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112316562  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
112304475  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
112322284  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
112314296  NLRX1; NLR family member X1 [KO:K12653]
112303983  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
112300474  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112321547  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112296261  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112320245  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
112296519  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112317202  RELA; transcription factor p65 [KO:K04735]
112316317  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
112306726  TLR3; toll-like receptor 3 [KO:K05401]
112312662  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112311693  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
112319039  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112318201  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112310089  IRF3; interferon regulatory factor 3 [KO:K05411]
112321623  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112298356  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
112306266  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112313330  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
112309628  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112318391  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112317444  IRF7; interferon regulatory factor 7 [KO:K09447]
112303128  IL1A; interleukin-1 alpha [KO:K04383]
112302944  IL1B; interleukin-1 beta [KO:K04519]
112306851  IL6; interleukin-6 [KO:K05405]
112304655  IL12A; interleukin-12 subunit alpha [KO:K05406]
112319648  IL12B; interleukin-12 subunit beta [KO:K05425]
112302067  TNF; tumor necrosis factor isoform X1 [KO:K03156]
112321932  CXCL8; interleukin-8 [KO:K10030]
112308943  C-C motif chemokine 2-like [KO:K14624]
112298838  CCL5; C-C motif chemokine 5 [KO:K12499]
112319846  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
112301541  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
112297048  interferon alpha-4-like [KO:K05414]
112302798  interferon alpha-4-like [KO:K05414]
112302800  interferon alpha-4-like [KO:K05414]
112300024  IFNB1; interferon beta [KO:K05415]
112305552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112305536  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
112309187  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112301524  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112298802  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112307780  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112319116  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112301148  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112305998  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
112304175  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
112316695  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
112301759  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
112319176  IFNG; interferon gamma [KO:K04687]
112297082  IFNGR1; interferon gamma receptor 1 [KO:K05132]
112308734  IFNGR2; interferon gamma receptor 2 [KO:K05133]
112299737  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112314942  CIITA; MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
112302159  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
112302160  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
112302240  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
112302328  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112302354  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112305210  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
112304817  PYCARD; LOW QUALITY PROTEIN: apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112304871  LOW QUALITY PROTEIN: apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112314315  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
112314192  IL18; interleukin-18 [KO:K05482]
112302823  IL33; interleukin-33 [KO:K12967]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112302074  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112319119  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112319896  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112307528  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
112305008  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
112317424  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
112297049  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112307358  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112321955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112300831  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112317320  FADD; FAS-associated death domain protein [KO:K02373]
112307787  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112310499  BID; BH3-interacting domain death agonist [KO:K04726]
112310132  BAX; apoptosis regulator BAX [KO:K02159]
112302219  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112318103  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112310580  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112313387  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
112301943  ADP/ATP translocase 3-like [KO:K05863]
112312642  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112306713  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112306993  cytochrome c [KO:K08738]
112320658  cytochrome c-like [KO:K08738]
112322221  cytochrome c-like [KO:K08738]
112321814  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
112299456  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112306749  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112314840  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
112316523  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
112301344  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
112300571  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
112296854  nuclear RNA export factor 2-like [KO:K14284]
112296855  NXF3; nuclear RNA export factor 3 [KO:K14284]
112321362  NXF5; nuclear RNA export factor 5 isoform X1 [KO:K14284]
112317185  NXF1; nuclear RNA export factor 1 [KO:K14284]
112296892  NXT2; NTF2-related export protein 2 [KO:K14285]
112303956  NXT1; NTF2-related export protein 1 [KO:K14285]
112319986  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
112304127  RAE1; mRNA export factor [KO:K14298]
112316095  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
112298065  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
112316896  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112301126  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112311345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112312483  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112304801  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112301746  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112298712  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112319437  ACTB; actin, cytoplasmic 1 [KO:K05692]
112311234  RAB11A; ras-related protein Rab-11A [KO:K07904]
112305101  RAB11B; ras-related protein Rab-11B [KO:K07905]
112297894  XPO1; exportin-1 [KO:K14290]
112320692  KPNA1; importin subunit alpha-5 [KO:K23940]
112305243  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
112316307  KPNA2; LOW QUALITY PROTEIN: importin subunit alpha-1 [KO:K15043]
112299307  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
112297340  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
dro00900  Terpenoid backbone biosynthesis
dro03013  Nucleocytoplasmic transport
dro03015  mRNA surveillance pathway
dro04010  MAPK signaling pathway
dro04110  Cell cycle
dro04144  Endocytosis
dro04210  Apoptosis
dro04620  Toll-like receptor signaling pathway
dro04621  NOD-like receptor signaling pathway
dro04622  RIG-I-like receptor signaling pathway
dro04630  JAK-STAT signaling pathway
dro05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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