KEGG   PATHWAY: efus04510
Entry
efus04510                   Pathway                                
Name
Focal adhesion - Eptesicus fuscus (big brown bat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
efus04510  Focal adhesion
efus04510

Other DBs
GO: 0005925
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103292730  COL1A2; collagen alpha-2(I) chain [KO:K06236]
103297064  COL1A1; collagen alpha-1(I) chain [KO:K06236]
103285236  COL2A1; collagen alpha-1(II) chain [KO:K19719]
103288305  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103288231  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
103289387  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
103289388  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103299489  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
103299486  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
103289767  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103296627  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
103296633  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
103299842  collagen alpha-4(VI) chain-like [KO:K06238]
103289864  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103283222  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
103300242  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103294776  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103284413  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
103285152  LAMA2; laminin subunit alpha-2 [KO:K05637]
103304570  LAMA1; laminin subunit alpha-1 [KO:K05637]
103300280  LAMA5; laminin subunit alpha-5 [KO:K06240]
103292196  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
103302909  LAMA4; laminin subunit alpha-4 [KO:K06241]
103293759  LAMB1; laminin subunit beta-1 [KO:K05636]
103300702  laminin subunit beta-2-like [KO:K06243]
103298900  LAMB2; laminin subunit beta-2 [KO:K06243]
103290074  LAMB3; laminin subunit beta-3 [KO:K06244]
103293765  LAMB4; laminin subunit beta-4 [KO:K06245]
103290016  LAMC1; laminin subunit gamma-1 [KO:K05635]
103290017  LAMC2; laminin subunit gamma-2 [KO:K06246]
103296167  LAMC3; laminin subunit gamma-3 [KO:K06247]
103297056  CHAD; chondroadherin [KO:K06248]
103293480  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
103287300  THBS1; thrombospondin-1 [KO:K16857]
103298897  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
103299530  COMP; cartilage oligomeric matrix protein [KO:K04659]
103305350  THBS4; thrombospondin-4 [KO:K04659]
103299845  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
103289335  FN1; fibronectin isoform X1 [KO:K05717]
103287865  SPP1; osteopontin isoform X1 [KO:K06250]
103291706  VTN; vitronectin [KO:K06251]
103295667  TNC; tenascin isoform X2 [KO:K06252]
103290097  TNN; tenascin-N [KO:K06252]
103300518  TNXB; tenascin-X [KO:K06252]
103289983  TNR; tenascin-R [KO:K06252]
103288998  VWF; von Willebrand factor [KO:K03900]
103287868  IBSP; bone sialoprotein 2 [KO:K06253]
103298091  ITGA1; integrin alpha-1 [KO:K06480]
103298090  ITGA2; integrin alpha-2 [KO:K06481]
103293222  ITGA2B; integrin alpha-IIb [KO:K06476]
103297069  ITGA3; integrin alpha-3 [KO:K06482]
103283472  ITGA4; integrin alpha-4 isoform X2 [KO:K06483]
103285371  ITGA5; integrin alpha-5 [KO:K06484]
103283312  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103292531  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103294018  ITGA8; integrin alpha-8 [KO:K06584]
103298209  ITGA9; integrin alpha-9 [KO:K06585]
103296529  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103283776  ITGA11; integrin alpha-11 [KO:K06587]
103290656  ITGAV; integrin alpha-V [KO:K06487]
103299452  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103293159  ITGB3; integrin beta-3 [KO:K06493]
103298282  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
103298729  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
103283378  ITGB6; integrin beta-6 [KO:K06589]
103285555  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
103292129  ITGB8; integrin beta-8 [KO:K06591]
103286118  EMP2; epithelial membrane protein 2 [KO:K26256]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103288794  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103293793  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103288953  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103296626  VEGFA; vascular endothelial growth factor A [KO:K05448]
103302042  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
103283571  PGF; placenta growth factor isoform X1 [KO:K16859]
103298181  VEGFD; vascular endothelial growth factor D [KO:K05449]
103295457  VEGFC; vascular endothelial growth factor C [KO:K05449]
103293251  HGF; hepatocyte growth factor [KO:K05460]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103301950  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103284973  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114229025  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
103301270  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103301676  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103295948  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103297187  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103285104  EMP1; epithelial membrane protein 1 [KO:K26255]
103293309  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103297688  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
103300306  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
103298865  RHOA; transforming protein RhoA [KO:K04513]
103295254  transforming protein RhoA-like [KO:K04513]
103289680  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103303158  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
103305588  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103287051  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103294591  MYL5; myosin light chain 5 isoform X2 [KO:K12753]
103303626  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103293324  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103286246  MYL10; myosin regulatory light chain 10 [KO:K12756]
103302989  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
114230017  myosin regulatory light chain 12B isoform X1 [KO:K12757]
103296328  MYL11; myosin regulatory light chain 11 isoform X2 [KO:K12758]
103287049  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
103290927  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103297381  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like isoform X2 [KO:K06269] [EC:3.1.3.16]
103305499  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103288089  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103302945  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
103303380  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103295907  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103285582  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103298735  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103301893  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103298997  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
103294396  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
103289128  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
103299154  ACTB; actin, cytoplasmic 1 [KO:K05692]
103298235  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103303839  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103293526  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
103283631  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
103284346  ACTN4; alpha-actinin-4 [KO:K05699]
103283838  TLN2; talin-2 [KO:K06271]
103286443  TLN1; talin-1 [KO:K06271]
103302227  FLNA; filamin-A isoform X1 [KO:K04437]
103290398  FLNB; filamin-B isoform X2 [KO:K27392]
103287102  PXN; paxillin isoform X1 [KO:K05760]
103302788  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
103297262  ZYX; zyxin [KO:K06273]
103301437  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
103289456  VCL; vinculin [KO:K05700]
103294615  PARVA; alpha-parvin [KO:K06275]
103298679  PARVG; gamma-parvin isoform X1 [KO:K06275]
103298678  PARVB; beta-parvin [KO:K06275]
103290523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103290720  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
103297942  CTNNB1; catenin beta-1 [KO:K02105]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103303678  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103299759  PTK2; focal adhesion kinase 1 isoform X3 [KO:K05725] [EC:2.7.10.2]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103296377  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103291132  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
103296145  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103303157  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103288892  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103298339  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103293618  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103303550  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103301610  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
103284333  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103285671  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
103287306  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103291971  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103289160  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
103286714  cell division control protein 42 homolog [KO:K04393]
103284373  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103286991  CRKL; crk-like protein [KO:K04438]
103291758  CRK; adapter molecule crk isoform X1 [KO:K04438]
103299320  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103296165  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
103291183  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103292519  RAP1B; ras-related protein Rap-1b [KO:K07836]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103284067  JUN; transcription factor Jun [KO:K04448]
103294085  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
103295928  CAV1; caveolin-1 isoform X2 [KO:K06278]
103295927  CAV2; caveolin-2 isoform X1 [KO:K12958]
103295265  CAV3; caveolin-3 [KO:K12959]
103302295  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
103298913  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103294446  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
103297925  SHC3; SHC-transforming protein 3 [KO:K17448]
103287410  SHC4; SHC-transforming protein 4 [KO:K17449]
103298291  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103283761  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103305666  SOS1; son of sevenless homolog 1 [KO:K03099]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103296406  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103290903  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103288032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103301919  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103292960  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103292961  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103301896  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
103302047  BAD; bcl2-associated agonist of cell death [KO:K02158]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
efus04010  MAPK signaling pathway
efus04060  Cytokine-cytokine receptor interaction
efus04070  Phosphatidylinositol signaling system
efus04110  Cell cycle
efus04151  PI3K-Akt signaling pathway
efus04310  Wnt signaling pathway
efus04512  ECM-receptor interaction
efus04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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