KEGG   PATHWAY: elk05010
Entry
elk05010                    Pathway                                
Name
Alzheimer disease - Enhydra lutris kenyoni (northern sea otter)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
elk05010  Alzheimer disease
elk05010

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111153288  disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
111154187  disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
111152475  amyloid beta A4 protein isoform X1 [KO:K04520]
111152806  NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
111159408  amyloid beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
111140561  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111140562  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111153258  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111160720  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111153592  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111151005  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111159713  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
111161852  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111153672  beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
111155713  beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
111149423  reticulon-3 [KO:K20723]
111148193  LOW QUALITY PROTEIN: reticulon-4 [KO:K20720]
111161372  gamma-secretase subunit PEN-2 [KO:K06170]
111148789  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
111150660  presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
111138884  nicastrin isoform X1 [KO:K06171]
111162023  gamma-secretase subunit APH-1A isoform X1 [KO:K06172]
111153322  gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
111144834  insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
111148232  neprilysin [KO:K01389] [EC:3.4.24.11]
111158157  microtubule-associated protein tau [KO:K04380]
111149612  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
111142406  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
111155738  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
111157253  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
111140937  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
111139570  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
111152555  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
111147374  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
111160211  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
111154239  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
111151938  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
111155596  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
111157547  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
111161756  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
111145557  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
111159811  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
111161328  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
111162309  acyl carrier protein, mitochondrial [KO:K03955]
111161769  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
111142148  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
111143867  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
111148723  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
111151936  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
111141342  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
111148802  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform X1 [KO:K03960]
111147306  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
111146284  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
111162542  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
111145242  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
111146716  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
111156034  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
111150594  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
111141377  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
111138869  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
111149396  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
111141116  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
111142993  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
111153450  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
111161695  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
111149681  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
111149131  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
111154340  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
111153400  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
111154638  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
111138865  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
111153893  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
111139384  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
111146626  cytochrome c1, heme protein, mitochondrial [KO:K00413]
111143869  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
111162256  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
111142816  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
111146514  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
111141027  cytochrome b-c1 complex subunit 8 isoform X1 [KO:K00418]
111160042  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
111161710  cytochrome b-c1 complex subunit 10 [KO:K00420]
111153043  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
111141707  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
111153215  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
111155858  cytochrome c oxidase subunit 5B, mitochondrial isoform X1 [KO:K02265]
111162190  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
111156401  cytochrome c oxidase subunit 6A1, mitochondrial isoform X1 [KO:K02266]
111161463  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
111155471  cytochrome c oxidase subunit 6B1-like [KO:K02267]
111139590  cytochrome c oxidase subunit 6B2 [KO:K02267]
111147664  cytochrome c oxidase subunit 6C [KO:K02268]
111146812  cytochrome c oxidase subunit 6C [KO:K02268]
111161502  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
111147649  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
111158437  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
111146524  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111156868  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
111160926  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111149314  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
111149315  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
111148335  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111152225  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111160948  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
111149630  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
111152453  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
111142536  ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
111160107  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
111158608  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
111161765  ATP synthase subunit delta, mitochondrial [KO:K02134]
111152423  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
111141583  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
111143342  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
111150035  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
111157857  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
111151344  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
111160337  ATP synthase subunit d, mitochondrial [KO:K02138]
111155772  ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
111147126  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
111151840  ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
111139811  3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
111153720  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
111141207  voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
111145442  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111144425  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111157245  ADP/ATP translocase 2 [KO:K05863]
111144412  ADP/ATP translocase 1 [KO:K05863]
111157056  ADP/ATP translocase 4 [KO:K05863]
111157123  ADP/ATP translocase 3 [KO:K05863]
111145350  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
111154450  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
111160621  apolipoprotein E [KO:K04524]
111160101  prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
111144883  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111159748  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111149616  FAS-associated death domain protein [KO:K02373]
111141026  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111159768  BH3-interacting domain death agonist [KO:K04726]
111158594  calmodulin-like [KO:K02183]
111158606  calmodulin-like protein 3 [KO:K02183]
111154855  calmodulin-like protein 6 [KO:K02183]
111160633  calmodulin-3 [KO:K02183]
111155835  calmodulin-2 [KO:K02183]
111148494  calmodulin-1 isoform X1 [KO:K02183]
111153268  calmodulin-like protein 4 isoform X1 [KO:K02183]
111144797  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111154144  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111154566  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111148007  calcineurin subunit B type 1 [KO:K06268]
111146053  calcineurin subunit B type 2 [KO:K06268]
111149975  bcl2-associated agonist of cell death [KO:K02158]
111147305  cytochrome c isoform X1 [KO:K08738]
111142635  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
111141900  LOW QUALITY PROTEIN: uncharacterized protein LOC111141900 [KO:K08738]
111142091  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
111154673  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111144607  caspase-3 [KO:K02187] [EC:3.4.22.56]
111150081  muscarinic acetylcholine receptor M1 [KO:K04129]
111144973  muscarinic acetylcholine receptor M3 [KO:K04131]
111140224  muscarinic acetylcholine receptor M5 [KO:K04133]
111154498  metabotropic glutamate receptor 5 [KO:K04604]
111153498  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111141432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111162302  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111141620  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111150005  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
111145480  glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
111145775  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
111156070  glutamate receptor ionotropic, NMDA 2A [KO:K05209]
111142166  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
111160373  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
111160688  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
111159674  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
111143738  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111150407  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
111150995  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
111152691  LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
111145292  calcium uniporter protein, mitochondrial [KO:K20858]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111159558  ryanodine receptor 3 [KO:K04963]
111144005  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111159979  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111152507  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111158763  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
111162286  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
111159008  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like [KO:K05853] [EC:7.2.2.10]
111156353  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111151136  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
111160084  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
111160240  DNA damage-inducible transcript 3 protein [KO:K04452]
111158091  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111148064  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
111145476  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111146100  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111147502  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111161723  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111144860  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111158897  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111154016  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111148773  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111157635  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111161782  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
111157026  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
111152671  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
111142650  LOW QUALITY PROTEIN: proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
111141333  proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
111143461  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
111159417  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
111140663  proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
111161100  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
111146069  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
111151691  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
111143148  proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
111139193  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
111158705  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
111161949  proteasome subunit beta type-4 isoform X1 [KO:K02736] [EC:3.4.25.1]
111162024  proteasome subunit beta type-4 isoform X1 [KO:K02736] [EC:3.4.25.1]
111155299  26S proteasome regulatory subunit 7 [KO:K03061]
111148465  26S proteasome regulatory subunit 4 [KO:K03062]
111161514  26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
111139115  26S proteasome regulatory subunit 10B [KO:K03064]
111149577  26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
111158036  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
111148031  26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
111143971  26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
111151573  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
111156408  26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
111158181  26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
111151359  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
111144078  26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
111152968  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
111149610  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
111161952  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
111140976  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
111161550  26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
111141807  LOW QUALITY PROTEIN: proteasomal ubiquitin receptor ADRM1 [KO:K06691]
111147630  LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
111153889  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
111156411  nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
111149415  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
111150685  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
111151672  cyclin-dependent kinase 5 activator 1 [KO:K11716]
111161714  zinc transporter ZIP3 isoform X1 [KO:K14709]
111138905  zinc transporter ZIP1 [KO:K14709]
111153291  zinc transporter ZIP2 isoform X1 [KO:K14709]
111146740  zinc transporter ZIP4 [KO:K14710]
111160193  zinc transporter ZIP5 [KO:K14711]
111142646  zinc transporter ZIP6 [KO:K14712]
111152197  zinc transporter SLC39A7 isoform X1 [KO:K14713]
111156218  zinc transporter ZIP8 isoform X1 [KO:K14714]
111148648  zinc transporter ZIP9 isoform X1 [KO:K14715]
111143095  zinc transporter ZIP10 [KO:K14716]
111158193  zinc transporter ZIP11 isoform X1 [KO:K14717]
111155587  zinc transporter ZIP12 isoform X1 [KO:K14718]
111150198  zinc transporter ZIP13 isoform X1 [KO:K14719]
111157452  zinc transporter ZIP14 isoform X1 [KO:K14720]
111157824  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
111154329  cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111145267  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
111157668  dickkopf-related protein 2 [KO:K02165]
111145243  dickkopf-related protein 1 [KO:K02165]
111144380  dickkopf-related protein 4 [KO:K02165]
111158015  proto-oncogene Wnt-1 [KO:K03209]
111143458  protein Wnt-2b [KO:K00182]
111152038  protein Wnt-2 [KO:K00182]
111139433  protein Wnt-3a [KO:K00312]
111158156  proto-oncogene Wnt-3 [KO:K00312]
111154909  protein Wnt-4 [KO:K00408]
111159795  protein Wnt-5b [KO:K00444]
111144172  protein Wnt-5a isoform X1 [KO:K00444]
111145739  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
111157688  protein Wnt-7b isoform X1 [KO:K00572]
111159004  protein Wnt-7a [KO:K00572]
111141267  protein Wnt-8a [KO:K00714]
111145241  protein Wnt-8b [KO:K00714]
111139428  protein Wnt-9a [KO:K01064]
111158202  LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
111157990  protein Wnt-10b [KO:K01357]
111144711  protein Wnt-10a [KO:K01357]
111159478  protein Wnt-11 [KO:K01384]
111152110  protein Wnt-16 [KO:K01558]
111141425  frizzled-7 [KO:K02432]
111147325  frizzled-1 [KO:K02432]
111158141  frizzled-2 [KO:K02235]
111156239  frizzled-3 [KO:K02329]
111154467  frizzled-4 [KO:K02354]
111155536  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
111143924  frizzled-5 [KO:K02375]
111146642  frizzled-6 [KO:K02376]
111156537  frizzled-10 [KO:K02842]
111146438  frizzled-9 [KO:K02842]
111142027  low-density lipoprotein receptor-related protein 6 [KO:K03068]
111149489  low-density lipoprotein receptor-related protein 5 [KO:K03068]
111157515  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
111154625  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
111161117  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
111148907  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
111149303  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
111145138  proto-oncogene FRAT1 [KO:K03069]
111145112  GSK-3-binding protein FRAT2 [KO:K03096]
111141414  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
111157353  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
111152166  casein kinase II subunit beta isoform X1 [KO:K03115]
111156118  axin-1 isoform X1 [KO:K02157]
111158088  axin-2 isoform X1 [KO:K04385]
111161627  adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
111148270  adenomatous polyposis coli protein isoform X1 [KO:K02085]
111159001  catenin beta-1 [KO:K02105]
111140875  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
111155551  kinesin-1 heavy chain [KO:K10396]
111160138  kinesin heavy chain isoform X1 [KO:K10396]
111142050  kinesin heavy chain [KO:K10396]
111160692  kinesin light chain 3 isoform X1 [KO:K10407]
111148551  kinesin light chain 1 isoform X1 [KO:K10407]
111149675  kinesin light chain 2 isoform X1 [KO:K10407]
111147688  kinesin light chain 4 isoform X1 [KO:K10407]
111143142  tubulin alpha-4A chain [KO:K07374]
111142067  tubulin alpha-1A chain-like [KO:K07374]
111157712  tubulin alpha-1B chain [KO:K07374]
111157713  tubulin alpha-1A chain [KO:K07374]
111158883  tubulin alpha-1A chain-like [KO:K07374]
111159721  tubulin alpha-8 chain isoform X1 [KO:K07374]
111157791  tubulin alpha-1C chain [KO:K07374]
111144980  putative tubulin-like protein alpha-4B [KO:K07374]
111151071  tubulin alpha-8 chain isoform X1 [KO:K07374]
111158635  LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
111142377  tubulin alpha-3 chain [KO:K07374]
111142381  tubulin alpha-3 chain [KO:K07374]
111141694  tubulin beta-1 chain [KO:K07375]
111142513  tubulin beta-6 chain isoform X1 [KO:K07375]
111161751  tubulin beta-4A chain isoform X1 [KO:K07375]
111156662  tubulin beta-2A chain isoform X1 [KO:K07375]
111152799  tubulin beta-3 chain [KO:K07375]
111156744  tubulin beta-2B chain isoform X1 [KO:K07375]
111146420  tubulin beta-4B chain isoform X1 [KO:K07375]
111152509  tubulin beta chain isoform X1 [KO:K07375]
111152179  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111150582  serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111151941  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111159214  NADPH oxidase 1 isoform X1 [KO:K08008]
111150330  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
111154476  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
111149956  transcription factor p65 [KO:K04735]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111151537  nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
111150791  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111152248  tumor necrosis factor isoform X1 [KO:K03156]
111147365  interleukin-6 isoform X1 [KO:K05405]
111158458  interleukin-1 alpha [KO:K04383]
111158456  interleukin-1 beta [KO:K04519]
111143313  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111156864  alpha-synuclein [KO:K04528]
111158436  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111139191  NF-kappa-B essential modulator [KO:K07210]
111150279  insulin [KO:K04526]
111161798  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
111143995  insulin receptor substrate 1 [KO:K16172]
111147115  insulin receptor substrate 2 [KO:K07187]
111146232  insulin receptor substrate 2-like [KO:K17445]
111161266  insulin receptor substrate 4 [KO:K17446]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111140006  serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
111139478  serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
111158002  autophagy-related protein 101 isoform X1 [KO:K19730]
111149764  autophagy-related protein 13 isoform X1 [KO:K08331]
111155388  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
111149427  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
111150658  beclin-2 [KO:K08334]
111151520  beclin-1 isoform X1 [KO:K08334]
111155119  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
111162436  beclin 1-associated autophagy-related key regulator [KO:K17889]
111144899  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
111142649  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
111149620  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
111148489  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
111145977  WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
111158171  WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
elk00190  Oxidative phosphorylation
elk03050  Proteasome
elk04020  Calcium signaling pathway
elk04140  Autophagy - animal
elk04141  Protein processing in endoplasmic reticulum
elk04210  Apoptosis
elk04310  Wnt signaling pathway
elk04910  Insulin signaling pathway
elk04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system