KEGG   PATHWAY: lav05165
Entry
lav05165                    Pathway                                
Name
Human papillomavirus infection - Loxodonta africana (African savanna elephant)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
lav05165  Human papillomavirus infection
lav05165

Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100653551  WNT2B; protein Wnt-2b [KO:K00182]
100657046  WNT2; protein Wnt-2 [KO:K00182]
100663058  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100662337  WNT3A; protein Wnt-3a [KO:K00312]
100664388  WNT4; LOW QUALITY PROTEIN: protein Wnt-4 [KO:K00408]
100664544  WNT5B; protein Wnt-5b isoform X2 [KO:K00444]
100658849  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100675069  WNT6; protein Wnt-6 [KO:K00445]
100675463  WNT7A; protein Wnt-7a [KO:K00572]
100660629  WNT7B; protein Wnt-7b [KO:K00572]
100665788  WNT8B; protein Wnt-8b [KO:K00714]
100668409  WNT8A; protein Wnt-8a [KO:K00714]
100658979  WNT9B; protein Wnt-9b [KO:K01064]
100662057  WNT9A; protein Wnt-9a [KO:K01064]
100674782  WNT10A; protein Wnt-10a [KO:K01357]
100655805  WNT10B; protein Wnt-10b [KO:K01357]
100656630  WNT11; protein Wnt-11 [KO:K01384]
100659037  WNT16; protein Wnt-16 [KO:K01558]
100657335  FZD1; frizzled-1 [KO:K02432]
100658936  FZD7; frizzled-7 [KO:K02432]
100654997  FZD2; frizzled-2 [KO:K02235]
100666465  FZD3; frizzled-3 [KO:K02329]
100675317  FZD4; frizzled-4 [KO:K02354]
100674586  FZD5; frizzled-5 [KO:K02375]
100666499  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100677440  FZD6; frizzled-6 [KO:K02376]
100660631  FZD10; frizzled-10 [KO:K02842]
100673586  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100657749  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100657649  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100675105  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100655765  AXIN1; axin-1 [KO:K02157]
100663921  AXIN2; axin-2 [KO:K04385]
100659017  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
100670988  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
100669057  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
100676312  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100663559  TCF7; transcription factor 7 isoform X3 [KO:K02620]
100656106  TCF7L2; transcription factor 7-like 2 isoform X22 [KO:K04491]
100663548  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
100672439  TLR3; toll-like receptor 3 [KO:K05401]
100654083  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100668716  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
100663886  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3 [KO:K07211] [EC:2.7.11.10]
100661026  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100667571  IRF3; interferon regulatory factor 3 [KO:K05411]
100666438  IFNB1; interferon beta [KO:K05415]
100661096  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100663731  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100661535  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
100663725  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100676034  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100660561  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100662336  PARD3; partitioning defective 3 homolog isoform X11 [KO:K04237]
100654053  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100661665  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100653628  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100662222  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100673102  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100664103  CDC42; cell division control protein 42 homolog [KO:K04393]
100673917  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
100662117  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
111752965  disks large homolog 2 [KO:K12075]
100671595  LOW QUALITY PROTEIN: disks large homolog 2 [KO:K12075]
100668545  DLG3; disks large homolog 3 [KO:K21098]
100654735  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X2 [KO:K06094]
100672463  LLGL2; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 2 [KO:K06094]
100660633  CRB3; protein crumbs homolog 3 [KO:K06090]
100657538  PATJ; inaD-like protein isoform X1 [KO:K06092]
100657914  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100671560  VWF; von Willebrand factor [KO:K03900]
100667431  THBS1; thrombospondin-1 [KO:K16857]
100673862  THBS4; thrombospondin-4 [KO:K04659]
100657841  THBS3; thrombospondin-3 isoform X2 [KO:K04659]
100677407  THBS2; thrombospondin-2 [KO:K04659]
100667600  COMP; cartilage oligomeric matrix protein [KO:K04659]
100667853  FN1; fibronectin isoform X8 [KO:K05717]
100668620  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100671297  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
100675826  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
100664111  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100664398  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100677472  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100667607  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
100667893  collagen alpha-6(IV) chain [KO:K06237]
100677754  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
100655197  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100663273  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100662988  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
100665075  LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
100665360  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
100664786  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
100668022  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100675250  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
100671962  collagen alpha-2(IX) chain [KO:K08131]
100672596  LAMA1; laminin subunit alpha-1 [KO:K05637]
100677404  LAMA2; laminin subunit alpha-2 [KO:K05637]
104845537  LAMA3; laminin subunit alpha-3 [KO:K06240]
100676944  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
111749628  laminin subunit alpha-3-like [KO:K06240]
100662531  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
100675837  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100655070  LAMB2; laminin subunit beta-2 [KO:K06243]
100666736  LAMB3; LOW QUALITY PROTEIN: laminin subunit beta-3 [KO:K06244]
100658659  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
100671561  LAMC1; laminin subunit gamma-1 [KO:K05635]
100661346  LAMC2; laminin subunit gamma-2 [KO:K06246]
100670126  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
100669678  CHAD; chondroadherin [KO:K06248]
100655250  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
100670250  SPP1; osteopontin [KO:K06250]
100653772  VTN; LOW QUALITY PROTEIN: vitronectin [KO:K06251]
100655345  TNC; tenascin isoform X1 [KO:K06252]
100667593  TNN; tenascin-N [KO:K06252]
100656584  TNR; tenascin-R isoform X1 [KO:K06252]
100657780  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100675022  IBSP; bone sialoprotein 2 [KO:K06253]
100674420  ITGA1; integrin alpha-1 [KO:K06480]
100674705  ITGA2; integrin alpha-2 [KO:K06481]
100654429  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
100671578  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
100674409  ITGA4; integrin alpha-4 [KO:K06483]
100676951  ITGA5; integrin alpha-5 [KO:K06484]
100661035  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100665471  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
100674808  ITGA8; integrin alpha-8 [KO:K06584]
100660884  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
100667832  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
100670461  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100671252  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100664978  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100660405  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100671877  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100676335  ITGB5; integrin beta-5 [KO:K06588]
100664907  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
100661118  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100661984  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100668436  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
100671127  PXN; paxillin isoform X5 [KO:K05760]
100677125  TNF; tumor necrosis factor isoform X2 [KO:K03156]
100672143  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100657751  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X4 [KO:K03171]
100662586  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100657715  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100662633  FADD; FAS-associated death domain protein [KO:K02373]
100663575  caspase-8 [KO:K04398] [EC:3.4.22.61]
100660542  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100672256  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100657092  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
100664132  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100676230  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100654486  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100663532  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100666680  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
100668825  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100666413  PPP2R2B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
100668487  PPP2R3A; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
100663566  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
100670795  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100659955  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100675562  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100676500  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100660424  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100659875  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100667008  TSC1; hamartin isoform X1 [KO:K07206]
100670924  TSC2; tuberin isoform X4 [KO:K07207]
100671462  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
100660112  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100665518  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100653946  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100671034  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100669799  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100668387  BAD; bcl2-associated agonist of cell death [KO:K02158]
100671240  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100655740  FOXO1; forkhead box protein O1 [KO:K07201]
100674125  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100671706  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100669703  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100668070  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100668683  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104847103  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100655429  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100668342  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100659451  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100668134  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100673196  RB1; retinoblastoma-associated protein [KO:K06618]
100673003  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100660308  RBL2; retinoblastoma-like protein 2 [KO:K16332]
100659329  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100664468  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
100667107  CCNA1; cyclin-A1 [KO:K06627]
100654979  CCNA2; cyclin-A2 [KO:K06627]
100663914  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100661281  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100661392  VEGFA; vascular endothelial growth factor A [KO:K05448]
100664361  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100657363  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100661492  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
100662194  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100654730  RELA; transcription factor p65 isoform X2 [KO:K04735]
100669448  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
100659323  NFX1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
100673540  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100666845  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100671941  CHD4; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
100663850  IRF1; interferon regulatory factor 1 [KO:K09444]
100665593  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
100676280  TBP; TATA-box-binding protein [KO:K03120]
100668871  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
100655144  HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
100656828  HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X1 [KO:K06751]
100653700  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100657492  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100667840  HLA class I histocompatibility antigen, B-40 alpha chain-like isoform X1 [KO:K06751]
100666699  HLA class I histocompatibility antigen, A-3 alpha chain-like isoform X1 [KO:K06751]
100676481  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
100676766  HLA class I histocompatibility antigen, A-3 alpha chain-like isoform X1 [KO:K06751]
100676584  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
100662084  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100661889  HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
100667271  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
100664043  patr class I histocompatibility antigen, A-5 alpha chain-like isoform X1 [KO:K06751]
100666034  HLA class I histocompatibility antigen, Cw-3 alpha chain-like isoform X1 [KO:K06751]
100664893  HLA class I histocompatibility antigen, A-3 alpha chain-like [KO:K06751]
100659386  HLA class I histocompatibility antigen, B-39 alpha chain-like [KO:K06751]
100669340  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
100655504  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
100653567  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
100666832  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
100666469  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100676877  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100665801  ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148]
100658198  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100662195  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100654530  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
100667006  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100668535  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100656481  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100653889  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
100668341  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100670350  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
100661949  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100664975  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100667060  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100662095  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100677484  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
100666036  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
111747829  ATP6V0E2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
100668758  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100669026  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100667446  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
100670137  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
100659125  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100655474  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100657379  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100656200  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100661512  KRAS; GTPase KRas isoform X2 [KO:K07827]
100659051  NRAS; GTPase NRas [KO:K07828]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100657587  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100666359  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100658841  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100655206  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100669226  neuroendocrine secretory protein 55-like [KO:K04632]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100673560  BAX; apoptosis regulator BAX [KO:K02159]
100675162  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100653565  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100673694  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100666211  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100670574  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100677344  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100675079  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100674342  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
100672249  tubulin gamma-1 chain-like [KO:K10389]
100672538  tubulin gamma-2 chain [KO:K10389]
100676056  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
100665583  interferon alpha-5-like [KO:K05414]
100659984  interferon alpha-5-like [KO:K05414]
100660270  interferon alpha-5-like [KO:K05414]
100661986  interferon alpha-5-like [KO:K05414]
100662831  interferon alpha-5-like [KO:K05414]
100663685  interferon alpha-6-like [KO:K05414]
100660554  interferon alpha-5-like [KO:K05414]
100661135  interferon alpha-5-like [KO:K05414]
100667586  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100672898  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100655548  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100672245  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100668424  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100656374  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100673235  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
100665908  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
100672179  2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
100668859  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
100654447  interferon-induced GTP-binding protein Mx1 [KO:K14754]
100654159  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
100654728  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
100661639  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100658294  JAG1; LOW QUALITY PROTEIN: protein jagged-1 [KO:K06052]
100659212  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
100665966  NOTCH2; neurogenic locus notch homolog protein 2 isoform X2 [KO:K20994]
100661550  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
100656367  NOTCH4; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 [KO:K20996]
100669746  PSEN1; LOW QUALITY PROTEIN: presenilin-1 [KO:K04505] [EC:3.4.23.-]
100669607  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
100655946  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
100677356  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
100653892  MAML1; mastermind-like protein 1 isoform X1 [KO:K06061]
100657378  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
100656967  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
100660392  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100660397  HES1; transcription factor HES-1 [KO:K06054]
100671381  HES2; transcription factor HES-2 [KO:K09087]
100666104  HES7; transcription factor HES-7 [KO:K09087]
100671667  HES3; transcription factor HES-3 [KO:K09088]
100675106  HES5; transcription factor HES-5 [KO:K06055]
100661585  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
100657428  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
100660120  HEYL; LOW QUALITY PROTEIN: hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Moody CA, Laimins LA
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
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Chen J
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Reference
PMID:19684440
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Lehoux M, D'Abramo CM, Archambault J
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Public Health Genomics 12:268-80 (2009)
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Reference
PMID:23164805
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Pang CL, Thierry F
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Human papillomavirus proteins as prospective therapeutic targets.
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Microb Pathog 58:55-65 (2013)
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Reference
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  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
PMID:16259056
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Kim YT, Zhao M
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
PMID:15342967
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Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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Shah M, Anwar MA, Park S, Jafri SS, Choi S
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Reference
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Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Reference
PMID:23175122
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Banks L, Pim D, Thomas M
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
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Human papillomaviruses, cervical cancer and cell polarity.
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Oncogene 27:7018-30 (2008)
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
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  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Reference
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Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Mol Cancer 14:87 (2015)
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Reference
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  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
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Mol Cancer 10:140 (2011)
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Reference
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Oncogene 20:7866-73 (2001)
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Reference
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Ganguly N
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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Cell Oncol (Dordr) 35:67-76 (2012)
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The E5 proteins.
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Reference
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Chung CH, Gillison ML
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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Control of interferon signaling in human papillomavirus infection.
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
lav04064  NF-kappa B signaling pathway
lav04110  Cell cycle
lav04115  p53 signaling pathway
lav04150  mTOR signaling pathway
lav04151  PI3K-Akt signaling pathway
lav04210  Apoptosis
lav04310  Wnt signaling pathway
lav04330  Notch signaling pathway
lav04510  Focal adhesion
lav04520  Adherens junction
lav04530  Tight junction
lav04612  Antigen processing and presentation
lav04620  Toll-like receptor signaling pathway
lav04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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