KEGG   PATHWAY: lcat05152
Entry
lcat05152                   Pathway                                
Name
Tuberculosis - Lemur catta (Ring-tailed lemur)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
lcat05152  Tuberculosis
lcat05152

Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123631724  TNF; tumor necrosis factor [KO:K03156]
123640135  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123625188  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
123642797  FADD; FAS-associated death domain protein [KO:K02373]
123643895  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
123643896  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123640175  BID; BH3-interacting domain death agonist [KO:K04726]
123623846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123638028  cytochrome c-like [KO:K08738]
123645426  cytochrome c-like [KO:K08738]
123638197  cytochrome c-like [KO:K08738]
123639916  cytochrome c, somatic-like [KO:K08738]
123647359  cytochrome c, somatic [KO:K08738]
123650585  cytochrome c-like [KO:K08738]
123620171  cytochrome c, somatic-like [KO:K08738]
123643690  cytochrome c 2 [KO:K08738]
123635958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123639404  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123621883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123638072  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
123647608  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123650285  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123627700  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123640661  IFNG; interferon gamma [KO:K04687]
123633306  IFNGR1; interferon gamma receptor 1 [KO:K05132]
123630699  IFNGR2; interferon gamma receptor 2 [KO:K05133]
123635562  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123646669  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
123643619  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
123632375  MHC class II transactivator-like isoform X1 [KO:K08060] [EC:2.7.11.1]
123633973  RFX5; DNA-binding protein RFX5 [KO:K08061]
123638339  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
123649092  regulatory factor X-associated protein [KO:K08063]
123632895  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
123639359  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
123635688  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
123644073  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123631796  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
123631797  HLA class II histocompatibility antigen, DRB1 beta chain-like [KO:K06752]
123631798  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
123631799  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
123631804  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
123631807  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
123631808  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
123631809  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
123631812  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
123631813  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752]
123631814  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
123638068  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
123632318  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
123640316  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
123627137  IL10; interleukin-10 isoform X1 [KO:K05443]
123641528  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
123630695  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
123633923  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
123640070  CLEC4E; LOW QUALITY PROTEIN: C-type lectin domain family 4 member E [KO:K10059]
123635221  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
123640019  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123646461  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
123645793  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
123621595  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
123635459  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
123625037  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
123645000  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
123637825  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
123643337  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
123622343  lipopolysaccharide-binding protein isoform X1 [KO:K05399]
123638501  TLR2; toll-like receptor 2 [KO:K10159]
123637364  toll-like receptor 6 [KO:K05398]
123637365  toll-like receptor 6 [KO:K10169]
123646094  TLR4; toll-like receptor 4 [KO:K10160]
123637863  CD14; monocyte differentiation antigen CD14 [KO:K04391]
123641582  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
123627174  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
123639836  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
123628474  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
123623057  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
123642600  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123620296  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123646908  IL6; interleukin-6 [KO:K05405]
123646097  IL12A; interleukin-12 subunit alpha [KO:K05406]
123638007  IL12B; interleukin-12 subunit beta [KO:K05425]
123641690  IL18; interleukin-18 [KO:K05482]
123639651  IL23A; interleukin-23 subunit alpha [KO:K05426]
123636470  IL1A; interleukin-1 alpha [KO:K04383]
123637166  IL1B; interleukin-1 beta [KO:K04519]
123622718  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
123624275  CEBPG; CCAAT/enhancer-binding protein gamma isoform X1 [KO:K10049]
123623201  TLR9; toll-like receptor 9 [KO:K10161]
123645632  interferon alpha-5-like [KO:K05414]
123645638  interferon alpha-10-like [KO:K05414]
123645752  interferon alpha-5-like [KO:K05414]
123645754  interferon alpha-5-like [KO:K05414]
123645755  interferon alpha-5-like [KO:K05414]
123645758  interferon alpha-10-like [KO:K05414]
123646712  interferon alpha-5-like [KO:K05414]
123646249  IFNB1; interferon beta [KO:K05415]
123635417  CD209 antigen-like protein 2 isoform X1 [KO:K06563]
123635437  LOW QUALITY PROTEIN: CD209 antigen-like [KO:K06563]
123641456  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
123623278  RHOA; transforming protein RhoA [KO:K04513]
123643616  transforming protein RhoA-like [KO:K04513]
123642911  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
123634221  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
123620298  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123624079  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123626839  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123646462  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
123639587  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
123640468  VDR; vitamin D3 receptor [KO:K08539]
123623322  cathelicidin antimicrobial peptide [KO:K13916]
123635930  C3; complement C3 [KO:K03990]
123626890  CR1; complement receptor type 1 isoform X1 [KO:K04011]
123632034  LOW QUALITY PROTEIN: integrin alpha-X-like [KO:K06462]
123630775  LOW QUALITY PROTEIN: integrin beta-2-like [KO:K06464]
123630818  ITGB2; integrin beta-2 [KO:K06464]
123632686  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123625713  MRC1; macrophage mannose receptor 1 [KO:K06560]
123620577  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
123643520  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
123623864  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
123620485  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
123636893  CALM2; calmodulin-2 [KO:K02183]
123645611  CALM1; calmodulin-1 [KO:K02183]
123623035  CALML3; calmodulin-like protein 3 [KO:K02183]
123623036  CALML5; calmodulin-like protein 5 [KO:K02183]
123631755  CALML4; calmodulin-like protein 4 [KO:K02183]
123623919  CALM3; calmodulin-3 [KO:K02183]
123634905  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123636681  calmodulin-alpha-like [KO:K02183]
123621514  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
123628394  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
123639672  RAB5B; ras-related protein Rab-5B [KO:K07888]
123620954  RAB5C; ras-related protein Rab-5C [KO:K07889]
123639450  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
123625652  RAB7A; LOW QUALITY PROTEIN: ras-related protein Rab-7a [KO:K07897]
123642904  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
123620962  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
123647669  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
123626127  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
123642821  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
123644814  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
123625207  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
123644739  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
123628492  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
123631502  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
123634235  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
123628798  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
123648819  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
123626515  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123650296  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123627290  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123636996  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123645740  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123632780  CORO1A; coronin-1A [KO:K13882]
123643379  LOW QUALITY PROTEIN: uncharacterized protein LOC123643379 [KO:K06856]
123643441  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
123643449  immunoglobulin delta heavy chain-like [KO:K06856]
123643456  immunoglobulin epsilon heavy chain-like [KO:K06856]
123643464  uncharacterized protein LOC123643464 [KO:K06856]
123633892  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498]
123635230  low affinity immunoglobulin gamma Fc region receptor II-b-like isoform X1 [KO:K12560]
123635228  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A isoform X1 [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
lcat04010  MAPK signaling pathway
lcat04210  Apoptosis
lcat04612  Antigen processing and presentation
lcat04620  Toll-like receptor signaling pathway
lcat04621  NOD-like receptor signaling pathway
lcat04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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