KEGG   PATHWAY: leri05168
Entry
leri05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Leucoraja erinacea (little skate)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
leri05168  Herpes simplex virus 1 infection
leri05168

Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129694587  lymphotoxin-alpha-like [KO:K05468]
129694588  lymphotoxin-alpha-like [KO:K05468]
129711535  tumor necrosis factor receptor superfamily member 4-like isoform X1 [KO:K05152]
129711587  tumor necrosis factor receptor superfamily member 9-like [KO:K05152]
129711746  uncharacterized protein LOC129711746 isoform X1 [KO:K05152]
129711747  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
129711750  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
129714666  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
129711946  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
129693903  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
129694202  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
129699700  TNF receptor-associated factor 5-like isoform X1 [KO:K09849]
129713371  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129712925  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
129700231  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
129714112  NF-kappa-B inhibitor alpha-like [KO:K04734]
129702259  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
129698291  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
129712274  nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081]
129715269  nectin-1-like [KO:K06081]
129694764  LOW QUALITY PROTEIN: nectin-1-like [KO:K06531]
129694155  nectin-1-like [KO:K06531]
129693762  paired immunoglobulin-like type 2 receptor beta [KO:K15411]
129709167  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129711714  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
129714792  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
129710216  integrin beta-3-like [KO:K06493]
129707364  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
129695688  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
129712083  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
129714485  complement C3-like [KO:K03990]
129711789  c5; complement C5 [KO:K03994]
129694030  properdin-like [KO:K15412]
129702580  tlr2; toll-like receptor 2 [KO:K10159]
129701139  prg4b; proteoglycan 4b isoform X1 [KO:K10159]
129715134  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129695209  tlr3; toll-like receptor 3 [KO:K05401]
129706494  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
129704564  interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04730] [EC:2.7.11.1]
129716210  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
129705871  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
129697362  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129713740  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
129699346  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129713422  interleukin-1 beta-like [KO:K04519]
129705909  interleukin-6-like [KO:K05405]
129712701  il6; interleukin-6 [KO:K05405]
129694589  tumor necrosis factor-like [KO:K03156]
129694591  lymphotoxin-alpha-like [KO:K03156]
129715888  tumor necrosis factor-like [KO:K03156]
129703696  il12a; interleukin-12 subunit alpha [KO:K05406]
129694839  interleukin-12 subunit beta-like [KO:K05425]
129701885  interleukin-12 subunit beta-like [KO:K05425]
129695487  rigi; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
129698833  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
129700569  traf3; TNF receptor-associated factor 3 [KO:K03174]
129714099  TNF receptor-associated factor 3-like [KO:K03174]
129706378  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
129708572  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K05410] [EC:2.7.11.10]
129710038  interferon alpha-10-like [KO:K05414]
129710039  interferon alpha-2-like [KO:K05414]
129710040  interferon alpha-F-like [KO:K05414]
129710041  interferon alpha-2-like [KO:K05414]
129710045  interferon alpha-B-like isoform X1 [KO:K05414]
129710046  interferon alpha-21-like [KO:K05414]
129710396  interferon alpha-1/13-like [KO:K05414]
129710398  interferon tau-3-like [KO:K05414]
129710399  interferon alpha-1-like isoform X1 [KO:K05414]
129710400  interferon tau-3-like [KO:K05414]
129710401  interferon tau-3-like [KO:K05414]
129697021  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
129701715  sting1; stimulator of interferon genes protein [KO:K12654]
129709421  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
129697622  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129693451  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
129706932  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
129696980  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
129702561  eif2ak3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
129700512  eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
129700347  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
129709239  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
129700101  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
129700861  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
129697400  eif2b4; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit delta [KO:K03680]
129703401  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
129701072  LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease-like [KO:K01165]
129704671  LOW QUALITY PROTEIN: host cell factor 1-like [KO:K14966]
129706372  host cell factor 2-like [KO:K27390]
129702552  pou2f1b; POU domain, class 2, transcription factor 1b isoform X1 [KO:K09364]
129712379  pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
129708237  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
129701095  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129714534  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
129698644  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
129714674  signal transducer and activator of transcription 1-like isoform X1 [KO:K11220]
129694696  zinc finger protein 135-like [KO:K09228]
129694724  gastrula zinc finger protein XlCGF64.1-like [KO:K09228]
129694744  zinc finger protein 615-like [KO:K09228]
129695024  zinc finger protein 229-like [KO:K09228]
129695116  zinc finger protein 16-like [KO:K09228]
129695174  zinc finger protein 239-like [KO:K09228]
129705990  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
129713588  zinc finger protein 239-like [KO:K09228]
129697616  zinc finger protein 239-like [KO:K09228]
129697642  zinc finger protein OZF-like [KO:K09228]
129699558  zinc finger protein 664-like isoform X1 [KO:K09228]
129703864  zinc finger protein 585A-like [KO:K09228]
129707798  zinc finger protein 239-like [KO:K09228]
129693548  LOW QUALITY PROTEIN: zinc finger protein 239-like [KO:K09228]
129693632  zinc finger protein 239-like [KO:K09228]
129693658  zinc finger protein GLI4-like [KO:K09228]
129693898  zinc finger protein 239-like [KO:K09228]
129693985  zinc finger protein 432-like [KO:K09228]
129704304  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
129704312  zinc finger protein 420-like [KO:K09228]
129704319  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
129704324  zinc finger protein 239-like isoform X1 [KO:K09228]
129704331  zinc finger protein 239-like [KO:K09228]
129704338  zinc finger protein 34-like [KO:K09228]
129704341  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
129704362  zinc finger protein 239-like [KO:K09228]
129694223  zinc finger protein 239-like [KO:K09228]
129694361  zinc finger protein 239-like [KO:K09228]
129694412  zinc finger protein 239-like [KO:K09228]
129694605  zinc finger protein OZF-like [KO:K09228]
129708708  zinc finger protein 771-like [KO:K09228]
129715299  zinc finger protein 239-like [KO:K09228]
129715528  zinc finger protein 239-like [KO:K09228]
129715666  histone-lysine N-methyltransferase PRDM9-like [KO:K09228]
129715800  zinc finger protein 391-like [KO:K09228]
129715815  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
129715860  zinc finger protein 135-like [KO:K09228]
129715956  zinc finger protein 239-like [KO:K09228]
129695436  tyrosine-protein kinase JAK2-like isoform X1 [KO:K04447] [EC:2.7.10.2]
129711208  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
129715263  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
129709515  uncharacterized protein LOC129709515 [KO:K10054] [EC:2.3.2.-]
129709516  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
129694074  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
129694463  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
129693359  antigen peptide transporter 2-like isoform X1 [KO:K05654] [EC:7.4.2.14]
129694462  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
129693422  tapasin-like [KO:K08058]
129712562  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
129711230  calr3a; calreticulin 3a [KO:K08057]
129700932  calr; calreticulin isoform X1 [KO:K08057]
129714497  calreticulin-like [KO:K08057]
129693670  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
129693831  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
129694076  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
129715938  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
129715939  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129716033  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
129716227  beta-2-microglobulin-like [KO:K08055]
129694455  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
129701569  HLA class II histocompatibility antigen gamma chain-like isoform X1 [KO:K06505]
129703732  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129711734  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
129695104  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
129700904  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
129699479  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129714205  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129712070  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
129706968  tsc2; tuberin isoform X1 [KO:K07207]
129714366  rheb; GTP-binding protein Rheb [KO:K07208]
129714726  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
129711647  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129708703  SRSF protein kinase 1-like [KO:K15409] [EC:2.7.11.1]
129710514  serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
129708445  serine/arginine-rich splicing factor 2-like [KO:K12891]
129708794  srsf3b; serine/arginine-rich splicing factor 3b [KO:K12892]
129713976  serine/arginine-rich splicing factor 3-like [KO:K12892]
129709887  serine/arginine-rich splicing factor 4-like isoform X1 [KO:K12893]
129707555  srsf6a; serine and arginine rich splicing factor 6a [KO:K12893]
129700374  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
129700375  serine/arginine-rich splicing factor 5-like [KO:K12893]
129700377  serine/arginine-rich splicing factor 5-like [KO:K12893]
129714139  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 5-like [KO:K12893]
129699504  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
129714257  srsf7a; serine and arginine rich splicing factor 7a [KO:K12896]
129709125  serine/arginine-rich splicing factor 1B-like [KO:K21123]
129693542  nxf1b; nuclear RNA export factor 1 isoform X1 [KO:K14284]
129708185  alyref; THO complex subunit 4 [KO:K12881]
129701294  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
129701295  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
129715694  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
129704265  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
129713374  uncharacterized protein LOC129713374 isoform X1 [KO:K03158]
129705160  tradd; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129698865  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
129706074  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
129705596  zgc:153993; apoptosis regulator BAX [KO:K02159]
129713845  apoptosis regulator BAX-like isoform X1 [KO:K02159]
129706538  bcl-2 homologous antagonist/killer-like [KO:K14021]
129708611  bcl-2 homologous antagonist/killer-like [KO:K14021]
129711578  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129707227  bcl2l1; bcl-2-like protein 1 [KO:K04570]
129698706  cytochrome c 2-like [KO:K08738]
129711636  cytochrome c, testis-specific [KO:K08738]
129707730  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129711508  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129695247  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
leri03040  Spliceosome
leri03050  Proteasome
leri04115  p53 signaling pathway
leri04210  Apoptosis
leri04620  Toll-like receptor signaling pathway
leri04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
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