Entry Name Herpes simplex virus 1 infection - Leucoraja erinaceus (little skate)
Description Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Disease H00365 Herpes simplex virus infection
Organism Leucoraja erinaceus (little skate) [GN:
leri ]
Gene 129697400 eif2b4; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit delta [KO:K03680 ]
129698833 ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647 ] [EC:5.6.2.6 ]
129699346 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
129700101 eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754 ]
129700231 nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734 ]
129700861 eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241 ]
129700904 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
129702552 pou2f1b; POU domain, class 2, transcription factor 1b isoform X1 [KO:K09364 ]
129702561 eif2ak3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860 ] [EC:2.7.11.1 ]
129703401 eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
129703732 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
129705160 tradd; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
129707730 apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
129709239 eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239 ]
129711734 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
129712083 card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
129712274 nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081 ]
129713371 ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209 ] [EC:2.7.11.10 ]
129713740 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
129715134 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Granger SW, Rickert S
Title LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal Reference Authors Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal Reference Authors MacLeod IJ, Minson T
Title Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal Reference Authors Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal Reference Authors Gianni T, Campadelli-Fiume G
Title The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal Reference Authors Spear PG
Title Herpes simplex virus: receptors and ligands for cell entry.
Journal Reference Authors Boutell C, Everett RD
Title The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal Reference Authors Ma Y, He B
Title Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal Reference Authors Su C, Zhan G, Zheng C
Title Evasion of host antiviral innate immunity by HSV-1, an update.
Journal Reference Authors Melchjorsen J, Matikainen S, Paludan SR
Title Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal Reference Authors Morrison LA
Title The Toll of herpes simplex virus infection.
Journal Reference Authors Zheng C
Title Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal Reference Authors Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal Reference Authors Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal Reference Authors Sanchez R, Mohr I
Title Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal Reference Authors Wysocka J, Herr W
Title The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal Reference Authors Fleming SB
Title Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal Reference Authors Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal Reference Authors Gu H, Zheng Y, Roizman B
Title Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal Reference Authors Tavalai N, Stamminger T
Title Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal Reference Authors Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal Reference Authors Neumann J, Eis-Hubinger AM, Koch N
Title Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal Reference Authors Liu X, Cohen JI
Title The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal Reference Authors Vink EI, Smiley JR, Mohr I
Title Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal Reference Authors Sandri-Goldin RM
Title The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal Reference Authors Sandri-Goldin RM
Title Viral regulation of mRNA export.
Journal Reference Authors Yu X, He S
Title The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal Related leri04620 Toll-like receptor signaling pathway
leri04622 RIG-I-like receptor signaling pathway
KO pathway
