Entry
Name
Influenza A - Macaca fascicularis (crab-eating macaque)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Macaca fascicularis (crab-eating macaque) [GN:
mcf ]
Gene
102128205 TMPRSS4; transmembrane protease serine 4 isoform X1 [KO:K09635 ] [EC:3.4.21.-]
102133163 TMPRSS11D; transmembrane protease serine 11D isoform X2 [KO:K09641 ] [EC:3.4.21.-]
102124745 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
101925386 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
102138273 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
101865725 CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348 ]
101866832 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
101925134 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
102133020 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
102136468 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752 ]
102137481 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
102140649 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
102139994 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
102145413 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
102132662 HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752 ]
102144414 HLA class II histocompatibility antigen, DR beta 5 chain isoform X1 [KO:K06752 ]
102144039 mamu class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
102136862 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
102133044 HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752 ]
123572852 H-2 class II histocompatibility antigen, A-D alpha chain-like [KO:K06752 ]
123572854 class II histocompatibility antigen, B-L beta chain-like [KO:K06752 ]
123572909 mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
102142532 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
102144771 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
102137291 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
101866246 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
102124804 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
102143464 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102142026 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102122725 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101864918 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
102139560 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
102133727 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
102139406 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
102135285 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
102125087 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171 ]
101864983 VDAC1; voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862 ]
102131983 CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404 ]
102141375 CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X2 [KO:K14404 ]
102123787 PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396 ]
102133156 LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284 ]
102126742 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047 ]
123569134 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein U-like protein 1 [KO:K15047 ]
102130385 NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297 ]
102135085 RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Edinger TO, Pohl MO, Stertz S
Title
Entry of influenza A virus: host factors and antiviral targets.
Journal
Reference
Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
Journal
J Mol Genet Med 3:167-75 (2008)
Reference
Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Journal
Reference
Authors
Thanh TT, van Doorn HR, de Jong MD
Title
Human H5N1 influenza: current insight into pathogenesis.
Journal
Reference
Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Title
Influenza A induced cellular signal transduction pathways.
Journal
Reference
Authors
Hale BG, Albrecht RA, Garcia-Sastre A
Title
Innate immune evasion strategies of influenza viruses.
Journal
Reference
Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Journal
Reference
Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Title
Interplay between influenza A virus and the innate immune signaling.
Journal
Reference
Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title
Evasion of influenza A viruses from innate and adaptive immune responses.
Journal
Reference
Authors
Long JS, Mistry B, Haslam SM, Barclay WS
Title
Host and viral determinants of influenza A virus species specificity.
Journal
Reference
Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Title
Host Immune Response to Influenza A Virus Infection.
Journal
Reference
Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
Journal
Reference
Authors
Ichinohe T, Iwasaki A, Hasegawa H
Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Journal
Reference
Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Journal
Reference
Authors
Fan Y, Sanyal S, Bruzzone R
Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal
Reference
Authors
Varga ZT, Palese P
Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
Journal
Reference
Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
Title
The induction and consequences of Influenza A virus-induced cell death.
Journal
Reference
Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Journal
Reference
Authors
Dai X, Zhang L, Hong T
Title
Host cellular signaling induced by influenza virus.
Journal
Reference
Authors
Li J, Yu M, Zheng W, Liu W
Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
Journal
Reference
Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Journal
Reference
Authors
Paterson D, Fodor E
Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
Journal
Related pathway
mcf00900 Terpenoid backbone biosynthesis
mcf04620 Toll-like receptor signaling pathway
mcf04621 NOD-like receptor signaling pathway
mcf04622 RIG-I-like receptor signaling pathway
KO pathway
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